Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ozlem Keskin, Niloufar Farzan, Esra Birben, Hayriye Akel, Cagatay Karaaslan, Anke H. Maitland-van der Zee, Michael E. Wechsler, Susanne J. Vijverberg, Omer Kalayci

ABSTRACT

There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influences response to treatment and genetic markers may help guide treatment. Over the past years, researchers have investigated the relationship between a large number of genetic variations and response to ICS by performing pharmacogenomic studies. In this systematic review we will provide a summary of recent pharmacogenomic studies on ICS and discuss the latest insight into the potential functional role of identified genetic variants. To date, seven genome wide association studies (GWAS) examining ICS response have been published. There is little overlap between identified variants and methodologies vary largely. However, in vitro and/or in silico analyses provide additional evidence that genes discovered in these GWAS (e.g. GLCCI1, FBXL7, T gene, ALLC, CMTR1) might play a direct or indirect role in asthma/treatment response pathways. Furthermore, more than 30 candidate-gene studies have been performed, mainly attempting to replicate variants discovered in GWAS or candidate genes likely involved in the corticosteroid drug pathway. Single nucleotide polymorphisms located in GLCCI1, NR3C1 and the 17q21 locus were positively replicated in independent populations. Although none of the genetic markers has currently reached clinical practise, these studies might provide novel insights in the complex pathways underlying corticosteroids response in asthmatic patients. More... »

PAGES

2

References to SciGraph publications

  • 2016-04. Genetic variation in uncontrolled childhood asthma despite ICS treatment in THE PHARMACOGENOMICS JOURNAL
  • 2015-02-05. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7 in CELL DEATH & DISEASE
  • 2005-08. Tankyrase-1 overexpression reduces genotoxin-induced cell death by inhibiting PARP1 in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2014-12. Cost Effectiveness of New Oral Anticoagulants for Stroke Prevention in Patients with Atrial Fibrillation in Two Different European Healthcare Settings in AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
  • 2017-03-13. Genetics of coronary artery disease: discovery, biology and clinical translation in NATURE REVIEWS GENETICS
  • 2013-06. Pharmacogenetics of asthma controller treatment in THE PHARMACOGENOMICS JOURNAL
  • 2017-12. The cost of systemic corticosteroid-induced morbidity in severe asthma: a health economic analysis in RESPIRATORY RESEARCH
  • 2003-12. Interferon-α/β receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006 in BMC IMMUNOLOGY
  • 2013-06. Mechanisms and function of substrate recruitment by F-box proteins in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-10. Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma in THE PHARMACOGENOMICS JOURNAL
  • 1994-07. An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus in NATURE GENETICS
  • 2013-12. Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene in SCIENTIFIC REPORTS
  • 2010-01. Genome-wide association study identifies five loci associated with lung function in NATURE GENETICS
  • 2013-12. Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma in THE PHARMACOGENOMICS JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13601-018-0239-2

    DOI

    http://dx.doi.org/10.1186/s13601-018-0239-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111312744

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30647901


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Gaziantep University", 
              "id": "https://www.grid.ac/institutes/grid.411549.c", 
              "name": [
                "Paediatric Allergy and Immunology Department, School of Medicine, Gaziantep University, Gaziantep, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Keskin", 
            "givenName": "Ozlem", 
            "id": "sg:person.0630441114.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630441114.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Department of Respiratory Medicine, University of Amsterdam, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Farzan", 
            "givenName": "Niloufar", 
            "id": "sg:person.013543143544.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543143544.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hacettepe University", 
              "id": "https://www.grid.ac/institutes/grid.14442.37", 
              "name": [
                "Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, 06100, Ankara, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Birben", 
            "givenName": "Esra", 
            "id": "sg:person.0766221720.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766221720.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hacettepe University", 
              "id": "https://www.grid.ac/institutes/grid.14442.37", 
              "name": [
                "Department of Molecular Biology, Faculty of Sciences, Hacettepe University, Ankara, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akel", 
            "givenName": "Hayriye", 
            "id": "sg:person.011575012721.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011575012721.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hacettepe University", 
              "id": "https://www.grid.ac/institutes/grid.14442.37", 
              "name": [
                "Department of Molecular Biology, Faculty of Sciences, Hacettepe University, Ankara, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karaaslan", 
            "givenName": "Cagatay", 
            "id": "sg:person.0637232476.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637232476.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Department of Respiratory Medicine, University of Amsterdam, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands", 
                "Department of Pediatric Respiratory Medicine and Allergy, University of Amsterdam, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maitland-van der Zee", 
            "givenName": "Anke H.", 
            "id": "sg:person.011734054627.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011734054627.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Jewish Health", 
              "id": "https://www.grid.ac/institutes/grid.240341.0", 
              "name": [
                "Department of Medicine, National Jewish Health, Denver, CO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wechsler", 
            "givenName": "Michael E.", 
            "id": "sg:person.0634720620.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634720620.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Department of Respiratory Medicine, University of Amsterdam, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vijverberg", 
            "givenName": "Susanne J.", 
            "id": "sg:person.014363334527.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014363334527.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hacettepe University", 
              "id": "https://www.grid.ac/institutes/grid.14442.37", 
              "name": [
                "Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, 06100, Ankara, Turkey"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kalayci", 
            "givenName": "Omer", 
            "id": "sg:person.01173157374.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173157374.21"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/(sici)1099-0496(200004)29:4<250::aid-ppul3>3.0.co;2-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002343927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.rmed.2008.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002501198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.arcmed.2016.04.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003134628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcp.0b013e32831da8be", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003248849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcp.0b013e32831da8be", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003248849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.06-7236com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003271801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(99)00917-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003276982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep02915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003656426", 
              "https://doi.org/10.1038/srep02915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(02)02264-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004345606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0303-7207(95)03481-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004451798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2014.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004474333", 
              "https://doi.org/10.1038/tpj.2014.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-005-4059-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004594614", 
              "https://doi.org/10.1007/s11010-005-4059-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-005-4059-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004594614", 
              "https://doi.org/10.1007/s11010-005-4059-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004800023", 
              "https://doi.org/10.1038/ng.501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004800023", 
              "https://doi.org/10.1038/ng.501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cca.2014.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008041953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cea.12844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008261377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2015.10.045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009841587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.11.4.19171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009966402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2478/v10039-008-0042-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010140372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2478/v10039-008-0042-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010140372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2015.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010901583", 
              "https://doi.org/10.1038/tpj.2015.36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2013.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011354267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200407-864oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013000568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200407-864oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013000568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.155283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014577169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-02-0608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015448072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jclinepi.2009.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016851659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1196/annals.1321.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017054560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2007.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018095739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mai.2002.128723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019973019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mai.2002.128723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019973019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.165.7.2109096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020185249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thoraxjnl-2013-204114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020542292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thoraxjnl-2013-204114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020542292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drudis.2011.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020608206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2004.11.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022430264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.16.9124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024286268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40256-014-0092-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025417612", 
              "https://doi.org/10.1007/s40256-014-0092-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40256-014-0092-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025417612", 
              "https://doi.org/10.1007/s40256-014-0092-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/iid3.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027161325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2265.2003.01888.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027656140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0960-0760(93)90052-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027803292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddh149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027992664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0794-383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028330135", 
              "https://doi.org/10.1038/ng0794-383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.2011.04130.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029515359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.05.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029607493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2005.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029868458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/pai.12566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030113083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.324.7340.763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031328927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2222.2003.01674.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034306593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2006/149863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035278477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cea.12492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035490480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2012.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035948302", 
              "https://doi.org/10.1038/tpj.2012.36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2710.2009.01054.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036225007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2710.2009.01054.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036225007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2008.04.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037558595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.14.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038296014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2013.08.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038632833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.2011.02701.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039764033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2014.585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043609829", 
              "https://doi.org/10.1038/cddis.2014.585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2172-4-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043825279", 
              "https://doi.org/10.1186/1471-2172-4-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0911353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044390108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1399-3003.1999.13e43.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045466065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.09.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047348152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0408532102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047515424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048273907", 
              "https://doi.org/10.1038/nrm3582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.629931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049564749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2013.12.1042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050689708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201111-2061oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051297401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.12400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053403948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2012.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053622094", 
              "https://doi.org/10.1038/tpj.2012.5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mcp.0000146781.11092.0d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060330992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mcp.0000146781.11092.0d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060330992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mcp.0000146781.11092.0d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060330992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mcp.0000146781.11092.0d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060330992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.284.5414.601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062565009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1258/0007142001903535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064532394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-130-6-199903160-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073703197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075004181", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs-2016-0174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083920431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2016.160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129678", 
              "https://doi.org/10.1038/nrg.2016.160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs-2017-0035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086120512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12931-017-0614-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086323258", 
              "https://doi.org/10.1186/s12931-017-0614-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12931-017-0614-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086323258", 
              "https://doi.org/10.1186/s12931-017-0614-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs-2017-0093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090373376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17476348.2018.1403318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092578194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000009442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100093241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000009442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100093241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000009442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100093241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18176/jiaci.0229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100515781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/oemed-2017-104787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101125673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/oemed-2017-104787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101125673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.13499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104494116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.13499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104494116"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influences response to treatment and genetic markers may help guide treatment. Over the past years, researchers have investigated the relationship between a large number of genetic variations and response to ICS by performing pharmacogenomic studies. In this systematic review we will provide a summary of recent pharmacogenomic studies on ICS and discuss the latest insight into the potential functional role of identified genetic variants. To date, seven genome wide association studies (GWAS) examining ICS response have been published. There is little overlap between identified variants and methodologies vary largely. However, in vitro and/or in silico analyses provide additional evidence that genes discovered in these GWAS (e.g. GLCCI1, FBXL7, T gene, ALLC, CMTR1) might play a direct or indirect role in asthma/treatment response pathways. Furthermore, more than 30 candidate-gene studies have been performed, mainly attempting to replicate variants discovered in GWAS or candidate genes likely involved in the corticosteroid drug pathway. Single nucleotide polymorphisms located in GLCCI1, NR3C1 and the 17q21 locus were positively replicated in independent populations. Although none of the genetic markers has currently reached clinical practise, these studies might provide novel insights in the complex pathways underlying corticosteroids response in asthmatic patients.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13601-018-0239-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1046232", 
            "issn": [
              "2045-7022"
            ], 
            "name": "Clinical and Translational Allergy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review", 
        "pagination": "2", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c39c7e0eb3ee70f0ff2d945a0bc8f0a171c66d5f91e7198bfe046aa499903164"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30647901"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101576043"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13601-018-0239-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111312744"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13601-018-0239-2", 
          "https://app.dimensions.ai/details/publication/pub.1111312744"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:41", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000320_0000000320/records_101387_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs13601-018-0239-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13601-018-0239-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13601-018-0239-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13601-018-0239-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13601-018-0239-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    382 TRIPLES      21 PREDICATES      107 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13601-018-0239-2 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N37623b2699894a779dc6cebb3dceca81
    4 schema:citation sg:pub.10.1007/s11010-005-4059-z
    5 sg:pub.10.1007/s40256-014-0092-1
    6 sg:pub.10.1038/cddis.2014.585
    7 sg:pub.10.1038/ng.501
    8 sg:pub.10.1038/ng0794-383
    9 sg:pub.10.1038/nrg.2016.160
    10 sg:pub.10.1038/nrm3582
    11 sg:pub.10.1038/srep02915
    12 sg:pub.10.1038/tpj.2012.36
    13 sg:pub.10.1038/tpj.2012.5
    14 sg:pub.10.1038/tpj.2014.83
    15 sg:pub.10.1038/tpj.2015.36
    16 sg:pub.10.1186/1471-2172-4-8
    17 sg:pub.10.1186/s12931-017-0614-x
    18 https://app.dimensions.ai/details/publication/pub.1075004181
    19 https://doi.org/10.1002/(sici)1099-0496(200004)29:4<250::aid-ppul3>3.0.co;2-4
    20 https://doi.org/10.1002/iid3.73
    21 https://doi.org/10.1016/0303-7207(95)03481-l
    22 https://doi.org/10.1016/0960-0760(93)90052-x
    23 https://doi.org/10.1016/j.arcmed.2016.04.005
    24 https://doi.org/10.1016/j.cca.2014.04.023
    25 https://doi.org/10.1016/j.drudis.2011.09.001
    26 https://doi.org/10.1016/j.jaci.2004.11.014
    27 https://doi.org/10.1016/j.jaci.2007.09.005
    28 https://doi.org/10.1016/j.jaci.2008.04.015
    29 https://doi.org/10.1016/j.jaci.2013.08.024
    30 https://doi.org/10.1016/j.jaci.2013.09.007
    31 https://doi.org/10.1016/j.jaci.2013.12.1042
    32 https://doi.org/10.1016/j.jaci.2015.10.045
    33 https://doi.org/10.1016/j.jaci.2016.05.032
    34 https://doi.org/10.1016/j.jclinepi.2009.06.005
    35 https://doi.org/10.1016/j.rmed.2008.08.003
    36 https://doi.org/10.1016/j.sbi.2005.01.009
    37 https://doi.org/10.1016/s0014-5793(02)02264-0
    38 https://doi.org/10.1016/s0014-5793(99)00917-5
    39 https://doi.org/10.1034/j.1399-3003.1999.13e43.x
    40 https://doi.org/10.1046/j.1365-2222.2003.01674.x
    41 https://doi.org/10.1046/j.1365-2265.2003.01888.x
    42 https://doi.org/10.1056/nejmoa0911353
    43 https://doi.org/10.1067/mai.2002.128723
    44 https://doi.org/10.1073/pnas.0408532102
    45 https://doi.org/10.1073/pnas.96.16.9124
    46 https://doi.org/10.1074/jbc.m110.155283
    47 https://doi.org/10.1074/jbc.m114.629931
    48 https://doi.org/10.1080/17476348.2018.1403318
    49 https://doi.org/10.1093/hmg/ddh149
    50 https://doi.org/10.1096/fj.06-7236com
    51 https://doi.org/10.1097/01.mcp.0000146781.11092.0d
    52 https://doi.org/10.1097/mcp.0b013e32831da8be
    53 https://doi.org/10.1097/md.0000000000009442
    54 https://doi.org/10.1111/all.12400
    55 https://doi.org/10.1111/all.13499
    56 https://doi.org/10.1111/cea.12492
    57 https://doi.org/10.1111/cea.12844
    58 https://doi.org/10.1111/j.1365-2125.2011.04130.x
    59 https://doi.org/10.1111/j.1365-2710.2009.01054.x
    60 https://doi.org/10.1111/j.1398-9995.2011.02701.x
    61 https://doi.org/10.1111/pai.12566
    62 https://doi.org/10.1126/science.284.5414.601
    63 https://doi.org/10.1136/bmj.324.7340.763
    64 https://doi.org/10.1136/oemed-2017-104787
    65 https://doi.org/10.1136/thoraxjnl-2013-204114
    66 https://doi.org/10.1155/2006/149863
    67 https://doi.org/10.1164/ajrccm.165.7.2109096
    68 https://doi.org/10.1164/rccm.200407-864oc
    69 https://doi.org/10.1164/rccm.201111-2061oc
    70 https://doi.org/10.1182/blood-2002-02-0608
    71 https://doi.org/10.1196/annals.1321.008
    72 https://doi.org/10.1258/0007142001903535
    73 https://doi.org/10.18176/jiaci.0229
    74 https://doi.org/10.2217/pgs-2016-0174
    75 https://doi.org/10.2217/pgs-2017-0035
    76 https://doi.org/10.2217/pgs-2017-0093
    77 https://doi.org/10.2217/pgs.09.86
    78 https://doi.org/10.2217/pgs.14.37
    79 https://doi.org/10.2478/v10039-008-0042-8
    80 https://doi.org/10.4161/cc.11.4.19171
    81 https://doi.org/10.7326/0003-4819-130-6-199903160-00005
    82 schema:datePublished 2019-12
    83 schema:datePublishedReg 2019-12-01
    84 schema:description There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influences response to treatment and genetic markers may help guide treatment. Over the past years, researchers have investigated the relationship between a large number of genetic variations and response to ICS by performing pharmacogenomic studies. In this systematic review we will provide a summary of recent pharmacogenomic studies on ICS and discuss the latest insight into the potential functional role of identified genetic variants. To date, seven genome wide association studies (GWAS) examining ICS response have been published. There is little overlap between identified variants and methodologies vary largely. However, in vitro and/or in silico analyses provide additional evidence that genes discovered in these GWAS (e.g. <i>GLCCI1</i>, <i>FBXL7</i>, <i>T gene</i>, <i>ALLC</i>, <i>CMTR1</i>) might play a direct or indirect role in asthma/treatment response pathways. Furthermore, more than 30 candidate-gene studies have been performed, mainly attempting to replicate variants discovered in GWAS or candidate genes likely involved in the corticosteroid drug pathway. Single nucleotide polymorphisms located in <i>GLCCI1</i>, <i>NR3C1</i> and the <i>17q21</i> locus were positively replicated in independent populations. Although none of the genetic markers has currently reached clinical practise, these studies might provide novel insights in the complex pathways underlying corticosteroids response in asthmatic patients.
    85 schema:genre research_article
    86 schema:inLanguage en
    87 schema:isAccessibleForFree true
    88 schema:isPartOf N2f0f388d58704866b2d3d3324bf3916a
    89 N73bf506b925f41a090d239ec353ea95f
    90 sg:journal.1046232
    91 schema:name Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review
    92 schema:pagination 2
    93 schema:productId N1e91053e1304430d979493a086a57c8e
    94 N758ee6bbdda94f118908281b5a87e217
    95 N80f1ed238bc24f9aa6e9a21a74e57e9e
    96 Nf715b765578946c0825703315601a232
    97 Nff27bd4796264b59965af0c6b2bd9700
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111312744
    99 https://doi.org/10.1186/s13601-018-0239-2
    100 schema:sdDatePublished 2019-04-11T08:41
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N56a456dd1f9549f0aa819f2fff9f8252
    103 schema:url https://link.springer.com/10.1186%2Fs13601-018-0239-2
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N1e91053e1304430d979493a086a57c8e schema:name pubmed_id
    108 schema:value 30647901
    109 rdf:type schema:PropertyValue
    110 N21b1b2883a4d4a32ba5e5a5f9f4be585 rdf:first sg:person.013543143544.95
    111 rdf:rest N76b18ad57ec94af4b678e9b3dcb2d7f0
    112 N2f0f388d58704866b2d3d3324bf3916a schema:volumeNumber 9
    113 rdf:type schema:PublicationVolume
    114 N37623b2699894a779dc6cebb3dceca81 rdf:first sg:person.0630441114.28
    115 rdf:rest N21b1b2883a4d4a32ba5e5a5f9f4be585
    116 N45740346015342deaf2a5e1d007359f0 rdf:first sg:person.0634720620.25
    117 rdf:rest N6b690788394a44629c238e433b635549
    118 N4a618ca222ac475f8b8571acb87dc72e rdf:first sg:person.01173157374.21
    119 rdf:rest rdf:nil
    120 N56a456dd1f9549f0aa819f2fff9f8252 schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 N6b690788394a44629c238e433b635549 rdf:first sg:person.014363334527.15
    123 rdf:rest N4a618ca222ac475f8b8571acb87dc72e
    124 N73bf506b925f41a090d239ec353ea95f schema:issueNumber 1
    125 rdf:type schema:PublicationIssue
    126 N758ee6bbdda94f118908281b5a87e217 schema:name nlm_unique_id
    127 schema:value 101576043
    128 rdf:type schema:PropertyValue
    129 N76b18ad57ec94af4b678e9b3dcb2d7f0 rdf:first sg:person.0766221720.38
    130 rdf:rest Nd7196a9ed68e4f43ae51f898ccd0f279
    131 N80f1ed238bc24f9aa6e9a21a74e57e9e schema:name readcube_id
    132 schema:value c39c7e0eb3ee70f0ff2d945a0bc8f0a171c66d5f91e7198bfe046aa499903164
    133 rdf:type schema:PropertyValue
    134 Naa40d7136c05471fb4256b04703c070b rdf:first sg:person.011734054627.26
    135 rdf:rest N45740346015342deaf2a5e1d007359f0
    136 Nc2b13c416d9146bf92d8dce7de80bf2a rdf:first sg:person.0637232476.95
    137 rdf:rest Naa40d7136c05471fb4256b04703c070b
    138 Nd7196a9ed68e4f43ae51f898ccd0f279 rdf:first sg:person.011575012721.26
    139 rdf:rest Nc2b13c416d9146bf92d8dce7de80bf2a
    140 Nf715b765578946c0825703315601a232 schema:name doi
    141 schema:value 10.1186/s13601-018-0239-2
    142 rdf:type schema:PropertyValue
    143 Nff27bd4796264b59965af0c6b2bd9700 schema:name dimensions_id
    144 schema:value pub.1111312744
    145 rdf:type schema:PropertyValue
    146 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    147 schema:name Biological Sciences
    148 rdf:type schema:DefinedTerm
    149 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Genetics
    151 rdf:type schema:DefinedTerm
    152 sg:journal.1046232 schema:issn 2045-7022
    153 schema:name Clinical and Translational Allergy
    154 rdf:type schema:Periodical
    155 sg:person.011575012721.26 schema:affiliation https://www.grid.ac/institutes/grid.14442.37
    156 schema:familyName Akel
    157 schema:givenName Hayriye
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011575012721.26
    159 rdf:type schema:Person
    160 sg:person.01173157374.21 schema:affiliation https://www.grid.ac/institutes/grid.14442.37
    161 schema:familyName Kalayci
    162 schema:givenName Omer
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173157374.21
    164 rdf:type schema:Person
    165 sg:person.011734054627.26 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
    166 schema:familyName Maitland-van der Zee
    167 schema:givenName Anke H.
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011734054627.26
    169 rdf:type schema:Person
    170 sg:person.013543143544.95 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
    171 schema:familyName Farzan
    172 schema:givenName Niloufar
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543143544.95
    174 rdf:type schema:Person
    175 sg:person.014363334527.15 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
    176 schema:familyName Vijverberg
    177 schema:givenName Susanne J.
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014363334527.15
    179 rdf:type schema:Person
    180 sg:person.0630441114.28 schema:affiliation https://www.grid.ac/institutes/grid.411549.c
    181 schema:familyName Keskin
    182 schema:givenName Ozlem
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630441114.28
    184 rdf:type schema:Person
    185 sg:person.0634720620.25 schema:affiliation https://www.grid.ac/institutes/grid.240341.0
    186 schema:familyName Wechsler
    187 schema:givenName Michael E.
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634720620.25
    189 rdf:type schema:Person
    190 sg:person.0637232476.95 schema:affiliation https://www.grid.ac/institutes/grid.14442.37
    191 schema:familyName Karaaslan
    192 schema:givenName Cagatay
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637232476.95
    194 rdf:type schema:Person
    195 sg:person.0766221720.38 schema:affiliation https://www.grid.ac/institutes/grid.14442.37
    196 schema:familyName Birben
    197 schema:givenName Esra
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766221720.38
    199 rdf:type schema:Person
    200 sg:pub.10.1007/s11010-005-4059-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004594614
    201 https://doi.org/10.1007/s11010-005-4059-z
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/s40256-014-0092-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025417612
    204 https://doi.org/10.1007/s40256-014-0092-1
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/cddis.2014.585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043609829
    207 https://doi.org/10.1038/cddis.2014.585
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ng.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004800023
    210 https://doi.org/10.1038/ng.501
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/ng0794-383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028330135
    213 https://doi.org/10.1038/ng0794-383
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nrg.2016.160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129678
    216 https://doi.org/10.1038/nrg.2016.160
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nrm3582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048273907
    219 https://doi.org/10.1038/nrm3582
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/srep02915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003656426
    222 https://doi.org/10.1038/srep02915
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/tpj.2012.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035948302
    225 https://doi.org/10.1038/tpj.2012.36
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/tpj.2012.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053622094
    228 https://doi.org/10.1038/tpj.2012.5
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/tpj.2014.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004474333
    231 https://doi.org/10.1038/tpj.2014.83
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/tpj.2015.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010901583
    234 https://doi.org/10.1038/tpj.2015.36
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1186/1471-2172-4-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043825279
    237 https://doi.org/10.1186/1471-2172-4-8
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1186/s12931-017-0614-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1086323258
    240 https://doi.org/10.1186/s12931-017-0614-x
    241 rdf:type schema:CreativeWork
    242 https://app.dimensions.ai/details/publication/pub.1075004181 schema:CreativeWork
    243 https://doi.org/10.1002/(sici)1099-0496(200004)29:4<250::aid-ppul3>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002343927
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1002/iid3.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027161325
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/0303-7207(95)03481-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1004451798
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/0960-0760(93)90052-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027803292
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.arcmed.2016.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003134628
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.cca.2014.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008041953
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.drudis.2011.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020608206
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.jaci.2004.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022430264
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.jaci.2007.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018095739
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.jaci.2008.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037558595
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.jaci.2013.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038632833
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.jaci.2013.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011354267
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.jaci.2013.12.1042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050689708
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.jaci.2015.10.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009841587
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.jaci.2016.05.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029607493
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.jclinepi.2009.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016851659
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.rmed.2008.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002501198
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.sbi.2005.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029868458
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/s0014-5793(02)02264-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004345606
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s0014-5793(99)00917-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003276982
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1034/j.1399-3003.1999.13e43.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045466065
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1046/j.1365-2222.2003.01674.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034306593
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1046/j.1365-2265.2003.01888.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027656140
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1056/nejmoa0911353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044390108
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1067/mai.2002.128723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019973019
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1073/pnas.0408532102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047515424
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1073/pnas.96.16.9124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024286268
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1074/jbc.m110.155283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014577169
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1074/jbc.m114.629931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049564749
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1080/17476348.2018.1403318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092578194
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1093/hmg/ddh149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027992664
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1096/fj.06-7236com schema:sameAs https://app.dimensions.ai/details/publication/pub.1003271801
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1097/01.mcp.0000146781.11092.0d schema:sameAs https://app.dimensions.ai/details/publication/pub.1060330992
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1097/mcp.0b013e32831da8be schema:sameAs https://app.dimensions.ai/details/publication/pub.1003248849
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1097/md.0000000000009442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100093241
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1111/all.12400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053403948
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1111/all.13499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104494116
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1111/cea.12492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035490480
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1111/cea.12844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008261377
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1111/j.1365-2125.2011.04130.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029515359
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1111/j.1365-2710.2009.01054.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036225007
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1111/j.1398-9995.2011.02701.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039764033
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1111/pai.12566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030113083
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1126/science.284.5414.601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565009
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1136/bmj.324.7340.763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031328927
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1136/oemed-2017-104787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101125673
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1136/thoraxjnl-2013-204114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020542292
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1155/2006/149863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035278477
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1164/ajrccm.165.7.2109096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020185249
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1164/rccm.200407-864oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1013000568
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1164/rccm.201111-2061oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1051297401
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1182/blood-2002-02-0608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015448072
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1196/annals.1321.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017054560
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1258/0007142001903535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064532394
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.18176/jiaci.0229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100515781
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.2217/pgs-2016-0174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083920431
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.2217/pgs-2017-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086120512
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.2217/pgs-2017-0093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090373376
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.2217/pgs.09.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047348152
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.2217/pgs.14.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038296014
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.2478/v10039-008-0042-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010140372
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.4161/cc.11.4.19171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009966402
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.7326/0003-4819-130-6-199903160-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073703197
    368 rdf:type schema:CreativeWork
    369 https://www.grid.ac/institutes/grid.14442.37 schema:alternateName Hacettepe University
    370 schema:name Department of Molecular Biology, Faculty of Sciences, Hacettepe University, Ankara, Turkey
    371 Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, 06100, Ankara, Turkey
    372 rdf:type schema:Organization
    373 https://www.grid.ac/institutes/grid.240341.0 schema:alternateName National Jewish Health
    374 schema:name Department of Medicine, National Jewish Health, Denver, CO, USA
    375 rdf:type schema:Organization
    376 https://www.grid.ac/institutes/grid.411549.c schema:alternateName Gaziantep University
    377 schema:name Paediatric Allergy and Immunology Department, School of Medicine, Gaziantep University, Gaziantep, Turkey
    378 rdf:type schema:Organization
    379 https://www.grid.ac/institutes/grid.7177.6 schema:alternateName University of Amsterdam
    380 schema:name Department of Pediatric Respiratory Medicine and Allergy, University of Amsterdam, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands
    381 Department of Respiratory Medicine, University of Amsterdam, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands
    382 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...