99mTc-radiolabeled GE11-modified peptide for ovarian tumor targeting View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Najmeh Rahmanian, Seyed Jalal Hosseinimehr, Ali Khalaj, Zohreh Noaparast, Seyed Mohammad Abedi, Omid Sabzevari

ABSTRACT

BACKGROUND: Ovarian cancer is a serious threat for women health and the early diagnosis of this cancer might improves the survival rate of patients. The use of the targeted radiopharmaceuticals could be a non-invasive and logical method for tumor imaging. The aim of this study was to radiolabel GE11 peptide as a new specific probe for imaging of ovarian tumor. METHODS: HYNIC-SSS-GE11 peptide was labeled with 99mTc using tricine as a coligand. The 99mTc-tricine-HYNIC-SSS-GE11 peptide was evaluated for specific cellular binding in three cell lines with different levels of EGFR expression. Tumor targeting was assessed in SKOV3 tumor bearing mice. RESULTS: By using tricine as a coligand, labeling yield was more than 98% and the stability of the radiolabelled peptide in human serum up to 4 h was 96%. The in vitro cell uptake test showed that this radiolabeled peptide had a good affinity to SKOV3 cells with dissociation constant of 73 nM. The in vivo results showed a tumor/muscle ratio of 3.2 at 4 h following injection of 99mTc-tricine-HYNIC-SSS-GE11 peptide. CONCLUSIONS: Results of this study showed that 99mTc-tricine-HYNIC-SSS-GE11 peptide could be a promising tool for diagnosis and staging of ovarian cancer. 99mTc-tricine-HYNIC-SSS-GE11, a novl targeted agent for ovarian tumor imaging. More... »

PAGES

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40199-017-0179-8

DOI

http://dx.doi.org/10.1186/s40199-017-0179-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084956287

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28464952


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