Disease stabilization with pembrolizumab for metastatic acral melanoma in the setting of autoimmune bullous pemphigoid View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04-19

AUTHORS

Kristen M. Beck, Joanna Dong, Larisa J. Geskin, Vincent P. Beltrani, Richard G. Phelps, Richard D. Carvajal, Gary Schwartz, Yvonne M. Saenger, Robyn D. Gartrell

ABSTRACT

BackgroundTo date, patients with pre-existing autoimmune conditions have been excluded from immunotherapy trials out of concern for severe autoimmune exacerbations.Case PresentationWe describe the first case of a patient with metastatic cKIT mutated acral melanoma, brain metastasis, and pre-existing severe autoimmune bullous pemphigoid (BP) with stable and asymptomatic disease 10 months after treatment with pembrolizumab. The patient experienced severe BP exacerbation after therapy with ipilimumab requiring systemic immune suppression, but nonetheless pembrolizumab was administered on further disease progression.ConclusionsThis case suggests that pembrolizumab may confer more benefit than risk even in patients with known severe autoimmune conditions who require intermittent systemic immunosuppression. More... »

PAGES

20

References to SciGraph publications

  • 2007-07-20. The Pathophysiology of Bullous Pemphigoid in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2014-10-14. Ipilimumab in patients with melanoma and autoimmune disease in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2015-06-23. Combined immunotherapy—a new standard in metastatic melanoma? in NATURE REVIEWS CLINICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40425-016-0123-3

    DOI

    http://dx.doi.org/10.1186/s40425-016-0123-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039076867

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27096097


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