Ontology type: schema:ScholarlyArticle Open Access: True
2016-11-15
AUTHORSBrian I. Rini, David F. McDermott, Hans Hammers, William Bro, Ronald M. Bukowski, Bernard Faba, Jo Faba, Robert A. Figlin, Thomas Hutson, Eric Jonasch, Richard W. Joseph, Bradley C. Leibovich, Thomas Olencki, Allan J. Pantuck, David I. Quinn, Virginia Seery, Martin H. Voss, Christopher G. Wood, Laura S. Wood, Michael B. Atkins
ABSTRACTImmunotherapy has produced durable clinical benefit in patients with metastatic renal cell cancer (RCC). In the past, patients treated with interferon-alpha (IFN) and interleukin-2 (IL-2) have achieved complete responses, many of which have lasted for multiple decades. More recently, a large number of new agents have been approved for RCC, several of which attack tumor angiogenesis by inhibiting vascular endothelial growth factors (VEGF) and VEGF receptors (VEGFR), as well as tumor metabolism, inhibiting the mammalian target of rapamycin (mTOR). Additionally, a new class of immunotherapy agents, immune checkpoint inhibitors, is emerging and will play a significant role in the treatment of patients with RCC. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a Task Force, which met to consider the current role of approved immunotherapy agents in RCC, to provide guidance to practicing clinicians by developing consensus recommendations and to set the stage for future immunotherapeutic developments in RCC. More... »
PAGES81
http://scigraph.springernature.com/pub.10.1186/s40425-016-0180-7
DOIhttp://dx.doi.org/10.1186/s40425-016-0180-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1048113477
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27891227
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents, Immunological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Renal Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunotherapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kidney Neoplasms",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Ave, 44195, Cleveland, OH, USA",
"id": "http://www.grid.ac/institutes/grid.239578.2",
"name": [
"Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Ave, 44195, Cleveland, OH, USA"
],
"type": "Organization"
},
"familyName": "Rini",
"givenName": "Brian I.",
"id": "sg:person.01113325143.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113325143.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, 10 Highfield Circle, 02186, Milton, MA, USA",
"id": "http://www.grid.ac/institutes/grid.239395.7",
"name": [
"Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, 10 Highfield Circle, 02186, Milton, MA, USA"
],
"type": "Organization"
},
"familyName": "McDermott",
"givenName": "David F.",
"id": "sg:person.0656541200.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656541200.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans St, 21287, Baltimore, MD, USA",
"id": "http://www.grid.ac/institutes/grid.280502.d",
"name": [
"Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans St, 21287, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Hammers",
"givenName": "Hans",
"id": "sg:person.01220204543.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220204543.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kidney Cancer Association, PO Box 4668 #38269, 60680, Chicago, IL, USA",
"id": "http://www.grid.ac/institutes/grid.429486.5",
"name": [
"Kidney Cancer Association, PO Box 4668 #38269, 60680, Chicago, IL, USA"
],
"type": "Organization"
},
"familyName": "Bro",
"givenName": "William",
"id": "sg:person.016007735261.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016007735261.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cleveland Clinic Taussig Cancer Institute, 1 Clinic Center, 44195, Cleveland, OH, USA",
"id": "http://www.grid.ac/institutes/grid.239578.2",
"name": [
"Cleveland Clinic Taussig Cancer Institute, 1 Clinic Center, 44195, Cleveland, OH, USA"
],
"type": "Organization"
},
"familyName": "Bukowski",
"givenName": "Ronald M.",
"id": "sg:person.016504525417.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016504525417.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Patient and Patient Advocate, Cleveland, USA",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Patient and Patient Advocate, Cleveland, USA"
],
"type": "Organization"
},
"familyName": "Faba",
"givenName": "Bernard",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Patient and Patient Advocate, Cleveland, USA",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Patient and Patient Advocate, Cleveland, USA"
],
"type": "Organization"
},
"familyName": "Faba",
"givenName": "Jo",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cedars-Sinai Medical Center, 8700 Beverly Blvd., Saperstein Critical Care Tower, 1S28, 90048, Los Angeles, CA, USA",
"id": "http://www.grid.ac/institutes/grid.50956.3f",
"name": [
"Cedars-Sinai Medical Center, 8700 Beverly Blvd., Saperstein Critical Care Tower, 1S28, 90048, Los Angeles, CA, USA"
],
"type": "Organization"
},
"familyName": "Figlin",
"givenName": "Robert A.",
"id": "sg:person.0664152550.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664152550.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Charles A. Sammons Cancer Center, Baylor University Medical Center, 3410 Worth Street, Suite 400, 75254, Dallas, TX, USA",
"id": "http://www.grid.ac/institutes/grid.411588.1",
"name": [
"Charles A. Sammons Cancer Center, Baylor University Medical Center, 3410 Worth Street, Suite 400, 75254, Dallas, TX, USA"
],
"type": "Organization"
},
"familyName": "Hutson",
"givenName": "Thomas",
"id": "sg:person.0626761272.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626761272.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA",
"id": "http://www.grid.ac/institutes/grid.240145.6",
"name": [
"M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Jonasch",
"givenName": "Eric",
"id": "sg:person.01172764022.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172764022.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA",
"id": "http://www.grid.ac/institutes/grid.417467.7",
"name": [
"Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA"
],
"type": "Organization"
},
"familyName": "Joseph",
"givenName": "Richard W.",
"id": "sg:person.0630150147.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630150147.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA",
"id": "http://www.grid.ac/institutes/grid.66875.3a",
"name": [
"Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA"
],
"type": "Organization"
},
"familyName": "Leibovich",
"givenName": "Bradley C.",
"id": "sg:person.01032433200.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032433200.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Ohio State University Medical Center, 320 W. 10th Avenue, 43210, Columbus, OH, USA",
"id": "http://www.grid.ac/institutes/grid.412332.5",
"name": [
"The Ohio State University Medical Center, 320 W. 10th Avenue, 43210, Columbus, OH, USA"
],
"type": "Organization"
},
"familyName": "Olencki",
"givenName": "Thomas",
"id": "sg:person.01336633224.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336633224.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "UCLA Institute of Urologic Oncology, 66-124 Center for Health Sciences, 90095, Los Angeles, CA, USA",
"id": "http://www.grid.ac/institutes/grid.19006.3e",
"name": [
"UCLA Institute of Urologic Oncology, 66-124 Center for Health Sciences, 90095, Los Angeles, CA, USA"
],
"type": "Organization"
},
"familyName": "Pantuck",
"givenName": "Allan J.",
"id": "sg:person.01365327543.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365327543.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kenneth J. Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave Suite 3451, 90033, Los Angeles, CA, USA",
"id": "http://www.grid.ac/institutes/grid.42505.36",
"name": [
"Kenneth J. Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave Suite 3451, 90033, Los Angeles, CA, USA"
],
"type": "Organization"
},
"familyName": "Quinn",
"givenName": "David I.",
"id": "sg:person.01013134010.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013134010.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, 10 Highfield Circle, 02186, Milton, MA, USA",
"id": "http://www.grid.ac/institutes/grid.239395.7",
"name": [
"Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, 10 Highfield Circle, 02186, Milton, MA, USA"
],
"type": "Organization"
},
"familyName": "Seery",
"givenName": "Virginia",
"id": "sg:person.01330202470.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330202470.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA",
"id": "http://www.grid.ac/institutes/grid.51462.34",
"name": [
"Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Voss",
"givenName": "Martin H.",
"id": "sg:person.0577111044.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577111044.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA",
"id": "http://www.grid.ac/institutes/grid.240145.6",
"name": [
"M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Wood",
"givenName": "Christopher G.",
"id": "sg:person.01040121722.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040121722.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Ave, 44195, Cleveland, OH, USA",
"id": "http://www.grid.ac/institutes/grid.239578.2",
"name": [
"Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Ave, 44195, Cleveland, OH, USA"
],
"type": "Organization"
},
"familyName": "Wood",
"givenName": "Laura S.",
"id": "sg:person.010243623117.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010243623117.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Georgetown-Lombardi Comprehensive Cancer Center, 3970 Reservoir Road, NW, Research Building, Room E501, 20057, Washington, DC, USA",
"id": "http://www.grid.ac/institutes/grid.213910.8",
"name": [
"Georgetown-Lombardi Comprehensive Cancer Center, 3970 Reservoir Road, NW, Research Building, Room E501, 20057, Washington, DC, USA"
],
"type": "Organization"
},
"familyName": "Atkins",
"givenName": "Michael B.",
"id": "sg:person.010266621557.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010266621557.13"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nrd2422",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017129957",
"https://doi.org/10.1038/nrd2422"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrclinonc.2013.153",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042806557",
"https://doi.org/10.1038/nrclinonc.2013.153"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02787344",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010497396",
"https://doi.org/10.1007/bf02787344"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s40425-014-0026-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026833788",
"https://doi.org/10.1186/s40425-014-0026-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/2051-1426-2-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044739200",
"https://doi.org/10.1186/2051-1426-2-13"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12032-009-9177-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015825260",
"https://doi.org/10.1007/s12032-009-9177-0"
],
"type": "CreativeWork"
}
],
"datePublished": "2016-11-15",
"datePublishedReg": "2016-11-15",
"description": "Immunotherapy has produced durable clinical benefit in patients with metastatic renal cell cancer (RCC). In the past, patients treated with interferon-alpha (IFN) and interleukin-2 (IL-2) have achieved complete responses, many of which have lasted for multiple decades. More recently, a large number of new agents have been approved for RCC, several of which attack tumor angiogenesis by inhibiting vascular endothelial growth factors (VEGF) and VEGF receptors (VEGFR), as well as tumor metabolism, inhibiting the mammalian target of rapamycin (mTOR). Additionally, a new class of immunotherapy agents, immune checkpoint inhibitors, is emerging and will play a significant role in the treatment of patients with RCC. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a Task Force, which met to consider the current role of approved immunotherapy agents in RCC, to provide guidance to practicing clinicians by developing consensus recommendations and to set the stage for future immunotherapeutic developments in RCC.",
"genre": "article",
"id": "sg:pub.10.1186/s40425-016-0180-7",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1049249",
"issn": [
"2051-1426"
],
"name": "Journal for ImmunoTherapy of Cancer",
"publisher": "BMJ",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "4"
}
],
"keywords": [
"renal cell cancer",
"vascular endothelial growth factor",
"immunotherapy agents",
"interleukin-2",
"metastatic renal cell cancer",
"VEGF receptors",
"Cancer consensus statement",
"immune checkpoint inhibitors",
"durable clinical benefit",
"treatment of patients",
"immunotherapy of cancer",
"renal cell carcinoma",
"endothelial growth factor",
"checkpoint inhibitors",
"complete response",
"cell cancer",
"clinical benefit",
"cell carcinoma",
"consensus statement",
"consensus recommendations",
"immunotherapeutic development",
"new agents",
"immunotherapy",
"tumor angiogenesis",
"tumor metabolism",
"mammalian target",
"patients",
"growth factor",
"current role",
"cancer",
"Task Force",
"treatment",
"agents",
"carcinoma",
"clinicians",
"receptors",
"angiogenesis",
"rapamycin",
"inhibitors",
"metabolism",
"role",
"significant role",
"response",
"target",
"factors",
"recommendations",
"benefits",
"large number",
"guidance",
"stage",
"development",
"number",
"new class",
"society",
"decades",
"statements",
"multiple decades",
"class",
"past",
"force"
],
"name": "Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of renal cell carcinoma",
"pagination": "81",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1048113477"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s40425-016-0180-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"27891227"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s40425-016-0180-7",
"https://app.dimensions.ai/details/publication/pub.1048113477"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_697.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s40425-016-0180-7"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40425-016-0180-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40425-016-0180-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40425-016-0180-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40425-016-0180-7'
This table displays all metadata directly associated to this object as RDF triples.
339 TRIPLES
21 PREDICATES
96 URIs
82 LITERALS
12 BLANK NODES