Sepsis and septic shock in France: incidences, outcomes and costs of care View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-20

AUTHORS

Claire Dupuis, Lila Bouadma, Stéphane Ruckly, Anne Perozziello, Damien Van-Gysel, Arthur Mageau, Bruno Mourvillier, Etienne de Montmollin, Sébastien Bailly, Gregory Papin, Fabrice Sinnah, Camille Vinclair, Sonia Abid, Romain Sonneville, Jean-François Timsit

ABSTRACT

BackgroundSepsis is one of the leading causes of death worldwide. The associated incidence, mortality and trends do not differ greatly between documented reports. The purpose of this study was to provide an in-depth description of patients with sepsis and septic shock hospitalized in France from 2010 to 2015 and to explore the temporal trends of their clinical characteristics, costs and outcomes.MethodsRetrospective cohort study of the French hospital administrative database in which organ failure therapies and severity scores are systematically registered. All patients admitted between 2010 and 2015 for sepsis and septic shock as defined by an ICD-10 code for infection, and for organ failure or the use of organ failure supplementation were included. Incidence, outcomes and trends were analyzed. Subgroup analyses based on several coding strategies and adjusted for severity scores were performed.ResultsA total of 737,147 patients with sepsis and 492,902 patients with septic shock were included. From 2010 to 2015, the incidence of sepsis and septic shock increased, respectively, from 206 to 243 and from 135 to 171 cases per 100,000 population. Case fatality remained at 34% for sepsis, but decreased from 46 to 44% for septic shock.Median hospital stay costs amounted to €11,400 (IQR: 5036; 24,364) for patients with sepsis and €16,439 (IQR: 7339; 29,360) for patients with septic shock.After adjustment for case-mix and illness severity, the risk of death was stable for sepsis (0.08% [− 0.04; 0.20] per year), but decreased for sepsis patients admitted to the intensive care unit and for cases of septic shock (− 0.33%[ − 0.40; − 0.27] per year).ConclusionsSepsis is common, frequently fatal and expensive to treat. Its incidence has increased. Case fatality has decreased in most severely affected patients, owing partly to general improvements in care. More... »

PAGES

145

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13613-020-00760-x

DOI

http://dx.doi.org/10.1186/s13613-020-00760-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131899553

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33079281


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12 schema:description BackgroundSepsis is one of the leading causes of death worldwide. The associated incidence, mortality and trends do not differ greatly between documented reports. The purpose of this study was to provide an in-depth description of patients with sepsis and septic shock hospitalized in France from 2010 to 2015 and to explore the temporal trends of their clinical characteristics, costs and outcomes.MethodsRetrospective cohort study of the French hospital administrative database in which organ failure therapies and severity scores are systematically registered. All patients admitted between 2010 and 2015 for sepsis and septic shock as defined by an ICD-10 code for infection, and for organ failure or the use of organ failure supplementation were included. Incidence, outcomes and trends were analyzed. Subgroup analyses based on several coding strategies and adjusted for severity scores were performed.ResultsA total of 737,147 patients with sepsis and 492,902 patients with septic shock were included. From 2010 to 2015, the incidence of sepsis and septic shock increased, respectively, from 206 to 243 and from 135 to 171 cases per 100,000 population. Case fatality remained at 34% for sepsis, but decreased from 46 to 44% for septic shock.Median hospital stay costs amounted to €11,400 (IQR: 5036; 24,364) for patients with sepsis and €16,439 (IQR: 7339; 29,360) for patients with septic shock.After adjustment for case-mix and illness severity, the risk of death was stable for sepsis (0.08% [− 0.04; 0.20] per year), but decreased for sepsis patients admitted to the intensive care unit and for cases of septic shock (− 0.33%[ − 0.40; − 0.27] per year).ConclusionsSepsis is common, frequently fatal and expensive to treat. Its incidence has increased. Case fatality has decreased in most severely affected patients, owing partly to general improvements in care.
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18 schema:keywords BackgroundSepsis
19 France
20 ICD-10 codes
21 MethodsRetrospective cohort study
22 ResultsA total
23 adjustment
24 administrative databases
25 analysis
26 care
27 care unit
28 case fatality
29 cases
30 cause
31 cause of death
32 characteristics
33 clinical characteristics
34 code
35 cohort study
36 cost
37 cost of care
38 database
39 death
40 depth description
41 description
42 failure
43 failure therapy
44 fatalities
45 general improvement
46 hospital administrative database
47 hospital stay costs
48 illness severity
49 improvement
50 incidence
51 incidence of sepsis
52 infection
53 intensive care unit
54 mortality
55 organ failure
56 outcomes
57 patients
58 population
59 purpose
60 report
61 risk
62 risk of death
63 scores
64 sepsis
65 sepsis patients
66 septic shock
67 severity
68 severity score
69 shock
70 stay costs
71 strategies
72 study
73 subgroup analysis
74 supplementation
75 temporal trends
76 therapy
77 total
78 trends
79 units
80 use
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