Immune-related adverse events with immune checkpoint inhibitors affecting the skeleton: a seminal case series View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Kendall F. Moseley, Jarushka Naidoo, Clifton O. Bingham, Michael A. Carducci, Patrick M. Forde, Geoffrey T. Gibney, Evan J. Lipson, Ami A. Shah, William H. Sharfman, Laura C. Cappelli

ABSTRACT

BACKGROUND: The use of immune checkpoint inhibitors is increasing in cancer therapy today. It is critical that treatment teams become familiar with the organ systems potentially impacted by immune-related adverse events associated with these drugs. Here, we report adverse skeletal effects of immunotherapy, a phenomenon not previously described. CASE PRESENTATIONS: In this retrospective case series, clinical, laboratory and imaging data were obtained in patients referred to endocrinology or rheumatology with new fractures (n = 3) or resorptive bone lesions (n = 3) that developed while on agents targeting PD-1, CTLA-4 or both. The average age of patients was 59.3 (SD 8.6), and five were male. Cancer types included melanoma, renal cell carcinoma and non-small cell lung cancer. All fracture patients had vertebral compression, and two of the three had multiple fracture sites involved. Sites of resorptive lesions included the shoulder, hand and clavicle. Biochemically, elevated or high-normal markers of bone resorption were seen in five of the six patients. Erythrocyte sedimentation rate was elevated in three of the four patients where checked. CONCLUSIONS: This case series represents the first description of potential skeletal adverse effects related to immune checkpoint inhibitors. These findings are important for providers caring for patients who experience musculoskeletal symptoms and may merit additional evaluation. More... »

PAGES

104

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-018-0417-8

DOI

http://dx.doi.org/10.1186/s40425-018-0417-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107538165

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30305172


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moseley", 
        "givenName": "Kendall F.", 
        "id": "sg:person.0625020577.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625020577.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naidoo", 
        "givenName": "Jarushka", 
        "id": "sg:person.01324076141.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324076141.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Medicine, Division of Rheumatology, Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bingham", 
        "givenName": "Clifton O.", 
        "id": "sg:person.012665640777.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012665640777.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carducci", 
        "givenName": "Michael A.", 
        "id": "sg:person.01266317743.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266317743.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forde", 
        "givenName": "Patrick M.", 
        "id": "sg:person.0760453113.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760453113.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MedStar Georgetown University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411663.7", 
          "name": [
            "Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington D.C., USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gibney", 
        "givenName": "Geoffrey T.", 
        "id": "sg:person.01065153434.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065153434.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lipson", 
        "givenName": "Evan J.", 
        "id": "sg:person.0717146534.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717146534.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Medicine, Division of Rheumatology, Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Ami A.", 
        "id": "sg:person.012320644667.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012320644667.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharfman", 
        "givenName": "William H.", 
        "id": "sg:person.01157620173.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157620173.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Medicine, Division of Rheumatology, Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cappelli", 
        "givenName": "Laura C.", 
        "id": "sg:person.012345144531.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012345144531.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/annrheumdis-2016-209595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001707216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2006.060180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002284969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.2905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004203198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20061775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021565940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000431091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026744653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-07-037994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029760348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2013.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030941261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-015-0572-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034032617", 
          "https://doi.org/10.1186/s12967-015-0572-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/125705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041962826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200526141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044420694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200526141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044420694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046951756", 
          "https://doi.org/10.1038/labinvest.3700701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780250907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049901841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000000918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050199280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000000918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050199280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2015.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053023000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2008.02.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053100475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/clica110811311140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078431948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cas.13226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084210997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/rmdopen-2016-000412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084225733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/rmdopen-2016-000412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084225733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2017-211216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085969559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085978916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2017.05.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086119092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.23467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092617586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.23467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092617586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.23467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092617586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1703481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100292997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2017.213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100316399", 
          "https://doi.org/10.1038/nrrheum.2017.213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2017.213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100316399", 
          "https://doi.org/10.1038/nrrheum.2017.213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-018-0417-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101785718", 
          "https://doi.org/10.1007/s00223-018-0417-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-018-0417-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101785718", 
          "https://doi.org/10.1007/s00223-018-0417-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-018-0417-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101785718", 
          "https://doi.org/10.1007/s00223-018-0417-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: The use of immune checkpoint inhibitors is increasing in cancer therapy today. It is critical that treatment teams become familiar with the organ systems potentially impacted by immune-related adverse events associated with these drugs. Here, we report adverse skeletal effects of immunotherapy, a phenomenon not previously described.\nCASE PRESENTATIONS: In this retrospective case series, clinical, laboratory and imaging data were obtained in patients referred to endocrinology or rheumatology with new fractures (n\u00a0=\u20093) or resorptive bone lesions (n\u2009=\u20093) that developed while on agents targeting PD-1, CTLA-4 or both. The average age of patients was 59.3 (SD 8.6), and five were male. Cancer types included melanoma, renal cell carcinoma and non-small cell lung cancer. All fracture patients had vertebral compression, and two of the three had multiple fracture sites involved. Sites of resorptive lesions included the shoulder, hand and clavicle. Biochemically, elevated or high-normal markers of bone resorption were seen in five of the six patients. Erythrocyte sedimentation rate was elevated in three of the four patients where checked.\nCONCLUSIONS: This case series represents the first description of potential skeletal adverse effects related to immune checkpoint inhibitors. These findings are important for providers caring for patients who experience musculoskeletal symptoms and may merit additional evaluation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40425-018-0417-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7614403", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6376883", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Immune-related adverse events with immune checkpoint inhibitors affecting the skeleton: a seminal case series", 
    "pagination": "104", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f0fece1ec669c3f1d3ffffedc0e42f8c9b8d4dfa3c28a981c3424333514784cc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30305172"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40425-018-0417-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107538165"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40425-018-0417-8", 
      "https://app.dimensions.ai/details/publication/pub.1107538165"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000566.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40425-018-0417-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0417-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0417-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0417-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0417-8'


 

This table displays all metadata directly associated to this object as RDF triples.

219 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40425-018-0417-8 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N82d63ac4d48e495195c11fc0ad48de63
4 schema:citation sg:pub.10.1007/s00223-018-0417-1
5 sg:pub.10.1038/labinvest.3700701
6 sg:pub.10.1038/nrrheum.2017.213
7 sg:pub.10.1186/s12967-015-0572-3
8 https://doi.org/10.1002/acr.23467
9 https://doi.org/10.1002/art.1780250907
10 https://doi.org/10.1002/eji.200526141
11 https://doi.org/10.1002/jbmr.2905
12 https://doi.org/10.1016/j.autrev.2013.03.015
13 https://doi.org/10.1016/j.bone.2008.02.017
14 https://doi.org/10.1016/j.ccell.2015.03.001
15 https://doi.org/10.1016/j.cyto.2017.05.024
16 https://doi.org/10.1056/nejmra1703481
17 https://doi.org/10.1084/jem.20061775
18 https://doi.org/10.1093/annonc/mdx306
19 https://doi.org/10.1097/qad.0000000000000918
20 https://doi.org/10.1111/cas.13226
21 https://doi.org/10.1136/annrheumdis-2016-209595
22 https://doi.org/10.1136/annrheumdis-2017-211216
23 https://doi.org/10.1136/rmdopen-2016-000412
24 https://doi.org/10.1155/2013/125705
25 https://doi.org/10.1159/000431091
26 https://doi.org/10.1182/blood-2006-07-037994
27 https://doi.org/10.2353/ajpath.2006.060180
28 https://doi.org/clica110811311140
29 schema:datePublished 2018-12
30 schema:datePublishedReg 2018-12-01
31 schema:description BACKGROUND: The use of immune checkpoint inhibitors is increasing in cancer therapy today. It is critical that treatment teams become familiar with the organ systems potentially impacted by immune-related adverse events associated with these drugs. Here, we report adverse skeletal effects of immunotherapy, a phenomenon not previously described. CASE PRESENTATIONS: In this retrospective case series, clinical, laboratory and imaging data were obtained in patients referred to endocrinology or rheumatology with new fractures (n = 3) or resorptive bone lesions (n = 3) that developed while on agents targeting PD-1, CTLA-4 or both. The average age of patients was 59.3 (SD 8.6), and five were male. Cancer types included melanoma, renal cell carcinoma and non-small cell lung cancer. All fracture patients had vertebral compression, and two of the three had multiple fracture sites involved. Sites of resorptive lesions included the shoulder, hand and clavicle. Biochemically, elevated or high-normal markers of bone resorption were seen in five of the six patients. Erythrocyte sedimentation rate was elevated in three of the four patients where checked. CONCLUSIONS: This case series represents the first description of potential skeletal adverse effects related to immune checkpoint inhibitors. These findings are important for providers caring for patients who experience musculoskeletal symptoms and may merit additional evaluation.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N64cd3bf1aa6f4ec8b93d07e1d7881ce7
36 Na8ad90d590ef4bad8e94985d7c92d08a
37 sg:journal.1049249
38 schema:name Immune-related adverse events with immune checkpoint inhibitors affecting the skeleton: a seminal case series
39 schema:pagination 104
40 schema:productId N3655c1fd38fc473ca767da90795130c7
41 N9d6fda46c25f4f528dd7080ff761a464
42 Nb38877d396a04905aee489ea10920a3b
43 Nb5050491c4394840a94a6c6f9357d03d
44 Nffba376c6afd437e8fcfc06504b4897e
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107538165
46 https://doi.org/10.1186/s40425-018-0417-8
47 schema:sdDatePublished 2019-04-11T00:25
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N84292e4f6ce94408931c1af412179a2c
50 schema:url https://link.springer.com/10.1186%2Fs40425-018-0417-8
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N01d33f2bf3414f8a905d634b26b8c968 rdf:first sg:person.012345144531.98
55 rdf:rest rdf:nil
56 N02d421043a7d4994a2963821b7c7a499 rdf:first sg:person.01266317743.88
57 rdf:rest Na60b30cb578c490e9132cd65b6b9b527
58 N29fdc70c49d74d808e539f08c2ca2844 rdf:first sg:person.01157620173.34
59 rdf:rest N01d33f2bf3414f8a905d634b26b8c968
60 N3655c1fd38fc473ca767da90795130c7 schema:name nlm_unique_id
61 schema:value 101620585
62 rdf:type schema:PropertyValue
63 N64cd3bf1aa6f4ec8b93d07e1d7881ce7 schema:issueNumber 1
64 rdf:type schema:PublicationIssue
65 N82d63ac4d48e495195c11fc0ad48de63 rdf:first sg:person.0625020577.44
66 rdf:rest Ndc71198a92ca459988e8c2508317bfcd
67 N84292e4f6ce94408931c1af412179a2c schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 N9d6fda46c25f4f528dd7080ff761a464 schema:name dimensions_id
70 schema:value pub.1107538165
71 rdf:type schema:PropertyValue
72 Na60b30cb578c490e9132cd65b6b9b527 rdf:first sg:person.0760453113.53
73 rdf:rest Nd1520eebdd4d4c75a09c2ba50426c6c8
74 Na8ad90d590ef4bad8e94985d7c92d08a schema:volumeNumber 6
75 rdf:type schema:PublicationVolume
76 Naba5d652a9fc40b0bca06fb6aa3695cb rdf:first sg:person.012320644667.43
77 rdf:rest N29fdc70c49d74d808e539f08c2ca2844
78 Nb38877d396a04905aee489ea10920a3b schema:name doi
79 schema:value 10.1186/s40425-018-0417-8
80 rdf:type schema:PropertyValue
81 Nb5050491c4394840a94a6c6f9357d03d schema:name readcube_id
82 schema:value f0fece1ec669c3f1d3ffffedc0e42f8c9b8d4dfa3c28a981c3424333514784cc
83 rdf:type schema:PropertyValue
84 Nccf79d2b8e224657bb51c3c9e8c78aa0 rdf:first sg:person.0717146534.21
85 rdf:rest Naba5d652a9fc40b0bca06fb6aa3695cb
86 Nd1520eebdd4d4c75a09c2ba50426c6c8 rdf:first sg:person.01065153434.51
87 rdf:rest Nccf79d2b8e224657bb51c3c9e8c78aa0
88 Ndc71198a92ca459988e8c2508317bfcd rdf:first sg:person.01324076141.76
89 rdf:rest Nfa0be3243bc0409d95368b440e1deabb
90 Nfa0be3243bc0409d95368b440e1deabb rdf:first sg:person.012665640777.51
91 rdf:rest N02d421043a7d4994a2963821b7c7a499
92 Nffba376c6afd437e8fcfc06504b4897e schema:name pubmed_id
93 schema:value 30305172
94 rdf:type schema:PropertyValue
95 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
96 schema:name Medical and Health Sciences
97 rdf:type schema:DefinedTerm
98 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
99 schema:name Clinical Sciences
100 rdf:type schema:DefinedTerm
101 sg:grant.6376883 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0417-8
102 rdf:type schema:MonetaryGrant
103 sg:grant.7614403 http://pending.schema.org/fundedItem sg:pub.10.1186/s40425-018-0417-8
104 rdf:type schema:MonetaryGrant
105 sg:journal.1049249 schema:issn 2051-1426
106 schema:name Journal for ImmunoTherapy of Cancer
107 rdf:type schema:Periodical
108 sg:person.01065153434.51 schema:affiliation https://www.grid.ac/institutes/grid.411663.7
109 schema:familyName Gibney
110 schema:givenName Geoffrey T.
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065153434.51
112 rdf:type schema:Person
113 sg:person.01157620173.34 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
114 schema:familyName Sharfman
115 schema:givenName William H.
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157620173.34
117 rdf:type schema:Person
118 sg:person.012320644667.43 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
119 schema:familyName Shah
120 schema:givenName Ami A.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012320644667.43
122 rdf:type schema:Person
123 sg:person.012345144531.98 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
124 schema:familyName Cappelli
125 schema:givenName Laura C.
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012345144531.98
127 rdf:type schema:Person
128 sg:person.01266317743.88 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
129 schema:familyName Carducci
130 schema:givenName Michael A.
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266317743.88
132 rdf:type schema:Person
133 sg:person.012665640777.51 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
134 schema:familyName Bingham
135 schema:givenName Clifton O.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012665640777.51
137 rdf:type schema:Person
138 sg:person.01324076141.76 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
139 schema:familyName Naidoo
140 schema:givenName Jarushka
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324076141.76
142 rdf:type schema:Person
143 sg:person.0625020577.44 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
144 schema:familyName Moseley
145 schema:givenName Kendall F.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625020577.44
147 rdf:type schema:Person
148 sg:person.0717146534.21 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
149 schema:familyName Lipson
150 schema:givenName Evan J.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717146534.21
152 rdf:type schema:Person
153 sg:person.0760453113.53 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
154 schema:familyName Forde
155 schema:givenName Patrick M.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760453113.53
157 rdf:type schema:Person
158 sg:pub.10.1007/s00223-018-0417-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101785718
159 https://doi.org/10.1007/s00223-018-0417-1
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/labinvest.3700701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046951756
162 https://doi.org/10.1038/labinvest.3700701
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/nrrheum.2017.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100316399
165 https://doi.org/10.1038/nrrheum.2017.213
166 rdf:type schema:CreativeWork
167 sg:pub.10.1186/s12967-015-0572-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034032617
168 https://doi.org/10.1186/s12967-015-0572-3
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/acr.23467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092617586
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/art.1780250907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049901841
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1002/eji.200526141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044420694
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/jbmr.2905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004203198
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.autrev.2013.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030941261
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.bone.2008.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053100475
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.ccell.2015.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053023000
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.cyto.2017.05.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086119092
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1056/nejmra1703481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100292997
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1084/jem.20061775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021565940
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1093/annonc/mdx306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085978916
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1097/qad.0000000000000918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050199280
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1111/cas.13226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084210997
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1136/annrheumdis-2016-209595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001707216
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1136/annrheumdis-2017-211216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085969559
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1136/rmdopen-2016-000412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084225733
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1155/2013/125705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041962826
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1159/000431091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026744653
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1182/blood-2006-07-037994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029760348
207 rdf:type schema:CreativeWork
208 https://doi.org/10.2353/ajpath.2006.060180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002284969
209 rdf:type schema:CreativeWork
210 https://doi.org/clica110811311140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078431948
211 rdf:type schema:CreativeWork
212 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
213 schema:name Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA
214 Department of Medicine, Division of Rheumatology, Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
215 Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
216 rdf:type schema:Organization
217 https://www.grid.ac/institutes/grid.411663.7 schema:alternateName MedStar Georgetown University Hospital
218 schema:name Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington D.C., USA
219 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...