Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Natalie J. Miller, Candice D. Church, Steven P. Fling, Rima Kulikauskas, Nirasha Ramchurren, Michi M. Shinohara, Harriet M. Kluger, Shailender Bhatia, Lisa Lundgren, Martin A. Cheever, Suzanne L. Topalian, Paul Nghiem

ABSTRACT

BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive skin cancer that frequently responds to anti-PD-1 therapy. MCC is associated with sun exposure and, in 80% of cases, Merkel cell polyomavirus (MCPyV). MCPyV-specific T and B cell responses provide a unique opportunity to study cancer-specific immunity throughout PD-1 blockade therapy. METHODS: Immune responses were assessed in patients (n = 26) with advanced MCC receiving pembrolizumab. Peripheral blood mononuclear cells (PBMC) were collected at baseline and throughout treatment. MCPyV-oncoprotein antibodies were quantified and T cells were assessed for MCPyV-specificity via tetramer staining and/or cytokine secretion. Pre-treatment tumor biopsies were analyzed for T cell receptor clonality. RESULTS: MCPyV oncoprotein antibodies were detectable in 15 of 17 (88%) of virus-positive MCC (VP-MCC) patients. Antibodies decreased in 10 of 11 (91%) patients with responding tumors. Virus-specific T cells decreased over time in patients who had a complete response, and increased in patients who had persistent disease. Tumors that were MCPyV(+) had a strikingly more clonal (less diverse) intratumoral TCR repertoire than virus-negative tumors (p = 0.0001). CONCLUSIONS: Cancer-specific T and B cell responses generally track with disease burden during PD-1 blockade, in proportion to presence of antigen. Intratumoral TCR clonality was significantly greater in VP-MCC than VN-MCC tumors, suggesting expansion of a limited number of dominant clones in response to fewer immunogenic MCPyV antigens. In contrast, VN-MCC tumors had lower clonality, suggesting a diverse T cell response to numerous neoantigens. These findings reveal differences in tumor-specific immunity for VP-MCC and VN-MCC, both of which often respond to anti-PD-1 therapy. More... »

PAGES

131

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-018-0450-7

DOI

http://dx.doi.org/10.1186/s40425-018-0450-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110232190

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30482247


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, 98109, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miller", 
        "givenName": "Natalie J.", 
        "id": "sg:person.0765705317.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765705317.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, 98109, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Church", 
        "givenName": "Candice D.", 
        "id": "sg:person.01061300025.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061300025.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fred Hutchinson Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fling", 
        "givenName": "Steven P.", 
        "id": "sg:person.012063205607.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012063205607.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, 98109, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kulikauskas", 
        "givenName": "Rima", 
        "id": "sg:person.01047305757.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047305757.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fred Hutchinson Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramchurren", 
        "givenName": "Nirasha", 
        "id": "sg:person.010702126474.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010702126474.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, 98109, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shinohara", 
        "givenName": "Michi M.", 
        "id": "sg:person.0602134176.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602134176.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Comprehensive Cancer Center, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kluger", 
        "givenName": "Harriet M.", 
        "id": "sg:person.01336750727.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336750727.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, 98109, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhatia", 
        "givenName": "Shailender", 
        "id": "sg:person.01034020517.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034020517.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fred Hutchinson Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lundgren", 
        "givenName": "Lisa", 
        "id": "sg:person.07363543611.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07363543611.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA", 
            "Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheever", 
        "givenName": "Martin A.", 
        "id": "sg:person.076055012.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.076055012.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, and Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Topalian", 
        "givenName": "Suzanne L.", 
        "id": "sg:person.01013060200.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013060200.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, 98109, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nghiem", 
        "givenName": "Paul", 
        "id": "sg:person.0717057310.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717057310.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002333180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/dxv034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002737237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/dxs098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003299808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003783619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003783619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003783619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010735855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-15-1877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012890521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-2697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013150452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1603702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014027039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-04-217604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014830407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-0035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018346650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jim.2007.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020268139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020455470", 
          "https://doi.org/10.1038/nature13954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021658404", 
          "https://doi.org/10.1038/nature07662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026558254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(16)30364-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027076842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/8.5.765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028435771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038211511", 
          "https://doi.org/10.1038/ng.3581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trecan.2016.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041573288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2326-6066.cir-13-0034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042788073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.30475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044249414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1152586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044765627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.a.22590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048423754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1120914109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048928326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049964494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2013.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053734264", 
          "https://doi.org/10.1038/jid.2013.75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa1348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062665078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa1348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062665078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature22079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084754692", 
          "https://doi.org/10.1038/nature22079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature22079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084754692", 
          "https://doi.org/10.1038/nature22079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan6733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aan6733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2017.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091208107", 
          "https://doi.org/10.1038/labinvest.2017.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrdp.2017.77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092350928", 
          "https://doi.org/10.1038/nrdp.2017.77"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive skin cancer that frequently responds to anti-PD-1 therapy. MCC is associated with sun exposure and, in 80% of cases, Merkel cell polyomavirus (MCPyV). MCPyV-specific T and B cell responses provide a unique opportunity to study cancer-specific immunity throughout PD-1 blockade therapy.\nMETHODS: Immune responses were assessed in patients (n\u2009=\u200926) with advanced MCC receiving pembrolizumab. Peripheral blood mononuclear cells (PBMC) were collected at baseline and throughout treatment. MCPyV-oncoprotein antibodies were quantified and T cells were assessed for MCPyV-specificity via tetramer staining and/or cytokine secretion. Pre-treatment tumor biopsies were analyzed for T cell receptor clonality.\nRESULTS: MCPyV oncoprotein antibodies were detectable in 15 of 17 (88%) of virus-positive MCC (VP-MCC) patients. Antibodies decreased in 10 of 11 (91%) patients with responding tumors. Virus-specific T cells decreased over time in patients who had a complete response, and increased in patients who had persistent disease. Tumors that were MCPyV(+) had a strikingly more clonal (less diverse) intratumoral TCR repertoire than virus-negative tumors (p\u2009=\u20090.0001).\nCONCLUSIONS: Cancer-specific T and B cell responses generally track with disease burden during PD-1 blockade, in proportion to presence of antigen. Intratumoral TCR clonality was significantly greater in VP-MCC than VN-MCC tumors, suggesting expansion of a limited number of dominant clones in response to fewer immunogenic MCPyV antigens. In contrast, VN-MCC tumors had lower clonality, suggesting a diverse T cell response to numerous neoantigens. These findings reveal differences in tumor-specific immunity for VP-MCC and VN-MCC, both of which often respond to anti-PD-1 therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40425-018-0450-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5475983", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2420944", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438816", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2481624", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy", 
    "pagination": "131", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3aafdb4cd6c50627961e57909a363c31cabc7a8bcfc3384f936cad87c9fd2e1d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30482247"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40425-018-0450-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110232190"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40425-018-0450-7", 
      "https://app.dimensions.ai/details/publication/pub.1110232190"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78970_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40425-018-0450-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0450-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0450-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0450-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0450-7'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      59 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40425-018-0450-7 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N642473d6a702481cac867fa60539b847
4 schema:citation sg:pub.10.1038/jid.2013.75
5 sg:pub.10.1038/labinvest.2017.80
6 sg:pub.10.1038/nature07662
7 sg:pub.10.1038/nature13954
8 sg:pub.10.1038/nature22079
9 sg:pub.10.1038/ng.3581
10 sg:pub.10.1038/nrdp.2017.77
11 https://doi.org/10.1002/cncr.30475
12 https://doi.org/10.1002/cyto.a.22590
13 https://doi.org/10.1002/ijc.24510
14 https://doi.org/10.1016/j.ejca.2008.10.026
15 https://doi.org/10.1016/j.jim.2007.03.002
16 https://doi.org/10.1016/j.trecan.2016.10.010
17 https://doi.org/10.1016/s1470-2045(16)30364-3
18 https://doi.org/10.1056/nejmoa1603702
19 https://doi.org/10.1073/pnas.1120914109
20 https://doi.org/10.1093/intimm/8.5.765
21 https://doi.org/10.1093/intimm/dxs098
22 https://doi.org/10.1093/intimm/dxv034
23 https://doi.org/10.1126/science.1152586
24 https://doi.org/10.1126/science.aaa1348
25 https://doi.org/10.1126/science.aan6733
26 https://doi.org/10.1158/0008-5472.can-10-2128
27 https://doi.org/10.1158/0008-5472.can-15-1877
28 https://doi.org/10.1158/1078-0432.ccr-11-1513
29 https://doi.org/10.1158/1078-0432.ccr-13-0035
30 https://doi.org/10.1158/1078-0432.ccr-13-2697
31 https://doi.org/10.1158/2326-6066.cir-13-0034
32 https://doi.org/10.1182/blood-2009-04-217604
33 https://doi.org/10.18632/oncotarget.6494
34 schema:datePublished 2018-12
35 schema:datePublishedReg 2018-12-01
36 schema:description BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive skin cancer that frequently responds to anti-PD-1 therapy. MCC is associated with sun exposure and, in 80% of cases, Merkel cell polyomavirus (MCPyV). MCPyV-specific T and B cell responses provide a unique opportunity to study cancer-specific immunity throughout PD-1 blockade therapy. METHODS: Immune responses were assessed in patients (n = 26) with advanced MCC receiving pembrolizumab. Peripheral blood mononuclear cells (PBMC) were collected at baseline and throughout treatment. MCPyV-oncoprotein antibodies were quantified and T cells were assessed for MCPyV-specificity via tetramer staining and/or cytokine secretion. Pre-treatment tumor biopsies were analyzed for T cell receptor clonality. RESULTS: MCPyV oncoprotein antibodies were detectable in 15 of 17 (88%) of virus-positive MCC (VP-MCC) patients. Antibodies decreased in 10 of 11 (91%) patients with responding tumors. Virus-specific T cells decreased over time in patients who had a complete response, and increased in patients who had persistent disease. Tumors that were MCPyV(+) had a strikingly more clonal (less diverse) intratumoral TCR repertoire than virus-negative tumors (p = 0.0001). CONCLUSIONS: Cancer-specific T and B cell responses generally track with disease burden during PD-1 blockade, in proportion to presence of antigen. Intratumoral TCR clonality was significantly greater in VP-MCC than VN-MCC tumors, suggesting expansion of a limited number of dominant clones in response to fewer immunogenic MCPyV antigens. In contrast, VN-MCC tumors had lower clonality, suggesting a diverse T cell response to numerous neoantigens. These findings reveal differences in tumor-specific immunity for VP-MCC and VN-MCC, both of which often respond to anti-PD-1 therapy.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N28dfcfc5078842bf9b58525e0f98841e
41 Nd92d98ed484f49af9fd0a2d75f11138c
42 sg:journal.1049249
43 schema:name Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy
44 schema:pagination 131
45 schema:productId N35e518a02acc4d61bed23171c564e062
46 N3fe26b996f754ae4977dbb93408c8c8f
47 N5c0a4b51338345df854da983e4b1efeb
48 N7e3e8919df344cffa9e1d23ae9c5cda5
49 N8445e4f194724eacafbaf47b0bb941d6
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110232190
51 https://doi.org/10.1186/s40425-018-0450-7
52 schema:sdDatePublished 2019-04-11T13:20
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher Ncf6e938279444e40935d059e8081141d
55 schema:url https://link.springer.com/10.1186%2Fs40425-018-0450-7
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N28dfcfc5078842bf9b58525e0f98841e schema:issueNumber 1
60 rdf:type schema:PublicationIssue
61 N28e9b2d3896544b7b24da1966761942e rdf:first sg:person.01047305757.47
62 rdf:rest Nc820a8ce04aa44a1923c14a0d0ba738c
63 N35e518a02acc4d61bed23171c564e062 schema:name nlm_unique_id
64 schema:value 101620585
65 rdf:type schema:PropertyValue
66 N382c4d35c6564a18a7431a5578cfb35f rdf:first sg:person.0602134176.86
67 rdf:rest N512d900fbc3e45f69bb55aad8f5c82c8
68 N3a866ea602384241b95da326fb358f1f rdf:first sg:person.01061300025.85
69 rdf:rest N56d0d4441bc843418a511747fd57f452
70 N3fe26b996f754ae4977dbb93408c8c8f schema:name dimensions_id
71 schema:value pub.1110232190
72 rdf:type schema:PropertyValue
73 N43af91f869ee4ac687ddb09ab0855011 rdf:first sg:person.076055012.52
74 rdf:rest N467d1d6367b149769d18a4b4eed43132
75 N467d1d6367b149769d18a4b4eed43132 rdf:first sg:person.01013060200.47
76 rdf:rest Nfa376ff14b124a04994d1fd7f9d5e193
77 N512d900fbc3e45f69bb55aad8f5c82c8 rdf:first sg:person.01336750727.45
78 rdf:rest Nb0422352240549b4a8fc900fe14c13fb
79 N56d0d4441bc843418a511747fd57f452 rdf:first sg:person.012063205607.60
80 rdf:rest N28e9b2d3896544b7b24da1966761942e
81 N5c0a4b51338345df854da983e4b1efeb schema:name doi
82 schema:value 10.1186/s40425-018-0450-7
83 rdf:type schema:PropertyValue
84 N642473d6a702481cac867fa60539b847 rdf:first sg:person.0765705317.93
85 rdf:rest N3a866ea602384241b95da326fb358f1f
86 N78ab721850f24d3f8924afa833bee031 rdf:first sg:person.07363543611.00
87 rdf:rest N43af91f869ee4ac687ddb09ab0855011
88 N7e3e8919df344cffa9e1d23ae9c5cda5 schema:name readcube_id
89 schema:value 3aafdb4cd6c50627961e57909a363c31cabc7a8bcfc3384f936cad87c9fd2e1d
90 rdf:type schema:PropertyValue
91 N8445e4f194724eacafbaf47b0bb941d6 schema:name pubmed_id
92 schema:value 30482247
93 rdf:type schema:PropertyValue
94 Nb0422352240549b4a8fc900fe14c13fb rdf:first sg:person.01034020517.30
95 rdf:rest N78ab721850f24d3f8924afa833bee031
96 Nc820a8ce04aa44a1923c14a0d0ba738c rdf:first sg:person.010702126474.16
97 rdf:rest N382c4d35c6564a18a7431a5578cfb35f
98 Ncf6e938279444e40935d059e8081141d schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 Nd92d98ed484f49af9fd0a2d75f11138c schema:volumeNumber 6
101 rdf:type schema:PublicationVolume
102 Nfa376ff14b124a04994d1fd7f9d5e193 rdf:first sg:person.0717057310.23
103 rdf:rest rdf:nil
104 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
105 schema:name Medical and Health Sciences
106 rdf:type schema:DefinedTerm
107 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
108 schema:name Immunology
109 rdf:type schema:DefinedTerm
110 sg:grant.2420944 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0450-7
111 rdf:type schema:MonetaryGrant
112 sg:grant.2438816 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0450-7
113 rdf:type schema:MonetaryGrant
114 sg:grant.2481624 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0450-7
115 rdf:type schema:MonetaryGrant
116 sg:grant.5475983 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0450-7
117 rdf:type schema:MonetaryGrant
118 sg:journal.1049249 schema:issn 2051-1426
119 schema:name Journal for ImmunoTherapy of Cancer
120 rdf:type schema:Periodical
121 sg:person.01013060200.47 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
122 schema:familyName Topalian
123 schema:givenName Suzanne L.
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013060200.47
125 rdf:type schema:Person
126 sg:person.01034020517.30 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
127 schema:familyName Bhatia
128 schema:givenName Shailender
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034020517.30
130 rdf:type schema:Person
131 sg:person.01047305757.47 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
132 schema:familyName Kulikauskas
133 schema:givenName Rima
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047305757.47
135 rdf:type schema:Person
136 sg:person.01061300025.85 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
137 schema:familyName Church
138 schema:givenName Candice D.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061300025.85
140 rdf:type schema:Person
141 sg:person.010702126474.16 schema:affiliation https://www.grid.ac/institutes/grid.270240.3
142 schema:familyName Ramchurren
143 schema:givenName Nirasha
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010702126474.16
145 rdf:type schema:Person
146 sg:person.012063205607.60 schema:affiliation https://www.grid.ac/institutes/grid.270240.3
147 schema:familyName Fling
148 schema:givenName Steven P.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012063205607.60
150 rdf:type schema:Person
151 sg:person.01336750727.45 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
152 schema:familyName Kluger
153 schema:givenName Harriet M.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336750727.45
155 rdf:type schema:Person
156 sg:person.0602134176.86 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
157 schema:familyName Shinohara
158 schema:givenName Michi M.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602134176.86
160 rdf:type schema:Person
161 sg:person.0717057310.23 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
162 schema:familyName Nghiem
163 schema:givenName Paul
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717057310.23
165 rdf:type schema:Person
166 sg:person.07363543611.00 schema:affiliation https://www.grid.ac/institutes/grid.270240.3
167 schema:familyName Lundgren
168 schema:givenName Lisa
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07363543611.00
170 rdf:type schema:Person
171 sg:person.076055012.52 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
172 schema:familyName Cheever
173 schema:givenName Martin A.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.076055012.52
175 rdf:type schema:Person
176 sg:person.0765705317.93 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
177 schema:familyName Miller
178 schema:givenName Natalie J.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765705317.93
180 rdf:type schema:Person
181 sg:pub.10.1038/jid.2013.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053734264
182 https://doi.org/10.1038/jid.2013.75
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/labinvest.2017.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091208107
185 https://doi.org/10.1038/labinvest.2017.80
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nature07662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021658404
188 https://doi.org/10.1038/nature07662
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nature13954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020455470
191 https://doi.org/10.1038/nature13954
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/nature22079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084754692
194 https://doi.org/10.1038/nature22079
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/ng.3581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038211511
197 https://doi.org/10.1038/ng.3581
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/nrdp.2017.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092350928
200 https://doi.org/10.1038/nrdp.2017.77
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/cncr.30475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044249414
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/cyto.a.22590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048423754
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/ijc.24510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003783619
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.jim.2007.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020268139
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.trecan.2016.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041573288
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s1470-2045(16)30364-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027076842
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1056/nejmoa1603702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014027039
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1073/pnas.1120914109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048928326
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/intimm/8.5.765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028435771
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/intimm/dxs098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003299808
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1093/intimm/dxv034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002737237
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1126/science.1152586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044765627
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1126/science.aaa1348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062665078
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1126/science.aan6733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085942187
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1158/0008-5472.can-10-2128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049964494
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1158/0008-5472.can-15-1877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012890521
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1158/1078-0432.ccr-11-1513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002333180
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1158/1078-0432.ccr-13-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018346650
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1158/1078-0432.ccr-13-2697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013150452
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1158/2326-6066.cir-13-0034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042788073
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1182/blood-2009-04-217604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014830407
245 rdf:type schema:CreativeWork
246 https://doi.org/10.18632/oncotarget.6494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010735855
247 rdf:type schema:CreativeWork
248 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
249 schema:name Department of Surgery, Johns Hopkins University School of Medicine, and Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA
250 rdf:type schema:Organization
251 https://www.grid.ac/institutes/grid.270240.3 schema:alternateName Fred Hutchinson Cancer Research Center
252 schema:name Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
255 schema:name Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
256 Department of Medicine, Divisions of Dermatology and Medical Oncology, University of Washington, 850 Republican Street, 98109, Seattle, WA, USA
257 Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
260 schema:name Comprehensive Cancer Center, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...