Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wnt/β-catenin and other signal transduction ... View Full Text


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Article Info

DATE

2019-02-01

AUTHORS

Suhail Razak, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam, Sarwat Jahan

ABSTRACT

BackgroundMore than the two decades, the question of whether vitamin D has a role in cancer frequency, development, and death has been premeditated in detail. Colorectal, breast, and prostate cancers have been a scrupulous spot of center, altogether, these three malignancies report for approximately 35% of cancer cases and 20% of cancer demises in the United States, and as such are a chief public health apprehension. The aim was to evaluate antitumor activity of Vitamin D-Nanoemulsion (NVD) in colorectal cancer cell lines and HCT116 xenograft model in a comprehensive approach.MethodsTwo human colorectal cancer cell lines HCT116 and HT29 (gained from College of Pharmacy, King Saud University, KSA were grown. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazoliumbromide protocol were performed to show the impact of NVD and β-catenin inhibitor (FH535) on the viability of HCT116 and HT29 cell lines. Apoptosis/cell cycle assay was performed. Analysis was done with a FACScan (Becton–Dickinson, NJ). About 10,000 cells per sample were harvested and Histograms of DNA were analyzed with ModiFitLT software (verity Software House, ME, USA). Western blotting and RT-PCR were performed for protein and gene expression respectively in in vitro and in vivo.ResultsWe found that NVD induced cytotoxicity in colorectal cells in a dose-dependent manner and time dependent approach. Further, our data validated that NVD administration of human colorectal cancer HCT116 and HT29 cells resulted in cell growth arrest, alteration in molecules regulating cell cycle operative in the G2 phase of the cell cycle and apoptosis in a dose dependent approach. Further our results concluded that NVD administration decreases expression of β-catenin gene, AKT gene and Survivin gene and protein expression in in vitro and in vivo.ConclusionOur findings suggest that targeting β-catenin gene may encourage the alterations of cell cycle and cell cycle regulators. Wnt/β-catenin signaling pathway possibly takes part in the genesis and progression of colorectal cancer cells through regulating cell cycle and the expression of cell cycle regulators. More... »

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References to SciGraph publications

  • 2005-05-15. An inhibitor of Bcl-2 family proteins induces regression of solid tumours in NATURE
  • 2010-06-14. SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity in ONCOGENE
  • 2018-10-26. Taxifolin, a natural flavonoid interacts with cell cycle regulators causes cell cycle arrest and causes tumor regression by activating Wnt/ β -catenin signaling pathway in BMC CANCER
  • 2008-01-25. Sprouty proteins, masterminds of receptor tyrosine kinase signaling in ANGIOGENESIS
  • 2012-12-21. WNT signalling pathways as therapeutic targets in cancer in NATURE REVIEWS CANCER
  • 2009. The Bradford Method For Protein Quantitation in THE PROTEIN PROTOCOLS HANDBOOK
  • 1997-08. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma in NATURE MEDICINE
  • 2000-05. Mitochondrial control of cell death in NATURE MEDICINE
  • 2008-01. Survivin, cancer networks and pathway-directed drug discovery in NATURE REVIEWS CANCER
  • 2011-07-15. Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2002-08. Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2005-04-01. Protein kinase CK2 phosphorylates and upregulates Akt/PKB in CELL DEATH & DIFFERENTIATION
  • 2003-01. Validating survivin as a cancer therapeutic target in NATURE REVIEWS CANCER
  • 2002-05-23. Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells in ONCOGENE
  • 2013-07-04. TGF-β1 regulates cell fate during epithelial–mesenchymal transition by upregulating survivin in CELL DEATH & DISEASE
  • 2007-08-01. Akt is involved in the inhibition of cell proliferation by EGF in EXPERIMENTAL & MOLECULAR MEDICINE
  • 2009-08-24. Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3 in ONCOGENE
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