In vivo evaluation of a regenerative approach to nasal dorsum augmentation with a polycaprolactone-based implant View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Paul S. Wiggenhauser, Elizabeth R. Balmayor, Nicole Rotter, Jan T. Schantz

ABSTRACT

BACKGROUND: Alternative techniques for nasal dorsum augmentation are of paramount importance in reconstructive and plastic surgery. In contrast to autologous cartilage grafts, tissue-engineered grafts can be created de novo and yield low-none donor site morbidity as compared to autologous grafts like rib or ear cartilage. To address this demand, this study investigated the in vivo regenerative potential of polycaprolactone-based implants as an alternative to autologous cartilage grafting during rhinoplasty. METHODS: Implants were placed at the nasal dorsum in two groups of minipigs and kept in situ for 2 and 6 months, respectively. Subsequently, the implants were harvested and examined by histology (hematoxylin-eosin, alcian blue, and safranin O) and immunostaining (collagen I and collagen II). Further analysis was performed to measure diameter and distance of polycaprolactone struts. RESULTS: Histological examination revealed a persistent formation of connective tissue with some spots resembling a cartilaginous-like matrix after 6 months. In such areas, cells of chondrocyte appearance could be identified. There was a significant decrease in strut diameter but a non-significant difference in strut distance. CONCLUSION: Our results indicated that the investigated polycaprolactone-based implants have shown a regenerative and stable nasal dorsum augmentation after 6 months in vivo. Thus, we believe that customized polycaprolactone-based implants could become an alternative technique for nasal dorsum augmentation without the need for autologous cartilage grafts. More... »

PAGES

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s40001-019-0364-y

DOI

http://dx.doi.org/10.1186/s40001-019-0364-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111757761

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30691516


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