Function and dysfunction of plasma cells in intestine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Xue Wang, Gui-liang Hao, Bo-ya Wang, Chen-chen Gao, Yue-xiu Wang, Li-sheng Li, Jing-dong Xu

ABSTRACT

As the main player in humoral immunity, antibodies play indispensable roles in the body's immune system. Plasma cells (PCs), as antibody factories, are important contributors to humoral immunity. PCs, recognized by their unique marker CD138, are always discovered in the medullary cords of spleen and lymph nodes and in bone marrow and mucosal lymphoid tissue. This article will review the origin and differentiation of PCs, characteristics of short- and long-lived PCs, and the secretion of antibodies, such as IgA, IgM, and IgG. PCs play a crucial role in the maintenance of intestinal homeostasis using immunomodulation though complex mechanisms. Clearly, PCs play functional roles in maintaining intestinal health, but more details are needed to fully understand all the other effects of intestinal PCs. More... »

PAGES

26

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    http://scigraph.springernature.com/pub.10.1186/s13578-019-0288-9

    DOI

    http://dx.doi.org/10.1186/s13578-019-0288-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112739261

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30911371


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    Turtle is a human-readable linked data format.

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    RDF/XML is a standard XML format for linked data.

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