Immune-checkpoint inhibitor-induced diarrhea and colitis in patients with advanced malignancies: retrospective review at MD Anderson View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Yinghong Wang, Hamzah Abu-Sbeih, Emily Mao, Noman Ali, Faisal Shaukat Ali, Wei Qiao, Phillip Lum, Gottumukkala Raju, Gladis Shuttlesworth, John Stroehlein, Adi Diab

ABSTRACT

BACKGROUND: Immune checkpoint inhibitors (ICPIs) are gaining increasing popularity as an efficacious treatment for advanced malignancies. ICPI treatment can be complicated by diarrhea and colitis. Systemic steroids are the first line treatment. Infliximab is reserved for severe refractory cases. We aimed to assess the impact of ICPI-induced diarrhea and colitis and their immunosuppressive treatment on patients' outcomes. METHODS: This retrospective analysis was conducted in 327 cancer patients who received ICPIs between 2011 and 2017. Patients with ICPI-induced toxicities in other organs were excluded. We collected data about patient demographics, clinical variables, and overall survival. We used descriptive analysis to compare different groups based on the occurrence and the treatment of diarrhea and colitis. Kaplan-Meier and log-rank test were used to estimate and compare overall survival durations between groups. RESULTS: Diarrhea was recorded in 117 (36%) patients; 79 (24%) of them required immunosuppressive treatment of either systemic corticosteroid without infliximab (n = 44) or with infliximab (n = 35). Caucasian ethnicity, melanoma, stage 3 cancer, and ipilimumab were predictors of colitis that requires immunosuppression. Patients who required immunosuppressants had better overall survival than those who did not require treatment for colitis or diarrhea (P < 0.001). Immunosuppression for diarrhea or colitis did not affect the overall survival significantly (P = 0.232), nor did the choice of treatment (corticosteroids with vs. without infliximab; P = 0.768). Diarrhea was an independent predictor of a favorable overall survival (P < 0.001), irrespective of treatment need (P = 0.003). We confirmed the same results in a subgroup analysis for patients with stage IV malignancies only. Patients who received long duration of steroid treatment (> 30 days) had numerically higher infection rate than those who received steroid for shorter duration (40.4 vs. 25.8%, P = 0.160). Likewise, long duration of steroid without infliximab was associated with increased risk of infection compared to short duration of steroid with infliximab (42.9% vs. 14.3%, P = 0.089). CONCLUSIONS: Patients with ICPI-induced diarrhea or colitis have improved survival outcomes. Diarrhea is an independent predictor of an improved survival regardless of treatment requirement. Immunosuppressive treatment for diarrhea did not significantly affect overall survival, however, infection rates were numerically higher among patients who received steroids for a long duration. Therefore, early non-steroid immunosuppressive therapy may ensure a more favorable overall outcome. More... »

PAGES

37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-018-0346-6

DOI

http://dx.doi.org/10.1186/s40425-018-0346-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103934884

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29747688


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yinghong", 
        "id": "sg:person.015665057020.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015665057020.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abu-Sbeih", 
        "givenName": "Hamzah", 
        "id": "sg:person.016550514710.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016550514710.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mao", 
        "givenName": "Emily", 
        "id": "sg:person.014642743712.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014642743712.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ali", 
        "givenName": "Noman", 
        "id": "sg:person.016235704712.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016235704712.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ali", 
        "givenName": "Faisal Shaukat", 
        "id": "sg:person.016272467732.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016272467732.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qiao", 
        "givenName": "Wei", 
        "id": "sg:person.01260600111.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260600111.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lum", 
        "givenName": "Phillip", 
        "id": "sg:person.014061542335.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014061542335.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raju", 
        "givenName": "Gottumukkala", 
        "id": "sg:person.01102030552.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102030552.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shuttlesworth", 
        "givenName": "Gladis", 
        "id": "sg:person.0737746044.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737746044.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stroehlein", 
        "givenName": "John", 
        "id": "sg:person.01267003224.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267003224.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diab", 
        "givenName": "Adi", 
        "id": "sg:person.01040471746.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040471746.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1507643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000663586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001896079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.5716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003868054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003953337", 
          "https://doi.org/10.1038/nature13904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1509660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007002632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0000000000000186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008385567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0000000000000186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008385567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.60.8448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009760042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1411087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014862127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.166.17.1907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015560126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.41.6750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019320335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1510665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019970557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1504030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024843336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2015.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034148114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041312915", 
          "https://doi.org/10.1038/nature14011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1200690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042896583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-198212000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045278392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-198212000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045278392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049037424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.4059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050191779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2016.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053153592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-1136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063224982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1509660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079154105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.66.1389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079388627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2017.00049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083728173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084178016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085249345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085848805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2017.2391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091229730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1709684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091588153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40425-017-0300-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092818845", 
          "https://doi.org/10.1186/s40425-017-0300-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ibd/izy104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103703419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ibd/izy104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103703419"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Immune checkpoint inhibitors (ICPIs) are gaining increasing popularity as an efficacious treatment for advanced malignancies. ICPI treatment can be complicated by diarrhea and colitis. Systemic steroids are the first line treatment. Infliximab is reserved for severe refractory cases. We aimed to assess the impact of ICPI-induced diarrhea and colitis and their immunosuppressive treatment on patients' outcomes.\nMETHODS: This retrospective analysis was conducted in 327 cancer patients who received ICPIs between 2011 and 2017. Patients with ICPI-induced toxicities in other organs were excluded. We collected data about patient demographics, clinical variables, and overall survival. We used descriptive analysis to compare different groups based on the occurrence and the treatment of diarrhea and colitis. Kaplan-Meier and log-rank test were used to estimate and compare overall survival durations between groups.\nRESULTS: Diarrhea was recorded in 117 (36%) patients; 79 (24%) of them required immunosuppressive treatment of either systemic corticosteroid without infliximab (n\u00a0=\u200944) or with infliximab (n\u00a0=\u200935). Caucasian ethnicity, melanoma, stage 3 cancer, and ipilimumab were predictors of colitis that requires immunosuppression. Patients who required immunosuppressants had better overall survival than those who did not require treatment for colitis or diarrhea (P\u00a0<\u20090.001). Immunosuppression for diarrhea or colitis did not affect the overall survival significantly (P\u00a0=\u20090.232), nor did the choice of treatment (corticosteroids with vs. without infliximab; P\u00a0=\u20090.768). Diarrhea was an independent predictor of a favorable overall survival (P\u00a0<\u20090.001), irrespective of treatment need (P\u00a0=\u20090.003). We confirmed the same results in a subgroup analysis for patients with stage IV malignancies only. Patients who received long duration of steroid treatment (>\u200930\u00a0days) had numerically higher infection rate than those who received steroid for shorter duration (40.4 vs. 25.8%, P\u00a0=\u20090.160). Likewise, long duration of steroid without infliximab was associated with increased risk of infection compared to short duration of steroid with infliximab (42.9% vs. 14.3%, P\u00a0=\u20090.089).\nCONCLUSIONS: Patients with ICPI-induced diarrhea or colitis have improved survival outcomes. Diarrhea is an independent predictor of an improved survival regardless of treatment requirement. Immunosuppressive treatment for diarrhea did not significantly affect overall survival, however, infection rates were numerically higher among patients who received steroids for a long duration. Therefore, early non-steroid immunosuppressive therapy may ensure a more favorable overall outcome.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40425-018-0346-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Immune-checkpoint inhibitor-induced diarrhea and colitis in patients with advanced malignancies: retrospective review at MD Anderson", 
    "pagination": "37", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3737a969ca3ac810c6314577960c8f90673fdfb3c19cedc73596dea76cf14fb0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29747688"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40425-018-0346-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103934884"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40425-018-0346-6", 
      "https://app.dimensions.ai/details/publication/pub.1103934884"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89826_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40425-018-0346-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0346-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0346-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0346-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-018-0346-6'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      21 PREDICATES      59 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40425-018-0346-6 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nfdedb9032b894178b1204dde4010704e
4 schema:citation sg:pub.10.1038/nature13904
5 sg:pub.10.1038/nature14011
6 sg:pub.10.1186/s40425-017-0300-z
7 https://doi.org/10.1001/archinte.166.17.1907
8 https://doi.org/10.1001/jama.2016.4059
9 https://doi.org/10.1001/jamaoncol.2017.2391
10 https://doi.org/10.1016/j.cell.2011.02.013
11 https://doi.org/10.1016/j.ctrv.2016.02.001
12 https://doi.org/10.1016/j.ejca.2015.11.016
13 https://doi.org/10.1056/nejmc1509660
14 https://doi.org/10.1056/nejmoa1200690
15 https://doi.org/10.1056/nejmoa1411087
16 https://doi.org/10.1056/nejmoa1504030
17 https://doi.org/10.1056/nejmoa1507643
18 https://doi.org/10.1056/nejmoa1510665
19 https://doi.org/10.1056/nejmoa1709684
20 https://doi.org/10.1093/annonc/mdx108
21 https://doi.org/10.1093/annonc/mdx225
22 https://doi.org/10.1093/annonc/mdx286
23 https://doi.org/10.1093/ibd/izy104
24 https://doi.org/10.1097/00000421-198212000-00014
25 https://doi.org/10.1097/ppo.0000000000000186
26 https://doi.org/10.1158/1078-0432.ccr-07-0187
27 https://doi.org/10.1158/1078-0432.ccr-10-2463
28 https://doi.org/10.1158/1078-0432.ccr-15-1136
29 https://doi.org/10.1200/jco.2005.04.5716
30 https://doi.org/10.1200/jco.2012.41.6750
31 https://doi.org/10.1200/jco.2015.60.8448
32 https://doi.org/10.1200/jco.2015.66.1389
33 https://doi.org/10.3389/fphar.2017.00049
34 schema:datePublished 2018-12
35 schema:datePublishedReg 2018-12-01
36 schema:description BACKGROUND: Immune checkpoint inhibitors (ICPIs) are gaining increasing popularity as an efficacious treatment for advanced malignancies. ICPI treatment can be complicated by diarrhea and colitis. Systemic steroids are the first line treatment. Infliximab is reserved for severe refractory cases. We aimed to assess the impact of ICPI-induced diarrhea and colitis and their immunosuppressive treatment on patients' outcomes. METHODS: This retrospective analysis was conducted in 327 cancer patients who received ICPIs between 2011 and 2017. Patients with ICPI-induced toxicities in other organs were excluded. We collected data about patient demographics, clinical variables, and overall survival. We used descriptive analysis to compare different groups based on the occurrence and the treatment of diarrhea and colitis. Kaplan-Meier and log-rank test were used to estimate and compare overall survival durations between groups. RESULTS: Diarrhea was recorded in 117 (36%) patients; 79 (24%) of them required immunosuppressive treatment of either systemic corticosteroid without infliximab (n = 44) or with infliximab (n = 35). Caucasian ethnicity, melanoma, stage 3 cancer, and ipilimumab were predictors of colitis that requires immunosuppression. Patients who required immunosuppressants had better overall survival than those who did not require treatment for colitis or diarrhea (P < 0.001). Immunosuppression for diarrhea or colitis did not affect the overall survival significantly (P = 0.232), nor did the choice of treatment (corticosteroids with vs. without infliximab; P = 0.768). Diarrhea was an independent predictor of a favorable overall survival (P < 0.001), irrespective of treatment need (P = 0.003). We confirmed the same results in a subgroup analysis for patients with stage IV malignancies only. Patients who received long duration of steroid treatment (> 30 days) had numerically higher infection rate than those who received steroid for shorter duration (40.4 vs. 25.8%, P = 0.160). Likewise, long duration of steroid without infliximab was associated with increased risk of infection compared to short duration of steroid with infliximab (42.9% vs. 14.3%, P = 0.089). CONCLUSIONS: Patients with ICPI-induced diarrhea or colitis have improved survival outcomes. Diarrhea is an independent predictor of an improved survival regardless of treatment requirement. Immunosuppressive treatment for diarrhea did not significantly affect overall survival, however, infection rates were numerically higher among patients who received steroids for a long duration. Therefore, early non-steroid immunosuppressive therapy may ensure a more favorable overall outcome.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N315a2c689a7e4850b802143276ebc25d
41 N5acff36547ac4a55acec7eb1b81cf700
42 sg:journal.1049249
43 schema:name Immune-checkpoint inhibitor-induced diarrhea and colitis in patients with advanced malignancies: retrospective review at MD Anderson
44 schema:pagination 37
45 schema:productId N134ef854f3234d1b9150bc40f613926a
46 N23601f4d16564989b35ccf8a28d2c463
47 N291683101c974090a859699b8f4be5d7
48 N3ccead6a3bb546aaaba21c8ea5c0503e
49 Nb82299eee46c4749b0773cd7aa74fd5c
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103934884
51 https://doi.org/10.1186/s40425-018-0346-6
52 schema:sdDatePublished 2019-04-11T10:04
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N53a8b1ab00da42bdafb744cba1314cdc
55 schema:url https://link.springer.com/10.1186%2Fs40425-018-0346-6
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N08fdc481100c4437ab5feebe61a4ba6a rdf:first sg:person.016550514710.13
60 rdf:rest Ne663b8aae2074ff79086a5b39e6cc358
61 N0c8b0968f9da413796cc4386214b1001 rdf:first sg:person.01267003224.75
62 rdf:rest Nb298ed011f8849d7bc26ea4714ff8f4e
63 N134ef854f3234d1b9150bc40f613926a schema:name readcube_id
64 schema:value 3737a969ca3ac810c6314577960c8f90673fdfb3c19cedc73596dea76cf14fb0
65 rdf:type schema:PropertyValue
66 N1ce7be93ab0f40749857ecd132e74c39 rdf:first sg:person.01260600111.09
67 rdf:rest N917314c1371a41d183b47b85832fcd58
68 N23601f4d16564989b35ccf8a28d2c463 schema:name doi
69 schema:value 10.1186/s40425-018-0346-6
70 rdf:type schema:PropertyValue
71 N291683101c974090a859699b8f4be5d7 schema:name pubmed_id
72 schema:value 29747688
73 rdf:type schema:PropertyValue
74 N315a2c689a7e4850b802143276ebc25d schema:volumeNumber 6
75 rdf:type schema:PublicationVolume
76 N3ccead6a3bb546aaaba21c8ea5c0503e schema:name nlm_unique_id
77 schema:value 101620585
78 rdf:type schema:PropertyValue
79 N53a8b1ab00da42bdafb744cba1314cdc schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N5acff36547ac4a55acec7eb1b81cf700 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N859aca0d2f6e426ea7ab326ad9aa321e rdf:first sg:person.0737746044.31
84 rdf:rest N0c8b0968f9da413796cc4386214b1001
85 N917314c1371a41d183b47b85832fcd58 rdf:first sg:person.014061542335.03
86 rdf:rest Ndf3f69c2068d47e682be1aa145b5c158
87 Na8f3f106971c42b9995699cb823247a1 rdf:first sg:person.016272467732.86
88 rdf:rest N1ce7be93ab0f40749857ecd132e74c39
89 Nb298ed011f8849d7bc26ea4714ff8f4e rdf:first sg:person.01040471746.47
90 rdf:rest rdf:nil
91 Nb82299eee46c4749b0773cd7aa74fd5c schema:name dimensions_id
92 schema:value pub.1103934884
93 rdf:type schema:PropertyValue
94 Ndf3f69c2068d47e682be1aa145b5c158 rdf:first sg:person.01102030552.92
95 rdf:rest N859aca0d2f6e426ea7ab326ad9aa321e
96 Ne663b8aae2074ff79086a5b39e6cc358 rdf:first sg:person.014642743712.02
97 rdf:rest Nf931b0988d63403186f821400a611bf6
98 Nf931b0988d63403186f821400a611bf6 rdf:first sg:person.016235704712.87
99 rdf:rest Na8f3f106971c42b9995699cb823247a1
100 Nfdedb9032b894178b1204dde4010704e rdf:first sg:person.015665057020.31
101 rdf:rest N08fdc481100c4437ab5feebe61a4ba6a
102 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
103 schema:name Medical and Health Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
106 schema:name Oncology and Carcinogenesis
107 rdf:type schema:DefinedTerm
108 sg:journal.1049249 schema:issn 2051-1426
109 schema:name Journal for ImmunoTherapy of Cancer
110 rdf:type schema:Periodical
111 sg:person.01040471746.47 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
112 schema:familyName Diab
113 schema:givenName Adi
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040471746.47
115 rdf:type schema:Person
116 sg:person.01102030552.92 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
117 schema:familyName Raju
118 schema:givenName Gottumukkala
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102030552.92
120 rdf:type schema:Person
121 sg:person.01260600111.09 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
122 schema:familyName Qiao
123 schema:givenName Wei
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260600111.09
125 rdf:type schema:Person
126 sg:person.01267003224.75 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
127 schema:familyName Stroehlein
128 schema:givenName John
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267003224.75
130 rdf:type schema:Person
131 sg:person.014061542335.03 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
132 schema:familyName Lum
133 schema:givenName Phillip
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014061542335.03
135 rdf:type schema:Person
136 sg:person.014642743712.02 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
137 schema:familyName Mao
138 schema:givenName Emily
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014642743712.02
140 rdf:type schema:Person
141 sg:person.015665057020.31 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
142 schema:familyName Wang
143 schema:givenName Yinghong
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015665057020.31
145 rdf:type schema:Person
146 sg:person.016235704712.87 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
147 schema:familyName Ali
148 schema:givenName Noman
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016235704712.87
150 rdf:type schema:Person
151 sg:person.016272467732.86 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
152 schema:familyName Ali
153 schema:givenName Faisal Shaukat
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016272467732.86
155 rdf:type schema:Person
156 sg:person.016550514710.13 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
157 schema:familyName Abu-Sbeih
158 schema:givenName Hamzah
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016550514710.13
160 rdf:type schema:Person
161 sg:person.0737746044.31 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
162 schema:familyName Shuttlesworth
163 schema:givenName Gladis
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737746044.31
165 rdf:type schema:Person
166 sg:pub.10.1038/nature13904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003953337
167 https://doi.org/10.1038/nature13904
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nature14011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041312915
170 https://doi.org/10.1038/nature14011
171 rdf:type schema:CreativeWork
172 sg:pub.10.1186/s40425-017-0300-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1092818845
173 https://doi.org/10.1186/s40425-017-0300-z
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1001/archinte.166.17.1907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015560126
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1001/jama.2016.4059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050191779
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1001/jamaoncol.2017.2391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091229730
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.ctrv.2016.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053153592
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.ejca.2015.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034148114
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1056/nejmc1509660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007002632
188 https://app.dimensions.ai/details/publication/pub.1079154105
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1056/nejmoa1200690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042896583
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1056/nejmoa1411087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014862127
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1056/nejmoa1504030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024843336
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1056/nejmoa1507643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000663586
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1056/nejmoa1510665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019970557
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1056/nejmoa1709684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091588153
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1093/annonc/mdx108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084178016
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1093/annonc/mdx225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085249345
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1093/annonc/mdx286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085848805
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1093/ibd/izy104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103703419
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1097/00000421-198212000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045278392
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1097/ppo.0000000000000186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008385567
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1158/1078-0432.ccr-07-0187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049037424
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1158/1078-0432.ccr-10-2463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001896079
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1158/1078-0432.ccr-15-1136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224982
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1200/jco.2005.04.5716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003868054
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1200/jco.2012.41.6750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019320335
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1200/jco.2015.60.8448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009760042
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1200/jco.2015.66.1389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079388627
227 rdf:type schema:CreativeWork
228 https://doi.org/10.3389/fphar.2017.00049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083728173
229 rdf:type schema:CreativeWork
230 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
231 schema:name Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
232 Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
233 Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
236 schema:name Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...