Assessment of the microbiome during bacteriophage therapy in combination with systemic antibiotics to treat a case of staphylococcal device infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-04-14

AUTHORS

Andre Mu, Daniel McDonald, Alan K. Jarmusch, Cameron Martino, Caitriona Brennan, Mackenzie Bryant, Gregory C. Humphrey, Julia Toronczak, Tara Schwartz, Dominic Nguyen, Gail Ackermann, Anthony D’Onofrio, Steffanie A. Strathdee, Robert T. Schooley, Pieter C. Dorrestein, Rob Knight, Saima Aslam

ABSTRACT

BackgroundInfectious bacterial diseases exhibiting increasing resistance to antibiotics are a serious global health issue. Bacteriophage therapy is an anti-microbial alternative to treat patients with serious bacterial infections. However, the impacts to the host microbiome in response to clinical use of phage therapy are not well understood.ResultsOur paper demonstrates a largely unchanged microbiota profile during 4 weeks of phage therapy when added to systemic antibiotics in a single patient with Staphylococcus aureus device infection. Metabolomic analyses suggest potential indirect cascading ecological impacts to the host (skin) microbiome. We did not detect genomes of the three phages used to treat the patient in metagenomic samples taken from saliva, stool, and skin; however, phages were detected using endpoint-PCR in patient serum.ConclusionResults from our proof-of-principal study supports the use of bacteriophages as a microbiome-sparing approach to treat bacterial infections.E21QRb1nrJpVFpfB3nSJ8UVideo abstract More... »

PAGES

92

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40168-021-01026-9

DOI

http://dx.doi.org/10.1186/s40168-021-01026-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137200965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33853672


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29 analysis
30 antibiotics
31 approach
32 assessment
33 bacterial diseases
34 bacterial infections
35 bacteriophage therapy
36 bacteriophages
37 cases
38 clinical use
39 combination
40 device infection
41 disease
42 ecological impacts
43 endpoint PCR
44 genome
45 global health issue
46 health issues
47 host microbiome
48 impact
49 infection
50 issues
51 metabolomic analysis
52 metagenomic samples
53 microbiome
54 microbiota profiles
55 paper
56 patient sera
57 patients
58 phage therapy
59 phages
60 principal studies
61 profile
62 proof
63 resistance
64 response
65 saliva
66 samples
67 serious bacterial infections
68 serious global health issue
69 serum
70 single patient
71 skin
72 stool
73 study
74 systemic antibiotics
75 therapy
76 use
77 use of bacteriophages
78 weeks
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