Targeting the indoleamine 2,3-dioxygenase pathway in cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Yong Wha Moon, Joud Hajjar, Patrick Hwu, Aung Naing

ABSTRACT

Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development. More... »

PAGES

51

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40425-015-0094-9

    DOI

    http://dx.doi.org/10.1186/s40425-015-0094-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022743938

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26674411


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