Immune checkpoint inhibitors in MITF family translocation renal cell carcinomas and genetic correlates of exceptional responders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

A. Boilève, M. I. Carlo, P. Barthélémy, S. Oudard, D. Borchiellini, M. H. Voss, S. George, C. Chevreau, J. Landman-Parker, M-D Tabone, D. D. Chism, A. Amin, M. A. Bilen, D. Bosse, A. Coulomb-L’hermine, Xiaoping Su, T. K. Choueiri, Nizar M. Tannir, Gabriel G. Malouf

ABSTRACT

BACKGROUND: Microphthalmia Transcription Factor (MITF)family translocation renal cell carcinoma (tRCC) is a rare RCC subtype harboring TFE3/TFEB translocations. The prognosis in the metastatic (m) setting is poor. Programmed death ligand-1 expression was reported in 90% of cases, prompting us to analyze the benefit of immune checkpoint inhibitors (ICI) in this population. PATIENTS AND METHODS: This multicenter retrospective study identified patients with MITF family mtRCC who had received an ICI in any of 12 referral centers in France or the USA. Response rate according to RECIST criteria, progression-free survival (PFS), and overall survival (OS) were analyzed. Genomic alterations associated with response were determined for 8 patients. RESULTS: Overall, 24 patients with metastatic disease who received an ICI as second or later line of treatment were identified. Nineteen (82.6%) of these patients had received a VEGFR inhibitor as first-line treatment, with a median PFS of 3 months (range, 1-22 months). The median PFS for patients during first ICI treatment was 2.5 months (range, 1-40 months); 4 patients experienced partial response (16,7%) and 3 (12,5%) had stable disease. Of the patients whose genomic alterations were analyzed, two patients with mutations in bromodomain-containing genes (PBRM1 and BRD8) had a clinical benefit. Resistant clones in a patient with exceptional response to ipilimumab showed loss of BRD8 mutations and increased mutational load driven by parallel evolution affecting 17 genes (median mutations per gene, 3), which were enriched mainly for O-glycan processing (29.4%, FDR = 9.7 × 10- 6). CONCLUSIONS: MITF family tRCC is an aggressive disease with similar responses to ICIs as clear-cell RCC. Mutations in bromodomain-containing genes might be associated with clinical benefit. The unexpected observation about parallel evolution of genes involved in O-glycosylation as a mechanism of resistance to ICI warrants exploration. More... »

PAGES

159

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-018-0482-z

DOI

http://dx.doi.org/10.1186/s40425-018-0482-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110911755

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30591082


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Department of Medical Oncology, H\u00f4pital Universitaire Piti\u00e9-Salp\u00e9tri\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boil\u00e8ve", 
        "givenName": "A.", 
        "id": "sg:person.012056423402.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012056423402.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carlo", 
        "givenName": "M. I.", 
        "id": "sg:person.013003741441.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013003741441.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Strasbourg", 
          "id": "https://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "Service d\u2019H\u00e9matologie et d\u2019Oncologie, Centre Hospitalier Universitaire de Strasbourg, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barth\u00e9l\u00e9my", 
        "givenName": "P.", 
        "id": "sg:person.01227445510.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227445510.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Association pour la Recherche de Th\u00e9rapeutiques Innovantes en Canc\u00e9rologie", 
          "id": "https://www.grid.ac/institutes/grid.476119.c", 
          "name": [
            "Oncology Department, European Georges Pompidou Hospital, Ren\u00e9 Descartes University, Paris, France", 
            "Association pour la Recherche sur les Th\u00e9rapeutiques Innovantes en Canc\u00e9rologie, Paris, France", 
            "U790 PARCC, European Georges Pompidou Hospital, Ren\u00e9 Descartes University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oudard", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Antoine Lacassagne", 
          "id": "https://www.grid.ac/institutes/grid.417812.9", 
          "name": [
            "Centre Antoine Lacassagne, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borchiellini", 
        "givenName": "D.", 
        "id": "sg:person.0675207541.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675207541.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voss", 
        "givenName": "M. H.", 
        "id": "sg:person.0577111044.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577111044.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roswell Park Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.240614.5", 
          "name": [
            "Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "George", 
        "givenName": "S.", 
        "id": "sg:person.01051777752.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051777752.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Claudius Regaud", 
          "id": "https://www.grid.ac/institutes/grid.417829.1", 
          "name": [
            "IUCT-Oncopole, Institut Claudius-Regaud, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chevreau", 
        "givenName": "C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Armand Trousseau", 
          "id": "https://www.grid.ac/institutes/grid.413776.0", 
          "name": [
            "Service d\u2019H\u00e9matologie et d\u2019Oncologie P\u00e9diatrique, Hopital Armand-Trousseau, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Landman-Parker", 
        "givenName": "J.", 
        "id": "sg:person.01337717664.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337717664.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Armand Trousseau", 
          "id": "https://www.grid.ac/institutes/grid.413776.0", 
          "name": [
            "Service d\u2019H\u00e9matologie et d\u2019Oncologie P\u00e9diatrique, Hopital Armand-Trousseau, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tabone", 
        "givenName": "M-D", 
        "id": "sg:person.0643123146.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643123146.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chism", 
        "givenName": "D. D.", 
        "id": "sg:person.01102635440.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102635440.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Levine Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.468189.a", 
          "name": [
            "Carolinas Healthcare System, Levine Cancer Institute, Charlotte, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amin", 
        "givenName": "A.", 
        "id": "sg:person.0616232204.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616232204.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bilen", 
        "givenName": "M. A.", 
        "id": "sg:person.0663317655.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663317655.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosse", 
        "givenName": "D.", 
        "id": "sg:person.01252560751.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252560751.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Armand Trousseau", 
          "id": "https://www.grid.ac/institutes/grid.413776.0", 
          "name": [
            "Service d\u2019Anatomopathologie, H\u00f4pital Armand-Trousseau, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coulomb-L\u2019hermine", 
        "givenName": "A.", 
        "id": "sg:person.01131024035.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131024035.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "Xiaoping", 
        "id": "sg:person.016563315207.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016563315207.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choueiri", 
        "givenName": "T. K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tannir", 
        "givenName": "Nizar M.", 
        "id": "sg:person.01004561122.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004561122.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Strasbourg", 
          "id": "https://www.grid.ac/institutes/grid.11843.3f", 
          "name": [
            "Department of Medical Oncology, H\u00f4pital Universitaire Piti\u00e9-Salp\u00e9tri\u00e8re, Paris, France", 
            "Service d\u2019H\u00e9matologie et d\u2019Oncologie, Centre Hospitalier Universitaire de Strasbourg, Strasbourg, France", 
            "Department of Functional Genomics and Cancer, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Illkirch, France", 
            "Department of Hematology and Oncology, Centre Hospitalier Universitaire de Strasbourg, 1, Place de l\u2019H\u00f4pital, 67000, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malouf", 
        "givenName": "Gabriel G.", 
        "id": "sg:person.01236645411.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236645411.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrurol.2014.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002943543", 
          "https://doi.org/10.1038/nrurol.2014.162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aad0095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005715050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-3825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006506894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009181784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31824f24a6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011226033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31824f24a6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011226033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-1183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014448303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-3036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016591405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2014.05.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017060974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018041741", 
          "https://doi.org/10.1038/ng.997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1510665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019970557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmoldx.2014.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021566264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027422113", 
          "https://doi.org/10.1038/nchembio.1403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-2839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032787294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035439881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046387046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050842404", 
          "https://doi.org/10.1038/nature12222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.13167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053823060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-16-0645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063281067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2017.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083858868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aah3560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084221594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2017.35.6_suppl.482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084255186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-17-1243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086133527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2017.05.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090654185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djx277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099765545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan5951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100200443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40425-018-0319-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100689551", 
          "https://doi.org/10.1186/s40425-018-0319-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1712126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101673751"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Microphthalmia Transcription Factor (MITF)family translocation renal cell carcinoma (tRCC) is a rare RCC subtype harboring TFE3/TFEB translocations. The prognosis in the metastatic (m) setting is poor. Programmed death ligand-1 expression was reported in 90% of cases, prompting us to analyze the benefit of immune checkpoint inhibitors (ICI) in this population.\nPATIENTS AND METHODS: This multicenter retrospective study identified patients with MITF family mtRCC who had received an ICI in any of 12 referral centers in France or the USA. Response rate according to RECIST criteria, progression-free survival (PFS), and overall survival (OS) were analyzed. Genomic alterations associated with response were determined for 8 patients.\nRESULTS: Overall, 24 patients with metastatic disease who received an ICI as second or later line of treatment were identified. Nineteen (82.6%) of these patients had received a VEGFR inhibitor as first-line treatment, with a median PFS of 3\u2009months (range, 1-22\u2009months). The median PFS for patients during first ICI treatment was 2.5\u2009months (range, 1-40\u2009months); 4 patients experienced partial response (16,7%) and 3 (12,5%) had stable disease. Of the patients whose genomic alterations were analyzed, two patients with mutations in bromodomain-containing genes (PBRM1 and BRD8) had a clinical benefit. Resistant clones in a patient with exceptional response to ipilimumab showed loss of BRD8 mutations and increased mutational load driven by parallel evolution affecting 17 genes (median mutations per gene, 3), which were enriched mainly for O-glycan processing (29.4%, FDR\u2009=\u20099.7\u2009\u00d7\u200910-\u20096).\nCONCLUSIONS: MITF family tRCC is an aggressive disease with similar responses to ICIs as clear-cell RCC. Mutations in bromodomain-containing genes might be associated with clinical benefit. The unexpected observation about parallel evolution of genes involved in O-glycosylation as a mechanism of resistance to ICI warrants exploration.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40425-018-0482-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Immune checkpoint inhibitors in MITF family translocation renal cell carcinomas and genetic correlates of exceptional responders", 
    "pagination": "159", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5ea798d77b5155982659b913071ca00528234cb6f3eceb56d40220a2c6dec3ef"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30591082"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40425-018-0482-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110911755"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40425-018-0482-z", 
      "https://app.dimensions.ai/details/publication/pub.1110911755"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000309_0000000309/records_106262_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40425-018-0482-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0482-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0482-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0482-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0482-z'


 

This table displays all metadata directly associated to this object as RDF triples.

320 TRIPLES      21 PREDICATES      56 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40425-018-0482-z schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N1eba2e33778544999c1b948c33f81e8b
4 schema:citation sg:pub.10.1038/nature12222
5 sg:pub.10.1038/nchembio.1403
6 sg:pub.10.1038/ng.997
7 sg:pub.10.1038/nrurol.2014.162
8 sg:pub.10.1186/s40425-018-0319-9
9 https://doi.org/10.1002/cncr.25512
10 https://doi.org/10.1016/j.ejca.2017.05.036
11 https://doi.org/10.1016/j.eururo.2014.05.027
12 https://doi.org/10.1016/j.immuni.2017.02.001
13 https://doi.org/10.1016/j.jmoldx.2014.12.006
14 https://doi.org/10.1056/nejmoa1510665
15 https://doi.org/10.1056/nejmoa1712126
16 https://doi.org/10.1093/annonc/mdq029
17 https://doi.org/10.1093/annonc/mdu445
18 https://doi.org/10.1093/jnci/djx277
19 https://doi.org/10.1097/pas.0b013e31824f24a6
20 https://doi.org/10.1111/his.13167
21 https://doi.org/10.1126/science.aad0095
22 https://doi.org/10.1126/science.aan5951
23 https://doi.org/10.1126/scitranslmed.aah3560
24 https://doi.org/10.1158/1078-0432.ccr-08-1183
25 https://doi.org/10.1158/1078-0432.ccr-12-3825
26 https://doi.org/10.1158/1078-0432.ccr-13-3036
27 https://doi.org/10.1158/1078-0432.ccr-15-2839
28 https://doi.org/10.1158/1078-0432.ccr-17-1243
29 https://doi.org/10.1158/2159-8290.cd-16-0645
30 https://doi.org/10.1200/jco.2017.35.6_suppl.482
31 schema:datePublished 2018-12
32 schema:datePublishedReg 2018-12-01
33 schema:description BACKGROUND: Microphthalmia Transcription Factor (MITF)family translocation renal cell carcinoma (tRCC) is a rare RCC subtype harboring TFE3/TFEB translocations. The prognosis in the metastatic (m) setting is poor. Programmed death ligand-1 expression was reported in 90% of cases, prompting us to analyze the benefit of immune checkpoint inhibitors (ICI) in this population. PATIENTS AND METHODS: This multicenter retrospective study identified patients with MITF family mtRCC who had received an ICI in any of 12 referral centers in France or the USA. Response rate according to RECIST criteria, progression-free survival (PFS), and overall survival (OS) were analyzed. Genomic alterations associated with response were determined for 8 patients. RESULTS: Overall, 24 patients with metastatic disease who received an ICI as second or later line of treatment were identified. Nineteen (82.6%) of these patients had received a VEGFR inhibitor as first-line treatment, with a median PFS of 3 months (range, 1-22 months). The median PFS for patients during first ICI treatment was 2.5 months (range, 1-40 months); 4 patients experienced partial response (16,7%) and 3 (12,5%) had stable disease. Of the patients whose genomic alterations were analyzed, two patients with mutations in bromodomain-containing genes (PBRM1 and BRD8) had a clinical benefit. Resistant clones in a patient with exceptional response to ipilimumab showed loss of BRD8 mutations and increased mutational load driven by parallel evolution affecting 17 genes (median mutations per gene, 3), which were enriched mainly for O-glycan processing (29.4%, FDR = 9.7 × 10- 6). CONCLUSIONS: MITF family tRCC is an aggressive disease with similar responses to ICIs as clear-cell RCC. Mutations in bromodomain-containing genes might be associated with clinical benefit. The unexpected observation about parallel evolution of genes involved in O-glycosylation as a mechanism of resistance to ICI warrants exploration.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N6f4fe9c8c0b145e49029fe39e368e3ae
38 Nc1d88847ee6c4b85a90cecf3f4883143
39 sg:journal.1049249
40 schema:name Immune checkpoint inhibitors in MITF family translocation renal cell carcinomas and genetic correlates of exceptional responders
41 schema:pagination 159
42 schema:productId N035939c517ea4eb18492189a5bcc4317
43 N2637b61c4fdb4f3c9828e6b80804bdd4
44 Nc67a56a272c347da94be5adb19ab48c3
45 Nd4d5bdada0ab4c79ad2767cd087aec19
46 Ndc623ff53e564296b7f0e399a0647f95
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110911755
48 https://doi.org/10.1186/s40425-018-0482-z
49 schema:sdDatePublished 2019-04-11T08:30
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher N1cd4e28bcd7b4d178631cac821727cf1
52 schema:url https://link.springer.com/10.1186%2Fs40425-018-0482-z
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N035939c517ea4eb18492189a5bcc4317 schema:name readcube_id
57 schema:value 5ea798d77b5155982659b913071ca00528234cb6f3eceb56d40220a2c6dec3ef
58 rdf:type schema:PropertyValue
59 N1cd4e28bcd7b4d178631cac821727cf1 schema:name Springer Nature - SN SciGraph project
60 rdf:type schema:Organization
61 N1eba2e33778544999c1b948c33f81e8b rdf:first sg:person.012056423402.13
62 rdf:rest N36c27941e8e5496d96c4fd24d3a21164
63 N2637b61c4fdb4f3c9828e6b80804bdd4 schema:name pubmed_id
64 schema:value 30591082
65 rdf:type schema:PropertyValue
66 N2d1ccde195624065b9acabfed8aaae09 schema:affiliation https://www.grid.ac/institutes/grid.417829.1
67 schema:familyName Chevreau
68 schema:givenName C.
69 rdf:type schema:Person
70 N36c27941e8e5496d96c4fd24d3a21164 rdf:first sg:person.013003741441.64
71 rdf:rest N717ed073a279416d936953eb1702ebed
72 N41b74612f6b043c196cd99aa47e156bb rdf:first sg:person.0663317655.45
73 rdf:rest N7b4f12da47944118b62689ba9be572a1
74 N4ad76ebce8884edf932dcb293ac76692 rdf:first sg:person.01337717664.13
75 rdf:rest Na8bb1e7d8db8457dba63cd063d217bc3
76 N4b7d5651e9984d17acd221182de55864 rdf:first sg:person.016563315207.95
77 rdf:rest Ne0323c96f2d740db958dd70fe3410fbe
78 N58a4a19c63364b6594c28918bf2396f4 rdf:first Nb600a58836364838a2a0934c8df32f8a
79 rdf:rest N712eca122021475ebda03cccb5d1a462
80 N5d201b6f21d74b7094d926c3fca7cfd7 rdf:first sg:person.01102635440.48
81 rdf:rest N91c59bb538314873b874ca2373418b54
82 N6f4fe9c8c0b145e49029fe39e368e3ae schema:issueNumber 1
83 rdf:type schema:PublicationIssue
84 N712eca122021475ebda03cccb5d1a462 rdf:first sg:person.0675207541.34
85 rdf:rest Na0ea4daceff14e0caee29b06eaac176d
86 N717ed073a279416d936953eb1702ebed rdf:first sg:person.01227445510.72
87 rdf:rest N58a4a19c63364b6594c28918bf2396f4
88 N77f45aa9a8db4921841e59ef84e8da86 rdf:first N2d1ccde195624065b9acabfed8aaae09
89 rdf:rest N4ad76ebce8884edf932dcb293ac76692
90 N7b4f12da47944118b62689ba9be572a1 rdf:first sg:person.01252560751.47
91 rdf:rest Nbacd5682673f4bcb9997c287770d7289
92 N91c59bb538314873b874ca2373418b54 rdf:first sg:person.0616232204.47
93 rdf:rest N41b74612f6b043c196cd99aa47e156bb
94 N9a57afc34bc84d94b60e347235480333 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
95 schema:familyName Choueiri
96 schema:givenName T. K.
97 rdf:type schema:Person
98 Na0ea4daceff14e0caee29b06eaac176d rdf:first sg:person.0577111044.36
99 rdf:rest Ncdf9aea7334542c5917c577e3a8f15a8
100 Na8bb1e7d8db8457dba63cd063d217bc3 rdf:first sg:person.0643123146.91
101 rdf:rest N5d201b6f21d74b7094d926c3fca7cfd7
102 Nb600a58836364838a2a0934c8df32f8a schema:affiliation https://www.grid.ac/institutes/grid.476119.c
103 schema:familyName Oudard
104 schema:givenName S.
105 rdf:type schema:Person
106 Nbacd5682673f4bcb9997c287770d7289 rdf:first sg:person.01131024035.33
107 rdf:rest N4b7d5651e9984d17acd221182de55864
108 Nc1809ea40d004fe6b3dea27df27f2878 rdf:first sg:person.01004561122.13
109 rdf:rest Nd24dc5cc85714968a1172a96c3819d95
110 Nc1d88847ee6c4b85a90cecf3f4883143 schema:volumeNumber 6
111 rdf:type schema:PublicationVolume
112 Nc67a56a272c347da94be5adb19ab48c3 schema:name dimensions_id
113 schema:value pub.1110911755
114 rdf:type schema:PropertyValue
115 Ncdf9aea7334542c5917c577e3a8f15a8 rdf:first sg:person.01051777752.35
116 rdf:rest N77f45aa9a8db4921841e59ef84e8da86
117 Nd24dc5cc85714968a1172a96c3819d95 rdf:first sg:person.01236645411.07
118 rdf:rest rdf:nil
119 Nd4d5bdada0ab4c79ad2767cd087aec19 schema:name nlm_unique_id
120 schema:value 101620585
121 rdf:type schema:PropertyValue
122 Ndc623ff53e564296b7f0e399a0647f95 schema:name doi
123 schema:value 10.1186/s40425-018-0482-z
124 rdf:type schema:PropertyValue
125 Ne0323c96f2d740db958dd70fe3410fbe rdf:first N9a57afc34bc84d94b60e347235480333
126 rdf:rest Nc1809ea40d004fe6b3dea27df27f2878
127 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
128 schema:name Biological Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
131 schema:name Genetics
132 rdf:type schema:DefinedTerm
133 sg:journal.1049249 schema:issn 2051-1426
134 schema:name Journal for ImmunoTherapy of Cancer
135 rdf:type schema:Periodical
136 sg:person.01004561122.13 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
137 schema:familyName Tannir
138 schema:givenName Nizar M.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004561122.13
140 rdf:type schema:Person
141 sg:person.01051777752.35 schema:affiliation https://www.grid.ac/institutes/grid.240614.5
142 schema:familyName George
143 schema:givenName S.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051777752.35
145 rdf:type schema:Person
146 sg:person.01102635440.48 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
147 schema:familyName Chism
148 schema:givenName D. D.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102635440.48
150 rdf:type schema:Person
151 sg:person.01131024035.33 schema:affiliation https://www.grid.ac/institutes/grid.413776.0
152 schema:familyName Coulomb-L’hermine
153 schema:givenName A.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131024035.33
155 rdf:type schema:Person
156 sg:person.012056423402.13 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
157 schema:familyName Boilève
158 schema:givenName A.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012056423402.13
160 rdf:type schema:Person
161 sg:person.01227445510.72 schema:affiliation https://www.grid.ac/institutes/grid.11843.3f
162 schema:familyName Barthélémy
163 schema:givenName P.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227445510.72
165 rdf:type schema:Person
166 sg:person.01236645411.07 schema:affiliation https://www.grid.ac/institutes/grid.11843.3f
167 schema:familyName Malouf
168 schema:givenName Gabriel G.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236645411.07
170 rdf:type schema:Person
171 sg:person.01252560751.47 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
172 schema:familyName Bosse
173 schema:givenName D.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252560751.47
175 rdf:type schema:Person
176 sg:person.013003741441.64 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
177 schema:familyName Carlo
178 schema:givenName M. I.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013003741441.64
180 rdf:type schema:Person
181 sg:person.01337717664.13 schema:affiliation https://www.grid.ac/institutes/grid.413776.0
182 schema:familyName Landman-Parker
183 schema:givenName J.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337717664.13
185 rdf:type schema:Person
186 sg:person.016563315207.95 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
187 schema:familyName Su
188 schema:givenName Xiaoping
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016563315207.95
190 rdf:type schema:Person
191 sg:person.0577111044.36 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
192 schema:familyName Voss
193 schema:givenName M. H.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577111044.36
195 rdf:type schema:Person
196 sg:person.0616232204.47 schema:affiliation https://www.grid.ac/institutes/grid.468189.a
197 schema:familyName Amin
198 schema:givenName A.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616232204.47
200 rdf:type schema:Person
201 sg:person.0643123146.91 schema:affiliation https://www.grid.ac/institutes/grid.413776.0
202 schema:familyName Tabone
203 schema:givenName M-D
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643123146.91
205 rdf:type schema:Person
206 sg:person.0663317655.45 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
207 schema:familyName Bilen
208 schema:givenName M. A.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663317655.45
210 rdf:type schema:Person
211 sg:person.0675207541.34 schema:affiliation https://www.grid.ac/institutes/grid.417812.9
212 schema:familyName Borchiellini
213 schema:givenName D.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675207541.34
215 rdf:type schema:Person
216 sg:pub.10.1038/nature12222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050842404
217 https://doi.org/10.1038/nature12222
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nchembio.1403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027422113
220 https://doi.org/10.1038/nchembio.1403
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/ng.997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018041741
223 https://doi.org/10.1038/ng.997
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nrurol.2014.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002943543
226 https://doi.org/10.1038/nrurol.2014.162
227 rdf:type schema:CreativeWork
228 sg:pub.10.1186/s40425-018-0319-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100689551
229 https://doi.org/10.1186/s40425-018-0319-9
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/cncr.25512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009181784
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.ejca.2017.05.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090654185
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.eururo.2014.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017060974
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.immuni.2017.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083858868
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.jmoldx.2014.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021566264
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejmoa1510665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019970557
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1056/nejmoa1712126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101673751
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/annonc/mdq029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035439881
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/annonc/mdu445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046387046
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1093/jnci/djx277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099765545
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1097/pas.0b013e31824f24a6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011226033
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1111/his.13167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053823060
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1126/science.aad0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005715050
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1126/science.aan5951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100200443
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1126/scitranslmed.aah3560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084221594
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1158/1078-0432.ccr-08-1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014448303
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1158/1078-0432.ccr-12-3825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006506894
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1158/1078-0432.ccr-13-3036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016591405
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1158/1078-0432.ccr-15-2839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032787294
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1158/1078-0432.ccr-17-1243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086133527
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1158/2159-8290.cd-16-0645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063281067
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1200/jco.2017.35.6_suppl.482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084255186
274 rdf:type schema:CreativeWork
275 https://www.grid.ac/institutes/grid.11843.3f schema:alternateName University of Strasbourg
276 schema:name Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
277 Department of Hematology and Oncology, Centre Hospitalier Universitaire de Strasbourg, 1, Place de l’Hôpital, 67000, Strasbourg, France
278 Department of Medical Oncology, Hôpital Universitaire Pitié-Salpétrière, Paris, France
279 Service d’Hématologie et d’Oncologie, Centre Hospitalier Universitaire de Strasbourg, Strasbourg, France
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
282 schema:name Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
285 schema:name Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
286 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
287 rdf:type schema:Organization
288 https://www.grid.ac/institutes/grid.240614.5 schema:alternateName Roswell Park Cancer Institute
289 schema:name Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
290 rdf:type schema:Organization
291 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
292 schema:name Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
295 schema:name Department of Medical Oncology, Hôpital Universitaire Pitié-Salpétrière, Paris, France
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
298 schema:name Division of Hematology and Oncology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.413776.0 schema:alternateName Hôpital Armand Trousseau
301 schema:name Service d’Anatomopathologie, Hôpital Armand-Trousseau, Paris, France
302 Service d’Hématologie et d’Oncologie Pédiatrique, Hopital Armand-Trousseau, Paris, France
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.417812.9 schema:alternateName Centre Antoine Lacassagne
305 schema:name Centre Antoine Lacassagne, Nice, France
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.417829.1 schema:alternateName Institut Claudius Regaud
308 schema:name IUCT-Oncopole, Institut Claudius-Regaud, Toulouse, France
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.468189.a schema:alternateName Levine Cancer Institute
311 schema:name Carolinas Healthcare System, Levine Cancer Institute, Charlotte, NC, USA
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.476119.c schema:alternateName Association pour la Recherche de Thérapeutiques Innovantes en Cancérologie
314 schema:name Association pour la Recherche sur les Thérapeutiques Innovantes en Cancérologie, Paris, France
315 Oncology Department, European Georges Pompidou Hospital, René Descartes University, Paris, France
316 U790 PARCC, European Georges Pompidou Hospital, René Descartes University, Paris, France
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
319 schema:name Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
320 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...