Perioperative use of gabapentinoids for the management of postoperative acute pain: protocol of a systematic review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-16

AUTHORS

Michael Verret, François Lauzier, Ryan Zarychanski, Xavier Savard, Marie-Joëlle Cossi, Anne-Marie Pinard, Guillaume Leblanc, Alexis F. Turgeon

ABSTRACT

BACKGROUND: Opioids are commonly used for the management of postoperative pain, but their use is limited by important adverse events, such as respiratory depression and the potential for addiction. Multimodal opioid-sparing analgesia regimens can be effectively employed to manage postoperative pain and reduce exposure to opioids. Gabapentinoids (pregabalin and gabapentin) represent an attractive class of drugs for use in multimodal regimens. The American Pain Society recommends the use of gabapentinoids during the perioperative period; however, evidence to inform such a recommendation is unclear. METHODS: We will conduct a systematic review and meta-analysis of randomized clinical trials evaluating the use of systemic gabapentinoids, in comparison to other analgesic regimens or placebo in adult patients undergoing surgery. We will search MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), the Web of Science, and ClinicalTrials.gov databases for relevant citations. Our primary outcome will be intensity of postoperative acute pain (12 h). Our secondary outcomes will be postoperative pain intensity at 6, 24, 48 h, and 72 h, cumulative dose of opioids administered within 24, 48, and 72 h following surgery, the length of stay, chronic pain, and adverse events. Two investigators will independently select trials and extract data. We will evaluate the risk of bias of included trials using the Cochrane risk of bias tools. We will represent pooled continuous data as weighted mean differences and pooled dichotomous data as risk ratios with a 95% confidence interval. We will use random effect models and assess statistical heterogeneity with the I2 index. DISCUSSION: Our study will provide the best level of evidence to inform the effect of gabapentinoids in the management of postoperative acute pain. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017067029. More... »

PAGES

24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13643-018-0906-3

DOI

http://dx.doi.org/10.1186/s13643-018-0906-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111461234

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30651123


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Pain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analgesics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gabapentin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meta-Analysis as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain, Postoperative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Perioperative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregabalin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Systematic Reviews as Topic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC Canada", 
            "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verret", 
        "givenName": "Michael", 
        "id": "sg:person.014172536143.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014172536143.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Universit\u00e9 Laval and CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, Qu\u00e9bec, QC Canada", 
          "id": "http://www.grid.ac/institutes/grid.411065.7", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC Canada", 
            "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada", 
            "Department of Medicine, Universit\u00e9 Laval and CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, Qu\u00e9bec, QC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lauzier", 
        "givenName": "Fran\u00e7ois", 
        "id": "sg:person.01066142337.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Care Manitoba, Department of Hematology and Medical Oncology, Winnipeg, MN Canada", 
          "id": "http://www.grid.ac/institutes/grid.419404.c", 
          "name": [
            "Cancer Care Manitoba, Department of Hematology and Medical Oncology, Winnipeg, MN Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zarychanski", 
        "givenName": "Ryan", 
        "id": "sg:person.0617260043.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617260043.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Savard", 
        "givenName": "Xavier", 
        "id": "sg:person.014240651343.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014240651343.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cossi", 
        "givenName": "Marie-Jo\u00eblle", 
        "id": "sg:person.0723016305.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723016305.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC Canada", 
          "id": "http://www.grid.ac/institutes/grid.23856.3a", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinard", 
        "givenName": "Anne-Marie", 
        "id": "sg:person.012071535663.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012071535663.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC Canada", 
          "id": "http://www.grid.ac/institutes/grid.23856.3a", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leblanc", 
        "givenName": "Guillaume", 
        "id": "sg:person.016407551151.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016407551151.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CHU de Qu\u00e9bec - Universit\u00e9 Laval (H\u00f4pital de l\u2019Enfant-J\u00e9sus), 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC Canada", 
            "CHU de Qu\u00e9bec - Universit\u00e9 Laval Research Center, 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada", 
            "CHU de Qu\u00e9bec - Universit\u00e9 Laval (H\u00f4pital de l\u2019Enfant-J\u00e9sus), 1401, 18e rue, Qu\u00e9bec, Qu\u00e9bec G1J 1Z4 Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turgeon", 
        "givenName": "Alexis F.", 
        "id": "sg:person.01253006352.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253006352.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/2046-4053-4-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024252988", 
          "https://doi.org/10.1186/2046-4053-4-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12871-017-0373-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086104976", 
          "https://doi.org/10.1186/s12871-017-0373-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2288-5-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046347100", 
          "https://doi.org/10.1186/1471-2288-5-13"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-16", 
    "datePublishedReg": "2019-01-16", 
    "description": "BACKGROUND: Opioids are commonly used for the management of postoperative pain, but their use is limited by important adverse events, such as respiratory depression and the potential for addiction. Multimodal opioid-sparing analgesia regimens can be effectively employed to manage postoperative pain and reduce exposure to opioids. Gabapentinoids (pregabalin and gabapentin) represent an attractive class of drugs for use in multimodal regimens. The American Pain Society recommends the use of gabapentinoids during the perioperative period; however, evidence to inform such a recommendation is unclear.\nMETHODS: We will conduct a systematic review and meta-analysis of randomized clinical trials evaluating the use of systemic gabapentinoids, in comparison to other analgesic regimens or placebo in adult patients undergoing surgery. We will search MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), the Web of Science, and ClinicalTrials.gov databases for relevant citations. Our primary outcome will be intensity of postoperative acute pain (12\u2009h). Our secondary outcomes will be postoperative pain intensity at 6, 24, 48\u2009h, and 72\u2009h, cumulative dose of opioids administered within 24, 48, and 72\u2009h following surgery, the length of stay, chronic pain, and adverse events. Two investigators will independently select trials and extract data. We will evaluate the risk of bias of included trials using the Cochrane risk of bias tools. We will represent pooled continuous data as weighted mean differences and pooled dichotomous data as risk ratios with a 95% confidence interval. We will use random effect models and assess statistical heterogeneity with the I2 index.\nDISCUSSION: Our study will provide the best level of evidence to inform the effect of gabapentinoids in the management of postoperative acute pain.\nSYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017067029.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13643-018-0906-3", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1046628", 
        "issn": [
          "2046-4053"
        ], 
        "name": "Systematic Reviews", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "postoperative acute pain", 
      "acute pain", 
      "postoperative pain", 
      "adverse events", 
      "systematic review", 
      "use of gabapentinoids", 
      "effects of gabapentinoids", 
      "important adverse events", 
      "American Pain Society", 
      "Cochrane Central Register", 
      "postoperative pain intensity", 
      "randomized clinical trials", 
      "length of stay", 
      "risk of bias", 
      "random-effects model", 
      "Web of Science", 
      "analgesic regimens", 
      "respiratory depression", 
      "perioperative period", 
      "Central Register", 
      "Secondary outcomes", 
      "Cochrane risk", 
      "adult patients", 
      "primary outcome", 
      "pain intensity", 
      "bias tool", 
      "perioperative use", 
      "analgesia regimens", 
      "Pain Society", 
      "Controlled Trials", 
      "multimodal regimens", 
      "chronic pain", 
      "cumulative dose", 
      "risk ratio", 
      "clinical trials", 
      "statistical heterogeneity", 
      "gabapentinoids", 
      "pain", 
      "dichotomous data", 
      "opioids", 
      "regimens", 
      "mean difference", 
      "relevant citations", 
      "trials", 
      "confidence intervals", 
      "surgery", 
      "effects model", 
      "outcomes", 
      "risk", 
      "continuous data", 
      "placebo", 
      "EMBASE", 
      "review", 
      "patients", 
      "stay", 
      "MEDLINE", 
      "management", 
      "dose", 
      "drugs", 
      "evidence", 
      "depression", 
      "good level", 
      "addiction", 
      "exposure", 
      "Register", 
      "use", 
      "events", 
      "investigators", 
      "data", 
      "intervals", 
      "index", 
      "period", 
      "recommendations", 
      "levels", 
      "differences", 
      "study", 
      "database", 
      "protocol", 
      "effect", 
      "heterogeneity", 
      "citations", 
      "intensity", 
      "ratio", 
      "bias", 
      "potential", 
      "comparison", 
      "length", 
      "Web", 
      "attractive class", 
      "tool", 
      "society", 
      "model", 
      "class", 
      "science", 
      "Multimodal opioid-sparing analgesia regimens", 
      "opioid-sparing analgesia regimens", 
      "systemic gabapentinoids", 
      "PROSPERO CRD42017067029", 
      "CRD42017067029"
    ], 
    "name": "Perioperative use of gabapentinoids for the management of postoperative acute pain: protocol of a systematic review and meta-analysis", 
    "pagination": "24", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111461234"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13643-018-0906-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30651123"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13643-018-0906-3", 
      "https://app.dimensions.ai/details/publication/pub.1111461234"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_816.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13643-018-0906-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13643-018-0906-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13643-018-0906-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13643-018-0906-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13643-018-0906-3'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      22 PREDICATES      141 URIs      129 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13643-018-0906-3 schema:about N0d7e43f2ad5b4322aa5f05bab53cc91b
2 N20e13b4599a64702addd4dbefa1afb42
3 N24c8f5b642ec4ca19bf842e714028d7f
4 N43c05753ef6a4e62a96a4f9fc4adfdc3
5 N6cd4e27ff58542c9bd1812dd8c48f8fd
6 N76cb27b39d30467ebee0637f5d32bd29
7 Nabdde5fff9c24c4b86aca1cb7f8018b3
8 Naf6687955e5749dcbefda29001a747f1
9 Ncd59d729535845c091b9d8b8bcadf1eb
10 Ncd8064a747ce437f82bbb6ec659b217f
11 Ndbb2b66556254be0a9f41dd81bd3d3d7
12 Nf56df9d87c334d34927ca282765fe2bf
13 anzsrc-for:11
14 anzsrc-for:1103
15 anzsrc-for:1117
16 schema:author Nf748f2a1a3eb4f8992f84724222deb2e
17 schema:citation sg:pub.10.1186/1471-2288-5-13
18 sg:pub.10.1186/2046-4053-4-1
19 sg:pub.10.1186/s12871-017-0373-8
20 schema:datePublished 2019-01-16
21 schema:datePublishedReg 2019-01-16
22 schema:description BACKGROUND: Opioids are commonly used for the management of postoperative pain, but their use is limited by important adverse events, such as respiratory depression and the potential for addiction. Multimodal opioid-sparing analgesia regimens can be effectively employed to manage postoperative pain and reduce exposure to opioids. Gabapentinoids (pregabalin and gabapentin) represent an attractive class of drugs for use in multimodal regimens. The American Pain Society recommends the use of gabapentinoids during the perioperative period; however, evidence to inform such a recommendation is unclear. METHODS: We will conduct a systematic review and meta-analysis of randomized clinical trials evaluating the use of systemic gabapentinoids, in comparison to other analgesic regimens or placebo in adult patients undergoing surgery. We will search MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), the Web of Science, and ClinicalTrials.gov databases for relevant citations. Our primary outcome will be intensity of postoperative acute pain (12 h). Our secondary outcomes will be postoperative pain intensity at 6, 24, 48 h, and 72 h, cumulative dose of opioids administered within 24, 48, and 72 h following surgery, the length of stay, chronic pain, and adverse events. Two investigators will independently select trials and extract data. We will evaluate the risk of bias of included trials using the Cochrane risk of bias tools. We will represent pooled continuous data as weighted mean differences and pooled dichotomous data as risk ratios with a 95% confidence interval. We will use random effect models and assess statistical heterogeneity with the I<sup>2</sup> index. DISCUSSION: Our study will provide the best level of evidence to inform the effect of gabapentinoids in the management of postoperative acute pain. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42017067029.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree true
26 schema:isPartOf N68e189cb5f6b4c03af30904f5e2bc948
27 Nbe4d4c08eab94357b44c2bdb27891a34
28 sg:journal.1046628
29 schema:keywords American Pain Society
30 CRD42017067029
31 Central Register
32 Cochrane Central Register
33 Cochrane risk
34 Controlled Trials
35 EMBASE
36 MEDLINE
37 Multimodal opioid-sparing analgesia regimens
38 PROSPERO CRD42017067029
39 Pain Society
40 Register
41 Secondary outcomes
42 Web
43 Web of Science
44 acute pain
45 addiction
46 adult patients
47 adverse events
48 analgesia regimens
49 analgesic regimens
50 attractive class
51 bias
52 bias tool
53 chronic pain
54 citations
55 class
56 clinical trials
57 comparison
58 confidence intervals
59 continuous data
60 cumulative dose
61 data
62 database
63 depression
64 dichotomous data
65 differences
66 dose
67 drugs
68 effect
69 effects model
70 effects of gabapentinoids
71 events
72 evidence
73 exposure
74 gabapentinoids
75 good level
76 heterogeneity
77 important adverse events
78 index
79 intensity
80 intervals
81 investigators
82 length
83 length of stay
84 levels
85 management
86 mean difference
87 model
88 multimodal regimens
89 opioid-sparing analgesia regimens
90 opioids
91 outcomes
92 pain
93 pain intensity
94 patients
95 period
96 perioperative period
97 perioperative use
98 placebo
99 postoperative acute pain
100 postoperative pain
101 postoperative pain intensity
102 potential
103 primary outcome
104 protocol
105 random-effects model
106 randomized clinical trials
107 ratio
108 recommendations
109 regimens
110 relevant citations
111 respiratory depression
112 review
113 risk
114 risk of bias
115 risk ratio
116 science
117 society
118 statistical heterogeneity
119 stay
120 study
121 surgery
122 systematic review
123 systemic gabapentinoids
124 tool
125 trials
126 use
127 use of gabapentinoids
128 schema:name Perioperative use of gabapentinoids for the management of postoperative acute pain: protocol of a systematic review and meta-analysis
129 schema:pagination 24
130 schema:productId N30c1097634e7431eac304705c1b69681
131 Ndb0dc2a0ce51429aad54fccd6693f62f
132 Ne12a1aff8b9e43d18bdc09c0f23b3a98
133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111461234
134 https://doi.org/10.1186/s13643-018-0906-3
135 schema:sdDatePublished 2021-12-01T19:46
136 schema:sdLicense https://scigraph.springernature.com/explorer/license/
137 schema:sdPublisher N7b5e6143e9384383a2d814c45702da44
138 schema:url https://doi.org/10.1186/s13643-018-0906-3
139 sgo:license sg:explorer/license/
140 sgo:sdDataset articles
141 rdf:type schema:ScholarlyArticle
142 N0bdfb490046f45a5baa0ad5b1b7eb721 rdf:first sg:person.01253006352.94
143 rdf:rest rdf:nil
144 N0d7e43f2ad5b4322aa5f05bab53cc91b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Systematic Reviews as Topic
146 rdf:type schema:DefinedTerm
147 N11535d1091814abe8696929e63df3d0e rdf:first sg:person.0723016305.04
148 rdf:rest N7e784ea2cc4544789317d5047effea75
149 N20e13b4599a64702addd4dbefa1afb42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Risk Assessment
151 rdf:type schema:DefinedTerm
152 N211bbc68fc8542a0acf7a76e4edc1010 rdf:first sg:person.01066142337.60
153 rdf:rest Nf22a39a0e7d7497494e2cb3841f80996
154 N23a2aeaf4d814f8eaf58e6f51900775b rdf:first sg:person.016407551151.90
155 rdf:rest N0bdfb490046f45a5baa0ad5b1b7eb721
156 N24c8f5b642ec4ca19bf842e714028d7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Pregabalin
158 rdf:type schema:DefinedTerm
159 N30c1097634e7431eac304705c1b69681 schema:name doi
160 schema:value 10.1186/s13643-018-0906-3
161 rdf:type schema:PropertyValue
162 N43c05753ef6a4e62a96a4f9fc4adfdc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Analgesics
164 rdf:type schema:DefinedTerm
165 N68e189cb5f6b4c03af30904f5e2bc948 schema:volumeNumber 8
166 rdf:type schema:PublicationVolume
167 N6cd4e27ff58542c9bd1812dd8c48f8fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Randomized Controlled Trials as Topic
169 rdf:type schema:DefinedTerm
170 N76cb27b39d30467ebee0637f5d32bd29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Pain, Postoperative
172 rdf:type schema:DefinedTerm
173 N7b5e6143e9384383a2d814c45702da44 schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 N7e784ea2cc4544789317d5047effea75 rdf:first sg:person.012071535663.22
176 rdf:rest N23a2aeaf4d814f8eaf58e6f51900775b
177 N895622ef05464bd581bcb43388340234 rdf:first sg:person.014240651343.14
178 rdf:rest N11535d1091814abe8696929e63df3d0e
179 Nabdde5fff9c24c4b86aca1cb7f8018b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Gabapentin
181 rdf:type schema:DefinedTerm
182 Naf6687955e5749dcbefda29001a747f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Research Design
184 rdf:type schema:DefinedTerm
185 Nbe4d4c08eab94357b44c2bdb27891a34 schema:issueNumber 1
186 rdf:type schema:PublicationIssue
187 Ncd59d729535845c091b9d8b8bcadf1eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Acute Pain
189 rdf:type schema:DefinedTerm
190 Ncd8064a747ce437f82bbb6ec659b217f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Perioperative Care
192 rdf:type schema:DefinedTerm
193 Ndb0dc2a0ce51429aad54fccd6693f62f schema:name pubmed_id
194 schema:value 30651123
195 rdf:type schema:PropertyValue
196 Ndbb2b66556254be0a9f41dd81bd3d3d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Humans
198 rdf:type schema:DefinedTerm
199 Ne12a1aff8b9e43d18bdc09c0f23b3a98 schema:name dimensions_id
200 schema:value pub.1111461234
201 rdf:type schema:PropertyValue
202 Nf22a39a0e7d7497494e2cb3841f80996 rdf:first sg:person.0617260043.47
203 rdf:rest N895622ef05464bd581bcb43388340234
204 Nf56df9d87c334d34927ca282765fe2bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Meta-Analysis as Topic
206 rdf:type schema:DefinedTerm
207 Nf748f2a1a3eb4f8992f84724222deb2e rdf:first sg:person.014172536143.30
208 rdf:rest N211bbc68fc8542a0acf7a76e4edc1010
209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
210 schema:name Medical and Health Sciences
211 rdf:type schema:DefinedTerm
212 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
213 schema:name Clinical Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
216 schema:name Public Health and Health Services
217 rdf:type schema:DefinedTerm
218 sg:journal.1046628 schema:issn 2046-4053
219 schema:name Systematic Reviews
220 schema:publisher Springer Nature
221 rdf:type schema:Periodical
222 sg:person.01066142337.60 schema:affiliation grid-institutes:grid.411065.7
223 schema:familyName Lauzier
224 schema:givenName François
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60
226 rdf:type schema:Person
227 sg:person.012071535663.22 schema:affiliation grid-institutes:grid.23856.3a
228 schema:familyName Pinard
229 schema:givenName Anne-Marie
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012071535663.22
231 rdf:type schema:Person
232 sg:person.01253006352.94 schema:affiliation grid-institutes:None
233 schema:familyName Turgeon
234 schema:givenName Alexis F.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253006352.94
236 rdf:type schema:Person
237 sg:person.014172536143.30 schema:affiliation grid-institutes:None
238 schema:familyName Verret
239 schema:givenName Michael
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014172536143.30
241 rdf:type schema:Person
242 sg:person.014240651343.14 schema:affiliation grid-institutes:None
243 schema:familyName Savard
244 schema:givenName Xavier
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014240651343.14
246 rdf:type schema:Person
247 sg:person.016407551151.90 schema:affiliation grid-institutes:grid.23856.3a
248 schema:familyName Leblanc
249 schema:givenName Guillaume
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016407551151.90
251 rdf:type schema:Person
252 sg:person.0617260043.47 schema:affiliation grid-institutes:grid.419404.c
253 schema:familyName Zarychanski
254 schema:givenName Ryan
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617260043.47
256 rdf:type schema:Person
257 sg:person.0723016305.04 schema:affiliation grid-institutes:None
258 schema:familyName Cossi
259 schema:givenName Marie-Joëlle
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723016305.04
261 rdf:type schema:Person
262 sg:pub.10.1186/1471-2288-5-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046347100
263 https://doi.org/10.1186/1471-2288-5-13
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/2046-4053-4-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024252988
266 https://doi.org/10.1186/2046-4053-4-1
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/s12871-017-0373-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086104976
269 https://doi.org/10.1186/s12871-017-0373-8
270 rdf:type schema:CreativeWork
271 grid-institutes:None schema:alternateName CHU de Québec - Université Laval (Hôpital de l’Enfant-Jésus), 1401, 18e rue, Québec, Québec G1J 1Z4 Canada
272 CHU de Québec - Université Laval Research Center, 1401, 18e rue, Québec, Québec G1J 1Z4 Canada
273 schema:name CHU de Québec - Université Laval (Hôpital de l’Enfant-Jésus), 1401, 18e rue, Québec, Québec G1J 1Z4 Canada
274 CHU de Québec - Université Laval Research Center, 1401, 18e rue, Québec, Québec G1J 1Z4 Canada
275 Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Université Laval, Québec, QC Canada
276 rdf:type schema:Organization
277 grid-institutes:grid.23856.3a schema:alternateName Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Université Laval, Québec, QC Canada
278 schema:name Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Université Laval, Québec, QC Canada
279 rdf:type schema:Organization
280 grid-institutes:grid.411065.7 schema:alternateName Department of Medicine, Université Laval and CHU de Québec - Université Laval Research Center, Québec, QC Canada
281 schema:name CHU de Québec - Université Laval Research Center, 1401, 18e rue, Québec, Québec G1J 1Z4 Canada
282 Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Université Laval, Québec, QC Canada
283 Department of Medicine, Université Laval and CHU de Québec - Université Laval Research Center, Québec, QC Canada
284 rdf:type schema:Organization
285 grid-institutes:grid.419404.c schema:alternateName Cancer Care Manitoba, Department of Hematology and Medical Oncology, Winnipeg, MN Canada
286 schema:name Cancer Care Manitoba, Department of Hematology and Medical Oncology, Winnipeg, MN Canada
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...