Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSMark Rockley, Prasad Jetty, George Wells, Kathleen Rockley, Dean Fergusson
ABSTRACTBACKGROUND: Angioplasty is a fundamental treatment for atherosclerotic disease in the cardiac, cerebrovascular, and peripheral vascular beds. However, the optimal duration of balloon inflation has not been identified. Our study will investigate whether prolonged angioplasty balloon inflation of at least 1 min duration, when compared with brief inflation, affects residual stenosis after arterial angioplasty. METHODS: In compliance with PRISMA, two independent reviewers will conduct a systematic review of EMBASE, MEDLINE, CENTRAL, trial registries, grey literature, and ancestry and citation search. Data abstraction, quantitative, and quantitative meta-analysis will be performed according to pre-specified criteria. The primary outcome is residual stenosis immediately after initial angioplasty; however, secondary outcomes will include multiple short and long term pre-specific clinical and radiographic outcomes. Risk of bias, subgroup analyses, and sensitivity analyses are planned. DISCUSSION: Despite the ubiquitous use of angioplasty in atherosclerotic disease and multiple trials investigating the ideal balloon inflation duration, there are no systematic reviews evaluating prolonged angioplasty balloon inflation. Currently synthesized evidence is insufficient to confidently direct clinical decision-making, and the current variation in operator preference of balloon angioplasty duration suggests ongoing clinical equipoise. Given the known availability of current primary evidence, our study intends to synthesize the evidence and guide future clinical decision making and investigation. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018092702. More... »
PAGES45
http://scigraph.springernature.com/pub.10.1186/s13643-019-0955-2
DOIhttp://dx.doi.org/10.1186/s13643-019-0955-2
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30722783
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