Fat and vitamin intakes during pregnancy have stronger relations with a pro-inflammatory maternal microbiota than does carbohydrate intake View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-19

AUTHORS

Siddhartha Mandal, Keith M. Godfrey, Daniel McDonald, Will V. Treuren, Jørgen V. Bjørnholt, Tore Midtvedt, Birgitte Moen, Knut Rudi, Rob Knight, Anne Lise Brantsæter, Shyamal D. Peddada, Merete Eggesbø

ABSTRACT

BACKGROUND: Although diet is known to have a major modulatory influence on gut microbiota, knowledge of the specific roles of particular vitamins, minerals, and other nutrients is limited. Modulation of the composition of the microbiota in pregnant women is especially important as maternal microbes are transferred during delivery and initiate the colonization process in the infant. We studied the associations between intake of specific dietary nutrients during pregnancy and gut microbiota composition. METHODS: Utilizing the Norwegian NoMIC cohort, we examined the relations between intakes of 28 dietary macro- and micronutrients during pregnancy, derived from food frequency questionnaires administered to 60 women in the second trimester, and observed taxonomic differences in their gut microbiota four days after delivery (assessed through Illumina 16S rRNA amplicon analysis). RESULTS: Higher dietary intakes of fat-soluble vitamins, especially vitamin D, were associated with reduced microbial alpha diversity (p value <0.001). Furthermore, using recently developed statistical methodology, we discovered that the variations in fat-soluble vitamins, saturated and mono-unsaturated fat, and cholesterol intake, were associated with changes in phyla composition. Specifically, vitamin D, mono-unsaturated fat, cholesterol, and retinol were associated with relative increases in Proteobacteria, which is a phylum known to encompass multiple pathogens and to have pro-inflammatory properties. In contrast, saturated fat, vitamin E, and protein were associated with relative decreases in Proteobacteria. CONCLUSIONS: The results in this article indicate that fats and fat-soluble vitamins are among the most potent dietary modulators of gut microbiota in mothers. The shifts in microbiota due to diet need to be further studied alongside gut microbiota changes during pregnancy to better understand the impact on infant gut microbiota. More... »

PAGES

55

Journal

TITLE

Microbiome

ISSUE

1

VOLUME

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40168-016-0200-3

DOI

http://dx.doi.org/10.1186/s40168-016-0200-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020042376

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27756413


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30 schema:description BACKGROUND: Although diet is known to have a major modulatory influence on gut microbiota, knowledge of the specific roles of particular vitamins, minerals, and other nutrients is limited. Modulation of the composition of the microbiota in pregnant women is especially important as maternal microbes are transferred during delivery and initiate the colonization process in the infant. We studied the associations between intake of specific dietary nutrients during pregnancy and gut microbiota composition. METHODS: Utilizing the Norwegian NoMIC cohort, we examined the relations between intakes of 28 dietary macro- and micronutrients during pregnancy, derived from food frequency questionnaires administered to 60 women in the second trimester, and observed taxonomic differences in their gut microbiota four days after delivery (assessed through Illumina 16S rRNA amplicon analysis). RESULTS: Higher dietary intakes of fat-soluble vitamins, especially vitamin D, were associated with reduced microbial alpha diversity (p value <0.001). Furthermore, using recently developed statistical methodology, we discovered that the variations in fat-soluble vitamins, saturated and mono-unsaturated fat, and cholesterol intake, were associated with changes in phyla composition. Specifically, vitamin D, mono-unsaturated fat, cholesterol, and retinol were associated with relative increases in Proteobacteria, which is a phylum known to encompass multiple pathogens and to have pro-inflammatory properties. In contrast, saturated fat, vitamin E, and protein were associated with relative decreases in Proteobacteria. CONCLUSIONS: The results in this article indicate that fats and fat-soluble vitamins are among the most potent dietary modulators of gut microbiota in mothers. The shifts in microbiota due to diet need to be further studied alongside gut microbiota changes during pregnancy to better understand the impact on infant gut microbiota.
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38 Norwegian NoMIC cohort
39 Proteobacteria
40 alpha diversity
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42 association
43 carbohydrates
44 changes
45 cholesterol
46 cholesterol intake
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48 colonization process
49 composition
50 contrast
51 days
52 decrease
53 delivery
54 diet
55 dietary intake
56 dietary macro
57 dietary modulators
58 dietary nutrients
59 differences
60 diversity
61 fat
62 fat-soluble vitamins
63 food frequency questionnaire
64 four
65 frequency questionnaire
66 gut microbiota
67 gut microbiota changes
68 gut microbiota composition
69 gut microbiota four
70 high dietary intake
71 impact
72 increase
73 infant gut microbiota
74 infants
75 influence
76 intake
77 knowledge
78 macro
79 major modulatory influence
80 maternal microbes
81 maternal microbiota
82 methodology
83 microbes
84 microbial alpha diversity
85 microbiota
86 microbiota changes
87 microbiota composition
88 microbiota four
89 micronutrients
90 minerals
91 modulation
92 modulator
93 modulatory influence
94 mono-unsaturated fat
95 mothers
96 multiple pathogens
97 nutrients
98 particular vitamin
99 pathogens
100 phyla
101 phyla composition
102 potent dietary modulators
103 pregnancy
104 pregnant women
105 pro-inflammatory maternal microbiota
106 pro-inflammatory properties
107 process
108 properties
109 protein
110 questionnaire
111 relation
112 relative decrease
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114 results
115 retinol
116 role
117 second trimester
118 shift
119 specific dietary nutrients
120 specific role
121 statistical methodology
122 strong relation
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124 trimester
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126 vitamin
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