A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Adam T. Fox, Harm Wopereis, Marleen T. J. Van Ampting, Manon M. Oude Nijhuis, Assad M. Butt, Diego G. Peroni, Yvan Vandenplas, David C. A. Candy, Neil Shah, Christina E. West, Johan Garssen, Lucien F. Harthoorn, Jan Knol, Louise J. Michaelis, ASSIGN study group

ABSTRACT

Background: Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infants with non-immunoglobulin E (IgE)-mediated cow's milk allergy (CMA). Methods: Subjects were randomized to receive test product (AAF including fructo-oligosaccharides and Bifidobacterium breve M-16V) or control product (AAF) for 8 weeks, after which infants could continue study product until 26 weeks. Fecal percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) were assessed at 0, 8, 12, and 26 weeks. Additional endpoints included stool markers of gut immune status, clinical symptoms, and safety assessments including adverse events and medication use. Results: The trial included 35 test subjects, 36 controls, and 51 in the healthy reference group. Study product was continued by 86% and 92% of test and control subjects between week 8-12, and by 71% and 80%, respectively until week 26. At week 26 median percentages of bifidobacteria were significantly higher in test than control [47.0% vs. 11.8% (p < 0.001)], whereas percentages of ER/CC were significantly lower [(13.7% vs. 23.6% (p = 0.003)]. Safety parameters were similar between groups. Interestingly use of dermatological medication and reported ear infections were lower in test versus control, p = 0.019 and 0.011, respectively. Baseline clinical symptoms and stool markers were mild (but persistent) and low, respectively. Symptoms reduced towards lowest score in both groups. Conclusion: Beneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26 weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.Trial Registration NTR3979. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13601-019-0241-3

DOI

http://dx.doi.org/10.1186/s13601-019-0241-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111412605

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30651972


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Health Service", 
          "id": "https://www.grid.ac/institutes/grid.451052.7", 
          "name": [
            "Guy\u2019s and St Thomas\u2019 Hospitals NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fox", 
        "givenName": "Adam T.", 
        "id": "sg:person.01103533410.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103533410.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wageningen University & Research", 
          "id": "https://www.grid.ac/institutes/grid.4818.5", 
          "name": [
            "Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands", 
            "Wageningen University, Wageningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wopereis", 
        "givenName": "Harm", 
        "id": "sg:person.0656362714.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656362714.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Ampting", 
        "givenName": "Marleen T. J.", 
        "id": "sg:person.01335025775.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335025775.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oude Nijhuis", 
        "givenName": "Manon M.", 
        "id": "sg:person.011634747413.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011634747413.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Alexandra Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416080.b", 
          "name": [
            "Royal Alexandra Children\u2019s Hospital, Brighton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Butt", 
        "givenName": "Assad M.", 
        "id": "sg:person.0750764175.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750764175.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Integrata Verona", 
          "id": "https://www.grid.ac/institutes/grid.411475.2", 
          "name": [
            "University Hospital Verona, Verona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peroni", 
        "givenName": "Diego G.", 
        "id": "sg:person.014172205313.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014172205313.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandenplas", 
        "givenName": "Yvan", 
        "id": "sg:person.01214066013.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214066013.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Alexandra Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416080.b", 
          "name": [
            "Royal Alexandra Children\u2019s Hospital, Brighton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Candy", 
        "givenName": "David C. A.", 
        "id": "sg:person.015072522144.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015072522144.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Great Ormond Street, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Neil", 
        "id": "sg:person.0701136062.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701136062.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ume\u00e5 University", 
          "id": "https://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "Ume\u00e5 University, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "West", 
        "givenName": "Christina E.", 
        "id": "sg:person.01302733510.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302733510.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands", 
            "Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garssen", 
        "givenName": "Johan", 
        "id": "sg:person.01170650437.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170650437.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harthoorn", 
        "givenName": "Lucien F.", 
        "id": "sg:person.01146253504.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146253504.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wageningen University & Research", 
          "id": "https://www.grid.ac/institutes/grid.4818.5", 
          "name": [
            "Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands", 
            "Wageningen University, Wageningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knol", 
        "givenName": "Jan", 
        "id": "sg:person.0677165525.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677165525.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Great North Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.459561.a", 
          "name": [
            "Great North Children\u2019s Hospital, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michaelis", 
        "givenName": "Louise J.", 
        "id": "sg:person.014304431275.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014304431275.20"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "ASSIGN study group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cyto.2016.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000359113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2010.03465.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000889734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2013.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001161658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2013.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001161658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2011-000637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001638213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.05.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004362686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pai.12390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006302862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s000711451500015x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006334088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0158498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007710132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/iid3.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007799516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0009922811425234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007894194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0009922811425234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007894194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2891-12-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008760660", 
          "https://doi.org/10.1186/1475-2891-12-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aad0917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012295476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2013.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012444968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000001360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014648342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0000000000001360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014648342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-014-2422-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017245004", 
          "https://doi.org/10.1007/s00431-014-2422-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-014-2422-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017245004", 
          "https://doi.org/10.1007/s00431-014-2422-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-3038.2009.00907.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017258364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-3038.2009.00907.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017258364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pai.12232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018969590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2013.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019678205", 
          "https://doi.org/10.1038/pr.2013.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.47.4.506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020344510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.02063-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020376256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2015.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020928769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)92650-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021794273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)92650-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021794273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cea.12332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022534310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3182993fe0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022639696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e3182993fe0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022639696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/all.12630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022916529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ismej.2015.177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026945768", 
          "https://doi.org/10.1038/ismej.2015.177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/1744666x.2014.874946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027738982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2332/allergolint.13-oa-0683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027869727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.04.060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028984795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apa.12349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030602359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2016.03.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031772289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e31825c9482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033283016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpg.0b013e31825c9482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033283016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000236000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035444222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0004563216653417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037553060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0004563216653417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037553060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042887509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2008.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044313046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aad9378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045400470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2222.1999.00666.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047487462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40168-015-0104-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049392580", 
          "https://doi.org/10.1186/s40168-015-0104-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/249784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051697313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1573396311666150731113059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069204843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/138.6.1141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077651467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078714184", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078757632", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078915192", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079059299", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079331253", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2017.00356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084433294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcf.2017.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084851655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcf.2017.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084851655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13601-017-0162-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090795945", 
          "https://doi.org/10.1186/s13601-017-0162-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13601-017-0162-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090795945", 
          "https://doi.org/10.1186/s13601-017-0162-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2017.270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092792014", 
          "https://doi.org/10.1038/pr.2017.270"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Background: Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infants with non-immunoglobulin E (IgE)-mediated cow's milk allergy (CMA).\nMethods: Subjects were randomized to receive test product (AAF including fructo-oligosaccharides and Bifidobacterium breve M-16V) or control product (AAF) for 8\u00a0weeks, after which infants could continue study product until 26\u00a0weeks. Fecal percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) were assessed at 0, 8, 12, and 26\u00a0weeks. Additional endpoints included stool markers of gut immune status, clinical symptoms, and safety assessments including adverse events and medication use.\nResults: The trial included 35 test subjects, 36 controls, and 51 in the healthy reference group. Study product was continued by 86% and 92% of test and control subjects between week 8-12, and by 71% and 80%, respectively until week 26. At week 26 median percentages of bifidobacteria were significantly higher in test than control [47.0% vs. 11.8% (p\u2009<\u20090.001)], whereas percentages of ER/CC were significantly lower [(13.7% vs. 23.6% (p\u2009=\u20090.003)]. Safety parameters were similar between groups. Interestingly use of dermatological medication and reported ear infections were lower in test versus control, p\u2009=\u20090.019 and 0.011, respectively. Baseline clinical symptoms and stool markers were mild (but persistent) and low, respectively. Symptoms reduced towards lowest score in both groups.\nConclusion: Beneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26\u00a0weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.Trial Registration NTR3979.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13601-019-0241-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1046232", 
        "issn": [
          "2045-7022"
        ], 
        "name": "Clinical and Translational Allergy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "A specific synbiotic-containing amino acid-based formula in dietary management of cow\u2019s milk allergy: a randomized controlled trial", 
    "pagination": "5", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e81f37685b85daf2cd4c6de1aab1b58db689440188eb2ecd726aa7648b35181c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30651972"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101576043"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13601-019-0241-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111412605"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13601-019-0241-3", 
      "https://app.dimensions.ai/details/publication/pub.1111412605"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000321_0000000321/records_74938_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13601-019-0241-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13601-019-0241-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13601-019-0241-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13601-019-0241-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13601-019-0241-3'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      21 PREDICATES      80 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13601-019-0241-3 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N9be79884d2b145f29fc43d9945e54245
4 schema:citation sg:pub.10.1007/s00431-014-2422-3
5 sg:pub.10.1038/ismej.2015.177
6 sg:pub.10.1038/pr.2013.211
7 sg:pub.10.1038/pr.2017.270
8 sg:pub.10.1186/1475-2891-12-22
9 sg:pub.10.1186/s13601-017-0162-y
10 sg:pub.10.1186/s40168-015-0104-7
11 https://app.dimensions.ai/details/publication/pub.1078714184
12 https://app.dimensions.ai/details/publication/pub.1078757632
13 https://app.dimensions.ai/details/publication/pub.1078915192
14 https://app.dimensions.ai/details/publication/pub.1079059299
15 https://app.dimensions.ai/details/publication/pub.1079331253
16 https://doi.org/10.1002/iid3.101
17 https://doi.org/10.1016/j.celrep.2016.05.047
18 https://doi.org/10.1016/j.clim.2015.05.007
19 https://doi.org/10.1016/j.cyto.2016.09.014
20 https://doi.org/10.1016/j.jaci.2008.03.018
21 https://doi.org/10.1016/j.jaci.2011.04.060
22 https://doi.org/10.1016/j.jaci.2011.10.004
23 https://doi.org/10.1016/j.jaci.2016.03.041
24 https://doi.org/10.1016/j.jcf.2017.03.010
25 https://doi.org/10.1016/j.jpeds.2013.03.008
26 https://doi.org/10.1016/j.ymeth.2013.08.005
27 https://doi.org/10.1016/s0140-6736(78)92650-8
28 https://doi.org/10.1017/s000711451500015x
29 https://doi.org/10.1046/j.1365-2222.1999.00666.x
30 https://doi.org/10.1093/jn/138.6.1141
31 https://doi.org/10.1097/mpg.0000000000001360
32 https://doi.org/10.1097/mpg.0b013e31825c9482
33 https://doi.org/10.1097/mpg.0b013e3182993fe0
34 https://doi.org/10.1111/all.12630
35 https://doi.org/10.1111/apa.12349
36 https://doi.org/10.1111/cea.12332
37 https://doi.org/10.1111/j.1365-2222.2010.03465.x
38 https://doi.org/10.1111/j.1399-3038.2009.00907.x
39 https://doi.org/10.1111/pai.12232
40 https://doi.org/10.1111/pai.12390
41 https://doi.org/10.1126/science.aad9378
42 https://doi.org/10.1126/scitranslmed.aad0917
43 https://doi.org/10.1128/aem.02063-08
44 https://doi.org/10.1136/bmjopen-2011-000637
45 https://doi.org/10.1136/gut.47.4.506
46 https://doi.org/10.1155/2014/249784
47 https://doi.org/10.1159/000236000
48 https://doi.org/10.1177/0004563216653417
49 https://doi.org/10.1177/0009922811425234
50 https://doi.org/10.1371/journal.pone.0158498
51 https://doi.org/10.1586/1744666x.2014.874946
52 https://doi.org/10.2174/1573396311666150731113059
53 https://doi.org/10.2332/allergolint.13-oa-0683
54 https://doi.org/10.3389/fmicb.2017.00356
55 schema:datePublished 2019-12
56 schema:datePublishedReg 2019-12-01
57 schema:description Background: Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infants with non-immunoglobulin E (IgE)-mediated cow's milk allergy (CMA). Methods: Subjects were randomized to receive test product (AAF including fructo-oligosaccharides and Bifidobacterium breve M-16V) or control product (AAF) for 8 weeks, after which infants could continue study product until 26 weeks. Fecal percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) were assessed at 0, 8, 12, and 26 weeks. Additional endpoints included stool markers of gut immune status, clinical symptoms, and safety assessments including adverse events and medication use. Results: The trial included 35 test subjects, 36 controls, and 51 in the healthy reference group. Study product was continued by 86% and 92% of test and control subjects between week 8-12, and by 71% and 80%, respectively until week 26. At week 26 median percentages of bifidobacteria were significantly higher in test than control [47.0% vs. 11.8% (p < 0.001)], whereas percentages of ER/CC were significantly lower [(13.7% vs. 23.6% (p = 0.003)]. Safety parameters were similar between groups. Interestingly use of dermatological medication and reported ear infections were lower in test versus control, p = 0.019 and 0.011, respectively. Baseline clinical symptoms and stool markers were mild (but persistent) and low, respectively. Symptoms reduced towards lowest score in both groups. Conclusion: Beneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26 weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.Trial Registration NTR3979.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N2e9b69191d1242079afd9d2e70f35d71
62 N8bee8116227a4a1bb6293f9e4d7efc86
63 sg:journal.1046232
64 schema:name A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial
65 schema:pagination 5
66 schema:productId N5e68643ae632414f89491a82738084d3
67 Na58e8f2a24994836b2227728a78e2a54
68 Na999964c5d9045689f547bcef6e26ffc
69 Nf5a4a14424e440068f998121dd8d3354
70 Nfb0fa59d8bee407e88991e8229936eba
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111412605
72 https://doi.org/10.1186/s13601-019-0241-3
73 schema:sdDatePublished 2019-04-11T08:42
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nba24bc47bceb4bd6870cc0eb66923021
76 schema:url https://link.springer.com/10.1186%2Fs13601-019-0241-3
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N086b5e23bcea40729fb6bfa9faa049a0 rdf:first sg:person.015072522144.27
81 rdf:rest Nb1238abec2144cd39bee27755436e28c
82 N0ca8ac874ed543458c5b8bd9c55b6924 rdf:first N3b97039469ae424b9586075d9011d7c4
83 rdf:rest rdf:nil
84 N19bc01714064417a94bd511821773d4c schema:name UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
85 rdf:type schema:Organization
86 N2e9b69191d1242079afd9d2e70f35d71 schema:issueNumber 1
87 rdf:type schema:PublicationIssue
88 N39fd60c8662941fa888b016194f9c74d schema:name Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands
89 rdf:type schema:Organization
90 N3b97039469ae424b9586075d9011d7c4 schema:familyName ASSIGN study group
91 rdf:type schema:Person
92 N5e68643ae632414f89491a82738084d3 schema:name pubmed_id
93 schema:value 30651972
94 rdf:type schema:PropertyValue
95 N5e797c6b4553448b941a14b6e0dfaa5f rdf:first sg:person.0750764175.71
96 rdf:rest Ncfd43fce12a0497e92f3a51200ab5980
97 N61fe312a5317445194cada58468bd3d2 rdf:first sg:person.01302733510.58
98 rdf:rest Nf9ad0c76907f4e9f944f376ef8d2675f
99 N636e8d47832b48b1a96beecab3ba9de2 rdf:first sg:person.0677165525.69
100 rdf:rest N83b72b1826de4f9384821cd879526bff
101 N69434c7b364949a3b303f4c58d5197b1 rdf:first sg:person.011634747413.84
102 rdf:rest N5e797c6b4553448b941a14b6e0dfaa5f
103 N83b72b1826de4f9384821cd879526bff rdf:first sg:person.014304431275.20
104 rdf:rest N0ca8ac874ed543458c5b8bd9c55b6924
105 N8bee8116227a4a1bb6293f9e4d7efc86 schema:volumeNumber 9
106 rdf:type schema:PublicationVolume
107 N91de33e89a3041c4a2ea8cd70945cf9f schema:name Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands
108 rdf:type schema:Organization
109 N9be79884d2b145f29fc43d9945e54245 rdf:first sg:person.01103533410.32
110 rdf:rest Na25cba493aa6464191cfe35c2e093add
111 Na25cba493aa6464191cfe35c2e093add rdf:first sg:person.0656362714.08
112 rdf:rest Nf7f797850d64481e82260261067c2e3a
113 Na58e8f2a24994836b2227728a78e2a54 schema:name doi
114 schema:value 10.1186/s13601-019-0241-3
115 rdf:type schema:PropertyValue
116 Na999964c5d9045689f547bcef6e26ffc schema:name readcube_id
117 schema:value e81f37685b85daf2cd4c6de1aab1b58db689440188eb2ecd726aa7648b35181c
118 rdf:type schema:PropertyValue
119 Nb1238abec2144cd39bee27755436e28c rdf:first sg:person.0701136062.18
120 rdf:rest N61fe312a5317445194cada58468bd3d2
121 Nba24bc47bceb4bd6870cc0eb66923021 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 Ncfd43fce12a0497e92f3a51200ab5980 rdf:first sg:person.014172205313.74
124 rdf:rest Ndc5aab0250c247819afd29c74715616e
125 Nd82442cc62e54cf68ecd0388ff2cb3c8 rdf:first sg:person.01146253504.03
126 rdf:rest N636e8d47832b48b1a96beecab3ba9de2
127 Ndc5aab0250c247819afd29c74715616e rdf:first sg:person.01214066013.68
128 rdf:rest N086b5e23bcea40729fb6bfa9faa049a0
129 Nef1e6a5b6e6644b581954edd50c290ec schema:name Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands
130 rdf:type schema:Organization
131 Nf5a4a14424e440068f998121dd8d3354 schema:name dimensions_id
132 schema:value pub.1111412605
133 rdf:type schema:PropertyValue
134 Nf7f797850d64481e82260261067c2e3a rdf:first sg:person.01335025775.15
135 rdf:rest N69434c7b364949a3b303f4c58d5197b1
136 Nf9ad0c76907f4e9f944f376ef8d2675f rdf:first sg:person.01170650437.06
137 rdf:rest Nd82442cc62e54cf68ecd0388ff2cb3c8
138 Nfb0fa59d8bee407e88991e8229936eba schema:name nlm_unique_id
139 schema:value 101576043
140 rdf:type schema:PropertyValue
141 Nfc2b4ae491be435591292ef617d2ce2c schema:name Great Ormond Street, London, UK
142 rdf:type schema:Organization
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
147 schema:name Clinical Sciences
148 rdf:type schema:DefinedTerm
149 sg:journal.1046232 schema:issn 2045-7022
150 schema:name Clinical and Translational Allergy
151 rdf:type schema:Periodical
152 sg:person.01103533410.32 schema:affiliation https://www.grid.ac/institutes/grid.451052.7
153 schema:familyName Fox
154 schema:givenName Adam T.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103533410.32
156 rdf:type schema:Person
157 sg:person.01146253504.03 schema:affiliation N39fd60c8662941fa888b016194f9c74d
158 schema:familyName Harthoorn
159 schema:givenName Lucien F.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146253504.03
161 rdf:type schema:Person
162 sg:person.011634747413.84 schema:affiliation Nef1e6a5b6e6644b581954edd50c290ec
163 schema:familyName Oude Nijhuis
164 schema:givenName Manon M.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011634747413.84
166 rdf:type schema:Person
167 sg:person.01170650437.06 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
168 schema:familyName Garssen
169 schema:givenName Johan
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170650437.06
171 rdf:type schema:Person
172 sg:person.01214066013.68 schema:affiliation N19bc01714064417a94bd511821773d4c
173 schema:familyName Vandenplas
174 schema:givenName Yvan
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214066013.68
176 rdf:type schema:Person
177 sg:person.01302733510.58 schema:affiliation https://www.grid.ac/institutes/grid.12650.30
178 schema:familyName West
179 schema:givenName Christina E.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302733510.58
181 rdf:type schema:Person
182 sg:person.01335025775.15 schema:affiliation N91de33e89a3041c4a2ea8cd70945cf9f
183 schema:familyName Van Ampting
184 schema:givenName Marleen T. J.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335025775.15
186 rdf:type schema:Person
187 sg:person.014172205313.74 schema:affiliation https://www.grid.ac/institutes/grid.411475.2
188 schema:familyName Peroni
189 schema:givenName Diego G.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014172205313.74
191 rdf:type schema:Person
192 sg:person.014304431275.20 schema:affiliation https://www.grid.ac/institutes/grid.459561.a
193 schema:familyName Michaelis
194 schema:givenName Louise J.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014304431275.20
196 rdf:type schema:Person
197 sg:person.015072522144.27 schema:affiliation https://www.grid.ac/institutes/grid.416080.b
198 schema:familyName Candy
199 schema:givenName David C. A.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015072522144.27
201 rdf:type schema:Person
202 sg:person.0656362714.08 schema:affiliation https://www.grid.ac/institutes/grid.4818.5
203 schema:familyName Wopereis
204 schema:givenName Harm
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656362714.08
206 rdf:type schema:Person
207 sg:person.0677165525.69 schema:affiliation https://www.grid.ac/institutes/grid.4818.5
208 schema:familyName Knol
209 schema:givenName Jan
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677165525.69
211 rdf:type schema:Person
212 sg:person.0701136062.18 schema:affiliation Nfc2b4ae491be435591292ef617d2ce2c
213 schema:familyName Shah
214 schema:givenName Neil
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701136062.18
216 rdf:type schema:Person
217 sg:person.0750764175.71 schema:affiliation https://www.grid.ac/institutes/grid.416080.b
218 schema:familyName Butt
219 schema:givenName Assad M.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750764175.71
221 rdf:type schema:Person
222 sg:pub.10.1007/s00431-014-2422-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017245004
223 https://doi.org/10.1007/s00431-014-2422-3
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ismej.2015.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026945768
226 https://doi.org/10.1038/ismej.2015.177
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/pr.2013.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019678205
229 https://doi.org/10.1038/pr.2013.211
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/pr.2017.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092792014
232 https://doi.org/10.1038/pr.2017.270
233 rdf:type schema:CreativeWork
234 sg:pub.10.1186/1475-2891-12-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008760660
235 https://doi.org/10.1186/1475-2891-12-22
236 rdf:type schema:CreativeWork
237 sg:pub.10.1186/s13601-017-0162-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1090795945
238 https://doi.org/10.1186/s13601-017-0162-y
239 rdf:type schema:CreativeWork
240 sg:pub.10.1186/s40168-015-0104-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049392580
241 https://doi.org/10.1186/s40168-015-0104-7
242 rdf:type schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1078714184 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1078757632 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1078915192 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1079059299 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1079331253 schema:CreativeWork
248 https://doi.org/10.1002/iid3.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007799516
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.celrep.2016.05.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004362686
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.clim.2015.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020928769
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.cyto.2016.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000359113
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.jaci.2008.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044313046
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.jaci.2011.04.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028984795
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.jaci.2011.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042887509
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.jaci.2016.03.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031772289
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.jcf.2017.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084851655
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.jpeds.2013.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012444968
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.ymeth.2013.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001161658
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0140-6736(78)92650-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021794273
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1017/s000711451500015x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006334088
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1046/j.1365-2222.1999.00666.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047487462
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1093/jn/138.6.1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077651467
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1097/mpg.0000000000001360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014648342
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1097/mpg.0b013e31825c9482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033283016
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1097/mpg.0b013e3182993fe0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022639696
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1111/all.12630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022916529
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1111/apa.12349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030602359
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1111/cea.12332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022534310
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1111/j.1365-2222.2010.03465.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000889734
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1111/j.1399-3038.2009.00907.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017258364
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1111/pai.12232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018969590
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1111/pai.12390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006302862
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1126/science.aad9378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045400470
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/scitranslmed.aad0917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012295476
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1128/aem.02063-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020376256
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1136/bmjopen-2011-000637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001638213
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1136/gut.47.4.506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020344510
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1155/2014/249784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051697313
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1159/000236000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035444222
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1177/0004563216653417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037553060
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1177/0009922811425234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007894194
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1371/journal.pone.0158498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007710132
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1586/1744666x.2014.874946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027738982
319 rdf:type schema:CreativeWork
320 https://doi.org/10.2174/1573396311666150731113059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069204843
321 rdf:type schema:CreativeWork
322 https://doi.org/10.2332/allergolint.13-oa-0683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027869727
323 rdf:type schema:CreativeWork
324 https://doi.org/10.3389/fmicb.2017.00356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084433294
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.12650.30 schema:alternateName Umeå University
327 schema:name Umeå University, Umeå, Sweden
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.411475.2 schema:alternateName Azienda Ospedaliera Universitaria Integrata Verona
330 schema:name University Hospital Verona, Verona, Italy
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.416080.b schema:alternateName Royal Alexandra Children's Hospital
333 schema:name Royal Alexandra Children’s Hospital, Brighton, UK
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.451052.7 schema:alternateName National Health Service
336 schema:name Guy’s and St Thomas’ Hospitals NHS Foundation Trust, London, UK
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.459561.a schema:alternateName Great North Children's Hospital
339 schema:name Great North Children’s Hospital, Newcastle upon Tyne, UK
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.4818.5 schema:alternateName Wageningen University & Research
342 schema:name Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands
343 Wageningen University, Wageningen, The Netherlands
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.5477.1 schema:alternateName Utrecht University
346 schema:name Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Uppsalalaan 12, 3584 CT, Utrecht, The Netherlands
347 Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...