Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-30

AUTHORS

Daiane Dias Ferreira, Juliana Tonini Mesquita, Thais Alves da Costa Silva, Maiara Maria Romanelli, Denise da Gama Jaen Batista, Cristiane França da Silva, Aline Nefertiti Silva da Gama, Bruno Junior Neves, Cleber Camilo Melo-Filho, Maria de Nazare Correia Soeiro, Carolina Horta Andrade, Andre Gustavo Tempone

ABSTRACT

BackgroundDrug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease.MethodsIn this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its action mode using cell biology and in silico approaches.ResultsSertraline demonstrated in vitro efficacy against intracellular amastigotes of both T. cruzi strains inside different host cells, including cardiomyocytes, with IC50 values between 1 to 10 μM, and activity against bloodstream trypomastigotes, with IC50 of 14 μM. Considering the mammalian cytotoxicity, the drug resulted in a selectivity index of 17.8. Sertraline induced a change in the mitochondrial integrity of T. cruzi, resulting in a decrease in ATP levels, but not affecting reactive oxygen levels or plasma membrane permeability. In silico approaches using chemogenomic target fishing, homology modeling and molecular docking suggested the enzyme isocitrate dehydrogenase 2 of T. cruzi (TcIDH2) as a potential target for sertraline.ConclusionsThe present study demonstrated that sertraline had a lethal effect on different forms and strains of T. cruzi, by affecting the bioenergetic metabolism of the parasite. These findings provide a starting point for future experimental assays and may contribute to the development of new compounds. More... »

PAGES

30

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40409-018-0165-8

DOI

http://dx.doi.org/10.1186/s40409-018-0165-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107931562

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30450114


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.417672.1", 
          "name": [
            "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferreira", 
        "givenName": "Daiane Dias", 
        "id": "sg:person.0762061573.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762061573.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.417672.1", 
          "name": [
            "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mesquita", 
        "givenName": "Juliana Tonini", 
        "id": "sg:person.01102175110.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102175110.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.417672.1", 
          "name": [
            "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Costa Silva", 
        "givenName": "Thais Alves", 
        "id": "sg:person.01205472264.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205472264.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.417672.1", 
          "name": [
            "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romanelli", 
        "givenName": "Maiara Maria", 
        "id": "sg:person.07746265373.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746265373.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Gama Jaen Batista", 
        "givenName": "Denise", 
        "id": "sg:person.010233065063.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010233065063.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Silva", 
        "givenName": "Cristiane Fran\u00e7a", 
        "id": "sg:person.01063651575.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063651575.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Gama", 
        "givenName": "Aline Nefertiti Silva", 
        "id": "sg:person.014105214500.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014105214500.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Rua 240 Setor Leste Universit\u00e1rio, 74605170, Goi\u00e2nia, GO, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Rua 240 Setor Leste Universit\u00e1rio, 74605170, Goi\u00e2nia, GO, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neves", 
        "givenName": "Bruno Junior", 
        "id": "sg:person.01006343022.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006343022.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Rua 240 Setor Leste Universit\u00e1rio, 74605170, Goi\u00e2nia, GO, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Rua 240 Setor Leste Universit\u00e1rio, 74605170, Goi\u00e2nia, GO, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melo-Filho", 
        "givenName": "Cleber Camilo", 
        "id": "sg:person.0654642252.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654642252.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Funda\u00e7\u00e3o Oswaldo Cruz, Laborat\u00f3rio de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Correia Soeiro", 
        "givenName": "Maria de Nazare", 
        "id": "sg:person.014114235237.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014114235237.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Rua 240 Setor Leste Universit\u00e1rio, 74605170, Goi\u00e2nia, GO, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.411195.9", 
          "name": [
            "Faculdade de Farm\u00e1cia, Universidade Federal de Goi\u00e1s, Rua 240 Setor Leste Universit\u00e1rio, 74605170, Goi\u00e2nia, GO, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrade", 
        "givenName": "Carolina Horta", 
        "id": "sg:person.01155206633.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155206633.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.417672.1", 
          "name": [
            "Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8\u00b0 andar, sala 9, CEP, 01246-000, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tempone", 
        "givenName": "Andre Gustavo", 
        "id": "sg:person.01044254247.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044254247.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11010-013-1954-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002356657", 
          "https://doi.org/10.1007/s11010-013-1954-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1678-9199-19-34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024522616", 
          "https://doi.org/10.1186/1678-9199-19-34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-18457-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100320524", 
          "https://doi.org/10.1038/s41598-017-18457-w"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010026640", 
          "https://doi.org/10.1038/nrd4683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013635299", 
          "https://doi.org/10.1038/sj.cdd.4401435"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-10-30", 
    "datePublishedReg": "2018-10-30", 
    "description": "BackgroundDrug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease.MethodsIn this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its action mode using cell biology and in silico approaches.ResultsSertraline demonstrated in vitro efficacy against intracellular amastigotes of both T. cruzi strains inside different host cells, including cardiomyocytes, with IC50 values between 1 to 10\u00a0\u03bcM, and activity against bloodstream trypomastigotes, with IC50 of 14\u00a0\u03bcM. Considering the mammalian cytotoxicity, the drug resulted in a selectivity index of 17.8. Sertraline induced a change in the mitochondrial integrity of T. cruzi, resulting in a decrease in ATP levels, but not affecting reactive oxygen levels or plasma membrane permeability. In silico approaches using chemogenomic target fishing, homology modeling and molecular docking suggested the enzyme isocitrate dehydrogenase 2 of T. cruzi (TcIDH2) as a potential target for sertraline.ConclusionsThe present study demonstrated that sertraline had a lethal effect on different forms and strains of T. cruzi, by affecting the bioenergetic metabolism of the parasite. These findings provide a starting point for future experimental assays and may contribute to the development of new compounds.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s40409-018-0165-8", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4899615", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1357529", 
        "issn": [
          "1678-9180", 
          "1678-9199"
        ], 
        "name": "Journal of Venomous Animals and Toxins including Tropical Diseases", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "keywords": [
      "T. cruzi", 
      "silico approach", 
      "future experimental assays", 
      "Trypanosoma cruzi trypomastigotes", 
      "different host cells", 
      "isocitrate dehydrogenase 2", 
      "reactive oxygen levels", 
      "cell biology", 
      "mitochondrial integrity", 
      "homology modeling", 
      "bioenergetic metabolism", 
      "host cells", 
      "Trypanosoma cruzi", 
      "cruzi trypomastigotes", 
      "cruzi", 
      "mammalian cytotoxicity", 
      "experimental assays", 
      "ATP levels", 
      "potential target", 
      "dehydrogenase 2", 
      "membrane permeability", 
      "action mode", 
      "Chagas disease", 
      "bloodstream trypomastigotes", 
      "intracellular amastigotes", 
      "molecular docking", 
      "trypomastigotes", 
      "lethal effects", 
      "target fishing", 
      "oxygen levels", 
      "silico studies", 
      "amastigotes", 
      "biology", 
      "antidepressant drug sertraline", 
      "parasites", 
      "fishing", 
      "Tulahuen", 
      "docking", 
      "metabolism", 
      "activity", 
      "cells", 
      "assays", 
      "cardiomyocytes", 
      "IC50 values", 
      "strains", 
      "target", 
      "new compounds", 
      "present study", 
      "selectivity index", 
      "cost-effective approach", 
      "cytotoxicity", 
      "integrity", 
      "levels", 
      "different forms", 
      "repurposing", 
      "disease", 
      "\u03bcM", 
      "IC50", 
      "starting point", 
      "development", 
      "study", 
      "compounds", 
      "ConclusionsThe present study", 
      "changes", 
      "form", 
      "approach", 
      "findings", 
      "decrease", 
      "effect", 
      "efficacy of sertraline", 
      "permeability", 
      "drugs", 
      "sertraline", 
      "mode", 
      "efficacy", 
      "work", 
      "index", 
      "MethodsIn", 
      "modeling", 
      "point", 
      "values"
    ], 
    "name": "Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study", 
    "pagination": "30", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107931562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40409-018-0165-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30450114"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40409-018-0165-8", 
      "https://app.dimensions.ai/details/publication/pub.1107931562"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_785.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s40409-018-0165-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40409-018-0165-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40409-018-0165-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40409-018-0165-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40409-018-0165-8'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      111 URIs      98 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40409-018-0165-8 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N07c4b5a91ac949b5860a254766354c2b
4 schema:citation sg:pub.10.1007/s11010-013-1954-6
5 sg:pub.10.1038/nrd4683
6 sg:pub.10.1038/s41598-017-18457-w
7 sg:pub.10.1038/sj.cdd.4401435
8 sg:pub.10.1186/1678-9199-19-34
9 schema:datePublished 2018-10-30
10 schema:datePublishedReg 2018-10-30
11 schema:description BackgroundDrug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease.MethodsIn this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its action mode using cell biology and in silico approaches.ResultsSertraline demonstrated in vitro efficacy against intracellular amastigotes of both T. cruzi strains inside different host cells, including cardiomyocytes, with IC50 values between 1 to 10 μM, and activity against bloodstream trypomastigotes, with IC50 of 14 μM. Considering the mammalian cytotoxicity, the drug resulted in a selectivity index of 17.8. Sertraline induced a change in the mitochondrial integrity of T. cruzi, resulting in a decrease in ATP levels, but not affecting reactive oxygen levels or plasma membrane permeability. In silico approaches using chemogenomic target fishing, homology modeling and molecular docking suggested the enzyme isocitrate dehydrogenase 2 of T. cruzi (TcIDH2) as a potential target for sertraline.ConclusionsThe present study demonstrated that sertraline had a lethal effect on different forms and strains of T. cruzi, by affecting the bioenergetic metabolism of the parasite. These findings provide a starting point for future experimental assays and may contribute to the development of new compounds.
12 schema:genre article
13 schema:isAccessibleForFree true
14 schema:isPartOf N65d1237f561749fdb6fb028107377e5c
15 N8e855d1f36de422196f2e49463080a80
16 sg:journal.1357529
17 schema:keywords ATP levels
18 Chagas disease
19 ConclusionsThe present study
20 IC50
21 IC50 values
22 MethodsIn
23 T. cruzi
24 Trypanosoma cruzi
25 Trypanosoma cruzi trypomastigotes
26 Tulahuen
27 action mode
28 activity
29 amastigotes
30 antidepressant drug sertraline
31 approach
32 assays
33 bioenergetic metabolism
34 biology
35 bloodstream trypomastigotes
36 cardiomyocytes
37 cell biology
38 cells
39 changes
40 compounds
41 cost-effective approach
42 cruzi
43 cruzi trypomastigotes
44 cytotoxicity
45 decrease
46 dehydrogenase 2
47 development
48 different forms
49 different host cells
50 disease
51 docking
52 drugs
53 effect
54 efficacy
55 efficacy of sertraline
56 experimental assays
57 findings
58 fishing
59 form
60 future experimental assays
61 homology modeling
62 host cells
63 index
64 integrity
65 intracellular amastigotes
66 isocitrate dehydrogenase 2
67 lethal effects
68 levels
69 mammalian cytotoxicity
70 membrane permeability
71 metabolism
72 mitochondrial integrity
73 mode
74 modeling
75 molecular docking
76 new compounds
77 oxygen levels
78 parasites
79 permeability
80 point
81 potential target
82 present study
83 reactive oxygen levels
84 repurposing
85 selectivity index
86 sertraline
87 silico approach
88 silico studies
89 starting point
90 strains
91 study
92 target
93 target fishing
94 trypomastigotes
95 values
96 work
97 μM
98 schema:name Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
99 schema:pagination 30
100 schema:productId N4933a3844810472481e228582dd89cd4
101 N9bcac27d7bd049af9b32cf56a6695b6e
102 Na4fa8e666bc7437ca492b8b45eb0c104
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107931562
104 https://doi.org/10.1186/s40409-018-0165-8
105 schema:sdDatePublished 2022-12-01T06:38
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Na38f391d26d84d419f9d635f823b517d
108 schema:url https://doi.org/10.1186/s40409-018-0165-8
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N07c4b5a91ac949b5860a254766354c2b rdf:first sg:person.0762061573.01
113 rdf:rest Nd6bc752065584cf09541ab9066f26ff0
114 N22384d62c61c44e49294c34ccf4f7ae5 rdf:first sg:person.01155206633.99
115 rdf:rest Ned0a0e1edc194358b8e579fa1784f4e8
116 N24d67da3212146adb6c7fb5e5aa41199 rdf:first sg:person.01063651575.73
117 rdf:rest N56985b68330d473e9c98c4adef7c44a7
118 N4933a3844810472481e228582dd89cd4 schema:name doi
119 schema:value 10.1186/s40409-018-0165-8
120 rdf:type schema:PropertyValue
121 N56985b68330d473e9c98c4adef7c44a7 rdf:first sg:person.014105214500.40
122 rdf:rest N8564638d23c14cbe9f2b153fd5d68a63
123 N5fe3894012fa44e8ad820ed11c0b98cd rdf:first sg:person.014114235237.15
124 rdf:rest N22384d62c61c44e49294c34ccf4f7ae5
125 N65d1237f561749fdb6fb028107377e5c schema:issueNumber 1
126 rdf:type schema:PublicationIssue
127 N8564638d23c14cbe9f2b153fd5d68a63 rdf:first sg:person.01006343022.29
128 rdf:rest Nb086e12124c14c94b2b9639c54568191
129 N8e855d1f36de422196f2e49463080a80 schema:volumeNumber 24
130 rdf:type schema:PublicationVolume
131 N9bcac27d7bd049af9b32cf56a6695b6e schema:name pubmed_id
132 schema:value 30450114
133 rdf:type schema:PropertyValue
134 Na38f391d26d84d419f9d635f823b517d schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 Na4fa8e666bc7437ca492b8b45eb0c104 schema:name dimensions_id
137 schema:value pub.1107931562
138 rdf:type schema:PropertyValue
139 Nb086e12124c14c94b2b9639c54568191 rdf:first sg:person.0654642252.28
140 rdf:rest N5fe3894012fa44e8ad820ed11c0b98cd
141 Nb0cab7d099d147db8093e951e71564ab rdf:first sg:person.01205472264.95
142 rdf:rest Nc94fd2e3890345728345a3240cbc2541
143 Nc94fd2e3890345728345a3240cbc2541 rdf:first sg:person.07746265373.40
144 rdf:rest Nd4a06d7cff064ce988261bda1f19cae8
145 Nd4a06d7cff064ce988261bda1f19cae8 rdf:first sg:person.010233065063.36
146 rdf:rest N24d67da3212146adb6c7fb5e5aa41199
147 Nd6bc752065584cf09541ab9066f26ff0 rdf:first sg:person.01102175110.43
148 rdf:rest Nb0cab7d099d147db8093e951e71564ab
149 Ned0a0e1edc194358b8e579fa1784f4e8 rdf:first sg:person.01044254247.31
150 rdf:rest rdf:nil
151 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
152 schema:name Biological Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
155 schema:name Biochemistry and Cell Biology
156 rdf:type schema:DefinedTerm
157 sg:grant.4899615 http://pending.schema.org/fundedItem sg:pub.10.1186/s40409-018-0165-8
158 rdf:type schema:MonetaryGrant
159 sg:journal.1357529 schema:issn 1678-9180
160 1678-9199
161 schema:name Journal of Venomous Animals and Toxins including Tropical Diseases
162 schema:publisher Springer Nature
163 rdf:type schema:Periodical
164 sg:person.01006343022.29 schema:affiliation grid-institutes:grid.411195.9
165 schema:familyName Neves
166 schema:givenName Bruno Junior
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006343022.29
168 rdf:type schema:Person
169 sg:person.010233065063.36 schema:affiliation grid-institutes:grid.418068.3
170 schema:familyName da Gama Jaen Batista
171 schema:givenName Denise
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010233065063.36
173 rdf:type schema:Person
174 sg:person.01044254247.31 schema:affiliation grid-institutes:grid.417672.1
175 schema:familyName Tempone
176 schema:givenName Andre Gustavo
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044254247.31
178 rdf:type schema:Person
179 sg:person.01063651575.73 schema:affiliation grid-institutes:grid.418068.3
180 schema:familyName da Silva
181 schema:givenName Cristiane França
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063651575.73
183 rdf:type schema:Person
184 sg:person.01102175110.43 schema:affiliation grid-institutes:grid.417672.1
185 schema:familyName Mesquita
186 schema:givenName Juliana Tonini
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102175110.43
188 rdf:type schema:Person
189 sg:person.01155206633.99 schema:affiliation grid-institutes:grid.411195.9
190 schema:familyName Andrade
191 schema:givenName Carolina Horta
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155206633.99
193 rdf:type schema:Person
194 sg:person.01205472264.95 schema:affiliation grid-institutes:grid.417672.1
195 schema:familyName da Costa Silva
196 schema:givenName Thais Alves
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205472264.95
198 rdf:type schema:Person
199 sg:person.014105214500.40 schema:affiliation grid-institutes:grid.418068.3
200 schema:familyName da Gama
201 schema:givenName Aline Nefertiti Silva
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014105214500.40
203 rdf:type schema:Person
204 sg:person.014114235237.15 schema:affiliation grid-institutes:grid.418068.3
205 schema:familyName Correia Soeiro
206 schema:givenName Maria de Nazare
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014114235237.15
208 rdf:type schema:Person
209 sg:person.0654642252.28 schema:affiliation grid-institutes:grid.411195.9
210 schema:familyName Melo-Filho
211 schema:givenName Cleber Camilo
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654642252.28
213 rdf:type schema:Person
214 sg:person.0762061573.01 schema:affiliation grid-institutes:grid.417672.1
215 schema:familyName Ferreira
216 schema:givenName Daiane Dias
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762061573.01
218 rdf:type schema:Person
219 sg:person.07746265373.40 schema:affiliation grid-institutes:grid.417672.1
220 schema:familyName Romanelli
221 schema:givenName Maiara Maria
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746265373.40
223 rdf:type schema:Person
224 sg:pub.10.1007/s11010-013-1954-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002356657
225 https://doi.org/10.1007/s11010-013-1954-6
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nrd4683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010026640
228 https://doi.org/10.1038/nrd4683
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/s41598-017-18457-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1100320524
231 https://doi.org/10.1038/s41598-017-18457-w
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/sj.cdd.4401435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013635299
234 https://doi.org/10.1038/sj.cdd.4401435
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/1678-9199-19-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024522616
237 https://doi.org/10.1186/1678-9199-19-34
238 rdf:type schema:CreativeWork
239 grid-institutes:grid.411195.9 schema:alternateName Faculdade de Farmácia, Universidade Federal de Goiás, Rua 240 Setor Leste Universitário, 74605170, Goiânia, GO, Brazil
240 schema:name Faculdade de Farmácia, Universidade Federal de Goiás, Rua 240 Setor Leste Universitário, 74605170, Goiânia, GO, Brazil
241 rdf:type schema:Organization
242 grid-institutes:grid.417672.1 schema:alternateName Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8° andar, sala 9, CEP, 01246-000, São Paulo, SP, Brazil
243 schema:name Instituto Adolfo Lutz, Centre for Parasitology and Mycology, Avenida Dr. Arnaldo 351, 8° andar, sala 9, CEP, 01246-000, São Paulo, SP, Brazil
244 rdf:type schema:Organization
245 grid-institutes:grid.418068.3 schema:alternateName Fundação Oswaldo Cruz, Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil
246 schema:name Fundação Oswaldo Cruz, Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, CEP, 21040-360, Rio de Janeiro, RJ, Brazil
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...