Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Ashish M. Kamat, Joaquim Bellmunt, Matthew D. Galsky, Badrinath R. Konety, Donald L. Lamm, David Langham, Cheryl T. Lee, Matthew I. Milowsky, Michael A. O’Donnell, Peter H. O’Donnell, Daniel P. Petrylak, Padmanee Sharma, Eila C. Skinner, Guru Sonpavde, John A. Taylor, Prasanth Abraham, Jonathan E. Rosenberg

ABSTRACT

The standard of care for most patients with non-muscle-invasive bladder cancer (NMIBC) is immunotherapy with intravesical Bacillus Calmette-Guérin (BCG), which activates the immune system to recognize and destroy malignant cells and has demonstrated durable clinical benefit. Urologic best-practice guidelines and consensus reports have been developed and strengthened based on data on the timing, dose, and duration of therapy from randomized clinical trials, as well as by critical evaluation of criteria for progression. However, these reports have not penetrated the community, and many patients do not receive appropriate therapy. Additionally, several immune checkpoint inhibitors have recently been approved for treatment of metastatic disease. The approval of immune checkpoint blockade for patients with platinum-resistant or -ineligible metastatic bladder cancer has led to considerations of expanded use for both advanced and, potentially, localized disease. To address these issues and others surrounding the appropriate use of immunotherapy for the treatment of bladder cancer, the Society for Immunotherapy of Cancer (SITC) convened a Task Force of experts, including physicians, patient advocates, and nurses, to address issues related to patient selection, toxicity management, clinical endpoints, as well as the combination and sequencing of therapies. Following the standard approach established by the Society for other cancers, a systematic literature review and analysis of data, combined with consensus voting was used to generate guidelines. Here, we provide a consensus statement for the use of immunotherapy in patients with bladder cancer, with plans to update these recommendations as the field progresses. More... »

PAGES

68

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-017-0271-0

DOI

http://dx.doi.org/10.1186/s40425-017-0271-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091167162

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28807024


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464 https://www.grid.ac/institutes/grid.468219.0 schema:alternateName University of Kansas Cancer Center
465 schema:name University of Kansas Cancer Center, 66160, Kansas City, KS, USA
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467 https://www.grid.ac/institutes/grid.473769.8 schema:alternateName Bladder Cancer Advocacy Network
468 schema:name Bladder Cancer Advocacy Network, North Carolina Triangle Chapter, 27517, Chapel Hill, NC, USA
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470 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
471 schema:name Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA
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473 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
474 schema:name Dana-Farber Cancer Institute, 02446, Brookline, MA, USA
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