Effect of pirfenidone on wound healing in lung transplant patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Amber Mortensen, Lauren Cherrier, Rajat Walia

ABSTRACT

Background: The drug pirfenidone has been shown to slow the progression and decrease mortality of idiopathic pulmonary fibrosis (IPF). Its exact mechanism is unknown, but it likely inhibits pro-fibrotic cytokine transforming growth factor beta, a known contributor to wound healing. We evaluated whether patients taking pirfenidone until lung transplantation had increased risk of impaired wound healing post-transplant. This information could determine whether pirfenidone should be discontinued prior to listing to allow for a wash-out period. Methods: We retrospectively reviewed patients who underwent lung transplantation for pulmonary fibrosis at Norton Thoracic Institute in Phoenix, Arizona, from January 2014 to December 2015. Results: We describe 18 patients who took pirfenidone up to a month before transplant. Aside from one patient who experienced sternal dehiscence due to a surgical issue, all remaining patients did well with no evidence of airway dehiscence. Each of these 17 patients had been on pirfenidone for at least 30 days; nine patients had been on pirfenidone for over 90 days. Baseline characteristics including age, sex, body mass index, renal function, liver function, glucose level, pre-transplant corticosteroid use, and post-transplant immunosuppressant therapy were similar. Conclusions: In our experience, pirfenidone may be safely continued until lung transplantation. Only one patient in our series experienced impaired wound healing related to a surgical issue, even when pirfenidone was continued until lung transplantation. We found no evidence of impaired wound healing or airway complications after lung transplantation in patients who were treated with pirfenidone before lung transplantation. More... »

PAGES

16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40248-018-0129-4

DOI

http://dx.doi.org/10.1186/s40248-018-0129-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104319678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29946463


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Joseph's Hospital and Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240866.e", 
          "name": [
            "Department of Pharmacy, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mortensen", 
        "givenName": "Amber", 
        "id": "sg:person.012343037265.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343037265.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Joseph's Hospital and Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240866.e", 
          "name": [
            "Department of Pharmacy, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cherrier", 
        "givenName": "Lauren", 
        "id": "sg:person.015330741265.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015330741265.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Joseph's Hospital and Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240866.e", 
          "name": [
            "Division of Pulmonology, Norton Thoracic Institute, St. Joseph\u2019s Hospital and Medical Center, 500 W. Thomas Rd., Ste. 500, Phoenix, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walia", 
        "givenName": "Rajat", 
        "id": "sg:person.01001112105.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001112105.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/ajt.13671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001650503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2014-206260.370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004066456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)60405-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009123817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.2009-040gl", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009587829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/wound.2013.0429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011166230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/pats.200808-094go", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011195458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1402582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013090473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2015.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014183845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/tcrm.s69716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016159217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3349/ymj.2015.56.5.1372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020439330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/resp.12691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020819255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thorsurg.2014.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022165440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ppa.s37233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026567595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2004.09.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032414147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201403-0509pp", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045500302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.healun.2017.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090346804"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Background: The drug pirfenidone has been shown to slow the progression and decrease mortality of idiopathic pulmonary fibrosis (IPF). Its exact mechanism is unknown, but it likely inhibits pro-fibrotic cytokine transforming growth factor beta, a known contributor to wound healing. We evaluated whether patients taking pirfenidone until lung transplantation had increased risk of impaired wound healing post-transplant. This information could determine whether pirfenidone should be discontinued prior to listing to allow for a wash-out period.\nMethods: We retrospectively reviewed patients who underwent lung transplantation for pulmonary fibrosis at Norton Thoracic Institute in Phoenix, Arizona, from January 2014 to December 2015.\nResults: We describe 18 patients who took pirfenidone up to a month before transplant. Aside from one patient who experienced sternal dehiscence due to a surgical issue, all remaining patients did well with no evidence of airway dehiscence. Each of these 17 patients had been on pirfenidone for at least 30\u00a0days; nine patients had been on pirfenidone for over 90\u00a0days. Baseline characteristics including age, sex, body mass index, renal function, liver function, glucose level, pre-transplant corticosteroid use, and post-transplant immunosuppressant therapy were similar.\nConclusions: In our experience, pirfenidone may be safely continued until lung transplantation. Only one patient in our series experienced impaired wound healing related to a surgical issue, even when pirfenidone was continued until lung transplantation. We found no evidence of impaired wound healing or airway complications after lung transplantation in patients who were treated with pirfenidone before lung transplantation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40248-018-0129-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1040211", 
        "issn": [
          "1828-695X", 
          "2049-6958"
        ], 
        "name": "Multidisciplinary Respiratory Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Effect of pirfenidone on wound healing in lung transplant patients", 
    "pagination": "16", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fa4888d00fde3a2f926519933d24302681297f9ef44408c2d6396204a9ac3f6e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29946463"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101477642"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40248-018-0129-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104319678"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40248-018-0129-4", 
      "https://app.dimensions.ai/details/publication/pub.1104319678"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000571.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40248-018-0129-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0129-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0129-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0129-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40248-018-0129-4'


 

This table displays all metadata directly associated to this object as RDF triples.

132 TRIPLES      21 PREDICATES      45 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40248-018-0129-4 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Nfecded7bb1b14199b7f5e5a223d41e02
4 schema:citation https://doi.org/10.1016/j.athoracsur.2004.09.039
5 https://doi.org/10.1016/j.healun.2017.07.002
6 https://doi.org/10.1016/j.thorsurg.2014.09.008
7 https://doi.org/10.1016/j.transproceed.2015.02.006
8 https://doi.org/10.1016/s0140-6736(11)60405-4
9 https://doi.org/10.1056/nejmoa1402582
10 https://doi.org/10.1089/wound.2013.0429
11 https://doi.org/10.1111/ajt.13671
12 https://doi.org/10.1111/resp.12691
13 https://doi.org/10.1136/thoraxjnl-2014-206260.370
14 https://doi.org/10.1164/rccm.2009-040gl
15 https://doi.org/10.1164/rccm.201403-0509pp
16 https://doi.org/10.1513/pats.200808-094go
17 https://doi.org/10.2147/ppa.s37233
18 https://doi.org/10.2147/tcrm.s69716
19 https://doi.org/10.3349/ymj.2015.56.5.1372
20 schema:datePublished 2018-12
21 schema:datePublishedReg 2018-12-01
22 schema:description Background: The drug pirfenidone has been shown to slow the progression and decrease mortality of idiopathic pulmonary fibrosis (IPF). Its exact mechanism is unknown, but it likely inhibits pro-fibrotic cytokine transforming growth factor beta, a known contributor to wound healing. We evaluated whether patients taking pirfenidone until lung transplantation had increased risk of impaired wound healing post-transplant. This information could determine whether pirfenidone should be discontinued prior to listing to allow for a wash-out period. Methods: We retrospectively reviewed patients who underwent lung transplantation for pulmonary fibrosis at Norton Thoracic Institute in Phoenix, Arizona, from January 2014 to December 2015. Results: We describe 18 patients who took pirfenidone up to a month before transplant. Aside from one patient who experienced sternal dehiscence due to a surgical issue, all remaining patients did well with no evidence of airway dehiscence. Each of these 17 patients had been on pirfenidone for at least 30 days; nine patients had been on pirfenidone for over 90 days. Baseline characteristics including age, sex, body mass index, renal function, liver function, glucose level, pre-transplant corticosteroid use, and post-transplant immunosuppressant therapy were similar. Conclusions: In our experience, pirfenidone may be safely continued until lung transplantation. Only one patient in our series experienced impaired wound healing related to a surgical issue, even when pirfenidone was continued until lung transplantation. We found no evidence of impaired wound healing or airway complications after lung transplantation in patients who were treated with pirfenidone before lung transplantation.
23 schema:genre research_article
24 schema:inLanguage en
25 schema:isAccessibleForFree true
26 schema:isPartOf N268eab76e876467d85f1e34962c30ef7
27 N63914938c6214a77a38586d4f1aac5be
28 sg:journal.1040211
29 schema:name Effect of pirfenidone on wound healing in lung transplant patients
30 schema:pagination 16
31 schema:productId N14309a31f8ef4bbb933d9b65be9d32fa
32 N2c6504d0b8f941aabe020e3dd246e520
33 N46827754142d40969930a770a26d44e2
34 N8c23967b01534ff7b3480970a941bfd3
35 Nb0a2eeae6d91479782e6329dc02c2a1c
36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104319678
37 https://doi.org/10.1186/s40248-018-0129-4
38 schema:sdDatePublished 2019-04-10T14:19
39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
40 schema:sdPublisher N2066b5b222434f579cf4e27a9df37df5
41 schema:url https://link.springer.com/10.1186%2Fs40248-018-0129-4
42 sgo:license sg:explorer/license/
43 sgo:sdDataset articles
44 rdf:type schema:ScholarlyArticle
45 N14309a31f8ef4bbb933d9b65be9d32fa schema:name nlm_unique_id
46 schema:value 101477642
47 rdf:type schema:PropertyValue
48 N2015c84105cc4506990e7d947c08d8e0 rdf:first sg:person.01001112105.15
49 rdf:rest rdf:nil
50 N2066b5b222434f579cf4e27a9df37df5 schema:name Springer Nature - SN SciGraph project
51 rdf:type schema:Organization
52 N268eab76e876467d85f1e34962c30ef7 schema:issueNumber 1
53 rdf:type schema:PublicationIssue
54 N2c6504d0b8f941aabe020e3dd246e520 schema:name pubmed_id
55 schema:value 29946463
56 rdf:type schema:PropertyValue
57 N46827754142d40969930a770a26d44e2 schema:name doi
58 schema:value 10.1186/s40248-018-0129-4
59 rdf:type schema:PropertyValue
60 N63914938c6214a77a38586d4f1aac5be schema:volumeNumber 13
61 rdf:type schema:PublicationVolume
62 N8c23967b01534ff7b3480970a941bfd3 schema:name readcube_id
63 schema:value fa4888d00fde3a2f926519933d24302681297f9ef44408c2d6396204a9ac3f6e
64 rdf:type schema:PropertyValue
65 Nb0a2eeae6d91479782e6329dc02c2a1c schema:name dimensions_id
66 schema:value pub.1104319678
67 rdf:type schema:PropertyValue
68 Nd5d9b710803d43159af2facc9fd15834 rdf:first sg:person.015330741265.36
69 rdf:rest N2015c84105cc4506990e7d947c08d8e0
70 Nfecded7bb1b14199b7f5e5a223d41e02 rdf:first sg:person.012343037265.33
71 rdf:rest Nd5d9b710803d43159af2facc9fd15834
72 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
73 schema:name Medical and Health Sciences
74 rdf:type schema:DefinedTerm
75 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
76 schema:name Cardiorespiratory Medicine and Haematology
77 rdf:type schema:DefinedTerm
78 sg:journal.1040211 schema:issn 1828-695X
79 2049-6958
80 schema:name Multidisciplinary Respiratory Medicine
81 rdf:type schema:Periodical
82 sg:person.01001112105.15 schema:affiliation https://www.grid.ac/institutes/grid.240866.e
83 schema:familyName Walia
84 schema:givenName Rajat
85 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001112105.15
86 rdf:type schema:Person
87 sg:person.012343037265.33 schema:affiliation https://www.grid.ac/institutes/grid.240866.e
88 schema:familyName Mortensen
89 schema:givenName Amber
90 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343037265.33
91 rdf:type schema:Person
92 sg:person.015330741265.36 schema:affiliation https://www.grid.ac/institutes/grid.240866.e
93 schema:familyName Cherrier
94 schema:givenName Lauren
95 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015330741265.36
96 rdf:type schema:Person
97 https://doi.org/10.1016/j.athoracsur.2004.09.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032414147
98 rdf:type schema:CreativeWork
99 https://doi.org/10.1016/j.healun.2017.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090346804
100 rdf:type schema:CreativeWork
101 https://doi.org/10.1016/j.thorsurg.2014.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022165440
102 rdf:type schema:CreativeWork
103 https://doi.org/10.1016/j.transproceed.2015.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014183845
104 rdf:type schema:CreativeWork
105 https://doi.org/10.1016/s0140-6736(11)60405-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009123817
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1056/nejmoa1402582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013090473
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1089/wound.2013.0429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011166230
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1111/ajt.13671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001650503
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1111/resp.12691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020819255
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1136/thoraxjnl-2014-206260.370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004066456
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1164/rccm.2009-040gl schema:sameAs https://app.dimensions.ai/details/publication/pub.1009587829
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1164/rccm.201403-0509pp schema:sameAs https://app.dimensions.ai/details/publication/pub.1045500302
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1513/pats.200808-094go schema:sameAs https://app.dimensions.ai/details/publication/pub.1011195458
122 rdf:type schema:CreativeWork
123 https://doi.org/10.2147/ppa.s37233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026567595
124 rdf:type schema:CreativeWork
125 https://doi.org/10.2147/tcrm.s69716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016159217
126 rdf:type schema:CreativeWork
127 https://doi.org/10.3349/ymj.2015.56.5.1372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020439330
128 rdf:type schema:CreativeWork
129 https://www.grid.ac/institutes/grid.240866.e schema:alternateName St. Joseph's Hospital and Medical Center
130 schema:name Department of Pharmacy, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA
131 Division of Pulmonology, Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, 500 W. Thomas Rd., Ste. 500, Phoenix, AZ, USA
132 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...