Fat and vitamin intakes during pregnancy have stronger relations with a pro-inflammatory maternal microbiota than does carbohydrate intake View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-19

AUTHORS

Siddhartha Mandal, Keith M. Godfrey, Daniel McDonald, Will V. Treuren, Jørgen V. Bjørnholt, Tore Midtvedt, Birgitte Moen, Knut Rudi, Rob Knight, Anne Lise Brantsæter, Shyamal D. Peddada, Merete Eggesbø

ABSTRACT

BackgroundAlthough diet is known to have a major modulatory influence on gut microbiota, knowledge of the specific roles of particular vitamins, minerals, and other nutrients is limited.Modulation of the composition of the microbiota in pregnant women is especially important as maternal microbes are transferred during delivery and initiate the colonization process in the infant. We studied the associations between intake of specific dietary nutrients during pregnancy and gut microbiota composition.MethodsUtilizing the Norwegian NoMIC cohort, we examined the relations between intakes of 28 dietary macro- and micronutrients during pregnancy, derived from food frequency questionnaires administered to 60 women in the second trimester, and observed taxonomic differences in their gut microbiota four days after delivery (assessed through Illumina 16S rRNA amplicon analysis).ResultsHigher dietary intakes of fat-soluble vitamins, especially vitamin D, were associated with reduced microbial alpha diversity (p value <0.001). Furthermore, using recently developed statistical methodology, we discovered that the variations in fat-soluble vitamins, saturated and mono-unsaturated fat, and cholesterol intake, were associated with changes in phyla composition. Specifically, vitamin D, mono-unsaturated fat, cholesterol, and retinol were associated with relative increases in Proteobacteria, which is a phylum known to encompass multiple pathogens and to have pro-inflammatory properties. In contrast, saturated fat, vitamin E, and protein were associated with relative decreases in Proteobacteria.ConclusionsThe results in this article indicate that fats and fat-soluble vitamins are among the most potent dietary modulators of gut microbiota in mothers. The shifts in microbiota due to diet need to be further studied alongside gut microbiota changes during pregnancy to better understand the impact on infant gut microbiota. More... »

PAGES

55

Journal

TITLE

Microbiome

ISSUE

1

VOLUME

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40168-016-0200-3

DOI

http://dx.doi.org/10.1186/s40168-016-0200-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020042376

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27756413


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30 schema:description BackgroundAlthough diet is known to have a major modulatory influence on gut microbiota, knowledge of the specific roles of particular vitamins, minerals, and other nutrients is limited.Modulation of the composition of the microbiota in pregnant women is especially important as maternal microbes are transferred during delivery and initiate the colonization process in the infant. We studied the associations between intake of specific dietary nutrients during pregnancy and gut microbiota composition.MethodsUtilizing the Norwegian NoMIC cohort, we examined the relations between intakes of 28 dietary macro- and micronutrients during pregnancy, derived from food frequency questionnaires administered to 60 women in the second trimester, and observed taxonomic differences in their gut microbiota four days after delivery (assessed through Illumina 16S rRNA amplicon analysis).ResultsHigher dietary intakes of fat-soluble vitamins, especially vitamin D, were associated with reduced microbial alpha diversity (p value <0.001). Furthermore, using recently developed statistical methodology, we discovered that the variations in fat-soluble vitamins, saturated and mono-unsaturated fat, and cholesterol intake, were associated with changes in phyla composition. Specifically, vitamin D, mono-unsaturated fat, cholesterol, and retinol were associated with relative increases in Proteobacteria, which is a phylum known to encompass multiple pathogens and to have pro-inflammatory properties. In contrast, saturated fat, vitamin E, and protein were associated with relative decreases in Proteobacteria.ConclusionsThe results in this article indicate that fats and fat-soluble vitamins are among the most potent dietary modulators of gut microbiota in mothers. The shifts in microbiota due to diet need to be further studied alongside gut microbiota changes during pregnancy to better understand the impact on infant gut microbiota.
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38 Proteobacteria
39 alpha diversity
40 article
41 association
42 carbohydrates
43 changes
44 cholesterol
45 cholesterol intake
46 cohort
47 colonization process
48 composition
49 contrast
50 days
51 decrease
52 delivery
53 diet
54 dietary intake
55 dietary macro
56 dietary modulators
57 dietary nutrients
58 differences
59 diversity
60 fat
61 fat-soluble vitamins
62 food frequency questionnaire
63 four
64 frequency questionnaire
65 gut microbiota
66 gut microbiota changes
67 gut microbiota composition
68 impact
69 increase
70 infant gut microbiota
71 infants
72 influence
73 intake
74 knowledge
75 macro
76 major modulatory influence
77 maternal microbes
78 maternal microbiota
79 methodology
80 microbes
81 microbial alpha diversity
82 microbiota
83 microbiota changes
84 microbiota composition
85 micronutrients
86 minerals
87 modulation
88 modulator
89 modulatory influence
90 mono-unsaturated fat
91 mothers
92 multiple pathogens
93 nutrients
94 particular vitamin
95 pathogens
96 phyla
97 phyla composition
98 pregnancy
99 pregnant women
100 pro-inflammatory properties
101 process
102 properties
103 protein
104 questionnaire
105 relation
106 relative decrease
107 relative increase
108 results
109 retinol
110 role
111 second trimester
112 shift
113 specific dietary nutrients
114 specific role
115 statistical methodology
116 strong relation
117 taxonomic differences
118 trimester
119 variation
120 vitamin
121 vitamin D
122 vitamin E
123 vitamin intake
124 women
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