Antivenomic approach of different Crotalus durissus collilineatus venoms View Full Text


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Article Info

DATE

2018-11-26

AUTHORS

Isadora Sousa de Oliveira, Manuela Berto Pucca, Suely Vilela Sampaio, Eliane Candiani Arantes

ABSTRACT

BackgroundOur group has previously performed a proteomic study verifying that individual variations can occur among Crotalus durissus collilineatus venoms. These variations may lead to differences in venom toxicity and may result in lack of neutralization of some components by antivenom. In this way, this study aimed to evaluate the Brazilian anticrotalic serum capacity in recognizing twenty-two Crotalus durissus collilineatus venoms, as well as their fractions.MethodsThe indirect enzyme-linked immunosorbent assay (ELISA) was chosen to evaluate the efficacy of heterologous anticrotalic serum produced by Instituto Butantan (Brazil) in recognizing the twenty-two Crotalus durissus collilineatus venoms and the pool of them. Moreover, the venom pool was fractionated using reversed-phase fast protein liquid chromatography (RP-FPLC) and the obtained fractions were analyzed concerning antivenom recognition.ResultsEvaluation of venom variability by ELISA showed that all venom samples were recognized by the Brazilian anticrotalic antivenom. However, some particular venom fractions were poorly recognized.ConclusionThis study demonstrated that the Brazilian anticrotalic serum recognizes all the different twenty-two venoms of C. d. collilineatus and their fractions, although in a quantitatively different way, which may impact the effectiveness of the antivenom therapy. These results confirm the need to use a pool of venoms with the greatest possible variability in the preparation of antivenoms, in order to improve their effectiveness. More... »

PAGES

34

References to SciGraph publications

  • 2015-05-13. Epidemiology of envenomations by terrestrial venomous animals in Brazil based on case reporting: from obvious facts to contingencies in JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
  • 2016-06-08. Paths to the discovery of antivenom serotherapy in France in JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
  • 2017-05-12. Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine in JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
  • 2017-08-08. Snakebite envenomation turns again into a neglected tropical disease! in JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
  • 2016-03-16. The 6th international conference on envenomation by Snakebites and Scorpion Stings in Africa: a crucial step for the management of envenomation in JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
  • 2017-04-28. Strategies in ‘snake venomics’ aiming at an integrative view of compositional, functional, and immunological characteristics of venoms in JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
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    http://scigraph.springernature.com/pub.10.1186/s40409-018-0169-4

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    http://dx.doi.org/10.1186/s40409-018-0169-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110209911

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30534148


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