Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Junji Ohnishi, Satoshi Ayuzawa, Seiji Nakamura, Shigeko Sakamoto, Miyo Hori, Tomoko Sasaoka, Eriko Takimoto-Ohnishi, Masakazu Tanatsugu, Kazuo Murakami

ABSTRACT

BACKGROUND: Growing evidence suggests that spiritual/religious involvement may have beneficial effects on both psychological and physical functions. However, the biological basis for this relationship remains unclear. This study explored the role of spiritual/religious involvement across a wide range of biological markers, including transcripts and metabolites, associated with the psychological aspects of empathy in Buddhist priests. METHODS: Ten professional Buddhist priests and 10 age-matched non-priest controls were recruited. The participants provided peripheral blood samples for the analysis of gene expression and metabolic profiles. The participants also completed validated questionnaires measuring empathy, the Health-Promoting Lifestyle Profile-II (HPLP-II), and a brief-type self-administered diet history questionnaire (BDHQ). RESULTS: The microarray analyses revealed that the distinct transcripts in the Buddhist priests included up-regulated genes related to type I interferon (IFN) innate anti-viral responses (i.e., MX1, RSAD2, IFIT1, IFIT3, IFI27, IFI44L, and HERC5), and the genes C17orf97 (ligand of arginyltranseferase 1; ATE1), hemoglobin γA (HBG1), keratin-associated protein (KRTAP10-12), and sialic acid Ig-like lectin 14 (SIGLEC14) were down-regulated at baseline. The metabolomics analysis revealed that the metabolites, including 3-aminoisobutylic acid (BAIBA), choline, several essential amino acids (e.g., methionine, phenylalanine), and amino acid derivatives (e.g., 2-aminoadipic acid, asymmetric dimethyl-arginine (ADMA), symmetric dimethyl-arginine (SMDA)), were elevated in the Buddhist priests. By contrast, there was no significant difference of healthy lifestyle behaviors and daily nutrient intakes between the priests and the controls in this study. With regard to the psychological aspects, the Buddhist priests showed significantly higher empathy compared with the control. Spearman's rank correlation analysis showed that empathy aspects in the priests were significantly correlated with the certain transcripts and metabolites. CONCLUSIONS: We performed in vivo phenotyping using transcriptomics, metabolomics, and psychological analyses and found an association between empathy and the phenotype of Buddhist priests in this pilot study. The up-regulation of the anti-viral type I IFN responsive genes and distinct metabolites in the plasma may represent systemic biological adaptations with a unique signature underlying spiritual/religious practices for Buddhists. More... »

PAGES

21

References to SciGraph publications

  • 2008-07. Interferon-inducible antiviral effectors in NATURE REVIEWS IMMUNOLOGY
  • 2006-12. Comparison and evaluation of methods for generating differentially expressed gene lists from microarray data in BMC BIOINFORMATICS
  • 2015-12. Whole-Blood Gene Expression Profiles in Large-Scale Epidemiological Studies: What Do They Tell? in CURRENT NUTRITION REPORTS
  • 2011-02. Choline and betaine in health and disease in JOURNAL OF INHERITED METABOLIC DISEASE
  • 2013-01. The broad-spectrum antiviral functions of IFIT and IFITM proteins in NATURE REVIEWS IMMUNOLOGY
  • 2011-12. The distinct roles of spirituality and religiosity in physical and mental health after collective trauma: a national longitudinal study of responses to the 9/11 attacks in JOURNAL OF BEHAVIORAL MEDICINE
  • 2011-01. Autophagy in immunity and inflammation in NATURE
  • 2008-03. Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology in ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY
  • 2013-07. Relationship between lifestyle and lifestyle-related factors in a rural–urban population of Japan in ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
  • 2015. Autophagy and Aging in LONGEVITY GENES
  • 2005-03. Stress-induced immune dysfunction: implications for health in NATURE REVIEWS IMMUNOLOGY
  • 2011-09. Reciprocal regulation of the neural and innate immune systems in NATURE REVIEWS IMMUNOLOGY
  • 2011-09. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease in NATURE REVIEWS IMMUNOLOGY
  • 2015-07. Innate immune memory: a paradigm shift in understanding host defense in NATURE IMMUNOLOGY
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    http://scigraph.springernature.com/pub.10.1186/s40246-017-0117-3

    DOI

    http://dx.doi.org/10.1186/s40246-017-0117-3

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28865488


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