Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Lucia Rota, Carolina Pellegrini, Laura Benvenuti, Luca Antonioli, Matteo Fornai, Corrado Blandizzi, Antonino Cattaneo, Emanuela Colla

ABSTRACT

Background: Gastrointestinal dysfunction can affect Parkinson's disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuclein (αS) transgenic mice, Line G2-3, develops αS-driven neurological and motor impairments after 9 months of age, displaying a long presymptomatic phase free of central nervous system (CNS) dysfunction. Methods: To determine whether this line can be suitable to study constipation as it occurs in prodromal PD, gastrointestinal functionality was assessed in young mice through a multidisciplinary approach, based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations. Results: We found that the A53T αS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities and αS pathology in the CNS by at least 6 months. Young αS mice show a drastic delay in food transit along the gastrointestinal tract, of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months. Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted, suggesting a deficit in the intestinal peristalsis. In agreement with this, electrically evoked contractions of the colon, but not of the ileum, showed a reduced motor response in both longitudinal and circular muscle layers in αS mice already at 3 months of age, that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system. Interestingly, the presence of insoluble and aggregated αS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months old αS mice, but not in the small intestine, and exacerbated with age, mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data. Conclusions: Gastrointestinal dysfunction in A53T αS mice represents an early sign of αS-driven pathology without concomitant CNS involvement. We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and halt αS pathology from reaching the brain. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40035-019-0146-z

DOI

http://dx.doi.org/10.1186/s40035-019-0146-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111938636

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30774946


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Scuola Normale Superiore di Pisa", 
          "id": "https://www.grid.ac/institutes/grid.6093.c", 
          "name": [
            "Bio@SNS Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rota", 
        "givenName": "Lucia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Department of Pharmacy, University of Pisa, Via Roma 55, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pellegrini", 
        "givenName": "Carolina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benvenuti", 
        "givenName": "Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antonioli", 
        "givenName": "Luca", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fornai", 
        "givenName": "Matteo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pisa", 
          "id": "https://www.grid.ac/institutes/grid.5395.a", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blandizzi", 
        "givenName": "Corrado", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scuola Normale Superiore di Pisa", 
          "id": "https://www.grid.ac/institutes/grid.6093.c", 
          "name": [
            "Bio@SNS Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126, Pisa, Italy", 
            "Neurotrophins and Neurodegenerative Diseases Laboratory, Rita Levi-Montalcini European Brain Research Institute, Viale Regina Elena 295, 00161, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cattaneo", 
        "givenName": "Antonino", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scuola Normale Superiore di Pisa", 
          "id": "https://www.grid.ac/institutes/grid.6093.c", 
          "name": [
            "Bio@SNS Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colla", 
        "givenName": "Emanuela", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1743-3150.2004.00472.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002259292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4308-05.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002316136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4308-05.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002316136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awt037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002598055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0008762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003399139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-002-0808-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006623533", 
          "https://doi.org/10.1007/s00702-002-0808-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1227157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008634153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0116253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008762076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2009.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010254612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2010.07.076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010396994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2012.01887.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010903029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnr.0b013e3282ffda5e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011916644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wnr.0b013e3282ffda5e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011916644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2011.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012182266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1160-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012579381", 
          "https://doi.org/10.1007/s00401-013-1160-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1160-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012579381", 
          "https://doi.org/10.1007/s00401-013-1160-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-014-1343-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014557852", 
          "https://doi.org/10.1007/s00401-014-1343-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.25020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014893990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0908005106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015430122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2012.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016251788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016528708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016528708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5368-11.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017386756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.08.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017634348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017752678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017752678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017998374", 
          "https://doi.org/10.1038/nature14547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/169319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022044822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.04365.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022241747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.04365.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022241747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022461588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000001240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025216906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000001240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025216906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-012-6801-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026614307", 
          "https://doi.org/10.1007/s00415-012-6801-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.24066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026726931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-1838(00)00127-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028628109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.132197599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029156846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/42166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029460877", 
          "https://doi.org/10.1038/42166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/42166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029460877", 
          "https://doi.org/10.1038/42166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.25776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030357550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-005-0971-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031619743", 
          "https://doi.org/10.1007/s00415-005-0971-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-005-0971-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031619743", 
          "https://doi.org/10.1007/s00415-005-0971-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ene.13082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033587117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1321785111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041365688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnana.2014.00155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041724778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2012.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044267094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2009.01368.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045600678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2009.01368.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045600678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-015-1427-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046064719", 
          "https://doi.org/10.1007/s00702-015-1427-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5367-11.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047210851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddq038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048711413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0664-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050203734", 
          "https://doi.org/10.1007/s00401-010-0664-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0664-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050203734", 
          "https://doi.org/10.1007/s00401-010-0664-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2008.162503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052981950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00192.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063192806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000191154.78131.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000191154.78131.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000191154.78131.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.57.3.456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.57.3.456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.57.3.456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jns.2017.03.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084090188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn.2017.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085927494", 
          "https://doi.org/10.1038/nrn.2017.62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11302-017-9577-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091209242", 
          "https://doi.org/10.1007/s11302-017-9577-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11302-017-9577-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091209242", 
          "https://doi.org/10.1007/s11302-017-9577-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2017.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099652775"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Background: Gastrointestinal dysfunction can affect Parkinson's disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuclein (\u03b1S) transgenic mice, Line G2-3, develops \u03b1S-driven neurological and motor impairments after 9\u2009months of age, displaying a long presymptomatic phase free of central nervous system (CNS) dysfunction.\nMethods: To determine whether this line can be suitable to study constipation as it occurs in prodromal PD, gastrointestinal functionality was assessed in young mice through a multidisciplinary approach, based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations.\nResults: We found that the A53T \u03b1S mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities and \u03b1S pathology in the CNS by at least 6\u2009months. Young \u03b1S mice show a drastic delay in food transit along the gastrointestinal tract, of almost 2\u2009h in 3\u2009months old mice that increased to more than 3\u2009h at 6\u2009months. Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted, suggesting a deficit in the intestinal peristalsis. In agreement with this, electrically evoked contractions of the colon, but not of the ileum, showed a reduced motor response in both longitudinal and circular muscle layers in \u03b1S mice already at 3\u2009months of age, that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system. Interestingly, the presence of insoluble and aggregated \u03b1S was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3\u2009months old \u03b1S mice, but not in the small intestine, and exacerbated with age, mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data.\nConclusions: Gastrointestinal dysfunction in A53T \u03b1S mice represents an early sign of \u03b1S-driven pathology without concomitant CNS involvement. We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and halt \u03b1S pathology from reaching the brain.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s40035-019-0146-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1047422", 
        "issn": [
          "2047-9158"
        ], 
        "name": "Translational Neurodegeneration", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy", 
    "pagination": "5", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0026af4b0715fcc0fac592102795154cd3be84cd0ee59bb607de9f4792a63503"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30774946"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101591861"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s40035-019-0146-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111938636"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s40035-019-0146-z", 
      "https://app.dimensions.ai/details/publication/pub.1111938636"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47994_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs40035-019-0146-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s40035-019-0146-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s40035-019-0146-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s40035-019-0146-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s40035-019-0146-z'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s40035-019-0146-z schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nddfff33761d641cdba69376ecc436dca
4 schema:citation sg:pub.10.1007/s00401-010-0664-3
5 sg:pub.10.1007/s00401-013-1160-3
6 sg:pub.10.1007/s00401-014-1343-6
7 sg:pub.10.1007/s00415-005-0971-0
8 sg:pub.10.1007/s00415-012-6801-2
9 sg:pub.10.1007/s00702-002-0808-2
10 sg:pub.10.1007/s00702-015-1427-z
11 sg:pub.10.1007/s11302-017-9577-0
12 sg:pub.10.1038/42166
13 sg:pub.10.1038/nature14547
14 sg:pub.10.1038/nrn.2017.62
15 https://doi.org/10.1002/ana.22691
16 https://doi.org/10.1002/ana.24066
17 https://doi.org/10.1002/mds.25020
18 https://doi.org/10.1002/mds.25776
19 https://doi.org/10.1016/j.brainres.2010.07.076
20 https://doi.org/10.1016/j.jns.2017.03.049
21 https://doi.org/10.1016/j.nbd.2009.06.017
22 https://doi.org/10.1016/j.nbd.2011.08.014
23 https://doi.org/10.1016/j.nbd.2012.04.009
24 https://doi.org/10.1016/j.nbd.2012.07.018
25 https://doi.org/10.1016/j.nbd.2017.12.004
26 https://doi.org/10.1016/j.neuron.2011.08.033
27 https://doi.org/10.1016/s0165-1838(00)00127-2
28 https://doi.org/10.1016/s0197-4580(02)00065-9
29 https://doi.org/10.1073/pnas.0908005106
30 https://doi.org/10.1073/pnas.1321785111
31 https://doi.org/10.1073/pnas.132197599
32 https://doi.org/10.1093/brain/awt037
33 https://doi.org/10.1093/hmg/ddq038
34 https://doi.org/10.1097/wnr.0b013e3282ffda5e
35 https://doi.org/10.1111/ene.13082
36 https://doi.org/10.1111/j.1365-2982.2009.01368.x
37 https://doi.org/10.1111/j.1365-2982.2012.01887.x
38 https://doi.org/10.1111/j.1743-3150.2004.00472.x
39 https://doi.org/10.1111/j.1749-6632.2009.04365.x
40 https://doi.org/10.1126/science.1227157
41 https://doi.org/10.1136/gut.2008.162503
42 https://doi.org/10.1152/ajpgi.00192.2002
43 https://doi.org/10.1155/2011/169319
44 https://doi.org/10.1172/jci42642
45 https://doi.org/10.1212/01.wnl.0000191154.78131.f6
46 https://doi.org/10.1212/wnl.0000000000001240
47 https://doi.org/10.1212/wnl.57.3.456
48 https://doi.org/10.1371/journal.pone.0008762
49 https://doi.org/10.1371/journal.pone.0116253
50 https://doi.org/10.1523/jneurosci.4308-05.2006
51 https://doi.org/10.1523/jneurosci.5367-11.2012
52 https://doi.org/10.1523/jneurosci.5368-11.2012
53 https://doi.org/10.3389/fnana.2014.00155
54 schema:datePublished 2019-12
55 schema:datePublishedReg 2019-12-01
56 schema:description Background: Gastrointestinal dysfunction can affect Parkinson's disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuclein (αS) transgenic mice, Line G2-3, develops αS-driven neurological and motor impairments after 9 months of age, displaying a long presymptomatic phase free of central nervous system (CNS) dysfunction. Methods: To determine whether this line can be suitable to study constipation as it occurs in prodromal PD, gastrointestinal functionality was assessed in young mice through a multidisciplinary approach, based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations. Results: We found that the A53T αS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities and αS pathology in the CNS by at least 6 months. Young αS mice show a drastic delay in food transit along the gastrointestinal tract, of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months. Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted, suggesting a deficit in the intestinal peristalsis. In agreement with this, electrically evoked contractions of the colon, but not of the ileum, showed a reduced motor response in both longitudinal and circular muscle layers in αS mice already at 3 months of age, that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system. Interestingly, the presence of insoluble and aggregated αS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months old αS mice, but not in the small intestine, and exacerbated with age, mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data. Conclusions: Gastrointestinal dysfunction in A53T αS mice represents an early sign of αS-driven pathology without concomitant CNS involvement. We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and halt αS pathology from reaching the brain.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N18c9ae0bed2f46049ec8fe4f58ede4b1
61 N85db1760b7494094b9985876790ee03e
62 sg:journal.1047422
63 schema:name Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy
64 schema:pagination 5
65 schema:productId N06a653eb89c64c5bb508e1ac40975e06
66 N6f43245957df4d0ebbc003a4227a06fe
67 Nb985a6329ea64d1fb6ba021b2fdfc10d
68 Nd9a0c3af0621419598c3fcf2af3e0e5c
69 Nf699cd2166e14d48a3aafa9464e59645
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111938636
71 https://doi.org/10.1186/s40035-019-0146-z
72 schema:sdDatePublished 2019-04-11T09:13
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N83b774f3dfd846d99745339e517921ad
75 schema:url https://link.springer.com/10.1186%2Fs40035-019-0146-z
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N06a653eb89c64c5bb508e1ac40975e06 schema:name pubmed_id
80 schema:value 30774946
81 rdf:type schema:PropertyValue
82 N079668eb03f940648ad2a674055c9e88 rdf:first N819628a831484ca1ba117ab00d2d48d3
83 rdf:rest N7a5cfde0120543ddb6c9cb1cdd8a294d
84 N1099a2a092464db48cce40a305fae8ad schema:affiliation https://www.grid.ac/institutes/grid.6093.c
85 schema:familyName Rota
86 schema:givenName Lucia
87 rdf:type schema:Person
88 N161e9c43fe80496fbaee937cca59138f schema:affiliation https://www.grid.ac/institutes/grid.5395.a
89 schema:familyName Antonioli
90 schema:givenName Luca
91 rdf:type schema:Person
92 N18c9ae0bed2f46049ec8fe4f58ede4b1 schema:issueNumber 1
93 rdf:type schema:PublicationIssue
94 N23630eaec3924fcba3afa05cb04129ff rdf:first Nf61c4221f8d34fe790b8aff122092394
95 rdf:rest Nc8eeecdac4394fa9a3f3b488ab59e4b1
96 N435dd31b7abc4fc0ad012493b791992c schema:affiliation https://www.grid.ac/institutes/grid.6093.c
97 schema:familyName Cattaneo
98 schema:givenName Antonino
99 rdf:type schema:Person
100 N6f43245957df4d0ebbc003a4227a06fe schema:name nlm_unique_id
101 schema:value 101591861
102 rdf:type schema:PropertyValue
103 N72fc658cf8794f5e9d27d2880f46ddef rdf:first Nb78f83c658aa4ccaa75cacad76523dd9
104 rdf:rest N079668eb03f940648ad2a674055c9e88
105 N7a5cfde0120543ddb6c9cb1cdd8a294d rdf:first N161e9c43fe80496fbaee937cca59138f
106 rdf:rest N23630eaec3924fcba3afa05cb04129ff
107 N819628a831484ca1ba117ab00d2d48d3 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
108 schema:familyName Benvenuti
109 schema:givenName Laura
110 rdf:type schema:Person
111 N83b774f3dfd846d99745339e517921ad schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N858d5292a46644369eab7523ebcfe5c7 rdf:first N435dd31b7abc4fc0ad012493b791992c
114 rdf:rest N9abcb18647bb405ba76a200475bfadec
115 N85db1760b7494094b9985876790ee03e schema:volumeNumber 8
116 rdf:type schema:PublicationVolume
117 N9abcb18647bb405ba76a200475bfadec rdf:first Nf81bd6f0cd3c4bbda7dd21990b75c496
118 rdf:rest rdf:nil
119 Nb78f83c658aa4ccaa75cacad76523dd9 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
120 schema:familyName Pellegrini
121 schema:givenName Carolina
122 rdf:type schema:Person
123 Nb985a6329ea64d1fb6ba021b2fdfc10d schema:name readcube_id
124 schema:value 0026af4b0715fcc0fac592102795154cd3be84cd0ee59bb607de9f4792a63503
125 rdf:type schema:PropertyValue
126 Nc8eeecdac4394fa9a3f3b488ab59e4b1 rdf:first Nf0433cfecd834c93a529d8ca0b6d3590
127 rdf:rest N858d5292a46644369eab7523ebcfe5c7
128 Nd9a0c3af0621419598c3fcf2af3e0e5c schema:name doi
129 schema:value 10.1186/s40035-019-0146-z
130 rdf:type schema:PropertyValue
131 Nddfff33761d641cdba69376ecc436dca rdf:first N1099a2a092464db48cce40a305fae8ad
132 rdf:rest N72fc658cf8794f5e9d27d2880f46ddef
133 Nf0433cfecd834c93a529d8ca0b6d3590 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
134 schema:familyName Blandizzi
135 schema:givenName Corrado
136 rdf:type schema:Person
137 Nf61c4221f8d34fe790b8aff122092394 schema:affiliation https://www.grid.ac/institutes/grid.5395.a
138 schema:familyName Fornai
139 schema:givenName Matteo
140 rdf:type schema:Person
141 Nf699cd2166e14d48a3aafa9464e59645 schema:name dimensions_id
142 schema:value pub.1111938636
143 rdf:type schema:PropertyValue
144 Nf81bd6f0cd3c4bbda7dd21990b75c496 schema:affiliation https://www.grid.ac/institutes/grid.6093.c
145 schema:familyName Colla
146 schema:givenName Emanuela
147 rdf:type schema:Person
148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
149 schema:name Medical and Health Sciences
150 rdf:type schema:DefinedTerm
151 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
152 schema:name Neurosciences
153 rdf:type schema:DefinedTerm
154 sg:journal.1047422 schema:issn 2047-9158
155 schema:name Translational Neurodegeneration
156 rdf:type schema:Periodical
157 sg:pub.10.1007/s00401-010-0664-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050203734
158 https://doi.org/10.1007/s00401-010-0664-3
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s00401-013-1160-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012579381
161 https://doi.org/10.1007/s00401-013-1160-3
162 rdf:type schema:CreativeWork
163 sg:pub.10.1007/s00401-014-1343-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014557852
164 https://doi.org/10.1007/s00401-014-1343-6
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/s00415-005-0971-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031619743
167 https://doi.org/10.1007/s00415-005-0971-0
168 rdf:type schema:CreativeWork
169 sg:pub.10.1007/s00415-012-6801-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026614307
170 https://doi.org/10.1007/s00415-012-6801-2
171 rdf:type schema:CreativeWork
172 sg:pub.10.1007/s00702-002-0808-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006623533
173 https://doi.org/10.1007/s00702-002-0808-2
174 rdf:type schema:CreativeWork
175 sg:pub.10.1007/s00702-015-1427-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1046064719
176 https://doi.org/10.1007/s00702-015-1427-z
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/s11302-017-9577-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091209242
179 https://doi.org/10.1007/s11302-017-9577-0
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/42166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029460877
182 https://doi.org/10.1038/42166
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nature14547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017998374
185 https://doi.org/10.1038/nature14547
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nrn.2017.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085927494
188 https://doi.org/10.1038/nrn.2017.62
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/ana.22691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022461588
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/ana.24066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026726931
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/mds.25020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014893990
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/mds.25776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030357550
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.brainres.2010.07.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010396994
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.jns.2017.03.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084090188
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.nbd.2009.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010254612
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.nbd.2011.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012182266
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.nbd.2012.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016251788
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.nbd.2012.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044267094
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.nbd.2017.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099652775
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.neuron.2011.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017634348
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0165-1838(00)00127-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028628109
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0197-4580(02)00065-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016528708
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1073/pnas.0908005106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015430122
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1073/pnas.1321785111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041365688
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1073/pnas.132197599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029156846
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1093/brain/awt037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002598055
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1093/hmg/ddq038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048711413
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1097/wnr.0b013e3282ffda5e schema:sameAs https://app.dimensions.ai/details/publication/pub.1011916644
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1111/ene.13082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033587117
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1365-2982.2009.01368.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045600678
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1365-2982.2012.01887.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010903029
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1743-3150.2004.00472.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002259292
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1749-6632.2009.04365.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022241747
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1126/science.1227157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008634153
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1136/gut.2008.162503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052981950
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1152/ajpgi.00192.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063192806
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1155/2011/169319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022044822
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1172/jci42642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017752678
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1212/01.wnl.0000191154.78131.f6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347692
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1212/wnl.0000000000001240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025216906
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1212/wnl.57.3.456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064379976
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1371/journal.pone.0008762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003399139
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1371/journal.pone.0116253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008762076
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1523/jneurosci.4308-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002316136
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1523/jneurosci.5367-11.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047210851
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1523/jneurosci.5368-11.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017386756
265 rdf:type schema:CreativeWork
266 https://doi.org/10.3389/fnana.2014.00155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041724778
267 rdf:type schema:CreativeWork
268 https://www.grid.ac/institutes/grid.5395.a schema:alternateName University of Pisa
269 schema:name Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy
270 Department of Pharmacy, University of Pisa, Via Roma 55, 56126, Pisa, Italy
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.6093.c schema:alternateName Scuola Normale Superiore di Pisa
273 schema:name Bio@SNS Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126, Pisa, Italy
274 Neurotrophins and Neurodegenerative Diseases Laboratory, Rita Levi-Montalcini European Brain Research Institute, Viale Regina Elena 295, 00161, Rome, Italy
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...