Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Matahi Moarii, Fabien Reyal, Jean-Philippe Vert

ABSTRACT

BACKGROUND: The CpG island methylator phenotype (CIMP) was first characterized in colorectal cancer but since has been extensively studied in several other tumor types such as breast, bladder, lung, and gastric. CIMP is of clinical importance as it has been reported to be associated with prognosis or response to treatment. However, the identification of a universal molecular basis to define CIMP across tumors has remained elusive. RESULTS: We perform a genome-wide methylation analysis of over 2000 tumor samples from 5 cancer sites to assess the existence of a CIMP with common molecular basis across cancers. We then show that the CIMP phenotype is associated with specific gene expression variations. However, we do not find a common genetic signature in all tissues associated with CIMP. CONCLUSION: Our results suggest the existence of a universal epigenetic and transcriptomic signature that defines the CIMP across several tumor types but does not indicate the existence of a common genetic signature of CIMP. More... »

PAGES

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40246-015-0048-9

DOI

http://dx.doi.org/10.1186/s40246-015-0048-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031332900

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26463173


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