Clinical implications of c-maf expression in plasma cells from patients with multiple myeloma View Full Text


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Article Info

DATE

2017-05-26

AUTHORS

GuoQing Wei, LiJun Wang, HanJin Yang, XiaoYan Han, GaoFeng Zheng, WeiYan Zheng, Jie Sun, JiMin Shi, WenJun Wu, Yi Zhao, DongHua He, Bo Wang, Zhen Cai, JingSong He

ABSTRACT

BackgroundMultiple myeloma (MM) is a type of hematological malignancy with significant heterogeneity in clinical features and prognosis. Cytogenetic abnormalities are the major factors affecting patient outcomes. Studies have shown that immunohistochemistry (IHC)-based detection of cancer-related genes expression could be alternative indicators for the prognosis of MM.MethodsNuclear expression of c-maf protein in the bone marrow plasma cells of 128 multiple myeloma patients were examined by IHC, and its association with the clinicopathological features of MM patients was analyzed as well.ResultsAmong the 128 patients, the positive rate of c-maf protein expression was up to 30.5%, which had no correlation with patient age, M protein type, Durie-Salmon staging system, the International Staging System, abnormal plasma cell ratio in the bone marrow, or the level of peripheral blood hemoglobin, serum calcium or lactate dehydrogenase. However, the c-maf-positive patients had a significantly higher rate of hypoproteinemia (p = 0.026) and higher serum β2-microglobulin levels (>2500 μg/L) (p = 0.007). Patients with negative c-maf expression had higher remission rates upon the treatment of non-bortezomib-based regimens although no effect of c-maf expression on progression-free survival or overall survival was observed.ConclusionPatients with negative c-maf expression had higher remission rates upon the treatment of non-bortezomib-based regimens although no effect of c-maf expression on survival was observed. A further large-scale prospective study is required to verify these findings. More... »

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16

References to SciGraph publications

  • 2015-02-08. Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2007-03-29. c-Maf nuclear oncoprotein is frequently expressed in multiple myeloma in LEUKEMIA
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  • 2016-08-16. Target fluorescence in-situ hybridization (Target FISH) for plasma cell enrichment in myeloma in MOLECULAR CYTOGENETICS
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  • 2014-09-13. Circulating microRNA 483-5p as a novel biomarker for diagnosis survival prediction in multiple myeloma in MEDICAL ONCOLOGY
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  • 2015-02-27. t(14;16)-positive multiple myeloma shows negativity for CD56 expression and unfavorable outcome even in the era of novel drugs in BLOOD CANCER JOURNAL
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  • 2015-06-25. High expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myeloma in JOURNAL OF HEMATOLOGY & ONCOLOGY
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    http://scigraph.springernature.com/pub.10.1186/s40164-017-0076-3

    DOI

    http://dx.doi.org/10.1186/s40164-017-0076-3

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28560070


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    19 schema:description BackgroundMultiple myeloma (MM) is a type of hematological malignancy with significant heterogeneity in clinical features and prognosis. Cytogenetic abnormalities are the major factors affecting patient outcomes. Studies have shown that immunohistochemistry (IHC)-based detection of cancer-related genes expression could be alternative indicators for the prognosis of MM.MethodsNuclear expression of c-maf protein in the bone marrow plasma cells of 128 multiple myeloma patients were examined by IHC, and its association with the clinicopathological features of MM patients was analyzed as well.ResultsAmong the 128 patients, the positive rate of c-maf protein expression was up to 30.5%, which had no correlation with patient age, M protein type, Durie-Salmon staging system, the International Staging System, abnormal plasma cell ratio in the bone marrow, or the level of peripheral blood hemoglobin, serum calcium or lactate dehydrogenase. However, the c-maf-positive patients had a significantly higher rate of hypoproteinemia (p = 0.026) and higher serum β2-microglobulin levels (>2500 μg/L) (p = 0.007). Patients with negative c-maf expression had higher remission rates upon the treatment of non-bortezomib-based regimens although no effect of c-maf expression on progression-free survival or overall survival was observed.ConclusionPatients with negative c-maf expression had higher remission rates upon the treatment of non-bortezomib-based regimens although no effect of c-maf expression on survival was observed. A further large-scale prospective study is required to verify these findings.
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    26 ConclusionPatients
    27 Durie-Salmon staging system
    28 IHC
    29 International Staging System
    30 M protein types
    31 MM patients
    32 ResultsAmong
    33 abnormalities
    34 age
    35 alternative indicators
    36 association
    37 blood hemoglobin
    38 bone marrow
    39 bone marrow plasma cells
    40 c-Maf expression
    41 c-Maf protein
    42 calcium
    43 cancer-related gene expression
    44 cell ratio
    45 cells
    46 clinical features
    47 clinical implications
    48 clinicopathological features
    49 correlation
    50 cytogenetic abnormalities
    51 dehydrogenase
    52 detection
    53 effect
    54 expression
    55 factors
    56 features
    57 findings
    58 gene expression
    59 hematological malignancies
    60 hemoglobin
    61 heterogeneity
    62 high rate
    63 higher remission rates
    64 hypoproteinemia
    65 immunohistochemistry
    66 implications
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    68 lactate dehydrogenase
    69 large-scale prospective studies
    70 levels
    71 major factor
    72 malignancy
    73 marrow
    74 marrow plasma cells
    75 multiple myeloma
    76 multiple myeloma patients
    77 myeloma
    78 myeloma patients
    79 outcomes
    80 overall survival
    81 patient age
    82 patient outcomes
    83 patients
    84 peripheral blood hemoglobin
    85 plasma cell ratio
    86 plasma cells
    87 positive rate
    88 prognosis
    89 prognosis of myeloma
    90 progression-free survival
    91 prospective study
    92 protein
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    95 rate
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    99 serum calcium
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