Ipilimumab in patients with melanoma and autoimmune disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-14

AUTHORS

Chrisann Kyi, Richard D Carvajal, Jedd D Wolchok, Michael A Postow

ABSTRACT

Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), an immune-checkpoint receptor and regulator of T-cell activation, has become an important therapeutic target for immunotherapy in cancer and autoimmune diseases. To date, clinical trials involving cancer immunotherapies, such checkpoint blocking antibodies directed at CTLA-4 (ipilimumab), have excluded patients with underlying autoimmune disease given concern for potential triggering of autoimmune exacerbations. We present the first known cases to our knowledge of two patients with active autoimmune diseases who received ipilimumab. In this limited clinical experience, no serious exacerbations of underlying autoimmunity have yet been observed, and one patient benefited from ipilimumab. These cases advocate for further investigation of the safety of cancer immunotherapies in cancer patients with underlying autoimmune conditions in carefully designed clinical trials with cautious monitoring. More... »

PAGES

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40425-014-0035-z

DOI

http://dx.doi.org/10.1186/s40425-014-0035-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011546195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25349698


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