Composition and dynamics of the respiratory tract microbiome in intubated patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Brendan J. Kelly, Ize Imai, Kyle Bittinger, Alice Laughlin, Barry D. Fuchs, Frederic D. Bushman, Ronald G. Collman

ABSTRACT

BACKGROUND: Lower respiratory tract infection (LRTI) is a major contributor to respiratory failure requiring intubation and mechanical ventilation. LRTI also occurs during mechanical ventilation, increasing the morbidity and mortality of intubated patients. We sought to understand the dynamics of respiratory tract microbiota following intubation and the relationship between microbial community structure and infection. RESULTS: We enrolled a cohort of 15 subjects with respiratory failure requiring intubation and mechanical ventilation from the medical intensive care unit at an academic medical center. Oropharyngeal (OP) and deep endotracheal (ET) secretions were sampled within 24 h of intubation and every 48-72 h thereafter. Bacterial community profiling was carried out by purifying DNA, PCR amplification of 16S ribosomal RNA (rRNA) gene sequences, deep sequencing, and bioinformatic community analysis. We compared enrolled subjects to a cohort of healthy subjects who had lower respiratory tract sampling by bronchoscopy. In contrast to the diverse upper respiratory tract and lower respiratory tract microbiota found in healthy controls, critically ill subjects had lower initial diversity at both sites. Diversity further diminished over time on the ventilator. In several subjects, the bacterial community was dominated by a single taxon over multiple time points. The clinical diagnosis of LRTI ascertained by chart review correlated with low community diversity and dominance of a single taxon. Dominant taxa matched clinical bacterial cultures where cultures were obtained and positive. In several cases, dominant taxa included bacteria not detected by culture, including Ureaplasma parvum and Enterococcus faecalis. CONCLUSIONS: Longitudinal analysis of respiratory tract microbiota in critically ill patients provides insight into the pathogenesis and diagnosis of LRTI. 16S rRNA gene sequencing of endotracheal aspirate samples holds promise for expanded pathogen identification. More... »

PAGES

7

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40168-016-0151-8

DOI

http://dx.doi.org/10.1186/s40168-016-0151-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019831205

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26865050


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchoscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intubation, Intratracheal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microbiota", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oropharynx", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Ventilator-Associated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Ribosomal, 16S", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Tract Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trachea", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kelly", 
        "givenName": "Brendan J.", 
        "id": "sg:person.01104175321.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104175321.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imai", 
        "givenName": "Ize", 
        "id": "sg:person.01247266333.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247266333.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bittinger", 
        "givenName": "Kyle", 
        "id": "sg:person.01244225361.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244225361.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laughlin", 
        "givenName": "Alice", 
        "id": "sg:person.0625216340.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625216340.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fuchs", 
        "givenName": "Barry D.", 
        "id": "sg:person.01053715420.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053715420.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bushman", 
        "givenName": "Frederic D.", 
        "id": "sg:person.01216060406.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216060406.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collman", 
        "givenName": "Ronald G.", 
        "id": "sg:person.01222067106.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222067106.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1378/chest.122.6.2115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000994595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.122.6.2115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000994595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0006-341x.2001.00120.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001190289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0006-341x.2001.00120.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001190289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cit578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001513363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2004.030411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002112557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2004.030411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002112557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201211-2145oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003073775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/annalsats.201501-029oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003973048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200112000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005268084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200112000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005268084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007181271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200405-644st", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008391386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.f.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009032055", 
          "https://doi.org/10.1038/nmeth.f.303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.f.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009032055", 
          "https://doi.org/10.1038/nmeth.f.303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1824-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009089670", 
          "https://doi.org/10.1007/s00134-010-1824-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1824-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009089670", 
          "https://doi.org/10.1007/s00134-010-1824-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ismej.2015.148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009910264", 
          "https://doi.org/10.1038/ismej.2015.148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201105-0867oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010765678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsa0907130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011499690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.159.1.9803097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011932378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1843.2007.01211.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013131717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1843.2007.01211.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013131717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/421498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013709859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1000087107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015660267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.165.1.2105077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016238604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e31819dc2f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018215123", 
          "https://doi.org/10.1203/pdr.0b013e31819dc2f9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e31819dc2f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018215123", 
          "https://doi.org/10.1203/pdr.0b013e31819dc2f9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/fn.73.1.f37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018385491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1000080107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019627885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(13)70081-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019661348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/587103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022386548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001340000611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023243964", 
          "https://doi.org/10.1007/s001340000611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01678-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023907765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01494-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024265744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027248000", 
          "https://doi.org/10.1038/nature11209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cir045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028407453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31828a674a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029577432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31828a674a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029577432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.159.4.9807050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031488863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201204-0693oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033022352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0025959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033349309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/11956860.1995.11682297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035331897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajic.2013.06.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037688909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2013.333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038700120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ismej.2012.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038992953", 
          "https://doi.org/10.1038/ismej.2012.8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-012-2759-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039278769", 
          "https://doi.org/10.1007/s00134-012-2759-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.45.11.3202-3204.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039982174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btv183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040626563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0032486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042236416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1654-1103.2003.tb02228.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043141145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1442-9993.2001.01070.pp.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044499388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.100.2.439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044724213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044940798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/648678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045426681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmp1300633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045659512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201104-0655oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046729617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.1650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047029298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cir832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047658590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199512143332408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048326093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01028-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048408423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2011-201183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048417687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2011-201183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048417687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1405870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049015513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1996.03530260048030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050492439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.163.7.at1010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051296869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051403004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(14)61136-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051483805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051517589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.127.2.589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051851695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ismej.2011.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051863807", 
          "https://doi.org/10.1038/ismej.2011.139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.275.2.134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054159644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18637/jss.v015.i02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068672224"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Lower respiratory tract infection (LRTI) is a major contributor to respiratory failure requiring intubation and mechanical ventilation. LRTI also occurs during mechanical ventilation, increasing the morbidity and mortality of intubated patients. We sought to understand the dynamics of respiratory tract microbiota following intubation and the relationship between microbial community structure and infection.\nRESULTS: We enrolled a cohort of 15 subjects with respiratory failure requiring intubation and mechanical ventilation from the medical intensive care unit at an academic medical center. Oropharyngeal (OP) and deep endotracheal (ET) secretions were sampled within 24 h of intubation and every 48-72 h thereafter. Bacterial community profiling was carried out by purifying DNA, PCR amplification of 16S ribosomal RNA (rRNA) gene sequences, deep sequencing, and bioinformatic community analysis. We compared enrolled subjects to a cohort of healthy subjects who had lower respiratory tract sampling by bronchoscopy. In contrast to the diverse upper respiratory tract and lower respiratory tract microbiota found in healthy controls, critically ill subjects had lower initial diversity at both sites. Diversity further diminished over time on the ventilator. In several subjects, the bacterial community was dominated by a single taxon over multiple time points. The clinical diagnosis of LRTI ascertained by chart review correlated with low community diversity and dominance of a single taxon. Dominant taxa matched clinical bacterial cultures where cultures were obtained and positive. In several cases, dominant taxa included bacteria not detected by culture, including Ureaplasma parvum and Enterococcus faecalis.\nCONCLUSIONS: Longitudinal analysis of respiratory tract microbiota in critically ill patients provides insight into the pathogenesis and diagnosis of LRTI. 16S rRNA gene sequencing of endotracheal aspirate samples holds promise for expanded pathogen identification.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40168-016-0151-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2692080", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2543712", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682008", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691977", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438704", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1048878", 
        "issn": [
          "2049-2618"
        ], 
        "name": "Microbiome", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Composition and dynamics of the respiratory tract microbiome in intubated patients", 
    "pagination": "7", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5e7cc27cbe83e3d4dac03c4d113b7bcdedb7d6c58e8e3b82b85702ee4f095ddd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26865050"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101615147"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40168-016-0151-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019831205"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40168-016-0151-8", 
      "https://app.dimensions.ai/details/publication/pub.1019831205"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs40168-016-0151-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40168-016-0151-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40168-016-0151-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40168-016-0151-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40168-016-0151-8'


 

This table displays all metadata directly associated to this object as RDF triples.

411 TRIPLES      21 PREDICATES      115 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40168-016-0151-8 schema:about N00c55d4863fb45458442aff080eb11cd
2 N029663e029c04c5e9f28b2a60b379fc5
3 N0f80e405783743b99e1f605bfaf8388d
4 N2520800d30824bf79f44e9cba44e494c
5 N294ad52029514488a270d4c4d031ca8d
6 N2e7cc9a1f14845a9a506739d1fc5f19c
7 N3106e4a34b024904975c775275b17e79
8 N3475bb36ed444366a08a86929e6cc7b8
9 N37f26697ac9f4fec96591b72ef4b0646
10 N5337c20f33be45229645fa08ec54944d
11 N70c2f528cd554507b0689b30f9ac96c2
12 N85a451870e774dff9b85415036fd6343
13 N906d02d07fa44a51b4ff9ea520427d37
14 Nafd6dc65774b4286925cc6e88d50526c
15 Nb01f2b811bb7417dab39b3129829bc67
16 Nb5a0146643fe4012a1e7141337e03868
17 Nb860a0e8dbf941a4882762580e79b372
18 Nbc0fdb9b109948029ade29c865bb97e5
19 Nccc28d398d5e4e9eadf2515d1ce6c41a
20 Nccd42a6eabad4ad2892c9470ff3b1e5e
21 Ndb307b46911b4700b1a0279344eb0435
22 Nfad79c4abc804df39738ced26c0e5b08
23 Nfdc54fe2da8243b0943cfd155bf3bb62
24 anzsrc-for:11
25 anzsrc-for:1103
26 schema:author Ndf6bf9c960cd4bf98376181fa1230833
27 schema:citation sg:pub.10.1007/s00134-010-1824-6
28 sg:pub.10.1007/s00134-012-2759-x
29 sg:pub.10.1007/s001340000611
30 sg:pub.10.1038/ismej.2011.139
31 sg:pub.10.1038/ismej.2012.8
32 sg:pub.10.1038/ismej.2015.148
33 sg:pub.10.1038/nature11209
34 sg:pub.10.1038/nmeth.f.303
35 sg:pub.10.1203/pdr.0b013e31819dc2f9
36 https://doi.org/10.1001/jama.1996.03530260048030
37 https://doi.org/10.1001/jama.2013.333
38 https://doi.org/10.1001/jama.275.2.134
39 https://doi.org/10.1002/sim.1650
40 https://doi.org/10.1016/j.ajic.2013.06.021
41 https://doi.org/10.1016/s0140-6736(14)61136-3
42 https://doi.org/10.1016/s1473-3099(13)70081-1
43 https://doi.org/10.1056/nejm199512143332408
44 https://doi.org/10.1056/nejmoa052904
45 https://doi.org/10.1056/nejmoa1405870
46 https://doi.org/10.1056/nejmp1300633
47 https://doi.org/10.1056/nejmsa0907130
48 https://doi.org/10.1073/pnas.1000080107
49 https://doi.org/10.1073/pnas.1000087107
50 https://doi.org/10.1080/11956860.1995.11682297
51 https://doi.org/10.1086/421498
52 https://doi.org/10.1086/587103
53 https://doi.org/10.1086/648678
54 https://doi.org/10.1093/bioinformatics/btv183
55 https://doi.org/10.1093/cid/cir045
56 https://doi.org/10.1093/cid/cir832
57 https://doi.org/10.1093/cid/cit578
58 https://doi.org/10.1093/nar/gkt1209
59 https://doi.org/10.1097/00003246-200112000-00012
60 https://doi.org/10.1097/ccm.0b013e31828a674a
61 https://doi.org/10.1111/j.0006-341x.2001.00120.x
62 https://doi.org/10.1111/j.1440-1843.2007.01211.x
63 https://doi.org/10.1111/j.1442-9993.2001.01070.pp.x
64 https://doi.org/10.1111/j.1654-1103.2003.tb02228.x
65 https://doi.org/10.1128/aac.45.11.3202-3204.2001
66 https://doi.org/10.1128/jcm.01028-14
67 https://doi.org/10.1128/jcm.01494-14
68 https://doi.org/10.1128/jcm.01678-14
69 https://doi.org/10.1136/fn.73.1.f37
70 https://doi.org/10.1136/thoraxjnl-2011-201183
71 https://doi.org/10.1136/thx.2004.030411
72 https://doi.org/10.1164/ajrccm.159.1.9803097
73 https://doi.org/10.1164/ajrccm.159.4.9807050
74 https://doi.org/10.1164/ajrccm.163.7.at1010
75 https://doi.org/10.1164/ajrccm.165.1.2105077
76 https://doi.org/10.1164/rccm.200405-644st
77 https://doi.org/10.1164/rccm.201104-0655oc
78 https://doi.org/10.1164/rccm.201105-0867oc
79 https://doi.org/10.1164/rccm.201204-0693oc
80 https://doi.org/10.1164/rccm.201211-2145oc
81 https://doi.org/10.1371/journal.pbio.1001377
82 https://doi.org/10.1371/journal.pone.0015216
83 https://doi.org/10.1371/journal.pone.0025959
84 https://doi.org/10.1371/journal.pone.0032486
85 https://doi.org/10.1378/chest.100.2.439
86 https://doi.org/10.1378/chest.122.6.2115
87 https://doi.org/10.1378/chest.127.2.589
88 https://doi.org/10.1513/annalsats.201501-029oc
89 https://doi.org/10.18637/jss.v015.i02
90 schema:datePublished 2016-12
91 schema:datePublishedReg 2016-12-01
92 schema:description BACKGROUND: Lower respiratory tract infection (LRTI) is a major contributor to respiratory failure requiring intubation and mechanical ventilation. LRTI also occurs during mechanical ventilation, increasing the morbidity and mortality of intubated patients. We sought to understand the dynamics of respiratory tract microbiota following intubation and the relationship between microbial community structure and infection. RESULTS: We enrolled a cohort of 15 subjects with respiratory failure requiring intubation and mechanical ventilation from the medical intensive care unit at an academic medical center. Oropharyngeal (OP) and deep endotracheal (ET) secretions were sampled within 24 h of intubation and every 48-72 h thereafter. Bacterial community profiling was carried out by purifying DNA, PCR amplification of 16S ribosomal RNA (rRNA) gene sequences, deep sequencing, and bioinformatic community analysis. We compared enrolled subjects to a cohort of healthy subjects who had lower respiratory tract sampling by bronchoscopy. In contrast to the diverse upper respiratory tract and lower respiratory tract microbiota found in healthy controls, critically ill subjects had lower initial diversity at both sites. Diversity further diminished over time on the ventilator. In several subjects, the bacterial community was dominated by a single taxon over multiple time points. The clinical diagnosis of LRTI ascertained by chart review correlated with low community diversity and dominance of a single taxon. Dominant taxa matched clinical bacterial cultures where cultures were obtained and positive. In several cases, dominant taxa included bacteria not detected by culture, including Ureaplasma parvum and Enterococcus faecalis. CONCLUSIONS: Longitudinal analysis of respiratory tract microbiota in critically ill patients provides insight into the pathogenesis and diagnosis of LRTI. 16S rRNA gene sequencing of endotracheal aspirate samples holds promise for expanded pathogen identification.
93 schema:genre research_article
94 schema:inLanguage en
95 schema:isAccessibleForFree true
96 schema:isPartOf N8f15653f54e64948a1f05029b0265c9d
97 Ne00f0acea79d4803a060dc43dfede803
98 sg:journal.1048878
99 schema:name Composition and dynamics of the respiratory tract microbiome in intubated patients
100 schema:pagination 7
101 schema:productId N3c0679fa4ecd44538fd140885ad8541a
102 N5af9b15e869d4d859372aa4bb2478c8f
103 N7e5c4d2e42504a2699f797d9fb4bcb9c
104 Nece16539c94744adb8805acf6df84f24
105 Nf6494e99cf794370a7424df3803771b8
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019831205
107 https://doi.org/10.1186/s40168-016-0151-8
108 schema:sdDatePublished 2019-04-10T22:39
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N987cff39da974bfd86ca28b6cae9d702
111 schema:url http://link.springer.com/10.1186%2Fs40168-016-0151-8
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N00c55d4863fb45458442aff080eb11cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Longitudinal Studies
117 rdf:type schema:DefinedTerm
118 N029663e029c04c5e9f28b2a60b379fc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Genetic Variation
120 rdf:type schema:DefinedTerm
121 N09b7650685d448fca0298ba7da52277e rdf:first sg:person.01244225361.13
122 rdf:rest Nc77f1d2f9c98453cba13d18b8ea8d47a
123 N0f80e405783743b99e1f605bfaf8388d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Aged, 80 and over
125 rdf:type schema:DefinedTerm
126 N14edae0bd44a4c48a866907364ac14fb rdf:first sg:person.01247266333.57
127 rdf:rest N09b7650685d448fca0298ba7da52277e
128 N2520800d30824bf79f44e9cba44e494c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Aged
130 rdf:type schema:DefinedTerm
131 N28c873d64eff4412bbc6edec334105d7 rdf:first sg:person.01216060406.79
132 rdf:rest N973eb273576b4f23b19d13bac6719a95
133 N294ad52029514488a270d4c4d031ca8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Intubation, Intratracheal
135 rdf:type schema:DefinedTerm
136 N2e7cc9a1f14845a9a506739d1fc5f19c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Respiratory Tract Infections
138 rdf:type schema:DefinedTerm
139 N3106e4a34b024904975c775275b17e79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Female
141 rdf:type schema:DefinedTerm
142 N3475bb36ed444366a08a86929e6cc7b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Pneumonia, Ventilator-Associated
144 rdf:type schema:DefinedTerm
145 N37f26697ac9f4fec96591b72ef4b0646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Male
147 rdf:type schema:DefinedTerm
148 N3c0679fa4ecd44538fd140885ad8541a schema:name doi
149 schema:value 10.1186/s40168-016-0151-8
150 rdf:type schema:PropertyValue
151 N5337c20f33be45229645fa08ec54944d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Critical Illness
153 rdf:type schema:DefinedTerm
154 N5af9b15e869d4d859372aa4bb2478c8f schema:name readcube_id
155 schema:value 5e7cc27cbe83e3d4dac03c4d113b7bcdedb7d6c58e8e3b82b85702ee4f095ddd
156 rdf:type schema:PropertyValue
157 N70c2f528cd554507b0689b30f9ac96c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Case-Control Studies
159 rdf:type schema:DefinedTerm
160 N71c3270bcfe24ffeba87e9e296f0b1e5 rdf:first sg:person.01053715420.08
161 rdf:rest N28c873d64eff4412bbc6edec334105d7
162 N7e5c4d2e42504a2699f797d9fb4bcb9c schema:name pubmed_id
163 schema:value 26865050
164 rdf:type schema:PropertyValue
165 N85a451870e774dff9b85415036fd6343 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Sequence Analysis, RNA
167 rdf:type schema:DefinedTerm
168 N8f15653f54e64948a1f05029b0265c9d schema:issueNumber 1
169 rdf:type schema:PublicationIssue
170 N906d02d07fa44a51b4ff9ea520427d37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Trachea
172 rdf:type schema:DefinedTerm
173 N973eb273576b4f23b19d13bac6719a95 rdf:first sg:person.01222067106.41
174 rdf:rest rdf:nil
175 N987cff39da974bfd86ca28b6cae9d702 schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Nafd6dc65774b4286925cc6e88d50526c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Adult
179 rdf:type schema:DefinedTerm
180 Nb01f2b811bb7417dab39b3129829bc67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Respiration, Artificial
182 rdf:type schema:DefinedTerm
183 Nb5a0146643fe4012a1e7141337e03868 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name DNA, Bacterial
185 rdf:type schema:DefinedTerm
186 Nb860a0e8dbf941a4882762580e79b372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Oropharynx
188 rdf:type schema:DefinedTerm
189 Nbc0fdb9b109948029ade29c865bb97e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Bronchoscopy
191 rdf:type schema:DefinedTerm
192 Nc77f1d2f9c98453cba13d18b8ea8d47a rdf:first sg:person.0625216340.23
193 rdf:rest N71c3270bcfe24ffeba87e9e296f0b1e5
194 Nccc28d398d5e4e9eadf2515d1ce6c41a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name RNA, Ribosomal, 16S
196 rdf:type schema:DefinedTerm
197 Nccd42a6eabad4ad2892c9470ff3b1e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Humans
199 rdf:type schema:DefinedTerm
200 Ndb307b46911b4700b1a0279344eb0435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Microbiota
202 rdf:type schema:DefinedTerm
203 Ndf6bf9c960cd4bf98376181fa1230833 rdf:first sg:person.01104175321.21
204 rdf:rest N14edae0bd44a4c48a866907364ac14fb
205 Ne00f0acea79d4803a060dc43dfede803 schema:volumeNumber 4
206 rdf:type schema:PublicationVolume
207 Nece16539c94744adb8805acf6df84f24 schema:name nlm_unique_id
208 schema:value 101615147
209 rdf:type schema:PropertyValue
210 Nf6494e99cf794370a7424df3803771b8 schema:name dimensions_id
211 schema:value pub.1019831205
212 rdf:type schema:PropertyValue
213 Nfad79c4abc804df39738ced26c0e5b08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Intensive Care Units
215 rdf:type schema:DefinedTerm
216 Nfdc54fe2da8243b0943cfd155bf3bb62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Middle Aged
218 rdf:type schema:DefinedTerm
219 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
220 schema:name Medical and Health Sciences
221 rdf:type schema:DefinedTerm
222 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
223 schema:name Clinical Sciences
224 rdf:type schema:DefinedTerm
225 sg:grant.2438704 http://pending.schema.org/fundedItem sg:pub.10.1186/s40168-016-0151-8
226 rdf:type schema:MonetaryGrant
227 sg:grant.2543712 http://pending.schema.org/fundedItem sg:pub.10.1186/s40168-016-0151-8
228 rdf:type schema:MonetaryGrant
229 sg:grant.2682008 http://pending.schema.org/fundedItem sg:pub.10.1186/s40168-016-0151-8
230 rdf:type schema:MonetaryGrant
231 sg:grant.2691977 http://pending.schema.org/fundedItem sg:pub.10.1186/s40168-016-0151-8
232 rdf:type schema:MonetaryGrant
233 sg:grant.2692080 http://pending.schema.org/fundedItem sg:pub.10.1186/s40168-016-0151-8
234 rdf:type schema:MonetaryGrant
235 sg:journal.1048878 schema:issn 2049-2618
236 schema:name Microbiome
237 rdf:type schema:Periodical
238 sg:person.01053715420.08 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
239 schema:familyName Fuchs
240 schema:givenName Barry D.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053715420.08
242 rdf:type schema:Person
243 sg:person.01104175321.21 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
244 schema:familyName Kelly
245 schema:givenName Brendan J.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104175321.21
247 rdf:type schema:Person
248 sg:person.01216060406.79 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
249 schema:familyName Bushman
250 schema:givenName Frederic D.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216060406.79
252 rdf:type schema:Person
253 sg:person.01222067106.41 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
254 schema:familyName Collman
255 schema:givenName Ronald G.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222067106.41
257 rdf:type schema:Person
258 sg:person.01244225361.13 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
259 schema:familyName Bittinger
260 schema:givenName Kyle
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244225361.13
262 rdf:type schema:Person
263 sg:person.01247266333.57 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
264 schema:familyName Imai
265 schema:givenName Ize
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247266333.57
267 rdf:type schema:Person
268 sg:person.0625216340.23 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
269 schema:familyName Laughlin
270 schema:givenName Alice
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625216340.23
272 rdf:type schema:Person
273 sg:pub.10.1007/s00134-010-1824-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009089670
274 https://doi.org/10.1007/s00134-010-1824-6
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s00134-012-2759-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039278769
277 https://doi.org/10.1007/s00134-012-2759-x
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/s001340000611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023243964
280 https://doi.org/10.1007/s001340000611
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/ismej.2011.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051863807
283 https://doi.org/10.1038/ismej.2011.139
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/ismej.2012.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038992953
286 https://doi.org/10.1038/ismej.2012.8
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/ismej.2015.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009910264
289 https://doi.org/10.1038/ismej.2015.148
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nature11209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027248000
292 https://doi.org/10.1038/nature11209
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nmeth.f.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009032055
295 https://doi.org/10.1038/nmeth.f.303
296 rdf:type schema:CreativeWork
297 sg:pub.10.1203/pdr.0b013e31819dc2f9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018215123
298 https://doi.org/10.1203/pdr.0b013e31819dc2f9
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1001/jama.1996.03530260048030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050492439
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1001/jama.2013.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038700120
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1001/jama.275.2.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054159644
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/sim.1650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047029298
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.ajic.2013.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037688909
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0140-6736(14)61136-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051483805
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s1473-3099(13)70081-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019661348
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1056/nejm199512143332408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048326093
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1056/nejmoa052904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044940798
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1056/nejmoa1405870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049015513
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1056/nejmp1300633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045659512
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1056/nejmsa0907130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011499690
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.1000080107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019627885
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.1000087107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015660267
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1080/11956860.1995.11682297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035331897
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1086/421498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013709859
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1086/587103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022386548
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1086/648678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045426681
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/bioinformatics/btv183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040626563
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/cid/cir045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028407453
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/cid/cir832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047658590
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/cid/cit578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001513363
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/nar/gkt1209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007181271
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/00003246-200112000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005268084
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1097/ccm.0b013e31828a674a schema:sameAs https://app.dimensions.ai/details/publication/pub.1029577432
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/j.0006-341x.2001.00120.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001190289
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1111/j.1440-1843.2007.01211.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013131717
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1111/j.1442-9993.2001.01070.pp.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044499388
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1111/j.1654-1103.2003.tb02228.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043141145
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1128/aac.45.11.3202-3204.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039982174
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1128/jcm.01028-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048408423
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1128/jcm.01494-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024265744
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1128/jcm.01678-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023907765
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1136/fn.73.1.f37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018385491
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1136/thoraxjnl-2011-201183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048417687
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1136/thx.2004.030411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002112557
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1164/ajrccm.159.1.9803097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011932378
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1164/ajrccm.159.4.9807050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031488863
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1164/ajrccm.163.7.at1010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051296869
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1164/ajrccm.165.1.2105077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016238604
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1164/rccm.200405-644st schema:sameAs https://app.dimensions.ai/details/publication/pub.1008391386
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1164/rccm.201104-0655oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1046729617
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1164/rccm.201105-0867oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1010765678
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1164/rccm.201204-0693oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1033022352
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1164/rccm.201211-2145oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1003073775
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1371/journal.pbio.1001377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051517589
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1371/journal.pone.0015216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051403004
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1371/journal.pone.0025959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033349309
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1371/journal.pone.0032486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042236416
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1378/chest.100.2.439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044724213
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1378/chest.122.6.2115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000994595
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1378/chest.127.2.589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051851695
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1513/annalsats.201501-029oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1003973048
405 rdf:type schema:CreativeWork
406 https://doi.org/10.18637/jss.v015.i02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068672224
407 rdf:type schema:CreativeWork
408 https://www.grid.ac/institutes/grid.25879.31 schema:alternateName University of Pennsylvania
409 schema:name Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA
410 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA
411 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...