Management of severe acute exacerbations of COPD: an updated narrative review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Ernesto Crisafulli, Enric Barbeta, Antonella Ielpo, Antoni Torres

ABSTRACT

Background: Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital. Main body: In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD. Conclusion: Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. More... »

PAGES

36

References to SciGraph publications

  • 2018-12. Ultrasound-assessed diaphragmatic impairment is a predictor of outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease undergoing noninvasive ventilation in CRITICAL CARE
  • 2014-12. Daily activity during stability and exacerbation of chronic obstructive pulmonary disease in BMC PULMONARY MEDICINE
  • 2011-12. Optimization of ventilator setting by flow and pressure waveforms analysis during noninvasive ventilation for acute exacerbations of COPD: a multicentric randomized controlled trial in CRITICAL CARE
  • 2017-12. Efficacy and safety of nasal high-flow oxygen in COPD patients in BMC PULMONARY MEDICINE
  • 2011-11. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study in INTENSIVE CARE MEDICINE
  • 2014-02. Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation in INTERNAL AND EMERGENCY MEDICINE
  • 2010-12. Measures of dyspnea in pulmonary rehabilitation in MULTIDISCIPLINARY RESPIRATORY MEDICINE
  • 2017-12. Noninvasive ventilation with helium–oxygen mixture in hypercapnic COPD exacerbation: aggregate meta-analysis of randomized controlled trials in ANNALS OF INTENSIVE CARE
  • 2016-07. Impact of renal dysfunction on in-hospital mortality of patients with severe chronic obstructive pulmonary disease: a single-center Italian study in GERIATRIC NEPHROLOGY AND UROLOGY
  • 2018-12. Microorganisms resistant to conventional antimicrobials in acute exacerbations of chronic obstructive pulmonary disease in RESPIRATORY RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40248-018-0149-0

    DOI

    http://dx.doi.org/10.1186/s40248-018-0149-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106989874

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30302247


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Parma", 
              "id": "https://www.grid.ac/institutes/grid.10383.39", 
              "name": [
                "Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Crisafulli", 
            "givenName": "Ernesto", 
            "id": "sg:person.0736125502.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736125502.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Barcelona", 
              "id": "https://www.grid.ac/institutes/grid.5841.8", 
              "name": [
                "Pneumology Department, Clinic Institute of Thorax, Hospital Clinic of Barcelona - Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barbeta", 
            "givenName": "Enric", 
            "id": "sg:person.012046751277.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012046751277.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Parma", 
              "id": "https://www.grid.ac/institutes/grid.10383.39", 
              "name": [
                "Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ielpo", 
            "givenName": "Antonella", 
            "id": "sg:person.015645563064.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015645563064.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Barcelona", 
              "id": "https://www.grid.ac/institutes/grid.5841.8", 
              "name": [
                "Pneumology Department, Clinic Institute of Thorax, Hospital Clinic of Barcelona - Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Torres", 
            "givenName": "Antoni", 
            "id": "sg:person.013354236302.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013354236302.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.rmed.2009.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000399928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s103063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001061120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1516385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001162677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1516385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001162677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11739-011-0727-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002421565", 
              "https://doi.org/10.1007/s11739-011-0727-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1513/annalsats.201308-254oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002640339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0150737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003313787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2016.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003532745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.apmr.2014.05.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003728517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2003.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003839169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2003.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003839169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1513/annalsats.201310-358oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003989890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/erp.13.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004243849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0158727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004532170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11255-016-1272-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004584031", 
              "https://doi.org/10.1007/s11255-016-1272-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/15412555.2010.540273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004623440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201309-1634st", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005146657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200906-0837oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005938876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(98)11326-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006657575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.161.3.9808143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006892834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1513/annalsats.201208-043oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006917208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.47.1.34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007122929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.47.1.34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007122929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(00)02323-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007268326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00088611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007663848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200908-1203oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007667198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.05.00085304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007908705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-011-2354-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008384679", 
              "https://doi.org/10.1007/s00134-011-2354-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pupt.2013.03.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009039217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.151.6.7767523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009099000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2010.152876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009273110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2010.152876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009273110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/653527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009304303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.58.9.752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009839284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.58.9.752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009839284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.g4315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009957161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pri.1541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010047977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0924-8579(01)00435-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010202132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.56.9.708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010897366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.56.9.708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010897366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00042111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010927619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199906243402502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011157248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2010.796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011305992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4187/respcare.02160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011514808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.50.7.755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011629228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.50.7.755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011629228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201401-0058oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012592562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s85831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014422480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2008.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014794552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.119.3.726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015009034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.119.3.726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015009034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12659/msm.892769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015132631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.2.5607.735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015830023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc10567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015954724", 
              "https://doi.org/10.1186/cc10567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijid.2016.04.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016236774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.157.5.9711044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017573704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thoraxjnl-2016-208460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017809216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thoraxjnl-2016-208460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017809216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199509283331301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020073107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd010257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021023754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.55.7.550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021248435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.55.7.550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021248435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(01)07097-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021995818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pupt.2013.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022514223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejim.2014.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022531200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(93)90696-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023030791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2009.1297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023080028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200604-506oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023120582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4187/respcare.02086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023482651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1157/13091646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023972134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201001-0054ed", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024370523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thoraxjnl-2011-201518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024541525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thoraxjnl-2011-201518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024541525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(09)60496-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025594191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.165.5.2109093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026057025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.c5462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026429736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00112909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026922404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-6958-5-3-202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026925902", 
              "https://doi.org/10.1186/2049-6958-5-3-202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.326.7382.185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027698495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.06-1500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028459514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0007-0971(72)90016-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029011050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2016.10.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029828737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00002913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030408437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.02.00287402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030767343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.58.7.589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031583771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.58.7.589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031583771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/15412555.2015.1057276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031990231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2013.10.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032408553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pupt.2016.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032651085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2012.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033950535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12659/msm.895027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034473833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.161.4.9904065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034778549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/15412555.2014.933954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035017325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1579-2129(06)60551-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036110649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3181b78abe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036161844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3181b78abe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036161844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2466-14-98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036329511", 
              "https://doi.org/10.1186/1471-2466-14-98"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15412555.2016.1209476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036375608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hcr.0b013e318252f0b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036405070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hcr.0b013e318252f0b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036405070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201106-1094oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036663164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00109906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036939816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hcr.0b013e3181ac7bb8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037336877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hcr.0b013e3181ac7bb8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037336877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00203809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037995545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.07-0208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038354874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2013.5023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038948273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s112820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039112017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa023161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040568939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0800353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041633279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinternmed.2011.530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042014414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1843.2008.01418.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042140681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2011.07.075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042438775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4187/respcare.03036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042774610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000192773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043289006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.326.7396.956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043589397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.13-0488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043928934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(07)61382-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043982593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000324259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044408621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.114.6.1636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044515491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2007.086371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044616160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2007.086371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044616160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2007.086371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044616160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.1997.00440360162018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045086934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2003.008730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045097512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2003.008730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045097512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0909883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045411383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/15412555.2015.1101435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046100683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s43992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046483700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cpm.0000000000000090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046986766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cpm.0000000000000090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046986766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.58.1.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047428738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thorax.58.1.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047428738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s104616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047950243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.14-0655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048409309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4187/respcare.03009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048497803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2010.153114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050197958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2010.153114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050197958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s115581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050249759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5588/ijtld.10.0540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050701535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1094-5539(03)00025-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051233600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1094-5539(03)00025-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051233600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd011826.pub2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051407370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s78952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052015275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.15-1504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052683408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00043710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053330936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.10-3058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053461478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.157.15.1736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054115364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201601-0083oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063365503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201601-0083oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063365503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00053814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00053814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00053814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00053814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00426-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064124149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00426-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064124149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00426-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064124149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00426-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064124149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4187/respcare.04597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072348749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-106-2-196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073691599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076114208", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077829201", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078354516", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079224281", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201610-2102ed", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084237106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00791-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084249632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00791-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084249632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00791-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084249632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/resp.13050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085130517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd010172.pub2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085713323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0273-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085900809", 
              "https://doi.org/10.1186/s13613-017-0273-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0273-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085900809", 
              "https://doi.org/10.1186/s13613-017-0273-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd004104.pub4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090658158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.21037/atm.2017.06.52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090888114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2017.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091103920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.02426-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091408467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.02426-2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091408467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s145253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091545091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.01432-2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091972554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.01432-2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091972554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00075-2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091974794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.00075-2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091974794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd007498.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092191486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12890-017-0486-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092753944", 
              "https://doi.org/10.1186/s12890-017-0486-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pupt.2017.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099724826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.01312-2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100337524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.01312-2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100337524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/13993003.01312-2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100337524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0191243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100481342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/crj.12772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100779697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2146/ajhp160979", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101412840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2146/ajhp160979", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101412840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2146/ajhp160979", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101412840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd006897.pub4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101566961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.s153631", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103612561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-018-2033-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103669306", 
              "https://doi.org/10.1186/s13054-018-2033-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-018-2033-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103669306", 
              "https://doi.org/10.1186/s13054-018-2033-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12931-018-0820-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104597990", 
              "https://doi.org/10.1186/s12931-018-0820-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/medsci6020050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104601283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/crj.12942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105639159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/crj.12942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105639159"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Background: Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital.\nMain body: In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD.\nConclusion: Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s40248-018-0149-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1040211", 
            "issn": [
              "1828-695X", 
              "2049-6958"
            ], 
            "name": "Multidisciplinary Respiratory Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "13"
          }
        ], 
        "name": "Management of severe acute exacerbations of COPD: an updated narrative review", 
        "pagination": "36", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ffb44219480306dc66818c83ad4893986a3698f111cbc395629d7c5f671284c6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30302247"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101477642"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s40248-018-0149-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1106989874"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s40248-018-0149-0", 
          "https://app.dimensions.ai/details/publication/pub.1106989874"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000561.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs40248-018-0149-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0149-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0149-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0149-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0149-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    579 TRIPLES      21 PREDICATES      189 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s40248-018-0149-0 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author Nd90b0561c564465084f73b0163a00cf1
    4 schema:citation sg:pub.10.1007/s00134-011-2354-6
    5 sg:pub.10.1007/s11255-016-1272-5
    6 sg:pub.10.1007/s11739-011-0727-z
    7 sg:pub.10.1186/1471-2466-14-98
    8 sg:pub.10.1186/2049-6958-5-3-202
    9 sg:pub.10.1186/cc10567
    10 sg:pub.10.1186/s12890-017-0486-3
    11 sg:pub.10.1186/s12931-018-0820-1
    12 sg:pub.10.1186/s13054-018-2033-x
    13 sg:pub.10.1186/s13613-017-0273-6
    14 https://app.dimensions.ai/details/publication/pub.1076114208
    15 https://app.dimensions.ai/details/publication/pub.1077829201
    16 https://app.dimensions.ai/details/publication/pub.1078354516
    17 https://app.dimensions.ai/details/publication/pub.1079224281
    18 https://doi.org/10.1001/archinte.157.15.1736
    19 https://doi.org/10.1001/archinte.1997.00440360162018
    20 https://doi.org/10.1001/archinternmed.2011.530
    21 https://doi.org/10.1001/jama.2009.1297
    22 https://doi.org/10.1001/jama.2010.796
    23 https://doi.org/10.1001/jama.2013.5023
    24 https://doi.org/10.1002/14651858.cd004104.pub4
    25 https://doi.org/10.1002/14651858.cd006897.pub4
    26 https://doi.org/10.1002/14651858.cd007498.pub3
    27 https://doi.org/10.1002/14651858.cd010172.pub2
    28 https://doi.org/10.1002/14651858.cd010257
    29 https://doi.org/10.1002/14651858.cd011826.pub2
    30 https://doi.org/10.1002/pri.1541
    31 https://doi.org/10.1016/0007-0971(72)90016-2
    32 https://doi.org/10.1016/0140-6736(93)90696-e
    33 https://doi.org/10.1016/j.apmr.2014.05.007
    34 https://doi.org/10.1016/j.ejim.2014.01.003
    35 https://doi.org/10.1016/j.ijid.2016.04.024
    36 https://doi.org/10.1016/j.jcrc.2008.08.007
    37 https://doi.org/10.1016/j.jcrc.2011.07.075
    38 https://doi.org/10.1016/j.pupt.2013.03.004
    39 https://doi.org/10.1016/j.pupt.2013.03.020
    40 https://doi.org/10.1016/j.pupt.2016.01.002
    41 https://doi.org/10.1016/j.pupt.2017.12.007
    42 https://doi.org/10.1016/j.rmed.2003.09.001
    43 https://doi.org/10.1016/j.rmed.2009.04.011
    44 https://doi.org/10.1016/j.rmed.2012.05.005
    45 https://doi.org/10.1016/j.rmed.2013.10.022
    46 https://doi.org/10.1016/j.rmed.2016.05.003
    47 https://doi.org/10.1016/j.rmed.2016.10.013
    48 https://doi.org/10.1016/j.rmed.2017.08.005
    49 https://doi.org/10.1016/s0140-6736(00)02323-0
    50 https://doi.org/10.1016/s0140-6736(01)07097-0
    51 https://doi.org/10.1016/s0140-6736(07)61382-8
    52 https://doi.org/10.1016/s0140-6736(09)60496-7
    53 https://doi.org/10.1016/s0140-6736(98)11326-0
    54 https://doi.org/10.1016/s0924-8579(01)00435-6
    55 https://doi.org/10.1016/s1094-5539(03)00025-7
    56 https://doi.org/10.1016/s1579-2129(06)60551-x
    57 https://doi.org/10.1056/nejm199509283331301
    58 https://doi.org/10.1056/nejm199906243402502
    59 https://doi.org/10.1056/nejmoa023161
    60 https://doi.org/10.1056/nejmoa0909883
    61 https://doi.org/10.1056/nejmoa1516385
    62 https://doi.org/10.1056/nejmra0800353
    63 https://doi.org/10.1080/15412555.2016.1209476
    64 https://doi.org/10.1086/653527
    65 https://doi.org/10.1097/ccm.0b013e3181b78abe
    66 https://doi.org/10.1097/cpm.0000000000000090
    67 https://doi.org/10.1097/hcr.0b013e3181ac7bb8
    68 https://doi.org/10.1097/hcr.0b013e318252f0b2
    69 https://doi.org/10.1111/crj.12772
    70 https://doi.org/10.1111/crj.12942
    71 https://doi.org/10.1111/j.1440-1843.2008.01418.x
    72 https://doi.org/10.1111/resp.13050
    73 https://doi.org/10.1136/bmj.2.5607.735
    74 https://doi.org/10.1136/bmj.326.7382.185
    75 https://doi.org/10.1136/bmj.326.7396.956
    76 https://doi.org/10.1136/bmj.c5462
    77 https://doi.org/10.1136/bmj.g4315
    78 https://doi.org/10.1136/thorax.55.7.550
    79 https://doi.org/10.1136/thorax.56.9.708
    80 https://doi.org/10.1136/thorax.58.1.73
    81 https://doi.org/10.1136/thorax.58.7.589
    82 https://doi.org/10.1136/thorax.58.9.752
    83 https://doi.org/10.1136/thoraxjnl-2011-201518
    84 https://doi.org/10.1136/thoraxjnl-2016-208460
    85 https://doi.org/10.1136/thx.2003.008730
    86 https://doi.org/10.1136/thx.2007.086371
    87 https://doi.org/10.1136/thx.2010.152876
    88 https://doi.org/10.1136/thx.2010.153114
    89 https://doi.org/10.1136/thx.47.1.34
    90 https://doi.org/10.1136/thx.50.7.755
    91 https://doi.org/10.1157/13091646
    92 https://doi.org/10.1159/000192773
    93 https://doi.org/10.1159/000324259
    94 https://doi.org/10.1164/ajrccm.151.6.7767523
    95 https://doi.org/10.1164/ajrccm.157.5.9711044
    96 https://doi.org/10.1164/ajrccm.161.3.9808143
    97 https://doi.org/10.1164/ajrccm.161.4.9904065
    98 https://doi.org/10.1164/ajrccm.165.5.2109093
    99 https://doi.org/10.1164/rccm.200604-506oc
    100 https://doi.org/10.1164/rccm.200906-0837oc
    101 https://doi.org/10.1164/rccm.200908-1203oc
    102 https://doi.org/10.1164/rccm.201001-0054ed
    103 https://doi.org/10.1164/rccm.201106-1094oc
    104 https://doi.org/10.1164/rccm.201309-1634st
    105 https://doi.org/10.1164/rccm.201401-0058oc
    106 https://doi.org/10.1164/rccm.201601-0083oc
    107 https://doi.org/10.1164/rccm.201610-2102ed
    108 https://doi.org/10.1183/09031936.00002913
    109 https://doi.org/10.1183/09031936.00042111
    110 https://doi.org/10.1183/09031936.00043710
    111 https://doi.org/10.1183/09031936.00053814
    112 https://doi.org/10.1183/09031936.00088611
    113 https://doi.org/10.1183/09031936.00109906
    114 https://doi.org/10.1183/09031936.00112909
    115 https://doi.org/10.1183/09031936.00203809
    116 https://doi.org/10.1183/09031936.02.00287402
    117 https://doi.org/10.1183/09031936.05.00085304
    118 https://doi.org/10.1183/13993003.00075-2017
    119 https://doi.org/10.1183/13993003.00426-2016
    120 https://doi.org/10.1183/13993003.00791-2016
    121 https://doi.org/10.1183/13993003.01312-2017
    122 https://doi.org/10.1183/13993003.01432-2017
    123 https://doi.org/10.1183/13993003.02426-2016
    124 https://doi.org/10.12659/msm.892769
    125 https://doi.org/10.12659/msm.895027
    126 https://doi.org/10.1371/journal.pone.0150737
    127 https://doi.org/10.1371/journal.pone.0158727
    128 https://doi.org/10.1371/journal.pone.0191243
    129 https://doi.org/10.1378/chest.06-1500
    130 https://doi.org/10.1378/chest.07-0208
    131 https://doi.org/10.1378/chest.10-3058
    132 https://doi.org/10.1378/chest.114.6.1636
    133 https://doi.org/10.1378/chest.119.3.726
    134 https://doi.org/10.1378/chest.13-0488
    135 https://doi.org/10.1378/chest.14-0655
    136 https://doi.org/10.1378/chest.15-1504
    137 https://doi.org/10.1513/annalsats.201208-043oc
    138 https://doi.org/10.1513/annalsats.201308-254oc
    139 https://doi.org/10.1513/annalsats.201310-358oc
    140 https://doi.org/10.1586/erp.13.9
    141 https://doi.org/10.21037/atm.2017.06.52
    142 https://doi.org/10.2146/ajhp160979
    143 https://doi.org/10.2147/copd.s103063
    144 https://doi.org/10.2147/copd.s104616
    145 https://doi.org/10.2147/copd.s112820
    146 https://doi.org/10.2147/copd.s115581
    147 https://doi.org/10.2147/copd.s145253
    148 https://doi.org/10.2147/copd.s153631
    149 https://doi.org/10.2147/copd.s43992
    150 https://doi.org/10.2147/copd.s78952
    151 https://doi.org/10.2147/copd.s85831
    152 https://doi.org/10.3109/15412555.2010.540273
    153 https://doi.org/10.3109/15412555.2014.933954
    154 https://doi.org/10.3109/15412555.2015.1057276
    155 https://doi.org/10.3109/15412555.2015.1101435
    156 https://doi.org/10.3390/medsci6020050
    157 https://doi.org/10.4187/respcare.02086
    158 https://doi.org/10.4187/respcare.02160
    159 https://doi.org/10.4187/respcare.03009
    160 https://doi.org/10.4187/respcare.03036
    161 https://doi.org/10.4187/respcare.04597
    162 https://doi.org/10.5588/ijtld.10.0540
    163 https://doi.org/10.7326/0003-4819-106-2-196
    164 schema:datePublished 2018-12
    165 schema:datePublishedReg 2018-12-01
    166 schema:description Background: Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital. Main body: In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD. Conclusion: Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs.
    167 schema:genre research_article
    168 schema:inLanguage en
    169 schema:isAccessibleForFree true
    170 schema:isPartOf N81cd6a319a914ea6804a7211542eb0f3
    171 N8a51b98f973c4312970e69b52ffc33de
    172 sg:journal.1040211
    173 schema:name Management of severe acute exacerbations of COPD: an updated narrative review
    174 schema:pagination 36
    175 schema:productId N871b98e3be8545a9be59dba0ce00213c
    176 Naf9117c1eaaf494a8f76fc143f33cba5
    177 Nbb8018c1408e4b6f9d31dac64b22db8a
    178 Nefef547dd51b422ea249e8452d0eac5f
    179 Nf8ad80e322944ba191acc3511a79d9d9
    180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106989874
    181 https://doi.org/10.1186/s40248-018-0149-0
    182 schema:sdDatePublished 2019-04-10T21:46
    183 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    184 schema:sdPublisher N2e072fe54bf046338abe113e49cadddd
    185 schema:url https://link.springer.com/10.1186%2Fs40248-018-0149-0
    186 sgo:license sg:explorer/license/
    187 sgo:sdDataset articles
    188 rdf:type schema:ScholarlyArticle
    189 N2e072fe54bf046338abe113e49cadddd schema:name Springer Nature - SN SciGraph project
    190 rdf:type schema:Organization
    191 N34f0de94f399494685ad4bfc88863373 rdf:first sg:person.015645563064.26
    192 rdf:rest Naa76ff6255ff4a67be4bdbdb2576593b
    193 N81cd6a319a914ea6804a7211542eb0f3 schema:issueNumber 1
    194 rdf:type schema:PublicationIssue
    195 N871b98e3be8545a9be59dba0ce00213c schema:name nlm_unique_id
    196 schema:value 101477642
    197 rdf:type schema:PropertyValue
    198 N8a51b98f973c4312970e69b52ffc33de schema:volumeNumber 13
    199 rdf:type schema:PublicationVolume
    200 Naa76ff6255ff4a67be4bdbdb2576593b rdf:first sg:person.013354236302.01
    201 rdf:rest rdf:nil
    202 Naf9117c1eaaf494a8f76fc143f33cba5 schema:name dimensions_id
    203 schema:value pub.1106989874
    204 rdf:type schema:PropertyValue
    205 Nbb8018c1408e4b6f9d31dac64b22db8a schema:name readcube_id
    206 schema:value ffb44219480306dc66818c83ad4893986a3698f111cbc395629d7c5f671284c6
    207 rdf:type schema:PropertyValue
    208 Nbe1b9b87d2e14bd2ba265108c0617037 rdf:first sg:person.012046751277.97
    209 rdf:rest N34f0de94f399494685ad4bfc88863373
    210 Nd90b0561c564465084f73b0163a00cf1 rdf:first sg:person.0736125502.47
    211 rdf:rest Nbe1b9b87d2e14bd2ba265108c0617037
    212 Nefef547dd51b422ea249e8452d0eac5f schema:name pubmed_id
    213 schema:value 30302247
    214 rdf:type schema:PropertyValue
    215 Nf8ad80e322944ba191acc3511a79d9d9 schema:name doi
    216 schema:value 10.1186/s40248-018-0149-0
    217 rdf:type schema:PropertyValue
    218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Medical and Health Sciences
    220 rdf:type schema:DefinedTerm
    221 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Clinical Sciences
    223 rdf:type schema:DefinedTerm
    224 sg:journal.1040211 schema:issn 1828-695X
    225 2049-6958
    226 schema:name Multidisciplinary Respiratory Medicine
    227 rdf:type schema:Periodical
    228 sg:person.012046751277.97 schema:affiliation https://www.grid.ac/institutes/grid.5841.8
    229 schema:familyName Barbeta
    230 schema:givenName Enric
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012046751277.97
    232 rdf:type schema:Person
    233 sg:person.013354236302.01 schema:affiliation https://www.grid.ac/institutes/grid.5841.8
    234 schema:familyName Torres
    235 schema:givenName Antoni
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013354236302.01
    237 rdf:type schema:Person
    238 sg:person.015645563064.26 schema:affiliation https://www.grid.ac/institutes/grid.10383.39
    239 schema:familyName Ielpo
    240 schema:givenName Antonella
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015645563064.26
    242 rdf:type schema:Person
    243 sg:person.0736125502.47 schema:affiliation https://www.grid.ac/institutes/grid.10383.39
    244 schema:familyName Crisafulli
    245 schema:givenName Ernesto
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736125502.47
    247 rdf:type schema:Person
    248 sg:pub.10.1007/s00134-011-2354-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008384679
    249 https://doi.org/10.1007/s00134-011-2354-6
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s11255-016-1272-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004584031
    252 https://doi.org/10.1007/s11255-016-1272-5
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s11739-011-0727-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1002421565
    255 https://doi.org/10.1007/s11739-011-0727-z
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/1471-2466-14-98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036329511
    258 https://doi.org/10.1186/1471-2466-14-98
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1186/2049-6958-5-3-202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026925902
    261 https://doi.org/10.1186/2049-6958-5-3-202
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/cc10567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015954724
    264 https://doi.org/10.1186/cc10567
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1186/s12890-017-0486-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092753944
    267 https://doi.org/10.1186/s12890-017-0486-3
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1186/s12931-018-0820-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104597990
    270 https://doi.org/10.1186/s12931-018-0820-1
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1186/s13054-018-2033-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103669306
    273 https://doi.org/10.1186/s13054-018-2033-x
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1186/s13613-017-0273-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085900809
    276 https://doi.org/10.1186/s13613-017-0273-6
    277 rdf:type schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1076114208 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1077829201 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1078354516 schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1079224281 schema:CreativeWork
    282 https://doi.org/10.1001/archinte.157.15.1736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054115364
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1001/archinte.1997.00440360162018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045086934
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1001/archinternmed.2011.530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042014414
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1001/jama.2009.1297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023080028
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1001/jama.2010.796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011305992
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1001/jama.2013.5023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038948273
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1002/14651858.cd004104.pub4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090658158
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1002/14651858.cd006897.pub4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101566961
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1002/14651858.cd007498.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092191486
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1002/14651858.cd010172.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085713323
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1002/14651858.cd010257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021023754
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1002/14651858.cd011826.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051407370
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1002/pri.1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010047977
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/0007-0971(72)90016-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029011050
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/0140-6736(93)90696-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1023030791
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.apmr.2014.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003728517
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.ejim.2014.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022531200
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.ijid.2016.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016236774
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.jcrc.2008.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014794552
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.jcrc.2011.07.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042438775
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.pupt.2013.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022514223
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.pupt.2013.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009039217
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/j.pupt.2016.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032651085
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/j.pupt.2017.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099724826
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/j.rmed.2003.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003839169
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/j.rmed.2009.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000399928
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/j.rmed.2012.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033950535
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/j.rmed.2013.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032408553
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/j.rmed.2016.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003532745
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/j.rmed.2016.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029828737
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1016/j.rmed.2017.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091103920
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1016/s0140-6736(00)02323-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007268326
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/s0140-6736(01)07097-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021995818
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/s0140-6736(07)61382-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043982593
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/s0140-6736(09)60496-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025594191
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/s0140-6736(98)11326-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006657575
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/s0924-8579(01)00435-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010202132
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/s1094-5539(03)00025-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051233600
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/s1579-2129(06)60551-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036110649
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1056/nejm199509283331301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020073107
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1056/nejm199906243402502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011157248
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1056/nejmoa023161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040568939
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1056/nejmoa0909883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045411383
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1056/nejmoa1516385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001162677
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1056/nejmra0800353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041633279
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1080/15412555.2016.1209476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036375608
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1086/653527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009304303
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1097/ccm.0b013e3181b78abe schema:sameAs https://app.dimensions.ai/details/publication/pub.1036161844
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1097/cpm.0000000000000090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046986766
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1097/hcr.0b013e3181ac7bb8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037336877
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1097/hcr.0b013e318252f0b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036405070
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1111/crj.12772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100779697
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1111/crj.12942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105639159
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1111/j.1440-1843.2008.01418.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042140681
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1111/resp.13050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085130517
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1136/bmj.2.5607.735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015830023
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1136/bmj.326.7382.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027698495
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1136/bmj.326.7396.956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043589397
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1136/bmj.c5462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026429736
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1136/bmj.g4315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009957161
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1136/thorax.55.7.550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021248435
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1136/thorax.56.9.708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010897366
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1136/thorax.58.1.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047428738
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1136/thorax.58.7.589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031583771
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1136/thorax.58.9.752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009839284
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1136/thoraxjnl-2011-201518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024541525
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1136/thoraxjnl-2016-208460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017809216
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1136/thx.2003.008730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045097512
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1136/thx.2007.086371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044616160
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1136/thx.2010.152876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009273110
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1136/thx.2010.153114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050197958
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1136/thx.47.1.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007122929
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1136/thx.50.7.755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011629228
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1157/13091646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023972134
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1159/000192773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043289006
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1159/000324259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044408621
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1164/ajrccm.151.6.7767523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009099000
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1164/ajrccm.157.5.9711044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017573704
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1164/ajrccm.161.3.9808143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006892834
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1164/ajrccm.161.4.9904065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034778549
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1164/ajrccm.165.5.2109093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026057025
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1164/rccm.200604-506oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1023120582
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1164/rccm.200906-0837oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1005938876
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1164/rccm.200908-1203oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1007667198
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1164/rccm.201001-0054ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1024370523
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1164/rccm.201106-1094oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1036663164
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1164/rccm.201309-1634st schema:sameAs https://app.dimensions.ai/details/publication/pub.1005146657
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1164/rccm.201401-0058oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1012592562
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1164/rccm.201601-0083oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1063365503
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1164/rccm.201610-2102ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1084237106
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1183/09031936.00002913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030408437
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1183/09031936.00042111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010927619
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1183/09031936.00043710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053330936
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1183/09031936.00053814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123675
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1183/09031936.00088611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007663848
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1183/09031936.00109906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036939816
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1183/09031936.00112909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026922404
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1183/09031936.00203809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037995545
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1183/09031936.02.00287402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030767343
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1183/09031936.05.00085304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007908705
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1183/13993003.00075-2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091974794
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1183/13993003.00426-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064124149
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1183/13993003.00791-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084249632
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1183/13993003.01312-2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100337524
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1183/13993003.01432-2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091972554
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1183/13993003.02426-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091408467
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.12659/msm.892769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015132631
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.12659/msm.895027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034473833
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1371/journal.pone.0150737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003313787
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1371/journal.pone.0158727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004532170
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1371/journal.pone.0191243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100481342
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1378/chest.06-1500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028459514
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1378/chest.07-0208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038354874
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1378/chest.10-3058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053461478
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1378/chest.114.6.1636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044515491
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1378/chest.119.3.726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015009034
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1378/chest.13-0488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043928934
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1378/chest.14-0655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048409309
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1378/chest.15-1504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052683408
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1513/annalsats.201208-043oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1006917208
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1513/annalsats.201308-254oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1002640339
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1513/annalsats.201310-358oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1003989890
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1586/erp.13.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004243849
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.21037/atm.2017.06.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090888114
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.2146/ajhp160979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101412840
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.2147/copd.s103063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001061120
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.2147/copd.s104616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047950243
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.2147/copd.s112820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039112017
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.2147/copd.s115581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050249759
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.2147/copd.s145253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091545091
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.2147/copd.s153631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103612561
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.2147/copd.s43992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046483700
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.2147/copd.s78952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052015275
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.2147/copd.s85831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014422480
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.3109/15412555.2010.540273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004623440
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.3109/15412555.2014.933954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035017325
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.3109/15412555.2015.1057276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031990231
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.3109/15412555.2015.1101435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046100683
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.3390/medsci6020050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104601283
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.4187/respcare.02086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023482651
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.4187/respcare.02160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011514808
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.4187/respcare.03009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048497803
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.4187/respcare.03036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042774610
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.4187/respcare.04597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072348749
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.5588/ijtld.10.0540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050701535
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.7326/0003-4819-106-2-196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073691599
    573 rdf:type schema:CreativeWork
    574 https://www.grid.ac/institutes/grid.10383.39 schema:alternateName University of Parma
    575 schema:name Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy
    576 rdf:type schema:Organization
    577 https://www.grid.ac/institutes/grid.5841.8 schema:alternateName University of Barcelona
    578 schema:name Pneumology Department, Clinic Institute of Thorax, Hospital Clinic of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain
    579 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...