Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Xiaoli Huang, Yang Feng, Guanqing Xiong, Shona Whyte, Jing Duan, Yucen Yang, Kaiyu Wang, Shiyong Yang, Yi Geng, Yangping Ou, Defang Chen

ABSTRACT

Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical inflammatory pathway. The non-canonical inflammatory pathway-induced pyroptosis is a unique immune response in response to gram-negative (G-) bacteria. It is induced by lipopolysaccharide (LPS) on the surface of G- bacteria. This activates caspase-11 which, in turn, activates a series of downstream proteins eventually forming protein pores on the cell membrane and inducing cell sacrificial processes. Caspase-11 belongs to the caspase family and is an homologous protein of caspase-1. It has the ability to specifically hydrolyze proteins, but it is still unclear how it regulates cell death caused by non-canonical inflammatory pathways. The present study describes a pathway that enables LPS to directly enter the cell and activate caspase-11, and the key role caspase-11 plays in the activation of pyroptosis and inflammation. More... »

PAGES

31

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13578-019-0292-0

DOI

http://dx.doi.org/10.1186/s13578-019-0292-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113045834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30962873


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