The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-20

AUTHORS

Ignacio Martin-Loeches, Arturo Muriel-Bombín, Ricard Ferrer, Antonio Artigas, Jordi Sole-Violan, Leonardo Lorente, David Andaluz-Ojeda, Adriele Prina-Mello, Ruben Herrán-Monge, Borja Suberviola, Ana Rodriguez-Fernandez, Pedro Merino, Ana M. Loza, Pablo Garcia-Olivares, Eduardo Anton, Eduardo Tamayo, Wysali Trapiello, Jesús Blanco, Jesús F. Bermejo-Martin, the GRECIA group

ABSTRACT

BackgroundPre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment. The objective of this study was to evaluate the impact of endogenous immunoglobulins on the mortality risk in sepsis depending on disease severity.MethodsThis was a retrospective observational study including 278 patients admitted to the ICU with sepsis fulfilling the SEPSIS-3 criteria, coming from the Spanish GRECIA and ABISS-EDUSEPSIS cohorts. Patients were distributed into two groups depending on their Sequential Organ Failure Assessment score at ICU admission (SOFA < 8, n = 122 and SOFA ≥ 8, n = 156), and the association between immunoglobulin levels at ICU admission with mortality was studied in each group by Kaplan–Meier and multivariate logistic regression analysis.ResultsICU/hospital mortality in the SOFA < 8 group was 14.8/23.0%, compared to 30.1/35.3% in the SOFA ≥ 8 group. In the group with SOFA < 8, the simultaneous presence of total IgG < 407 mg/dl, IgM < 43 mg/dl and IgA < 219 mg/dl was associated with a reduction in the survival mean time of 6.6 days in the first 28 days and was a robust predictor of mortality risk either during the acute or during the post-acute phase of the disease (OR for ICU mortality: 13.79; OR for hospital mortality: 7.98). This predictive ability remained in the absence of prior immunosuppression (OR for ICU mortality: 17.53; OR for hospital mortality: 5.63). Total IgG < 407 mg/dl or IgG1 < 332 mg/dl was also an independent predictor of ICU mortality in this group. In contrast, in the SOFA ≥ 8 group, we found no immunoglobulin thresholds associated with neither ICU nor hospital mortality.ConclusionsEndogenous immunoglobulin levels may have a different impact on the mortality risk of sepsis patients based on their severity. In patients with moderate organ failure, the simultaneous presence of low levels of IgG, IgA and IgM was a consistent predictor of both acute and post-acute mortalities. More... »

PAGES

44

Journal

TITLE

Annals of Intensive Care

ISSUE

1

VOLUME

7

Author Affiliations

  • Multidisciplinary Intensive Care Research Organization (MICRO), St. James’s University Hospitals Dublin, James’s St, Ushers, Dublin 8, Ireland
  • Intensive Care Department, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain
  • ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
  • CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, C/Sinesio Delgado,4, 28029, Madrid, Spain
  • Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena, s/n, 35010 Las Palmas de Gran Canaria, Las Palmas, Spain
  • Critical Care Medicine Service, Hospital Universitario de Canarias, Carretera de Ofra, s/n, 38320 San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain
  • Critical Care Medicine Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 3, 47003, Valladolid, Spain
  • Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI), James’s St, Dublin 8, Ireland
  • Critical Care Medicine Service, Hospital Universitario Marqués de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain
  • Microbiology Service, Hospital Marques de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain
  • Critical Care Medicine Service, Hospital Nuestra Señora de Valme, Av. de Bellavista, s/n, 41014, Seville, Spain
  • Critical Care Medicine Service, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007, Madrid, Spain
  • Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia, s/n, 07500, Manacor, Spain
  • Anesthesiology Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 47003, Valladolid, Spain
  • BIO∙SEPSIS (Laboratory of Biomedical Research in Sepsis), Hospital Clínico Universitario, SACYL, Av. Ramón y Cajal 3, 47003, Valladolid, Spain
  • GRECIA Group (Grupo de Estudios y Análisis en Cuidados Intensivos), Critical Care Medicine Service, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13613-017-0268-3

    DOI

    http://dx.doi.org/10.1186/s13613-017-0268-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085000657

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28429310


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Multidisciplinary Intensive Care Research Organization (MICRO), St. James\u2019s University Hospitals Dublin, James\u2019s St, Ushers, Dublin 8, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Multidisciplinary Intensive Care Research Organization (MICRO), St. James\u2019s University Hospitals Dublin, James\u2019s St, Ushers, Dublin 8, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin-Loeches", 
            "givenName": "Ignacio", 
            "id": "sg:person.01366266562.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366266562.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Intensive Care Department, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411280.e", 
              "name": [
                "Intensive Care Department, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muriel-Bomb\u00edn", 
            "givenName": "Arturo", 
            "id": "sg:person.0667546253.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667546253.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Intensive Care Department, Vall d\u2019Hebron University Hospital, Shock Organ Dysfunction and Resuscitation Research Group, Vall d\u2019 Hebron Research Institute, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferrer", 
            "givenName": "Ricard", 
            "id": "sg:person.01103311207.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103311207.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, C/Sinesio Delgado,4, 28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.512891.6", 
              "name": [
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "Critical Care Center, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Parc Taul\u00ed 1, 08208, Sabadell, Barcelona, Spain", 
                "CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, C/Sinesio Delgado,4, 28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Artigas", 
            "givenName": "Antonio", 
            "id": "sg:person.01307413475.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307413475.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena, s/n, 35010 Las Palmas de Gran Canaria, Las Palmas, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena, s/n, 35010 Las Palmas de Gran Canaria, Las Palmas, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sole-Violan", 
            "givenName": "Jordi", 
            "id": "sg:person.01142573341.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142573341.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Critical Care Medicine Service, Hospital Universitario de Canarias, Carretera de Ofra, s/n, 38320 San Crist\u00f3bal de La Laguna, Santa Cruz De Tenerife, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411220.4", 
              "name": [
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "Critical Care Medicine Service, Hospital Universitario de Canarias, Carretera de Ofra, s/n, 38320 San Crist\u00f3bal de La Laguna, Santa Cruz De Tenerife, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lorente", 
            "givenName": "Leonardo", 
            "id": "sg:person.01100400223.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100400223.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Critical Care Medicine Service, Hospital Cl\u00ednico Universitario de Valladolid, Av. Ram\u00f3n y Cajal, 3, 47003, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411057.6", 
              "name": [
                "Critical Care Medicine Service, Hospital Cl\u00ednico Universitario de Valladolid, Av. Ram\u00f3n y Cajal, 3, 47003, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andaluz-Ojeda", 
            "givenName": "David", 
            "id": "sg:person.01364167000.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364167000.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI), James\u2019s St, Dublin 8, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI), James\u2019s St, Dublin 8, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prina-Mello", 
            "givenName": "Adriele", 
            "id": "sg:person.0667217226.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667217226.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Intensive Care Department, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411280.e", 
              "name": [
                "Intensive Care Department, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herr\u00e1n-Monge", 
            "givenName": "Ruben", 
            "id": "sg:person.0610661124.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610661124.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Critical Care Medicine Service, Hospital Universitario Marqu\u00e9s de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411325.0", 
              "name": [
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "Critical Care Medicine Service, Hospital Universitario Marqu\u00e9s de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suberviola", 
            "givenName": "Borja", 
            "id": "sg:person.0604043203.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604043203.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Microbiology Service, Hospital Marques de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411325.0", 
              "name": [
                "Microbiology Service, Hospital Marques de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodriguez-Fernandez", 
            "givenName": "Ana", 
            "id": "sg:person.01246444715.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246444715.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Intensive Care Department, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411280.e", 
              "name": [
                "Intensive Care Department, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Merino", 
            "givenName": "Pedro", 
            "id": "sg:person.0604535320.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604535320.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Critical Care Medicine Service, Hospital Nuestra Se\u00f1ora de Valme, Av. de Bellavista, s/n, 41014, Seville, Spain", 
              "id": "http://www.grid.ac/institutes/grid.412800.f", 
              "name": [
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "Critical Care Medicine Service, Hospital Nuestra Se\u00f1ora de Valme, Av. de Bellavista, s/n, 41014, Seville, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loza", 
            "givenName": "Ana M.", 
            "id": "sg:person.0723043615.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723043615.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Critical Care Medicine Service, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Calle del Dr. Esquerdo, 46, 28007, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.410526.4", 
              "name": [
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "Critical Care Medicine Service, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Calle del Dr. Esquerdo, 46, 28007, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garcia-Olivares", 
            "givenName": "Pablo", 
            "id": "sg:person.01173077576.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173077576.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia, s/n, 07500, Manacor, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d\u2019Hebron University Hospital, Passeig de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain", 
                "Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia, s/n, 07500, Manacor, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anton", 
            "givenName": "Eduardo", 
            "id": "sg:person.015304320033.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015304320033.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anesthesiology Service, Hospital Cl\u00ednico Universitario de Valladolid, Av. Ram\u00f3n y Cajal, 47003, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411057.6", 
              "name": [
                "Anesthesiology Service, Hospital Cl\u00ednico Universitario de Valladolid, Av. Ram\u00f3n y Cajal, 47003, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tamayo", 
            "givenName": "Eduardo", 
            "id": "sg:person.01102333560.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102333560.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BIO\u2219SEPSIS (Laboratory of Biomedical Research in Sepsis), Hospital Cl\u00ednico Universitario, SACYL, Av. Ram\u00f3n y Cajal 3, 47003, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411057.6", 
              "name": [
                "BIO\u2219SEPSIS (Laboratory of Biomedical Research in Sepsis), Hospital Cl\u00ednico Universitario, SACYL, Av. Ram\u00f3n y Cajal 3, 47003, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trapiello", 
            "givenName": "Wysali", 
            "id": "sg:person.016677261033.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016677261033.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, C/Sinesio Delgado,4, 28029, Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.512891.6", 
              "name": [
                "Intensive Care Department, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain", 
                "CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, C/Sinesio Delgado,4, 28029, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blanco", 
            "givenName": "Jes\u00fas", 
            "id": "sg:person.01336550224.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336550224.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BIO\u2219SEPSIS (Laboratory of Biomedical Research in Sepsis), Hospital Cl\u00ednico Universitario, SACYL, Av. Ram\u00f3n y Cajal 3, 47003, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411057.6", 
              "name": [
                "BIO\u2219SEPSIS (Laboratory of Biomedical Research in Sepsis), Hospital Cl\u00ednico Universitario, SACYL, Av. Ram\u00f3n y Cajal 3, 47003, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bermejo-Martin", 
            "givenName": "Jes\u00fas F.", 
            "id": "sg:person.01056641115.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056641115.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GRECIA Group (Grupo de Estudios y An\u00e1lisis en Cuidados Intensivos), Critical Care Medicine Service, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411280.e", 
              "name": [
                "GRECIA Group (Grupo de Estudios y An\u00e1lisis en Cuidados Intensivos), Critical Care Medicine Service, Hospital Universitario R\u00edo Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "the GRECIA group", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/cc10597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050092298", 
              "https://doi.org/10.1186/cc10597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc11922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048606569", 
              "https://doi.org/10.1186/cc11922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-017-0238-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083738878", 
              "https://doi.org/10.1186/s13613-017-0238-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrdp.2016.45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053586679", 
              "https://doi.org/10.1038/nrdp.2016.45"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-3845-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051533276", 
              "https://doi.org/10.1007/s00134-015-3845-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00063-016-0220-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027587981", 
              "https://doi.org/10.1007/s00063-016-0220-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-015-0793-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028906832", 
              "https://doi.org/10.1186/s13054-015-0793-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-04-20", 
        "datePublishedReg": "2017-04-20", 
        "description": "BackgroundPre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment. The objective of this study was to evaluate the impact of endogenous immunoglobulins on the mortality risk in sepsis depending on disease severity.MethodsThis was a retrospective observational study including 278 patients admitted to the ICU with sepsis fulfilling the SEPSIS-3 criteria, coming from the Spanish GRECIA and ABISS-EDUSEPSIS cohorts. Patients were distributed into two groups depending on their Sequential Organ Failure Assessment score at ICU admission (SOFA\u00a0<\u00a08, n\u00a0=\u00a0122 and SOFA\u00a0\u2265\u00a08, n\u00a0=\u00a0156), and the association between immunoglobulin levels at ICU admission with mortality was studied in each group by Kaplan\u2013Meier and multivariate logistic regression analysis.ResultsICU/hospital mortality in the SOFA\u00a0<\u00a08 group was 14.8/23.0%, compared to 30.1/35.3% in the SOFA\u00a0\u2265\u00a08 group. In the group with SOFA\u00a0<\u00a08, the simultaneous presence of total IgG\u00a0<\u00a0407\u00a0mg/dl, IgM\u00a0<\u00a043\u00a0mg/dl and IgA\u00a0<\u00a0219\u00a0mg/dl was associated with a reduction in the survival mean time of 6.6\u00a0days in the first 28\u00a0days and was a robust predictor of mortality risk either during the acute or during the post-acute phase of the disease (OR for ICU mortality: 13.79; OR for hospital mortality: 7.98). This predictive ability remained in the absence of prior immunosuppression (OR for ICU mortality: 17.53; OR for hospital mortality: 5.63). Total IgG\u00a0<\u00a0407\u00a0mg/dl or IgG1\u00a0<\u00a0332\u00a0mg/dl was also an independent predictor of ICU mortality in this group. In contrast, in the SOFA\u00a0\u2265\u00a08 group, we found no immunoglobulin thresholds associated with neither ICU nor hospital mortality.ConclusionsEndogenous immunoglobulin levels may have a different impact on the mortality risk of sepsis patients based on their severity. In patients with moderate organ failure, the simultaneous presence of low levels of IgG, IgA and IgM was a consistent predictor of both acute and post-acute mortalities.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13613-017-0268-3", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045300", 
            "issn": [
              "2110-5820"
            ], 
            "name": "Annals of Intensive Care", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "keywords": [
          "immunoglobulin levels", 
          "mortality risk", 
          "ICU admission", 
          "hospital mortality", 
          "organ failure", 
          "total IgG", 
          "Sequential Organ Failure Assessment score", 
          "endogenous immunoglobulins", 
          "Organ Failure Assessment score", 
          "survival mean time", 
          "post-acute mortality", 
          "retrospective observational study", 
          "Sepsis-3 criteria", 
          "post-acute phase", 
          "logistic regression analysis", 
          "prior immunosuppression", 
          "intravenous immunoglobulin", 
          "ICU mortality", 
          "sepsis patients", 
          "sepsis mortality", 
          "independent predictors", 
          "Kaplan-Meier", 
          "protective association", 
          "observational study", 
          "patients", 
          "disease severity", 
          "sepsis", 
          "mortality", 
          "assessment scores", 
          "dl", 
          "immunoglobulin", 
          "mean time", 
          "IgG", 
          "ICU", 
          "admission", 
          "regression analysis", 
          "IgA", 
          "IgM", 
          "SOFA", 
          "potential strategy", 
          "risk", 
          "predictors", 
          "severity", 
          "group", 
          "consistent predictor", 
          "robust predictor", 
          "association", 
          "simultaneous presence", 
          "low levels", 
          "days", 
          "MethodsThis", 
          "immunosuppression", 
          "failure", 
          "levels", 
          "cohort", 
          "IgG1", 
          "disease", 
          "predictive ability", 
          "treatment", 
          "scores", 
          "more work", 
          "study", 
          "presence", 
          "absence", 
          "criteria", 
          "impact", 
          "contrast", 
          "reduction", 
          "objective", 
          "ability", 
          "strategies", 
          "different impacts", 
          "time", 
          "analysis", 
          "results", 
          "phase", 
          "work", 
          "Grecia"
        ], 
        "name": "The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure", 
        "pagination": "44", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085000657"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13613-017-0268-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28429310"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13613-017-0268-3", 
          "https://app.dimensions.ai/details/publication/pub.1085000657"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_729.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13613-017-0268-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13613-017-0268-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13613-017-0268-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13613-017-0268-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13613-017-0268-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    344 TRIPLES      21 PREDICATES      110 URIs      95 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13613-017-0268-3 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author Na0a982a66b54471aa3ce1f4b2ff8fc9a
    4 schema:citation sg:pub.10.1007/s00063-016-0220-6
    5 sg:pub.10.1007/s00134-015-3845-7
    6 sg:pub.10.1038/nrdp.2016.45
    7 sg:pub.10.1186/cc10597
    8 sg:pub.10.1186/cc11922
    9 sg:pub.10.1186/s13054-015-0793-0
    10 sg:pub.10.1186/s13613-017-0238-9
    11 schema:datePublished 2017-04-20
    12 schema:datePublishedReg 2017-04-20
    13 schema:description BackgroundPre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment. The objective of this study was to evaluate the impact of endogenous immunoglobulins on the mortality risk in sepsis depending on disease severity.MethodsThis was a retrospective observational study including 278 patients admitted to the ICU with sepsis fulfilling the SEPSIS-3 criteria, coming from the Spanish GRECIA and ABISS-EDUSEPSIS cohorts. Patients were distributed into two groups depending on their Sequential Organ Failure Assessment score at ICU admission (SOFA < 8, n = 122 and SOFA ≥ 8, n = 156), and the association between immunoglobulin levels at ICU admission with mortality was studied in each group by Kaplan–Meier and multivariate logistic regression analysis.ResultsICU/hospital mortality in the SOFA < 8 group was 14.8/23.0%, compared to 30.1/35.3% in the SOFA ≥ 8 group. In the group with SOFA < 8, the simultaneous presence of total IgG < 407 mg/dl, IgM < 43 mg/dl and IgA < 219 mg/dl was associated with a reduction in the survival mean time of 6.6 days in the first 28 days and was a robust predictor of mortality risk either during the acute or during the post-acute phase of the disease (OR for ICU mortality: 13.79; OR for hospital mortality: 7.98). This predictive ability remained in the absence of prior immunosuppression (OR for ICU mortality: 17.53; OR for hospital mortality: 5.63). Total IgG < 407 mg/dl or IgG1 < 332 mg/dl was also an independent predictor of ICU mortality in this group. In contrast, in the SOFA ≥ 8 group, we found no immunoglobulin thresholds associated with neither ICU nor hospital mortality.ConclusionsEndogenous immunoglobulin levels may have a different impact on the mortality risk of sepsis patients based on their severity. In patients with moderate organ failure, the simultaneous presence of low levels of IgG, IgA and IgM was a consistent predictor of both acute and post-acute mortalities.
    14 schema:genre article
    15 schema:isAccessibleForFree true
    16 schema:isPartOf N0a7ddbfd7d5d4adb91277cd7f1da4eac
    17 N21f2cfd453d540b09f0e28a0bb2e9db5
    18 sg:journal.1045300
    19 schema:keywords Grecia
    20 ICU
    21 ICU admission
    22 ICU mortality
    23 IgA
    24 IgG
    25 IgG1
    26 IgM
    27 Kaplan-Meier
    28 MethodsThis
    29 Organ Failure Assessment score
    30 SOFA
    31 Sepsis-3 criteria
    32 Sequential Organ Failure Assessment score
    33 ability
    34 absence
    35 admission
    36 analysis
    37 assessment scores
    38 association
    39 cohort
    40 consistent predictor
    41 contrast
    42 criteria
    43 days
    44 different impacts
    45 disease
    46 disease severity
    47 dl
    48 endogenous immunoglobulins
    49 failure
    50 group
    51 hospital mortality
    52 immunoglobulin
    53 immunoglobulin levels
    54 immunosuppression
    55 impact
    56 independent predictors
    57 intravenous immunoglobulin
    58 levels
    59 logistic regression analysis
    60 low levels
    61 mean time
    62 more work
    63 mortality
    64 mortality risk
    65 objective
    66 observational study
    67 organ failure
    68 patients
    69 phase
    70 post-acute mortality
    71 post-acute phase
    72 potential strategy
    73 predictive ability
    74 predictors
    75 presence
    76 prior immunosuppression
    77 protective association
    78 reduction
    79 regression analysis
    80 results
    81 retrospective observational study
    82 risk
    83 robust predictor
    84 scores
    85 sepsis
    86 sepsis mortality
    87 sepsis patients
    88 severity
    89 simultaneous presence
    90 strategies
    91 study
    92 survival mean time
    93 time
    94 total IgG
    95 treatment
    96 work
    97 schema:name The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure
    98 schema:pagination 44
    99 schema:productId N2501ca0d5b0f4006a2ddb02c84c2017e
    100 N49f93fa103344b71a74860b2977861ac
    101 N5eda483a74724ac7a6bedcccd3d16fef
    102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085000657
    103 https://doi.org/10.1186/s13613-017-0268-3
    104 schema:sdDatePublished 2022-11-24T21:02
    105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    106 schema:sdPublisher N71dd940d8088450f86214b4d85a845c6
    107 schema:url https://doi.org/10.1186/s13613-017-0268-3
    108 sgo:license sg:explorer/license/
    109 sgo:sdDataset articles
    110 rdf:type schema:ScholarlyArticle
    111 N0a7ddbfd7d5d4adb91277cd7f1da4eac schema:volumeNumber 7
    112 rdf:type schema:PublicationVolume
    113 N0b72c808b8b34f31883e00ddde38a107 rdf:first Na96c1ee30c674e0f8dcd75334a4d497a
    114 rdf:rest rdf:nil
    115 N0efd83376d924344ad99afeac048e815 rdf:first sg:person.01056641115.34
    116 rdf:rest N0b72c808b8b34f31883e00ddde38a107
    117 N1e3874387b384799af3918091f19c296 rdf:first sg:person.01100400223.37
    118 rdf:rest N3bd2e0adea524efb853d24d9e979d33d
    119 N21f2cfd453d540b09f0e28a0bb2e9db5 schema:issueNumber 1
    120 rdf:type schema:PublicationIssue
    121 N2501ca0d5b0f4006a2ddb02c84c2017e schema:name pubmed_id
    122 schema:value 28429310
    123 rdf:type schema:PropertyValue
    124 N3651169c6ef84ee3a9a1a78b7c15d857 rdf:first sg:person.01307413475.98
    125 rdf:rest N41a685a7c4eb4ef4b9e204dda98b10ed
    126 N3bd2e0adea524efb853d24d9e979d33d rdf:first sg:person.01364167000.23
    127 rdf:rest Nd7e203dc83b84533ad3e51098c865b66
    128 N3c3646ea3bce4637bb58fe8807fc3d0b rdf:first sg:person.01246444715.05
    129 rdf:rest Nae9202f7d72e4223849d21adae4480f5
    130 N41a685a7c4eb4ef4b9e204dda98b10ed rdf:first sg:person.01142573341.81
    131 rdf:rest N1e3874387b384799af3918091f19c296
    132 N49f93fa103344b71a74860b2977861ac schema:name dimensions_id
    133 schema:value pub.1085000657
    134 rdf:type schema:PropertyValue
    135 N4d1d9d81ab2c4972a3170d0959176e10 rdf:first sg:person.0604043203.30
    136 rdf:rest N3c3646ea3bce4637bb58fe8807fc3d0b
    137 N594fdb11014246ada9a6ebaddff4945e rdf:first sg:person.016677261033.22
    138 rdf:rest N60fca290744f405dbab40b107de37b12
    139 N5eb4127e5b9f4655a2c5273409e486bb rdf:first sg:person.0610661124.44
    140 rdf:rest N4d1d9d81ab2c4972a3170d0959176e10
    141 N5eda483a74724ac7a6bedcccd3d16fef schema:name doi
    142 schema:value 10.1186/s13613-017-0268-3
    143 rdf:type schema:PropertyValue
    144 N60fca290744f405dbab40b107de37b12 rdf:first sg:person.01336550224.46
    145 rdf:rest N0efd83376d924344ad99afeac048e815
    146 N71dd940d8088450f86214b4d85a845c6 schema:name Springer Nature - SN SciGraph project
    147 rdf:type schema:Organization
    148 Na0a982a66b54471aa3ce1f4b2ff8fc9a rdf:first sg:person.01366266562.86
    149 rdf:rest Nfb86bee0612c44e0b930e8fbab1964c8
    150 Na18088d54b2844ecb09462db4cf57be2 rdf:first sg:person.01173077576.71
    151 rdf:rest Nf64150b05392411b9a965e28685a38c3
    152 Na96c1ee30c674e0f8dcd75334a4d497a schema:affiliation grid-institutes:grid.411280.e
    153 schema:familyName the GRECIA group
    154 rdf:type schema:Person
    155 Nacf06c93dc1c4931ba902eea398443a3 rdf:first sg:person.0723043615.11
    156 rdf:rest Na18088d54b2844ecb09462db4cf57be2
    157 Nae9202f7d72e4223849d21adae4480f5 rdf:first sg:person.0604535320.46
    158 rdf:rest Nacf06c93dc1c4931ba902eea398443a3
    159 Nd7192d06cde1413f8c2f2293801381eb rdf:first sg:person.01102333560.06
    160 rdf:rest N594fdb11014246ada9a6ebaddff4945e
    161 Nd7e203dc83b84533ad3e51098c865b66 rdf:first sg:person.0667217226.91
    162 rdf:rest N5eb4127e5b9f4655a2c5273409e486bb
    163 Ne3fdaf3197d5499198fbf7cd3b3ff400 rdf:first sg:person.01103311207.17
    164 rdf:rest N3651169c6ef84ee3a9a1a78b7c15d857
    165 Nf64150b05392411b9a965e28685a38c3 rdf:first sg:person.015304320033.54
    166 rdf:rest Nd7192d06cde1413f8c2f2293801381eb
    167 Nfb86bee0612c44e0b930e8fbab1964c8 rdf:first sg:person.0667546253.39
    168 rdf:rest Ne3fdaf3197d5499198fbf7cd3b3ff400
    169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Medical and Health Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Clinical Sciences
    174 rdf:type schema:DefinedTerm
    175 sg:journal.1045300 schema:issn 2110-5820
    176 schema:name Annals of Intensive Care
    177 schema:publisher Springer Nature
    178 rdf:type schema:Periodical
    179 sg:person.01056641115.34 schema:affiliation grid-institutes:grid.411057.6
    180 schema:familyName Bermejo-Martin
    181 schema:givenName Jesús F.
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056641115.34
    183 rdf:type schema:Person
    184 sg:person.01100400223.37 schema:affiliation grid-institutes:grid.411220.4
    185 schema:familyName Lorente
    186 schema:givenName Leonardo
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100400223.37
    188 rdf:type schema:Person
    189 sg:person.01102333560.06 schema:affiliation grid-institutes:grid.411057.6
    190 schema:familyName Tamayo
    191 schema:givenName Eduardo
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102333560.06
    193 rdf:type schema:Person
    194 sg:person.01103311207.17 schema:affiliation grid-institutes:grid.411083.f
    195 schema:familyName Ferrer
    196 schema:givenName Ricard
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103311207.17
    198 rdf:type schema:Person
    199 sg:person.01142573341.81 schema:affiliation grid-institutes:None
    200 schema:familyName Sole-Violan
    201 schema:givenName Jordi
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142573341.81
    203 rdf:type schema:Person
    204 sg:person.01173077576.71 schema:affiliation grid-institutes:grid.410526.4
    205 schema:familyName Garcia-Olivares
    206 schema:givenName Pablo
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173077576.71
    208 rdf:type schema:Person
    209 sg:person.01246444715.05 schema:affiliation grid-institutes:grid.411325.0
    210 schema:familyName Rodriguez-Fernandez
    211 schema:givenName Ana
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246444715.05
    213 rdf:type schema:Person
    214 sg:person.01307413475.98 schema:affiliation grid-institutes:grid.512891.6
    215 schema:familyName Artigas
    216 schema:givenName Antonio
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307413475.98
    218 rdf:type schema:Person
    219 sg:person.01336550224.46 schema:affiliation grid-institutes:grid.512891.6
    220 schema:familyName Blanco
    221 schema:givenName Jesús
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336550224.46
    223 rdf:type schema:Person
    224 sg:person.01364167000.23 schema:affiliation grid-institutes:grid.411057.6
    225 schema:familyName Andaluz-Ojeda
    226 schema:givenName David
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364167000.23
    228 rdf:type schema:Person
    229 sg:person.01366266562.86 schema:affiliation grid-institutes:None
    230 schema:familyName Martin-Loeches
    231 schema:givenName Ignacio
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366266562.86
    233 rdf:type schema:Person
    234 sg:person.015304320033.54 schema:affiliation grid-institutes:None
    235 schema:familyName Anton
    236 schema:givenName Eduardo
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015304320033.54
    238 rdf:type schema:Person
    239 sg:person.016677261033.22 schema:affiliation grid-institutes:grid.411057.6
    240 schema:familyName Trapiello
    241 schema:givenName Wysali
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016677261033.22
    243 rdf:type schema:Person
    244 sg:person.0604043203.30 schema:affiliation grid-institutes:grid.411325.0
    245 schema:familyName Suberviola
    246 schema:givenName Borja
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604043203.30
    248 rdf:type schema:Person
    249 sg:person.0604535320.46 schema:affiliation grid-institutes:grid.411280.e
    250 schema:familyName Merino
    251 schema:givenName Pedro
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604535320.46
    253 rdf:type schema:Person
    254 sg:person.0610661124.44 schema:affiliation grid-institutes:grid.411280.e
    255 schema:familyName Herrán-Monge
    256 schema:givenName Ruben
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610661124.44
    258 rdf:type schema:Person
    259 sg:person.0667217226.91 schema:affiliation grid-institutes:None
    260 schema:familyName Prina-Mello
    261 schema:givenName Adriele
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667217226.91
    263 rdf:type schema:Person
    264 sg:person.0667546253.39 schema:affiliation grid-institutes:grid.411280.e
    265 schema:familyName Muriel-Bombín
    266 schema:givenName Arturo
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667546253.39
    268 rdf:type schema:Person
    269 sg:person.0723043615.11 schema:affiliation grid-institutes:grid.412800.f
    270 schema:familyName Loza
    271 schema:givenName Ana M.
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723043615.11
    273 rdf:type schema:Person
    274 sg:pub.10.1007/s00063-016-0220-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027587981
    275 https://doi.org/10.1007/s00063-016-0220-6
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/s00134-015-3845-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051533276
    278 https://doi.org/10.1007/s00134-015-3845-7
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nrdp.2016.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053586679
    281 https://doi.org/10.1038/nrdp.2016.45
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1186/cc10597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050092298
    284 https://doi.org/10.1186/cc10597
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1186/cc11922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048606569
    287 https://doi.org/10.1186/cc11922
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/s13054-015-0793-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028906832
    290 https://doi.org/10.1186/s13054-015-0793-0
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/s13613-017-0238-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083738878
    293 https://doi.org/10.1186/s13613-017-0238-9
    294 rdf:type schema:CreativeWork
    295 grid-institutes:None schema:alternateName Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena, s/n, 35010 Las Palmas de Gran Canaria, Las Palmas, Spain
    296 Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia, s/n, 07500, Manacor, Spain
    297 Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI), James’s St, Dublin 8, Ireland
    298 Multidisciplinary Intensive Care Research Organization (MICRO), St. James’s University Hospitals Dublin, James’s St, Ushers, Dublin 8, Ireland
    299 schema:name ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    300 Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena, s/n, 35010 Las Palmas de Gran Canaria, Las Palmas, Spain
    301 Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia, s/n, 07500, Manacor, Spain
    302 Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI), James’s St, Dublin 8, Ireland
    303 Multidisciplinary Intensive Care Research Organization (MICRO), St. James’s University Hospitals Dublin, James’s St, Ushers, Dublin 8, Ireland
    304 rdf:type schema:Organization
    305 grid-institutes:grid.410526.4 schema:alternateName Critical Care Medicine Service, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007, Madrid, Spain
    306 schema:name ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    307 Critical Care Medicine Service, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007, Madrid, Spain
    308 rdf:type schema:Organization
    309 grid-institutes:grid.411057.6 schema:alternateName Anesthesiology Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 47003, Valladolid, Spain
    310 BIO∙SEPSIS (Laboratory of Biomedical Research in Sepsis), Hospital Clínico Universitario, SACYL, Av. Ramón y Cajal 3, 47003, Valladolid, Spain
    311 Critical Care Medicine Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 3, 47003, Valladolid, Spain
    312 schema:name Anesthesiology Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 47003, Valladolid, Spain
    313 BIO∙SEPSIS (Laboratory of Biomedical Research in Sepsis), Hospital Clínico Universitario, SACYL, Av. Ramón y Cajal 3, 47003, Valladolid, Spain
    314 Critical Care Medicine Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 3, 47003, Valladolid, Spain
    315 rdf:type schema:Organization
    316 grid-institutes:grid.411083.f schema:alternateName ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    317 schema:name ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    318 Intensive Care Department, Vall d’Hebron University Hospital, Shock Organ Dysfunction and Resuscitation Research Group, Vall d’ Hebron Research Institute, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    319 rdf:type schema:Organization
    320 grid-institutes:grid.411220.4 schema:alternateName Critical Care Medicine Service, Hospital Universitario de Canarias, Carretera de Ofra, s/n, 38320 San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain
    321 schema:name ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    322 Critical Care Medicine Service, Hospital Universitario de Canarias, Carretera de Ofra, s/n, 38320 San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain
    323 rdf:type schema:Organization
    324 grid-institutes:grid.411280.e schema:alternateName GRECIA Group (Grupo de Estudios y Análisis en Cuidados Intensivos), Critical Care Medicine Service, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain
    325 Intensive Care Department, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain
    326 schema:name GRECIA Group (Grupo de Estudios y Análisis en Cuidados Intensivos), Critical Care Medicine Service, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain
    327 Intensive Care Department, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain
    328 rdf:type schema:Organization
    329 grid-institutes:grid.411325.0 schema:alternateName Critical Care Medicine Service, Hospital Universitario Marqués de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain
    330 Microbiology Service, Hospital Marques de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain
    331 schema:name ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    332 Critical Care Medicine Service, Hospital Universitario Marqués de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain
    333 Microbiology Service, Hospital Marques de Valdecilla, Av. Valdecilla, 25, 39008, Santander, Spain
    334 rdf:type schema:Organization
    335 grid-institutes:grid.412800.f schema:alternateName Critical Care Medicine Service, Hospital Nuestra Señora de Valme, Av. de Bellavista, s/n, 41014, Seville, Spain
    336 schema:name ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    337 Critical Care Medicine Service, Hospital Nuestra Señora de Valme, Av. de Bellavista, s/n, 41014, Seville, Spain
    338 rdf:type schema:Organization
    339 grid-institutes:grid.512891.6 schema:alternateName CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, C/Sinesio Delgado,4, 28029, Madrid, Spain
    340 schema:name ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis), Intensive Care Department, Vall d’Hebron University Hospital, Passeig de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
    341 CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, C/Sinesio Delgado,4, 28029, Madrid, Spain
    342 Critical Care Center, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Parc Taulí 1, 08208, Sabadell, Barcelona, Spain
    343 Intensive Care Department, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2, 47012, Valladolid, Spain
    344 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...