Adult pulmonary tuberculosis as a pathological manifestation of hyperactive antimycobacterial immune response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Pawan Kumar

ABSTRACT

The intricate relationship between tuberculosis (TB) and immune system remains poorly understood. It is generally believed that weakening of the immune response against Mycobacterium tuberculosis leads to reactivation of latent infection into the active pulmonary disease. However, heterogeneous nature of TB and failure of rationally designed vaccines in clinical trials raises serious questions against the simplistic view of TB as an outcome of weakened immunity. In the wake of accumulating human TB data, it is argued here that a hyperactive antimycobacterial immune response is to blame for the pathogenesis of pulmonary TB in immunocompetent adults. Direct and indirect evidence supporting this notion is presented in this article. Revisiting the role of immune system in TB pathogenesis will pave the way for effective anti-TB vaccines. More... »

PAGES

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40169-016-0119-0

DOI

http://dx.doi.org/10.1186/s40169-016-0119-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042135322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27709522


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JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40169-016-0119-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40169-016-0119-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40169-016-0119-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40169-016-0119-0'


 

This table displays all metadata directly associated to this object as RDF triples.

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