Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Kellie N. Smith, Nicolas J. Llosa, Tricia R. Cottrell, Nicholas Siegel, Hongni Fan, Prerna Suri, Hok Yee Chan, Haidan Guo, Teniola Oke, Anas H. Awan, Franco Verde, Ludmila Danilova, Valsamo Anagnostou, Ada J. Tam, Brandon S. Luber, Bjarne R. Bartlett, Laveet K. Aulakh, John-William Sidhom, Qingfeng Zhu, Cynthia L. Sears, Leslie Cope, William H. Sharfman, Elizabeth D. Thompson, Joanne Riemer, Kristen A. Marrone, Jarushka Naidoo, Victor E. Velculescu, Patrick M. Forde, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Jennifer N. Durham, Hao Wang, Dung T. Le, Sune Justesen, Janis M. Taube, Luis A. Diaz, Julie R. Brahmer, Drew M. Pardoll, Robert A. Anders, Franck Housseau

ABSTRACT

BACKGROUND: Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (NSCLC) patients, with tumor mutational burden (TMB) also being explored with promising results, and mismatch-repair deficiency is approved for tumor site-agnostic disease. While tumors with high PD-L1 expression, high TMB, or mismatch repair deficiency respond well to checkpoint blockade, tumors with lower PD-L1 expression, lower mutational burdens, or mismatch repair proficiency respond much less frequently. CASE PRESENTATION: We studied two patients with unexpected responses to checkpoint blockade monotherapy: a patient with PD-L1-negative and low mutational burden NSCLC and one with mismatch repair proficient colorectal cancer (CRC), both of whom lack the biomarkers associated with response to checkpoint blockade, yet achieved durable clinical benefit. Both maintained T-cell responses in peripheral blood to oncogenic driver mutations - BRAF-N581I in the NSCLC and AKT1-E17K in the CRC - years after treatment initiation. Mutation-specific T cells were also found in the primary tumor and underwent dynamic perturbations in the periphery upon treatment. CONCLUSIONS: These findings suggest that T cell responses to oncogenic driver mutations may be more prevalent than previously appreciated and could be harnessed in immunotherapeutic treatment, particularly for patients who lack the traditional biomarkers associated with response. Comprehensive studies are warranted to further delineate additional predictive biomarkers and populations of patients who may benefit from checkpoint blockade. More... »

PAGES

40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-018-0492-x

DOI

http://dx.doi.org/10.1186/s40425-018-0492-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112064826

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30744692


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Kellie N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Llosa", 
        "givenName": "Nicolas J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cottrell", 
        "givenName": "Tricia R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Siegel", 
        "givenName": "Nicholas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fan", 
        "givenName": "Hongni", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suri", 
        "givenName": "Prerna", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Hok Yee", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Haidan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oke", 
        "givenName": "Teniola", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Awan", 
        "givenName": "Anas H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verde", 
        "givenName": "Franco", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "Division of Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Danilova", 
        "givenName": "Ludmila", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anagnostou", 
        "givenName": "Valsamo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tam", 
        "givenName": "Ada J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Division of Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luber", 
        "givenName": "Brandon S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hawaii at Manoa", 
          "id": "https://www.grid.ac/institutes/grid.410445.0", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "The Swim Across America Laboratory, John Hopkins University, Baltimore, MD, USA", 
            "Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA", 
            "Present address: B.R.B.,Bioinformatics Core, Department of Complementary & Integrative Medicine, University of Hawaii John A. Burns School of Medicine, 96813, Honolulu, HI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bartlett", 
        "givenName": "Bjarne R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "The Swim Across America Laboratory, John Hopkins University, Baltimore, MD, USA", 
            "Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aulakh", 
        "givenName": "Laveet K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sidhom", 
        "givenName": "John-William", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Qingfeng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sears", 
        "givenName": "Cynthia L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "Division of Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cope", 
        "givenName": "Leslie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharfman", 
        "givenName": "William H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "The Swim Across America Laboratory, John Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Elizabeth D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riemer", 
        "givenName": "Joanne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marrone", 
        "givenName": "Kristen A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naidoo", 
        "givenName": "Jarushka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velculescu", 
        "givenName": "Victor E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forde", 
        "givenName": "Patrick M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogelstein", 
        "givenName": "Bert", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinzler", 
        "givenName": "Kenneth W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papadopoulos", 
        "givenName": "Nickolas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Durham", 
        "givenName": "Jennifer N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "Division of Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Hao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le", 
        "givenName": "Dung T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Immunitrack, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Justesen", 
        "givenName": "Sune", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taube", 
        "givenName": "Janis M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "The Swim Across America Laboratory, John Hopkins University, Baltimore, MD, USA", 
            "Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diaz", 
        "givenName": "Luis A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brahmer", 
        "givenName": "Julie R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pardoll", 
        "givenName": "Drew M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA", 
            "Department of Pathology, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anders", 
        "givenName": "Robert A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA", 
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Housseau", 
        "givenName": "Franck", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/scitranslmed.aaa7161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002663197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-3271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004953031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011831914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023428666", 
          "https://doi.org/10.1038/nature05933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029134323", 
          "https://doi.org/10.1038/ncomms3680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-14-0863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029393757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032743970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2004088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033807182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1609279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033979635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(16)30624-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034482273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.12.7890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038699738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2004.022509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041261124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1302101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042011023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-15-0062-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049564054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1500596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053017729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa1348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062665078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa1348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062665078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/ajcp85atmjozoudj", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064985054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082399402", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan6733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan6733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature23291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090947343", 
          "https://doi.org/10.1038/nature23291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature23291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090947343", 
          "https://doi.org/10.1038/nature23291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci98689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100591040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12865-018-0250-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101678663", 
          "https://doi.org/10.1186/s12865-018-0250-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12865-018-0250-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101678663", 
          "https://doi.org/10.1186/s12865-018-0250-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12865-018-0250-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101678663", 
          "https://doi.org/10.1186/s12865-018-0250-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12865-018-0250-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101678663", 
          "https://doi.org/10.1186/s12865-018-0250-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1801946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103285297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtho.2018.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103687032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2326-6066.cir-18-0129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104545106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2326-6066.cir-18-0129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104545106"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (NSCLC) patients, with tumor mutational burden (TMB) also being explored with promising results, and mismatch-repair deficiency is approved for tumor site-agnostic disease. While tumors with high PD-L1 expression, high TMB, or mismatch repair deficiency respond well to checkpoint blockade, tumors with lower PD-L1 expression, lower mutational burdens, or mismatch repair proficiency respond much less frequently.\nCASE PRESENTATION: We studied two patients with unexpected responses to checkpoint blockade monotherapy: a patient with PD-L1-negative and low mutational burden NSCLC and one with mismatch repair proficient colorectal cancer (CRC), both of whom lack the biomarkers associated with response to checkpoint blockade, yet achieved durable clinical benefit. Both maintained T-cell responses in peripheral blood to oncogenic driver mutations - BRAF-N581I in the NSCLC and AKT1-E17K in the CRC - years after treatment initiation. Mutation-specific T cells were also found in the primary tumor and underwent dynamic perturbations in the periphery upon treatment.\nCONCLUSIONS: These findings suggest that T cell responses to oncogenic driver mutations may be more prevalent than previously appreciated and could be harnessed in immunotherapeutic treatment, particularly for patients who lack the traditional biomarkers associated with response. Comprehensive studies are warranted to further delineate additional predictive biomarkers and populations of patients who may benefit from checkpoint blockade.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40425-018-0492-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440141", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438791", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439055", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5476950", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3624253", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4455503", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2478763", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1", 
    "pagination": "40", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "312ab6e032a57f42ada50cea8d89f17760e804dfd9986e8e9de3b816315345b6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30744692"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40425-018-0492-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112064826"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40425-018-0492-x", 
      "https://app.dimensions.ai/details/publication/pub.1112064826"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000353_0000000353/records_45345_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40425-018-0492-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0492-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0492-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0492-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0492-x'


 

This table displays all metadata directly associated to this object as RDF triples.

419 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40425-018-0492-x schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nb8ac8f4638574ac5a65dfe88474a1b81
4 schema:citation sg:pub.10.1038/nature05933
5 sg:pub.10.1038/nature23291
6 sg:pub.10.1038/ncomms3680
7 sg:pub.10.1186/s12865-018-0250-3
8 https://app.dimensions.ai/details/publication/pub.1082399402
9 https://doi.org/10.1016/j.jtho.2018.04.024
10 https://doi.org/10.1016/s1470-2045(16)30624-6
11 https://doi.org/10.1056/nejmoa1500596
12 https://doi.org/10.1056/nejmoa1609279
13 https://doi.org/10.1056/nejmoa1801946
14 https://doi.org/10.1126/science.aaa1348
15 https://doi.org/10.1126/science.aan6733
16 https://doi.org/10.1126/scisignal.2004088
17 https://doi.org/10.1126/scitranslmed.aaa7161
18 https://doi.org/10.1136/jcp.2004.022509
19 https://doi.org/10.1158/0008-5472.can-03-3231
20 https://doi.org/10.1158/1078-0432.ccr-13-3271
21 https://doi.org/10.1158/1541-7786.mcr-15-0062-t
22 https://doi.org/10.1158/2159-8290.cd-12-0095
23 https://doi.org/10.1158/2159-8290.cd-14-0863
24 https://doi.org/10.1158/2326-6066.cir-18-0129
25 https://doi.org/10.1172/jci98689
26 https://doi.org/10.1309/ajcp85atmjozoudj
27 https://doi.org/10.4049/jimmunol.1302101
28 https://doi.org/10.4049/jimmunol.178.12.7890
29 schema:datePublished 2019-12
30 schema:datePublishedReg 2019-12-01
31 schema:description BACKGROUND: Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (NSCLC) patients, with tumor mutational burden (TMB) also being explored with promising results, and mismatch-repair deficiency is approved for tumor site-agnostic disease. While tumors with high PD-L1 expression, high TMB, or mismatch repair deficiency respond well to checkpoint blockade, tumors with lower PD-L1 expression, lower mutational burdens, or mismatch repair proficiency respond much less frequently. CASE PRESENTATION: We studied two patients with unexpected responses to checkpoint blockade monotherapy: a patient with PD-L1-negative and low mutational burden NSCLC and one with mismatch repair proficient colorectal cancer (CRC), both of whom lack the biomarkers associated with response to checkpoint blockade, yet achieved durable clinical benefit. Both maintained T-cell responses in peripheral blood to oncogenic driver mutations - BRAF-N581I in the NSCLC and AKT1-E17K in the CRC - years after treatment initiation. Mutation-specific T cells were also found in the primary tumor and underwent dynamic perturbations in the periphery upon treatment. CONCLUSIONS: These findings suggest that T cell responses to oncogenic driver mutations may be more prevalent than previously appreciated and could be harnessed in immunotherapeutic treatment, particularly for patients who lack the traditional biomarkers associated with response. Comprehensive studies are warranted to further delineate additional predictive biomarkers and populations of patients who may benefit from checkpoint blockade.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N5930871ae8454dc0ba0dba29fcff7e05
36 N8765f784ccc44e78a148e415fc50606e
37 sg:journal.1049249
38 schema:name Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
39 schema:pagination 40
40 schema:productId N5603d35276794ed79f7b889a6c5b4b25
41 N873e7a2dad0140d48ef8e1035179b630
42 Na5b0d45d032b4eb49969d4256b7dbb4e
43 Nd271193cd85c4047a1dfdd7786fa5a07
44 Nd53887d289b74083a892693f251704da
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112064826
46 https://doi.org/10.1186/s40425-018-0492-x
47 schema:sdDatePublished 2019-04-11T11:10
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher Ne37166216e9848ff87022516a20faaf8
50 schema:url https://link.springer.com/10.1186%2Fs40425-018-0492-x
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N021c110ce1b24164ba84ac94d20bb388 rdf:first N68c9175fee8c42e598e328053e775d50
55 rdf:rest N0d7ddd459fbd45e089b1a32fac4b2f74
56 N034fcb3a782a4e26b85bf4bab8634e7d schema:affiliation https://www.grid.ac/institutes/grid.21107.35
57 schema:familyName Luber
58 schema:givenName Brandon S.
59 rdf:type schema:Person
60 N04c79fedfd6f48ef8faafd709b7bf335 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
61 schema:familyName Oke
62 schema:givenName Teniola
63 rdf:type schema:Person
64 N05965ad555be425a86e7e6cc4602db74 rdf:first N259da4e817ce4455aa843dc7fa99bef9
65 rdf:rest Nb8880ced6f89472cbcf04ce7670acbc2
66 N08668a3b4f374dcfa51d09e5893d535c schema:affiliation Nf69625549bf64164b0b57e72e1fcaeee
67 schema:familyName Justesen
68 schema:givenName Sune
69 rdf:type schema:Person
70 N0b7e6d47530d42feb3b5790651eeb7e8 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
71 schema:familyName Awan
72 schema:givenName Anas H.
73 rdf:type schema:Person
74 N0d7ddd459fbd45e089b1a32fac4b2f74 rdf:first Nd061317d1a364c60a17ab7eb4aa072f7
75 rdf:rest Nf18953212c464f8087ddb69566e89264
76 N0d95106848674b5a9100ca60b6ccdc8b rdf:first N95fadffacf29448892412fb9341d3815
77 rdf:rest Ncbe4b9020c6e45fd9e1e876c19bae9e4
78 N0ed91adac8e54da0aa7ac32845639c72 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
79 schema:familyName Anagnostou
80 schema:givenName Valsamo
81 rdf:type schema:Person
82 N15db19e613ac434c90160377a66dd549 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
83 schema:familyName Guo
84 schema:givenName Haidan
85 rdf:type schema:Person
86 N1679d7dfca7948128e908415e48bad57 rdf:first N6c7935b54d3a4e958bbafef262d373fe
87 rdf:rest N0d95106848674b5a9100ca60b6ccdc8b
88 N1d385105f54143e296021ae27c3c01dd rdf:first Ne83a676d08ed4e0181421e72264c5c8b
89 rdf:rest Ne34d5d3e8bef480597876251b2a8138f
90 N259da4e817ce4455aa843dc7fa99bef9 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
91 schema:familyName Pardoll
92 schema:givenName Drew M.
93 rdf:type schema:Person
94 N2633995d228e45b3b4b32af008e6aaa0 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
95 schema:familyName Siegel
96 schema:givenName Nicholas
97 rdf:type schema:Person
98 N265463a34ae344b6a43ee2f1df686a07 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
99 schema:familyName Sidhom
100 schema:givenName John-William
101 rdf:type schema:Person
102 N2686557cbba2495186c27ab1a98b625b schema:affiliation https://www.grid.ac/institutes/grid.410445.0
103 schema:familyName Bartlett
104 schema:givenName Bjarne R.
105 rdf:type schema:Person
106 N2b76865e04ef41b695776d3aa49e8b3c schema:affiliation https://www.grid.ac/institutes/grid.21107.35
107 schema:familyName Naidoo
108 schema:givenName Jarushka
109 rdf:type schema:Person
110 N2cf594c6a3a94770951c8df36f7d92ab rdf:first N2b76865e04ef41b695776d3aa49e8b3c
111 rdf:rest N471b383de6da4e768e33bbe3e10055f9
112 N2d680c7d135b46aab09db53cd2fae817 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
113 schema:familyName Zhu
114 schema:givenName Qingfeng
115 rdf:type schema:Person
116 N2f0dbfe3738648898028c46a4085f58f schema:affiliation https://www.grid.ac/institutes/grid.21107.35
117 schema:familyName Forde
118 schema:givenName Patrick M.
119 rdf:type schema:Person
120 N390b8da265314fbba049e5edfc04756f schema:affiliation https://www.grid.ac/institutes/grid.21107.35
121 schema:familyName Marrone
122 schema:givenName Kristen A.
123 rdf:type schema:Person
124 N3b382f6fea3343e39544a7b0054db142 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
125 schema:familyName Brahmer
126 schema:givenName Julie R.
127 rdf:type schema:Person
128 N3b9e3bf47517449181cc9ccc15be0374 rdf:first N8de12d1639774f45ae9f2d6aa31d3587
129 rdf:rest Ned5ad664e5a64a4da24e8c89b258b5e6
130 N3eb7afea3f664ddca9bbfae9b310cfa5 rdf:first N08668a3b4f374dcfa51d09e5893d535c
131 rdf:rest N9474e991f2f74f01ac0754545e74de73
132 N40c99cfa5a3648bcb88ca5983a0163da rdf:first N390b8da265314fbba049e5edfc04756f
133 rdf:rest N2cf594c6a3a94770951c8df36f7d92ab
134 N4336a8ddc7f8458e935396db8ea2d7dc schema:affiliation https://www.grid.ac/institutes/grid.21107.35
135 schema:familyName Anders
136 schema:givenName Robert A.
137 rdf:type schema:Person
138 N471b383de6da4e768e33bbe3e10055f9 rdf:first Nbfc909bbbef04373a19f4827e3a8c98e
139 rdf:rest Nfce012a5688b46a7afb31cb530708a94
140 N4b01bb2998e74a81bb620859b7b12ab0 rdf:first N66c85c1181764e349dd2296e2e27e3c5
141 rdf:rest N9e3788b04f304e7a8bb3c92f7447fd1f
142 N4d576a2d539e476885b1dbe62ec0bf05 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
143 schema:familyName Kinzler
144 schema:givenName Kenneth W.
145 rdf:type schema:Person
146 N4e53f0c7a5ff49658e66b150dac8fff3 rdf:first N92d854efc2c646a3b822c14cda22c2cc
147 rdf:rest Nc20a3e338e5c43478176181979c7f737
148 N50d8e96dcb7742cab9f41737b2090623 rdf:first N8b9f10286a0e42798cbd02b10c9704ee
149 rdf:rest Nc119e53db5064576820aa3146c249ee2
150 N5435639e20da49fbb2daa7109ed1106a schema:affiliation https://www.grid.ac/institutes/grid.21107.35
151 schema:familyName Le
152 schema:givenName Dung T.
153 rdf:type schema:Person
154 N5603d35276794ed79f7b889a6c5b4b25 schema:name pubmed_id
155 schema:value 30744692
156 rdf:type schema:PropertyValue
157 N5930871ae8454dc0ba0dba29fcff7e05 schema:volumeNumber 7
158 rdf:type schema:PublicationVolume
159 N65b471773b0442768f1cfd051e4bfdc7 rdf:first Nfff06fae80f9476cba5a890bd5b32651
160 rdf:rest N1679d7dfca7948128e908415e48bad57
161 N66c85c1181764e349dd2296e2e27e3c5 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
162 schema:familyName Papadopoulos
163 schema:givenName Nickolas
164 rdf:type schema:Person
165 N6870dbbd642545a1b2c77019426a38fb schema:affiliation https://www.grid.ac/institutes/grid.21107.35
166 schema:familyName Riemer
167 schema:givenName Joanne
168 rdf:type schema:Person
169 N68c9175fee8c42e598e328053e775d50 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
170 schema:familyName Verde
171 schema:givenName Franco
172 rdf:type schema:Person
173 N6a4d639be0134d24aa508413a69fa081 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
174 schema:familyName Thompson
175 schema:givenName Elizabeth D.
176 rdf:type schema:Person
177 N6c7935b54d3a4e958bbafef262d373fe schema:affiliation https://www.grid.ac/institutes/grid.21107.35
178 schema:familyName Cope
179 schema:givenName Leslie
180 rdf:type schema:Person
181 N6d9a7f24ebbc4efdb256843f04c281b7 rdf:first N034fcb3a782a4e26b85bf4bab8634e7d
182 rdf:rest Ne0a21d064821402a80a537b362b9ef75
183 N71399b970cea48b797eb321b369910dd schema:affiliation https://www.grid.ac/institutes/grid.21107.35
184 schema:familyName Chan
185 schema:givenName Hok Yee
186 rdf:type schema:Person
187 N7fe9f2eaad144eafbe47f37059ff8464 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
188 schema:familyName Smith
189 schema:givenName Kellie N.
190 rdf:type schema:Person
191 N83c1d387e2884614bb314f58694347b3 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
192 schema:familyName Fan
193 schema:givenName Hongni
194 rdf:type schema:Person
195 N873e7a2dad0140d48ef8e1035179b630 schema:name readcube_id
196 schema:value 312ab6e032a57f42ada50cea8d89f17760e804dfd9986e8e9de3b816315345b6
197 rdf:type schema:PropertyValue
198 N8765f784ccc44e78a148e415fc50606e schema:issueNumber 1
199 rdf:type schema:PublicationIssue
200 N8769f614f5b34a4eaf2749d7c8971ed5 rdf:first Nf124ec24dd2a46cda0e1ecb4f7c525ae
201 rdf:rest rdf:nil
202 N8b9f10286a0e42798cbd02b10c9704ee schema:affiliation https://www.grid.ac/institutes/grid.21107.35
203 schema:familyName Vogelstein
204 schema:givenName Bert
205 rdf:type schema:Person
206 N8de12d1639774f45ae9f2d6aa31d3587 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
207 schema:familyName Diaz
208 schema:givenName Luis A.
209 rdf:type schema:Person
210 N92d854efc2c646a3b822c14cda22c2cc schema:affiliation https://www.grid.ac/institutes/grid.21107.35
211 schema:familyName Wang
212 schema:givenName Hao
213 rdf:type schema:Person
214 N9474e991f2f74f01ac0754545e74de73 rdf:first Nf7a2a9aedf0c4753b4f7139d509e0f0a
215 rdf:rest N3b9e3bf47517449181cc9ccc15be0374
216 N95fadffacf29448892412fb9341d3815 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
217 schema:familyName Sharfman
218 schema:givenName William H.
219 rdf:type schema:Person
220 N98725d78ec984c1c938bf327bead83b0 rdf:first N04c79fedfd6f48ef8faafd709b7bf335
221 rdf:rest Nd115375a88424d648a23461a68bde6a9
222 N9e3788b04f304e7a8bb3c92f7447fd1f rdf:first Ne870fae7dd5941048124e2c6c2a55df0
223 rdf:rest N4e53f0c7a5ff49658e66b150dac8fff3
224 N9fc53d59c76347fd9ffcdd3463c34ef0 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
225 schema:familyName Aulakh
226 schema:givenName Laveet K.
227 rdf:type schema:Person
228 Na5b0d45d032b4eb49969d4256b7dbb4e schema:name doi
229 schema:value 10.1186/s40425-018-0492-x
230 rdf:type schema:PropertyValue
231 Na6cb48935cdd463e867160ea0be671d2 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
232 schema:familyName Tam
233 schema:givenName Ada J.
234 rdf:type schema:Person
235 Nadff17e722624ce48b6fc50ebd60712d rdf:first N6870dbbd642545a1b2c77019426a38fb
236 rdf:rest N40c99cfa5a3648bcb88ca5983a0163da
237 Nb8880ced6f89472cbcf04ce7670acbc2 rdf:first N4336a8ddc7f8458e935396db8ea2d7dc
238 rdf:rest N8769f614f5b34a4eaf2749d7c8971ed5
239 Nb8ac8f4638574ac5a65dfe88474a1b81 rdf:first N7fe9f2eaad144eafbe47f37059ff8464
240 rdf:rest Ne3d9d314d4a040cfac8176d91bb047dc
241 Nbb670072151243ec9cf0cb0c79725eb8 rdf:first N83c1d387e2884614bb314f58694347b3
242 rdf:rest Nea3334997fb04ea4b15a46d228ab6f7f
243 Nbfc909bbbef04373a19f4827e3a8c98e schema:affiliation https://www.grid.ac/institutes/grid.21107.35
244 schema:familyName Velculescu
245 schema:givenName Victor E.
246 rdf:type schema:Person
247 Nc119e53db5064576820aa3146c249ee2 rdf:first N4d576a2d539e476885b1dbe62ec0bf05
248 rdf:rest N4b01bb2998e74a81bb620859b7b12ab0
249 Nc20a3e338e5c43478176181979c7f737 rdf:first N5435639e20da49fbb2daa7109ed1106a
250 rdf:rest N3eb7afea3f664ddca9bbfae9b310cfa5
251 Nc95f20df5f324a83a64759320c47b224 rdf:first Na6cb48935cdd463e867160ea0be671d2
252 rdf:rest N6d9a7f24ebbc4efdb256843f04c281b7
253 Ncbe4b9020c6e45fd9e1e876c19bae9e4 rdf:first N6a4d639be0134d24aa508413a69fa081
254 rdf:rest Nadff17e722624ce48b6fc50ebd60712d
255 Nce0e1d89993d4fd19d102274c3f2f323 rdf:first N2d680c7d135b46aab09db53cd2fae817
256 rdf:rest N65b471773b0442768f1cfd051e4bfdc7
257 Nd061317d1a364c60a17ab7eb4aa072f7 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
258 schema:familyName Danilova
259 schema:givenName Ludmila
260 rdf:type schema:Person
261 Nd115375a88424d648a23461a68bde6a9 rdf:first N0b7e6d47530d42feb3b5790651eeb7e8
262 rdf:rest N021c110ce1b24164ba84ac94d20bb388
263 Nd1862a3ba2f446b79c67073742bf8d70 rdf:first N9fc53d59c76347fd9ffcdd3463c34ef0
264 rdf:rest Nefca7754350245e6aa659d8e182603ec
265 Nd271193cd85c4047a1dfdd7786fa5a07 schema:name nlm_unique_id
266 schema:value 101620585
267 rdf:type schema:PropertyValue
268 Nd53887d289b74083a892693f251704da schema:name dimensions_id
269 schema:value pub.1112064826
270 rdf:type schema:PropertyValue
271 Nd56537467a054901ada81122d490d54b rdf:first N71399b970cea48b797eb321b369910dd
272 rdf:rest Neeaedaf7df4d45e280a5fcba95710db1
273 Ne0a21d064821402a80a537b362b9ef75 rdf:first N2686557cbba2495186c27ab1a98b625b
274 rdf:rest Nd1862a3ba2f446b79c67073742bf8d70
275 Ne34d5d3e8bef480597876251b2a8138f rdf:first N2633995d228e45b3b4b32af008e6aaa0
276 rdf:rest Nbb670072151243ec9cf0cb0c79725eb8
277 Ne37166216e9848ff87022516a20faaf8 schema:name Springer Nature - SN SciGraph project
278 rdf:type schema:Organization
279 Ne3d9d314d4a040cfac8176d91bb047dc rdf:first Nf59fbdc885fb45b0a56711a4ba23e885
280 rdf:rest N1d385105f54143e296021ae27c3c01dd
281 Ne83a676d08ed4e0181421e72264c5c8b schema:affiliation https://www.grid.ac/institutes/grid.21107.35
282 schema:familyName Cottrell
283 schema:givenName Tricia R.
284 rdf:type schema:Person
285 Ne870fae7dd5941048124e2c6c2a55df0 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
286 schema:familyName Durham
287 schema:givenName Jennifer N.
288 rdf:type schema:Person
289 Nea3334997fb04ea4b15a46d228ab6f7f rdf:first Nef08479cbcf64722b4862bd050be834d
290 rdf:rest Nd56537467a054901ada81122d490d54b
291 Ned5ad664e5a64a4da24e8c89b258b5e6 rdf:first N3b382f6fea3343e39544a7b0054db142
292 rdf:rest N05965ad555be425a86e7e6cc4602db74
293 Neeaedaf7df4d45e280a5fcba95710db1 rdf:first N15db19e613ac434c90160377a66dd549
294 rdf:rest N98725d78ec984c1c938bf327bead83b0
295 Nef08479cbcf64722b4862bd050be834d schema:affiliation https://www.grid.ac/institutes/grid.21107.35
296 schema:familyName Suri
297 schema:givenName Prerna
298 rdf:type schema:Person
299 Nefca7754350245e6aa659d8e182603ec rdf:first N265463a34ae344b6a43ee2f1df686a07
300 rdf:rest Nce0e1d89993d4fd19d102274c3f2f323
301 Nf124ec24dd2a46cda0e1ecb4f7c525ae schema:affiliation https://www.grid.ac/institutes/grid.21107.35
302 schema:familyName Housseau
303 schema:givenName Franck
304 rdf:type schema:Person
305 Nf18953212c464f8087ddb69566e89264 rdf:first N0ed91adac8e54da0aa7ac32845639c72
306 rdf:rest Nc95f20df5f324a83a64759320c47b224
307 Nf59fbdc885fb45b0a56711a4ba23e885 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
308 schema:familyName Llosa
309 schema:givenName Nicolas J.
310 rdf:type schema:Person
311 Nf69625549bf64164b0b57e72e1fcaeee schema:name Immunitrack, Copenhagen, Denmark
312 rdf:type schema:Organization
313 Nf7a2a9aedf0c4753b4f7139d509e0f0a schema:affiliation https://www.grid.ac/institutes/grid.21107.35
314 schema:familyName Taube
315 schema:givenName Janis M.
316 rdf:type schema:Person
317 Nfce012a5688b46a7afb31cb530708a94 rdf:first N2f0dbfe3738648898028c46a4085f58f
318 rdf:rest N50d8e96dcb7742cab9f41737b2090623
319 Nfff06fae80f9476cba5a890bd5b32651 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
320 schema:familyName Sears
321 schema:givenName Cynthia L.
322 rdf:type schema:Person
323 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
324 schema:name Medical and Health Sciences
325 rdf:type schema:DefinedTerm
326 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
327 schema:name Oncology and Carcinogenesis
328 rdf:type schema:DefinedTerm
329 sg:grant.2438791 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0492-x
330 rdf:type schema:MonetaryGrant
331 sg:grant.2439055 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0492-x
332 rdf:type schema:MonetaryGrant
333 sg:grant.2440141 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0492-x
334 rdf:type schema:MonetaryGrant
335 sg:grant.2478763 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0492-x
336 rdf:type schema:MonetaryGrant
337 sg:grant.3624253 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0492-x
338 rdf:type schema:MonetaryGrant
339 sg:grant.4455503 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0492-x
340 rdf:type schema:MonetaryGrant
341 sg:grant.5476950 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0492-x
342 rdf:type schema:MonetaryGrant
343 sg:journal.1049249 schema:issn 2051-1426
344 schema:name Journal for ImmunoTherapy of Cancer
345 rdf:type schema:Periodical
346 sg:pub.10.1038/nature05933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023428666
347 https://doi.org/10.1038/nature05933
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/nature23291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090947343
350 https://doi.org/10.1038/nature23291
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/ncomms3680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029134323
353 https://doi.org/10.1038/ncomms3680
354 rdf:type schema:CreativeWork
355 sg:pub.10.1186/s12865-018-0250-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101678663
356 https://doi.org/10.1186/s12865-018-0250-3
357 rdf:type schema:CreativeWork
358 https://app.dimensions.ai/details/publication/pub.1082399402 schema:CreativeWork
359 https://doi.org/10.1016/j.jtho.2018.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103687032
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/s1470-2045(16)30624-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034482273
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1056/nejmoa1500596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053017729
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1056/nejmoa1609279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033979635
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1056/nejmoa1801946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103285297
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1126/science.aaa1348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062665078
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1126/science.aan6733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085942187
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1126/scitranslmed.aaa7161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002663197
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1136/jcp.2004.022509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041261124
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/0008-5472.can-03-3231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032743970
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1158/1078-0432.ccr-13-3271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004953031
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1158/1541-7786.mcr-15-0062-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1049564054
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1158/2159-8290.cd-14-0863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029393757
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1158/2326-6066.cir-18-0129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104545106
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1172/jci98689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100591040
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1309/ajcp85atmjozoudj schema:sameAs https://app.dimensions.ai/details/publication/pub.1064985054
394 rdf:type schema:CreativeWork
395 https://doi.org/10.4049/jimmunol.1302101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042011023
396 rdf:type schema:CreativeWork
397 https://doi.org/10.4049/jimmunol.178.12.7890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038699738
398 rdf:type schema:CreativeWork
399 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
400 schema:name Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA
401 Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
402 Division of Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD, USA
403 Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA
404 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
405 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
406 The Swim Across America Laboratory, John Hopkins University, Baltimore, MD, USA
407 rdf:type schema:Organization
408 https://www.grid.ac/institutes/grid.410445.0 schema:alternateName University of Hawaii at Manoa
409 schema:name Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA
410 Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA
411 Present address: B.R.B.,Bioinformatics Core, Department of Complementary & Integrative Medicine, University of Hawaii John A. Burns School of Medicine, 96813, Honolulu, HI, USA
412 The Swim Across America Laboratory, John Hopkins University, Baltimore, MD, USA
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
415 schema:name Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, MD, USA
416 Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
417 Ludwig Center and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA
418 The Swim Across America Laboratory, John Hopkins University, Baltimore, MD, USA
419 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...