The rise and fall of basal bodies in the nematode Caenorhabditis elegans View Full Text


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Article Info

DATE

2017-12

AUTHORS

Inna V. Nechipurenko, Piali Sengupta

ABSTRACT

The free-living nematode, Caenorhabditis elegans, is a widely used genetic model organism for investigations into centriole and cilia biology. Only sensory neurons are ciliated in C. elegans; morphologically diverse cilia in these neurons are nucleated by basal bodies located at the dendritic endings. C. elegans centrioles comprise a central tube with a symmetric array of nine singlet microtubules. These singlet microtubules remodel in a subset of sensory neurons to form the doublet microtubules of the basal bodies. Following initiation of ciliogenesis, the central tube, but not the outer centriole wall, of the basal body degenerates. Recent ultrastructural characterization of basal body architecture and remodeling have laid the foundation for future studies into mechanisms underlying different aspects of basal body genesis, remodeling, and intracellular positioning. More... »

PAGES

9

References to SciGraph publications

  • 2012-07. Towards a molecular architecture of centriole assembly in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1998-12. A new look at kinetochore structure in vertebrate somatic cells using high-pressure freezing and freeze substitution in CHROMOSOMA
  • 2011-07. Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments in NATURE CELL BIOLOGY
  • 2016-08-18. The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate in NATURE COMMUNICATIONS
  • 2012-01. UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting in NATURE NEUROSCIENCE
  • 2015-12. KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome in GENOME BIOLOGY
  • 2005-02. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells in NATURE CELL BIOLOGY
  • 2004-07. Centriolar SAS-5 is required for centrosome duplication in C. elegans in NATURE CELL BIOLOGY
  • 2011-12. A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits in BMC EVOLUTIONARY BIOLOGY
  • 2006-11. Centriole assembly in Caenorhabditis elegans in NATURE
  • 2013-12. Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes in NATURE COMMUNICATIONS
  • 2012-12. Population dynamics and habitat sharing of natural populations of Caenorhabditis elegans and C. briggsae in BMC BIOLOGY
  • 2004-11. Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13630-017-0053-9

    DOI

    http://dx.doi.org/10.1186/s13630-017-0053-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090899393

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28770089


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