Weaning failure of cardiovascular origin: how to suspect, detect and treat—a review of the literature View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Christina Routsi, Ioannis Stanopoulos, Stelios Kokkoris, Antonios Sideris, Spyros Zakynthinos

ABSTRACT

Among the multiple causes of weaning failure from mechanical ventilation, cardiovascular dysfunction is increasingly recognized as a quite frequent cause that can be treated successfully. In this review, we summarize the contemporary evidence of the most important clinical and diagnostic aspects of weaning failure of cardiovascular origin with special focus on treatment. Pathophysiological mechanisms are complex and mainly include increase in right and left ventricular preload and afterload and potentially induce myocardial ischemia. Patients at risk include those with preexisting cardiopulmonary disease either known or suspected. Clinically, cardiovascular etiology as a predominant cause or a contributor to weaning failure, though critical for early diagnosis and intervention, may be difficult to be recognized and distinguished from noncardiac causes suggesting the need of high suspicion. A cardiovascular diagnostic workup including bedside echocardiography, lung ultrasound, electrocardiogram and biomarkers of cardiovascular dysfunction or other adjunct techniques and, in selected cases, right heart catheterization and/or coronary angiography, should be obtained to confirm the diagnosis. Official clinical practice guidelines that address treatment of a confirmed weaning-induced cardiovascular dysfunction do not exist. As the etiologies of weaning-induced cardiovascular dysfunction are diverse, principles of management depend on the individual pathophysiological mechanisms, including preload optimization by fluid removal, guided by B-type natriuretic peptide measurement, nitrates administration in excessive afterload and/or myocardial ischemia, contractility improvement in severe systolic dysfunction as well as other rational treatment in specific indications in order to lead to successful weaning from mechanical ventilation. More... »

PAGES

6

References to SciGraph publications

  • 2013-11. Managing the apparent and hidden difficulties of weaning from mechanical ventilation in INTENSIVE CARE MEDICINE
  • 2005-03. Coronary artery bypass graft surgery for persistent weaning failure in INTENSIVE CARE MEDICINE
  • 2008-04. Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome in CARDIOVASCULAR ULTRASOUND
  • 1991-04. Plasma catecholamines and oxygen consumption during weaning from mechanical ventilation in INTENSIVE CARE MEDICINE
  • 2018-06. A global perspective on vasoactive agents in shock in INTENSIVE CARE MEDICINE
  • 2010-06. Echocardiography: a help in the weaning process in CRITICAL CARE
  • 2005-12. Fluid balance and weaning outcomes in INTENSIVE CARE MEDICINE
  • 2010-12. Nitroglycerin can facilitate weaning of difficult-to-wean chronic obstructive pulmonary disease patients: a prospective interventional non-randomized study in CRITICAL CARE
  • 2011-07. Myocardial ischaemia and weaning failure: is angioplasty the heart of the problem? in INTENSIVE CARE MEDICINE
  • 2014-08. Weaning-induced cardiac dysfunction: where are we today? in INTENSIVE CARE MEDICINE
  • 2010-07. Physiological comparison of three spontaneous breathing trials in difficult-to-wean patients in INTENSIVE CARE MEDICINE
  • 2012-06. Transthoracic Echocardiography with Doppler Tissue Imaging predicts weaning failure from mechanical ventilation: evolution of the left ventricle relaxation rate during a spontaneous breathing trial is the key factor in weaning outcome in CRITICAL CARE
  • 2006-10. B-type natriuretic peptide and weaning from mechanical ventilation in INTENSIVE CARE MEDICINE
  • 2012. Pharmacologic Interventions to Improve Splanchnic Oxygenation During Ventilation with Positive End-Expiratory Pressure in OXYGEN TRANSPORT TO TISSUE XXXIII
  • 2003. Weaning-Induced Cardiac Failure in MECHANICAL VENTILATION AND WEANING
  • 2011-03. B-type natriuretic peptides for prediction and diagnosis of weaning failure from cardiac origin in INTENSIVE CARE MEDICINE
  • 2011-12. New insights into weaning from mechanical ventilation: left ventricular diastolic dysfunction is a key player in INTENSIVE CARE MEDICINE
  • 2007-07. Variation in natriuretic peptides and mitral flow indexes during successful ventilatory weaning: a preliminary study in INTENSIVE CARE MEDICINE
  • 2016-12. Cardiac dysfunction induced by weaning from mechanical ventilation: incidence, risk factors, and effects of fluid removal in CRITICAL CARE
  • 2016-07. Ultrasonography evaluation during the weaning process: the heart, the diaphragm, the pleura and the lung in INTENSIVE CARE MEDICINE
  • 2015-12. Extravascular lung water in critical care: recent advances and clinical applications in ANNALS OF INTENSIVE CARE
  • 2005-12. Differential cardiovascular responses during weaning failure: effects on tissue oxygenation and lactate in INTENSIVE CARE MEDICINE
  • 2008-04. Passive leg raising in INTENSIVE CARE MEDICINE
  • 2018-03. 38th International Symposium on Intensive Care and Emergency Medicine in CRITICAL CARE
  • 2016-09. Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives in INTENSIVE CARE MEDICINE
  • 2015-03. Passive leg raising performed before a spontaneous breathing trial predicts weaning-induced cardiac dysfunction in INTENSIVE CARE MEDICINE
  • 1997-08. Successful weaning from mechanical ventilation following balloon mitral commissurotomy in INTENSIVE CARE MEDICINE
  • 2005-05. Weaning failure from mechanical ventilation due to hypertrophic obstructive cardiomyopathy in INTENSIVE CARE MEDICINE
  • 2013-12. Control of hypertension in the critically ill: a pathophysiological approach in ANNALS OF INTENSIVE CARE
  • 2010-04. Weaning failure of cardiac origin: recent advances in CRITICAL CARE
  • 2008-07. Increase in plasma protein concentration for diagnosing weaning-induced pulmonary oedema in INTENSIVE CARE MEDICINE
  • 2018-12. Cardiac function during weaning failure: the role of diastolic dysfunction in ANNALS OF INTENSIVE CARE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13613-019-0481-3

    DOI

    http://dx.doi.org/10.1186/s13613-019-0481-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111312081

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30627804


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