Validation of a rapid one-step high sensitivity real-time quantitative PCR system for detecting major BCR-ABL1 mRNA on an International Scale View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-10

AUTHORS

Chikashi Yoshida, Hirohisa Nakamae, Linda Fletcher, Daisuke Koga, Takayuki Sogabe, Itaru Matsumura, Yuzuru Kanakura, Susan Branford, Tomoki Naoe

ABSTRACT

BackgroundDetection and quantitation of BCR-ABL1 transcripts are crucial for managing patients with chronic myeloid leukemia (CML). Although real-time quantitative polymerase chain reaction (RT-qPCR) can be measured on an International Scale (IS), this has not become fully universal. By using a WHO international standard panel established for calibrating secondary standards based on the IS, we have previously developed an RT-qPCR kit, ODK-1201, for quantification of major BCR-ABL1.ResultsIn this study, the reliability of kit-specific conversion factor 1.12 was validated by exchanging patients’ samples between three local clinical laboratories and a reference laboratory. The mean bias of the local method after IS conversion was 1.6 fold lower than the reference method. The clinically-useful sensitivity of the kit was further evaluated for monitoring patients with deep molecular response. Based on the correlation of the IS values between ODK-1201 and the reference laboratory method, the detection level of the kit was estimated as 0.0032 % BCR-ABL1IS.ConclusionsODK-1201 is a highly sensitive one-step RT-qPCR system for detecting BCR-ABL1 on the IS in 2 h after RNA extraction, thus contributing to standardization of molecular monitoring in CML. More... »

PAGES

569

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40064-016-2258-6

DOI

http://dx.doi.org/10.1186/s40064-016-2258-6

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https://app.dimensions.ai/details/publication/pub.1041073181

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27247866


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