Prokaryotic horizontal gene transfer within the human holobiont: ecological-evolutionary inferences, implications and possibilities View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Ramakrishnan Sitaraman

ABSTRACT

The ubiquity of horizontal gene transfer in the living world, especially among prokaryotes, raises interesting and important scientific questions regarding its effects on the human holobiont i.e., the human and its resident bacterial communities considered together as a unit of selection. Specifically, it would be interesting to determine how particular gene transfer events have influenced holobiont phenotypes in particular ecological niches and, conversely, how specific holobiont phenotypes have influenced gene transfer events. In this synthetic review, we list some notable and recent discoveries of horizontal gene transfer among the prokaryotic component of the human microbiota, and analyze their potential impact on the holobiont from an ecological-evolutionary viewpoint. Finally, the human-Helicobacter pylori association is presented as an illustration of these considerations, followed by a delineation of unresolved questions and avenues for future research. More... »

PAGES

163

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  • Journal

    TITLE

    Microbiome

    ISSUE

    1

    VOLUME

    6

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s40168-018-0551-z

    DOI

    http://dx.doi.org/10.1186/s40168-018-0551-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107066842

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30223892


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