The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Jie Cui, Xuxia Wei, Haijin Lv, Yuntao Li, Ping Li, Zhen Chen, Genglong Liu

ABSTRACT

BACKGROUND: Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock. METHODS: Four databases, PubMed, the Cochrane Library, the ISI Web of Knowledge, and Embase, were systematically searched from inception to June 2018 to update the 2013 edition of the Cochrane review by two investigators, who independently selected studies, extracted relevant data, and evaluated study quality. Data were subjected to a meta-analysis and trial sequential analysis (TSA) for the primary and secondary outcomes. Level of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) scale. RESULTS: Nineteen studies comprising 1530 patients were included in this meta-analysis. Pooled analyses showed that the use of IVIgGM reduced the mortality risk of septic patients (relative risk 0.60; 95% confidence interval [CI] 0.52-0.69, I2 = 0%). TSA showed that IVIgGM had a significant effect on mortality. Additionally, the meta-analysis suggested that use of IVIgGM shortened length of mechanical ventilation (mean difference - 3.16 days; 95% CI - 5.71 to - 0.61 days) and did not shorten length of stay in the intensive care unit (mean difference - 0.38 days; 95% CI - 3.55 to 2.80 days). The GRADE scale showed that the certainty of the body of evidence was low for both benefits and IVIgGM. CONCLUSION: Administration of IVIgGM to adult septic patients may be associated with reduced mortality. Treatment effects tended to be smaller or less consistent when including only those studies deemed adequate for each indicator. The available evidence is not clearly sufficient to support the widespread use of IVIgGM in the treatment of sepsis. Trial registration PROSPERO registration number: CRD42018084120. Registered on 11 February 2018. More... »

PAGES

27

References to SciGraph publications

  • 2013-12. Methodological developments in searching for studies for systematic reviews: past, present and future? in SYSTEMATIC REVIEWS
  • 2013-10. Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and/or myopathy in patients with multiple organ failure and SIRS/sepsis: a prospective, randomized, placebo-controlled, double-blinded trial in CRITICAL CARE
  • 2010-12. Genome-wide transcription profiling of human sepsis: a systematic review in CRITICAL CARE
  • 2018-04. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study) in INTENSIVE CARE MEDICINE
  • 1988. Bewertung der intravenösen IgM-Therapie bei schweren nosokomialen Infektionen (Ergebnis einer kontrollierten randomisierten Studie) in KLINISCH ANGEWANDTE IMMUNOLOGIE
  • 2017-03. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 in INTENSIVE CARE MEDICINE
  • 2002-12. The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis: another point of view in CRITICAL CARE
  • 2001. Markers of Inflammation for Prognosis and Control of Therapeutic Success in Patients with Abdominal Sepsis — Options for Using Adjuvant Intravenous Immunoglobulins in IMMUNOLOGICAL SCREENING AND IMMUNOTHERAPY IN CRITICALLY ILL PATIENTS WITH ABDOMINAL INFECTIONS
  • 2005-12. Estimating the mean and variance from the median, range, and the size of a sample in BMC MEDICAL RESEARCH METHODOLOGY
  • 2013-08. Effects of IgM-Enriched Immunoglobulin Therapy in Septic-Shock–Induced Multiple Organ Failure: Pilot Study in JOURNAL OF ANESTHESIA
  • 2017-12. The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure in ANNALS OF INTENSIVE CARE
  • 2015-12. The original sins of clinical trials with intravenous immunoglobulins in sepsis in CRITICAL CARE
  • 2014-12. Early therapy with IgM-enriched polyclonal immunoglobulin in patients with septic shock in INTENSIVE CARE MEDICINE
  • 2002-08. The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis [ISRCTN28863830] in CRITICAL CARE
  • 1986-03. Einfluß einer adjuvanten Immunglobulintherapie auf Infektionen bei Patienten einer operativen Intensiv-Therapie-Station in JOURNAL OF MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13613-019-0501-3

    DOI

    http://dx.doi.org/10.1186/s13613-019-0501-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111933454

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30725235


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Guangzhou Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410737.6", 
              "name": [
                "Head and Neck Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 510095, Guangzhou, Guangdong Province, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cui", 
            "givenName": "Jie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Third Affiliated Hospital of Sun Yat-sen University", 
              "id": "https://www.grid.ac/institutes/grid.412558.f", 
              "name": [
                "Surgical Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, 510630, Guangzhou, Guangdong Province, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wei", 
            "givenName": "Xuxia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Third Affiliated Hospital of Sun Yat-sen University", 
              "id": "https://www.grid.ac/institutes/grid.412558.f", 
              "name": [
                "Surgical Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, 510630, Guangzhou, Guangdong Province, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lv", 
            "givenName": "Haijin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Nursing Department, Shaodong County People\u2019s Hospital, 422800, Shaodong, Hunan Province, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Yuntao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guangdong Provincial Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413402.0", 
              "name": [
                "Department of Anesthesia, GuangDong Provincial Hospital of Chinese Medicine, 510120, Guangzhou, Guangdong Province, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Ping", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Southern Medical University", 
              "id": "https://www.grid.ac/institutes/grid.284723.8", 
              "name": [
                "Intensive Care Unit, Shunde Hospital, Southern Medical University, 528300, Foshan, Guangdong Province, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Zhen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guangzhou Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410737.6", 
              "name": [
                "Department of Pathology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 510095, Guangzhou, Guangdong Province, People\u2019s Republic of China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Genglong", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-014-3474-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000371443", 
              "https://doi.org/10.1007/s00134-014-3474-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00540-012-1553-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000893600", 
              "https://doi.org/10.1007/s00540-012-1553-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.1e040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002333577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.1e040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002333577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4683-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003731534", 
              "https://doi.org/10.1007/s00134-017-4683-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4683-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003731534", 
              "https://doi.org/10.1007/s00134-017-4683-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/shk.0b013e3181a2c0b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012596142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/shk.0b013e3181a2c0b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012596142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/shk.0b013e3181a2c0b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012596142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chest.2016.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014373948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/joim.12265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019017980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc1837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019700873", 
              "https://doi.org/10.1186/cc1837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-59455-7_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022580017", 
              "https://doi.org/10.1007/978-3-642-59455-7_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000215452.84291.c6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025238860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000215452.84291.c6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025238860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.jvca.2005.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028256517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-015-0793-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028906832", 
              "https://doi.org/10.1186/s13054-015-0793-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-015-0793-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028906832", 
              "https://doi.org/10.1186/s13054-015-0793-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-015-0793-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028906832", 
              "https://doi.org/10.1186/s13054-015-0793-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01711930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029263860", 
              "https://doi.org/10.1007/bf01711930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01711930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029263860", 
              "https://doi.org/10.1007/bf01711930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01711930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029263860", 
              "https://doi.org/10.1007/bf01711930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2046-4053-2-78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029573757", 
              "https://doi.org/10.1186/2046-4053-2-78"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd001090.pub2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029979164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc9392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030309905", 
              "https://doi.org/10.1186/cc9392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31829eb98f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034381249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31829eb98f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034381249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.2006.01726.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036357646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc13028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039267739", 
              "https://doi.org/10.1186/cc13028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc1523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040679675", 
              "https://doi.org/10.1186/cc1523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc1523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040679675", 
              "https://doi.org/10.1186/cc1523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000295312.13466.1c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041437009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-73415-1_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041961301", 
              "https://doi.org/10.1007/978-3-642-73415-1_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.shk.0000157302.69125.f8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043035960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.shk.0000157302.69125.f8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043035960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-199109000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044587481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-199109000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044587481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2016.0287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045696843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2005.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045776014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2005.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045776014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2288-5-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046347100", 
              "https://doi.org/10.1186/1471-2288-5-13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1305727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051747683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmi.2016.01.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052008067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/147323001204000337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052578563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/147323001204000337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052578563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3310/hta16070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071139275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-151-4-200908180-00136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073710983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077287831", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078245329", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1684/ecn.2011.0281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078404380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079165624", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083285860", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0268-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085000657", 
              "https://doi.org/10.1186/s13613-017-0268-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0268-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085000657", 
              "https://doi.org/10.1186/s13613-017-0268-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-200712000-00026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092218174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-200712000-00026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092218174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-200712000-00026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092218174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-018-5143-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103192205", 
              "https://doi.org/10.1007/s00134-018-5143-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-018-5143-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103192205", 
              "https://doi.org/10.1007/s00134-018-5143-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2018.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104369512"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "BACKGROUND: Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock.\nMETHODS: Four databases, PubMed, the Cochrane Library, the ISI Web of Knowledge, and Embase, were systematically searched from inception to June 2018 to update the 2013 edition of the Cochrane review by two investigators, who independently selected studies, extracted relevant data, and evaluated study quality. Data were subjected to a meta-analysis and trial sequential analysis (TSA) for the primary and secondary outcomes. Level of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) scale.\nRESULTS: Nineteen studies comprising 1530 patients were included in this meta-analysis. Pooled analyses showed that the use of IVIgGM reduced the mortality risk of septic patients (relative risk 0.60; 95% confidence interval [CI] 0.52-0.69, I2\u2009=\u20090%). TSA showed that IVIgGM had a significant effect on mortality. Additionally, the meta-analysis suggested that use of IVIgGM shortened length of mechanical ventilation (mean difference -\u20093.16\u00a0days; 95% CI -\u20095.71 to -\u20090.61\u00a0days) and did not shorten length of stay in the intensive care unit (mean difference -\u20090.38\u00a0days; 95% CI -\u20093.55 to 2.80\u00a0days). The GRADE scale showed that the certainty of the body of evidence was low for both benefits and IVIgGM.\nCONCLUSION: Administration of IVIgGM to adult septic patients may be associated with reduced mortality. Treatment effects tended to be smaller or less consistent when including only those studies deemed adequate for each indicator. The available evidence is not clearly sufficient to support the widespread use of IVIgGM in the treatment of sepsis. Trial registration PROSPERO registration number: CRD42018084120. Registered on 11 February 2018.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13613-019-0501-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1045300", 
            "issn": [
              "2110-5820"
            ], 
            "name": "Annals of Intensive Care", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis", 
        "pagination": "27", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d1758f2fc69cb1b078aec19a5e7f8f0ab2fd9a0fd15ea9accd28493d7660db3c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30725235"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101562873"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13613-019-0501-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111933454"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13613-019-0501-3", 
          "https://app.dimensions.ai/details/publication/pub.1111933454"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:34", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113661_00000005.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs13613-019-0501-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13613-019-0501-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13613-019-0501-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13613-019-0501-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13613-019-0501-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    249 TRIPLES      21 PREDICATES      70 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13613-019-0501-3 schema:about anzsrc-for:11
    2 anzsrc-for:1117
    3 schema:author N30d7900281fc4fd180868f93b0e589a8
    4 schema:citation sg:pub.10.1007/978-3-642-59455-7_2
    5 sg:pub.10.1007/978-3-642-73415-1_3
    6 sg:pub.10.1007/bf01711930
    7 sg:pub.10.1007/s00134-014-3474-6
    8 sg:pub.10.1007/s00134-017-4683-6
    9 sg:pub.10.1007/s00134-018-5143-7
    10 sg:pub.10.1007/s00540-012-1553-9
    11 sg:pub.10.1186/1471-2288-5-13
    12 sg:pub.10.1186/2046-4053-2-78
    13 sg:pub.10.1186/cc13028
    14 sg:pub.10.1186/cc1523
    15 sg:pub.10.1186/cc1837
    16 sg:pub.10.1186/cc9392
    17 sg:pub.10.1186/s13054-015-0793-0
    18 sg:pub.10.1186/s13613-017-0268-3
    19 https://app.dimensions.ai/details/publication/pub.1077287831
    20 https://app.dimensions.ai/details/publication/pub.1078245329
    21 https://app.dimensions.ai/details/publication/pub.1079165624
    22 https://app.dimensions.ai/details/publication/pub.1083285860
    23 https://doi.org/10.1001/jama.2016.0287
    24 https://doi.org/10.1002/14651858.cd001090.pub2
    25 https://doi.org/10.1016/j.chest.2016.07.010
    26 https://doi.org/10.1016/j.cmi.2016.01.021
    27 https://doi.org/10.1016/j.jcrc.2005.03.003
    28 https://doi.org/10.1016/j.jcrc.2018.06.005
    29 https://doi.org/10.1053/j.jvca.2005.05.003
    30 https://doi.org/10.1056/nejmoa1305727
    31 https://doi.org/10.1097/00003246-199109000-00003
    32 https://doi.org/10.1097/00003246-200712000-00026
    33 https://doi.org/10.1097/01.ccm.0000215452.84291.c6
    34 https://doi.org/10.1097/01.ccm.0000295312.13466.1c
    35 https://doi.org/10.1097/01.shk.0000157302.69125.f8
    36 https://doi.org/10.1097/ccm.0b013e31829eb98f
    37 https://doi.org/10.1097/shk.0b013e3181a2c0b2
    38 https://doi.org/10.1111/j.1365-2796.2006.01726.x
    39 https://doi.org/10.1111/joim.12265
    40 https://doi.org/10.1177/147323001204000337
    41 https://doi.org/10.1345/aph.1e040
    42 https://doi.org/10.1684/ecn.2011.0281
    43 https://doi.org/10.3310/hta16070
    44 https://doi.org/10.7326/0003-4819-151-4-200908180-00136
    45 schema:datePublished 2019-12
    46 schema:datePublishedReg 2019-12-01
    47 schema:description BACKGROUND: Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock. METHODS: Four databases, PubMed, the Cochrane Library, the ISI Web of Knowledge, and Embase, were systematically searched from inception to June 2018 to update the 2013 edition of the Cochrane review by two investigators, who independently selected studies, extracted relevant data, and evaluated study quality. Data were subjected to a meta-analysis and trial sequential analysis (TSA) for the primary and secondary outcomes. Level of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) scale. RESULTS: Nineteen studies comprising 1530 patients were included in this meta-analysis. Pooled analyses showed that the use of IVIgGM reduced the mortality risk of septic patients (relative risk 0.60; 95% confidence interval [CI] 0.52-0.69, I2 = 0%). TSA showed that IVIgGM had a significant effect on mortality. Additionally, the meta-analysis suggested that use of IVIgGM shortened length of mechanical ventilation (mean difference - 3.16 days; 95% CI - 5.71 to - 0.61 days) and did not shorten length of stay in the intensive care unit (mean difference - 0.38 days; 95% CI - 3.55 to 2.80 days). The GRADE scale showed that the certainty of the body of evidence was low for both benefits and IVIgGM. CONCLUSION: Administration of IVIgGM to adult septic patients may be associated with reduced mortality. Treatment effects tended to be smaller or less consistent when including only those studies deemed adequate for each indicator. The available evidence is not clearly sufficient to support the widespread use of IVIgGM in the treatment of sepsis. Trial registration PROSPERO registration number: CRD42018084120. Registered on 11 February 2018.
    48 schema:genre research_article
    49 schema:inLanguage en
    50 schema:isAccessibleForFree false
    51 schema:isPartOf Nea8c54170bbc4d6581551a10ecff6aa4
    52 Nfce8b4fe9f724b11809709464d2f2b77
    53 sg:journal.1045300
    54 schema:name The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis
    55 schema:pagination 27
    56 schema:productId N0f9255b9f00a4982b902ed373f28d5dd
    57 N14848cae8b7146e1807c121ff2d3d96c
    58 N1e70154a185f4063be28d71325b2a57c
    59 N7780b7cd75194929b78ffca432581b40
    60 Nf72060f4229149f89f3fe9ae209de324
    61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111933454
    62 https://doi.org/10.1186/s13613-019-0501-3
    63 schema:sdDatePublished 2019-04-11T10:34
    64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    65 schema:sdPublisher N156f63c221f84f14876392f5138d1f13
    66 schema:url https://link.springer.com/10.1186%2Fs13613-019-0501-3
    67 sgo:license sg:explorer/license/
    68 sgo:sdDataset articles
    69 rdf:type schema:ScholarlyArticle
    70 N0f81ce2f500a4f9f978f62a56a81efa8 schema:affiliation https://www.grid.ac/institutes/grid.413402.0
    71 schema:familyName Li
    72 schema:givenName Ping
    73 rdf:type schema:Person
    74 N0f9255b9f00a4982b902ed373f28d5dd schema:name nlm_unique_id
    75 schema:value 101562873
    76 rdf:type schema:PropertyValue
    77 N14848cae8b7146e1807c121ff2d3d96c schema:name readcube_id
    78 schema:value d1758f2fc69cb1b078aec19a5e7f8f0ab2fd9a0fd15ea9accd28493d7660db3c
    79 rdf:type schema:PropertyValue
    80 N156f63c221f84f14876392f5138d1f13 schema:name Springer Nature - SN SciGraph project
    81 rdf:type schema:Organization
    82 N1e70154a185f4063be28d71325b2a57c schema:name doi
    83 schema:value 10.1186/s13613-019-0501-3
    84 rdf:type schema:PropertyValue
    85 N235841708d094f0090da3de2feb5a4c6 rdf:first N239cefc7e58d4e328a0028e9ae174d84
    86 rdf:rest N29cce5d60ea64421b9027c65c66a1f54
    87 N239cefc7e58d4e328a0028e9ae174d84 schema:affiliation Ndd0a4e1312ad4a41bfbc44653cf83925
    88 schema:familyName Li
    89 schema:givenName Yuntao
    90 rdf:type schema:Person
    91 N29cce5d60ea64421b9027c65c66a1f54 rdf:first N0f81ce2f500a4f9f978f62a56a81efa8
    92 rdf:rest N9b7cf9ae96064d718c23dcce72006ef0
    93 N2c5ac038f5ca49ad918d9ed645bdf993 schema:affiliation https://www.grid.ac/institutes/grid.410737.6
    94 schema:familyName Cui
    95 schema:givenName Jie
    96 rdf:type schema:Person
    97 N30d7900281fc4fd180868f93b0e589a8 rdf:first N2c5ac038f5ca49ad918d9ed645bdf993
    98 rdf:rest Ndd63e6b7db954342ac67c0c01610a1b1
    99 N3937bcfb52c04ae8af4c63b00a83c240 schema:affiliation https://www.grid.ac/institutes/grid.410737.6
    100 schema:familyName Liu
    101 schema:givenName Genglong
    102 rdf:type schema:Person
    103 N3a6a5f67c23b4506b69afe55b5581960 rdf:first Nbe3cb01a67df44ce82b8eb7f19a5d4f1
    104 rdf:rest N235841708d094f0090da3de2feb5a4c6
    105 N7780b7cd75194929b78ffca432581b40 schema:name dimensions_id
    106 schema:value pub.1111933454
    107 rdf:type schema:PropertyValue
    108 N8db524cb5b6c440594f55f930e49d7de rdf:first N3937bcfb52c04ae8af4c63b00a83c240
    109 rdf:rest rdf:nil
    110 N9b7cf9ae96064d718c23dcce72006ef0 rdf:first Nc1f81b18f0304bfaa5db22c0539deb75
    111 rdf:rest N8db524cb5b6c440594f55f930e49d7de
    112 Nbe3cb01a67df44ce82b8eb7f19a5d4f1 schema:affiliation https://www.grid.ac/institutes/grid.412558.f
    113 schema:familyName Lv
    114 schema:givenName Haijin
    115 rdf:type schema:Person
    116 Nc1f81b18f0304bfaa5db22c0539deb75 schema:affiliation https://www.grid.ac/institutes/grid.284723.8
    117 schema:familyName Chen
    118 schema:givenName Zhen
    119 rdf:type schema:Person
    120 Ndd0a4e1312ad4a41bfbc44653cf83925 schema:name Nursing Department, Shaodong County People’s Hospital, 422800, Shaodong, Hunan Province, People’s Republic of China
    121 rdf:type schema:Organization
    122 Ndd63e6b7db954342ac67c0c01610a1b1 rdf:first Ne40aaaa6e0594b4c96c5078429fa019e
    123 rdf:rest N3a6a5f67c23b4506b69afe55b5581960
    124 Ne40aaaa6e0594b4c96c5078429fa019e schema:affiliation https://www.grid.ac/institutes/grid.412558.f
    125 schema:familyName Wei
    126 schema:givenName Xuxia
    127 rdf:type schema:Person
    128 Nea8c54170bbc4d6581551a10ecff6aa4 schema:volumeNumber 9
    129 rdf:type schema:PublicationVolume
    130 Nf72060f4229149f89f3fe9ae209de324 schema:name pubmed_id
    131 schema:value 30725235
    132 rdf:type schema:PropertyValue
    133 Nfce8b4fe9f724b11809709464d2f2b77 schema:issueNumber 1
    134 rdf:type schema:PublicationIssue
    135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Medical and Health Sciences
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Public Health and Health Services
    140 rdf:type schema:DefinedTerm
    141 sg:journal.1045300 schema:issn 2110-5820
    142 schema:name Annals of Intensive Care
    143 rdf:type schema:Periodical
    144 sg:pub.10.1007/978-3-642-59455-7_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022580017
    145 https://doi.org/10.1007/978-3-642-59455-7_2
    146 rdf:type schema:CreativeWork
    147 sg:pub.10.1007/978-3-642-73415-1_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041961301
    148 https://doi.org/10.1007/978-3-642-73415-1_3
    149 rdf:type schema:CreativeWork
    150 sg:pub.10.1007/bf01711930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029263860
    151 https://doi.org/10.1007/bf01711930
    152 rdf:type schema:CreativeWork
    153 sg:pub.10.1007/s00134-014-3474-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000371443
    154 https://doi.org/10.1007/s00134-014-3474-6
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1007/s00134-017-4683-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003731534
    157 https://doi.org/10.1007/s00134-017-4683-6
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1007/s00134-018-5143-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103192205
    160 https://doi.org/10.1007/s00134-018-5143-7
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1007/s00540-012-1553-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000893600
    163 https://doi.org/10.1007/s00540-012-1553-9
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1186/1471-2288-5-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046347100
    166 https://doi.org/10.1186/1471-2288-5-13
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1186/2046-4053-2-78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029573757
    169 https://doi.org/10.1186/2046-4053-2-78
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1186/cc13028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039267739
    172 https://doi.org/10.1186/cc13028
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1186/cc1523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040679675
    175 https://doi.org/10.1186/cc1523
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1186/cc1837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019700873
    178 https://doi.org/10.1186/cc1837
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1186/cc9392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030309905
    181 https://doi.org/10.1186/cc9392
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1186/s13054-015-0793-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028906832
    184 https://doi.org/10.1186/s13054-015-0793-0
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1186/s13613-017-0268-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085000657
    187 https://doi.org/10.1186/s13613-017-0268-3
    188 rdf:type schema:CreativeWork
    189 https://app.dimensions.ai/details/publication/pub.1077287831 schema:CreativeWork
    190 https://app.dimensions.ai/details/publication/pub.1078245329 schema:CreativeWork
    191 https://app.dimensions.ai/details/publication/pub.1079165624 schema:CreativeWork
    192 https://app.dimensions.ai/details/publication/pub.1083285860 schema:CreativeWork
    193 https://doi.org/10.1001/jama.2016.0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045696843
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1002/14651858.cd001090.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029979164
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/j.chest.2016.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014373948
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/j.cmi.2016.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052008067
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/j.jcrc.2005.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045776014
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/j.jcrc.2018.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104369512
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1053/j.jvca.2005.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028256517
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1056/nejmoa1305727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051747683
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1097/00003246-199109000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044587481
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1097/00003246-200712000-00026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092218174
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1097/01.ccm.0000215452.84291.c6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025238860
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1097/01.ccm.0000295312.13466.1c schema:sameAs https://app.dimensions.ai/details/publication/pub.1041437009
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1097/01.shk.0000157302.69125.f8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043035960
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1097/ccm.0b013e31829eb98f schema:sameAs https://app.dimensions.ai/details/publication/pub.1034381249
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1097/shk.0b013e3181a2c0b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012596142
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1111/j.1365-2796.2006.01726.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036357646
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1111/joim.12265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019017980
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1177/147323001204000337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052578563
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1345/aph.1e040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002333577
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1684/ecn.2011.0281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078404380
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.3310/hta16070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071139275
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.7326/0003-4819-151-4-200908180-00136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073710983
    236 rdf:type schema:CreativeWork
    237 https://www.grid.ac/institutes/grid.284723.8 schema:alternateName Southern Medical University
    238 schema:name Intensive Care Unit, Shunde Hospital, Southern Medical University, 528300, Foshan, Guangdong Province, People’s Republic of China
    239 rdf:type schema:Organization
    240 https://www.grid.ac/institutes/grid.410737.6 schema:alternateName Guangzhou Medical University
    241 schema:name Department of Pathology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 510095, Guangzhou, Guangdong Province, People’s Republic of China
    242 Head and Neck Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 510095, Guangzhou, Guangdong Province, People’s Republic of China
    243 rdf:type schema:Organization
    244 https://www.grid.ac/institutes/grid.412558.f schema:alternateName Third Affiliated Hospital of Sun Yat-sen University
    245 schema:name Surgical Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, 510630, Guangzhou, Guangdong Province, People’s Republic of China
    246 rdf:type schema:Organization
    247 https://www.grid.ac/institutes/grid.413402.0 schema:alternateName Guangdong Provincial Hospital
    248 schema:name Department of Anesthesia, GuangDong Provincial Hospital of Chinese Medicine, 510120, Guangzhou, Guangdong Province, People’s Republic of China
    249 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...