Retrospective audit of 957 consecutive 18F-FDG PET–CT scans compared to CT and MRI in 493 patients with different histological subtypes ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Ruth E. Macpherson, Sarah Pratap, Helen Tyrrell, Mehrdad Khonsari, Shaun Wilson, Max Gibbons, Duncan Whitwell, Henk Giele, Paul Critchley, Lucy Cogswell, Sally Trent, Nick Athanasou, Kevin M. Bradley, A. Bassim Hassan

ABSTRACT

Background: The use of 18F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre. We also sought to answer three questions. Firstly, the correlation between sarcoma sub-type and grade with 18FDG SUVmax, secondly, the practical uses of PET-CT in the clinical setting of staging (during initial diagnosis), restaging (new baseline prior to definitive intervention) and treatment response. Finally, we also attempted to evaluate the potential additional benefit of PET-CT over concurrent conventional CT and MRI. Methods: A total of 957 consecutive PET-CT scans were performed in a single supra-regional centre in 493 sarcoma patients (excluding GIST) between 2007 and 2014. We compared, PET-CT SUVmax values in relation to histology and FNCCC grading. We compared PET-CT findings relative to concurrent conventional imaging (MRI and CT) in staging, restaging and treatment responses. Results: High-grade (II/III) bone and soft tissue sarcoma correlated with high SUVmax, especially undifferentiated pleomorphic sarcoma, leiomyosarcoma, translocation induced sarcomas (Ewing, synovial, alveolar rhabdomyosarcoma), de-differentiated liposarcoma and osteosarcoma. Lower SUVmax values were observed in sarcomas of low histological grade (grade I), and in rare subtypes of intermediate grade soft tissue sarcoma (e.g. alveolar soft part sarcoma and solitary fibrous tumour). SUVmax variation was noted in malignant peripheral nerve sheath tumours, compared to the histologically benign plexiform neurofibroma, whereas PET-CT could clearly differentiate low from high-grade chondrosarcoma. We identified added utility of PET-CT in addition to MRI and CT in high-grade sarcoma of bone and soft tissues. An estimated 21% overall potential benefit was observed for PET-CT over CT/MRI, and in particular, in 'upstaging' of high-grade disease (from M0 to M1) where an additional 12% of cases were deemed M1 following PET-CT. Conclusions: PET-CT in high-grade bone and soft tissue sarcoma can add significant benefit to routine CT/MRI staging. Further prospective and multi-centre evaluation of PET-CT is warranted to determine the actual predictive value and cost-effectiveness of PET-CT in directing clinical management of clinically complex and heterogeneous high-grade sarcomas. More... »

PAGES

9

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13569-018-0095-9

DOI

http://dx.doi.org/10.1186/s13569-018-0095-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101592594

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30116519


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Department of Radiology, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macpherson", 
        "givenName": "Ruth E.", 
        "id": "sg:person.01010113713.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010113713.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Churchill Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415719.f", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pratap", 
        "givenName": "Sarah", 
        "id": "sg:person.01323557022.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323557022.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Churchill Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415719.f", 
          "name": [
            "Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tyrrell", 
        "givenName": "Helen", 
        "id": "sg:person.01106436407.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106436407.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Department of Radiology, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khonsari", 
        "givenName": "Mehrdad", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Department of Paediatric Oncology, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Shaun", 
        "id": "sg:person.012477120450.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012477120450.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nuffield Orthopaedic Centre", 
          "id": "https://www.grid.ac/institutes/grid.461589.7", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gibbons", 
        "givenName": "Max", 
        "id": "sg:person.014047201420.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014047201420.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nuffield Orthopaedic Centre", 
          "id": "https://www.grid.ac/institutes/grid.461589.7", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whitwell", 
        "givenName": "Duncan", 
        "id": "sg:person.0670420011.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670420011.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nuffield Orthopaedic Centre", 
          "id": "https://www.grid.ac/institutes/grid.461589.7", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giele", 
        "givenName": "Henk", 
        "id": "sg:person.0711707517.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711707517.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nuffield Orthopaedic Centre", 
          "id": "https://www.grid.ac/institutes/grid.461589.7", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Critchley", 
        "givenName": "Paul", 
        "id": "sg:person.0760022717.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760022717.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nuffield Orthopaedic Centre", 
          "id": "https://www.grid.ac/institutes/grid.461589.7", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cogswell", 
        "givenName": "Lucy", 
        "id": "sg:person.01124643531.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124643531.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Churchill Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415719.f", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trent", 
        "givenName": "Sally", 
        "id": "sg:person.01271220063.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271220063.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "NIHR Musculoskeletal Biomedical Research Unit (Sarcoma Theme), Sarcoma and TYA Unit of the NHS Oncology Department, and Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Athanasou", 
        "givenName": "Nick", 
        "id": "sg:person.013046236517.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Department of Radiology, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bradley", 
        "givenName": "Kevin M.", 
        "id": "sg:person.012153423337.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012153423337.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK", 
            "NIHR Musculoskeletal Biomedical Research Unit (Sarcoma Theme), Sarcoma and TYA Unit of the NHS Oncology Department, and Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hassan", 
        "givenName": "A. Bassim", 
        "id": "sg:person.01107657620.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107657620.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2014.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003649526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-2139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007319181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.soc.2007.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019034157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2152/jmi.60.184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019557430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cpet.2015.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020115770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/960194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021576923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.crad.2016.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022010554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1203-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023885252", 
          "https://doi.org/10.1007/s00259-009-1203-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1203-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023885252", 
          "https://doi.org/10.1007/s00259-009-1203-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1203-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023885252", 
          "https://doi.org/10.1007/s00259-009-1203-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024244986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-012-2159-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026128077", 
          "https://doi.org/10.1007/s00259-012-2159-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2011.01178.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036283132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(10)70010-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036598456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.14140510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038780387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000152663.61348.6f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039482592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000152663.61348.6f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039482592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.23523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039661559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-013-2511-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039775122", 
          "https://doi.org/10.1007/s00259-013-2511-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045267524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000355224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045594315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000355224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045594315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0085954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049490907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.11.7560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069302043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.14.12932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069303799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.179.5.1791145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069325044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074808947", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075281548", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077689341", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.169.3.3055041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079528496"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Background: The use of 18F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre. We also sought to answer three questions. Firstly, the correlation between sarcoma sub-type and grade with 18FDG SUVmax, secondly, the practical uses of PET-CT in the clinical setting of staging (during initial diagnosis), restaging (new baseline prior to definitive intervention) and treatment response. Finally, we also attempted to evaluate the potential additional benefit of PET-CT over concurrent conventional CT and MRI.\nMethods: A total of 957 consecutive PET-CT scans were performed in a single supra-regional centre in 493 sarcoma patients (excluding GIST) between 2007 and 2014. We compared, PET-CT SUVmax values in relation to histology and FNCCC grading. We compared PET-CT findings relative to concurrent conventional imaging (MRI and CT) in staging, restaging and treatment responses.\nResults: High-grade (II/III) bone and soft tissue sarcoma correlated with high SUVmax, especially undifferentiated pleomorphic sarcoma, leiomyosarcoma, translocation induced sarcomas (Ewing, synovial, alveolar rhabdomyosarcoma), de-differentiated liposarcoma and osteosarcoma. Lower SUVmax values were observed in sarcomas of low histological grade (grade I), and in rare subtypes of intermediate grade soft tissue sarcoma (e.g. alveolar soft part sarcoma and solitary fibrous tumour). SUVmax variation was noted in malignant peripheral nerve sheath tumours, compared to the histologically benign plexiform neurofibroma, whereas PET-CT could clearly differentiate low from high-grade chondrosarcoma. We identified added utility of PET-CT in addition to MRI and CT in high-grade sarcoma of bone and soft tissues. An estimated 21% overall potential benefit was observed for PET-CT over CT/MRI, and in particular, in 'upstaging' of high-grade disease (from M0 to M1) where an additional 12% of cases were deemed M1 following PET-CT.\nConclusions: PET-CT in high-grade bone and soft tissue sarcoma can add significant benefit to routine CT/MRI staging. Further prospective and multi-centre evaluation of PET-CT is warranted to determine the actual predictive value and cost-effectiveness of PET-CT in directing clinical management of clinically complex and heterogeneous high-grade sarcomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13569-018-0095-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1046367", 
        "issn": [
          "2045-3329"
        ], 
        "name": "Clinical Sarcoma Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Retrospective audit of 957 consecutive 18F-FDG PET\u2013CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma", 
    "pagination": "9", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13569-018-0095-9"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ac9e449c14b18c4735b7de4031d83ea0fdfdec195e8b7f5249566cb215e0cced"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101592594"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101577890"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30116519"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13569-018-0095-9", 
      "https://app.dimensions.ai/details/publication/pub.1101592594"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119752_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13569-018-0095-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0095-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0095-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0095-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0095-9'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      55 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13569-018-0095-9 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N4c71902d8b914844a6387a7263f68b64
4 schema:citation sg:pub.10.1007/s00259-009-1203-0
5 sg:pub.10.1007/s00259-012-2159-z
6 sg:pub.10.1007/s00259-013-2511-y
7 https://app.dimensions.ai/details/publication/pub.1074808947
8 https://app.dimensions.ai/details/publication/pub.1075281548
9 https://app.dimensions.ai/details/publication/pub.1077689341
10 https://doi.org/10.1002/cncr.27866
11 https://doi.org/10.1002/jso.23523
12 https://doi.org/10.1016/j.cpet.2015.03.003
13 https://doi.org/10.1016/j.crad.2016.05.001
14 https://doi.org/10.1016/j.ijrobp.2014.08.005
15 https://doi.org/10.1016/j.soc.2007.03.006
16 https://doi.org/10.1016/s1470-2045(10)70010-3
17 https://doi.org/10.1097/01.sla.0000152663.61348.6f
18 https://doi.org/10.1111/j.1600-0854.2011.01178.x
19 https://doi.org/10.1148/radiol.14140510
20 https://doi.org/10.1148/radiology.169.3.3055041
21 https://doi.org/10.1155/2012/960194
22 https://doi.org/10.1158/1078-0432.ccr-07-1762
23 https://doi.org/10.1158/1078-0432.ccr-11-2139
24 https://doi.org/10.1159/000355224
25 https://doi.org/10.1371/journal.pone.0085954
26 https://doi.org/10.2152/jmi.60.184
27 https://doi.org/10.2214/ajr.11.7560
28 https://doi.org/10.2214/ajr.14.12932
29 https://doi.org/10.2214/ajr.179.5.1791145
30 schema:datePublished 2018-12
31 schema:datePublishedReg 2018-12-01
32 schema:description Background: The use of 18F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre. We also sought to answer three questions. Firstly, the correlation between sarcoma sub-type and grade with 18FDG SUVmax, secondly, the practical uses of PET-CT in the clinical setting of staging (during initial diagnosis), restaging (new baseline prior to definitive intervention) and treatment response. Finally, we also attempted to evaluate the potential additional benefit of PET-CT over concurrent conventional CT and MRI. Methods: A total of 957 consecutive PET-CT scans were performed in a single supra-regional centre in 493 sarcoma patients (excluding GIST) between 2007 and 2014. We compared, PET-CT SUVmax values in relation to histology and FNCCC grading. We compared PET-CT findings relative to concurrent conventional imaging (MRI and CT) in staging, restaging and treatment responses. Results: High-grade (II/III) bone and soft tissue sarcoma correlated with high SUVmax, especially undifferentiated pleomorphic sarcoma, leiomyosarcoma, translocation induced sarcomas (Ewing, synovial, alveolar rhabdomyosarcoma), de-differentiated liposarcoma and osteosarcoma. Lower SUVmax values were observed in sarcomas of low histological grade (grade I), and in rare subtypes of intermediate grade soft tissue sarcoma (e.g. alveolar soft part sarcoma and solitary fibrous tumour). SUVmax variation was noted in malignant peripheral nerve sheath tumours, compared to the histologically benign plexiform neurofibroma, whereas PET-CT could clearly differentiate low from high-grade chondrosarcoma. We identified added utility of PET-CT in addition to MRI and CT in high-grade sarcoma of bone and soft tissues. An estimated 21% overall potential benefit was observed for PET-CT over CT/MRI, and in particular, in 'upstaging' of high-grade disease (from M0 to M1) where an additional 12% of cases were deemed M1 following PET-CT. Conclusions: PET-CT in high-grade bone and soft tissue sarcoma can add significant benefit to routine CT/MRI staging. Further prospective and multi-centre evaluation of PET-CT is warranted to determine the actual predictive value and cost-effectiveness of PET-CT in directing clinical management of clinically complex and heterogeneous high-grade sarcomas.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N1a0d93df6d8b46238d9fedfbe464a79f
37 Nd78dbe097f1c47ee8b4e276d33388d1b
38 sg:journal.1046367
39 schema:name Retrospective audit of 957 consecutive 18F-FDG PET–CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma
40 schema:pagination 9
41 schema:productId N1c3426cb79534099bfd551be00c430e6
42 N2104b5174866445893e523de7f59107b
43 N2b6a270ccc2442428207e28d3857bbb1
44 N3608cbd0de304cb193ac5afbd759d6e5
45 N4ec4b95a81af4a4fba9d354363799e66
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101592594
47 https://doi.org/10.1186/s13569-018-0095-9
48 schema:sdDatePublished 2019-04-15T08:54
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N3af4e52d6ed849c7bd59ed2c15cedbe9
51 schema:url https://link.springer.com/10.1186%2Fs13569-018-0095-9
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N06f31b79bf314d59997afba45ef170f2 rdf:first sg:person.012477120450.18
56 rdf:rest N7c4a9cb0a1764cd387fff85477050fe2
57 N1a0d93df6d8b46238d9fedfbe464a79f schema:issueNumber 1
58 rdf:type schema:PublicationIssue
59 N1c3426cb79534099bfd551be00c430e6 schema:name nlm_unique_id
60 schema:value 101577890
61 rdf:type schema:PropertyValue
62 N1e4599e77d0a475684cdc2e7f930d9ca schema:affiliation https://www.grid.ac/institutes/grid.4991.5
63 schema:familyName Khonsari
64 schema:givenName Mehrdad
65 rdf:type schema:Person
66 N1e4c61aa3742412688d7034430a7762c rdf:first N1e4599e77d0a475684cdc2e7f930d9ca
67 rdf:rest N06f31b79bf314d59997afba45ef170f2
68 N2104b5174866445893e523de7f59107b schema:name readcube_id
69 schema:value ac9e449c14b18c4735b7de4031d83ea0fdfdec195e8b7f5249566cb215e0cced
70 rdf:type schema:PropertyValue
71 N25aa83d9138d49d88d372800253a68b7 rdf:first sg:person.01106436407.26
72 rdf:rest N1e4c61aa3742412688d7034430a7762c
73 N2b6942a86ee44efa89dfcd64ccd8ff70 rdf:first sg:person.013046236517.87
74 rdf:rest Ncf4f1656925f449a969f99dc8028c2a2
75 N2b6a270ccc2442428207e28d3857bbb1 schema:name doi
76 schema:value 10.1186/s13569-018-0095-9
77 rdf:type schema:PropertyValue
78 N3608cbd0de304cb193ac5afbd759d6e5 schema:name dimensions_id
79 schema:value pub.1101592594
80 rdf:type schema:PropertyValue
81 N3af4e52d6ed849c7bd59ed2c15cedbe9 schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N422b6f8ec55040c2bd7c8e635736b07d rdf:first sg:person.01271220063.08
84 rdf:rest N2b6942a86ee44efa89dfcd64ccd8ff70
85 N4c71902d8b914844a6387a7263f68b64 rdf:first sg:person.01010113713.04
86 rdf:rest Nccfd254e10004e288bb271631db2bdf9
87 N4ec4b95a81af4a4fba9d354363799e66 schema:name pubmed_id
88 schema:value 30116519
89 rdf:type schema:PropertyValue
90 N5c45b305c76549d99799f2761ae8636f rdf:first sg:person.01124643531.95
91 rdf:rest N422b6f8ec55040c2bd7c8e635736b07d
92 N6ddfd61e55984eecb72b885288e83cdd rdf:first sg:person.0711707517.14
93 rdf:rest Nfa6631854caa47c2be6fe1c559202a07
94 N7c4a9cb0a1764cd387fff85477050fe2 rdf:first sg:person.014047201420.54
95 rdf:rest Ncdba5c4df5eb4ddf94898a3f905f871a
96 N857bc2dce26d458ea2368eee15383e1f rdf:first sg:person.01107657620.45
97 rdf:rest rdf:nil
98 Nccfd254e10004e288bb271631db2bdf9 rdf:first sg:person.01323557022.20
99 rdf:rest N25aa83d9138d49d88d372800253a68b7
100 Ncdba5c4df5eb4ddf94898a3f905f871a rdf:first sg:person.0670420011.72
101 rdf:rest N6ddfd61e55984eecb72b885288e83cdd
102 Ncf4f1656925f449a969f99dc8028c2a2 rdf:first sg:person.012153423337.05
103 rdf:rest N857bc2dce26d458ea2368eee15383e1f
104 Nd78dbe097f1c47ee8b4e276d33388d1b schema:volumeNumber 8
105 rdf:type schema:PublicationVolume
106 Nfa6631854caa47c2be6fe1c559202a07 rdf:first sg:person.0760022717.82
107 rdf:rest N5c45b305c76549d99799f2761ae8636f
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
112 schema:name Clinical Sciences
113 rdf:type schema:DefinedTerm
114 sg:journal.1046367 schema:issn 2045-3329
115 schema:name Clinical Sarcoma Research
116 rdf:type schema:Periodical
117 sg:person.01010113713.04 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
118 schema:familyName Macpherson
119 schema:givenName Ruth E.
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010113713.04
121 rdf:type schema:Person
122 sg:person.01106436407.26 schema:affiliation https://www.grid.ac/institutes/grid.415719.f
123 schema:familyName Tyrrell
124 schema:givenName Helen
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106436407.26
126 rdf:type schema:Person
127 sg:person.01107657620.45 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
128 schema:familyName Hassan
129 schema:givenName A. Bassim
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107657620.45
131 rdf:type schema:Person
132 sg:person.01124643531.95 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
133 schema:familyName Cogswell
134 schema:givenName Lucy
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124643531.95
136 rdf:type schema:Person
137 sg:person.012153423337.05 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
138 schema:familyName Bradley
139 schema:givenName Kevin M.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012153423337.05
141 rdf:type schema:Person
142 sg:person.012477120450.18 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
143 schema:familyName Wilson
144 schema:givenName Shaun
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012477120450.18
146 rdf:type schema:Person
147 sg:person.01271220063.08 schema:affiliation https://www.grid.ac/institutes/grid.415719.f
148 schema:familyName Trent
149 schema:givenName Sally
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271220063.08
151 rdf:type schema:Person
152 sg:person.013046236517.87 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
153 schema:familyName Athanasou
154 schema:givenName Nick
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87
156 rdf:type schema:Person
157 sg:person.01323557022.20 schema:affiliation https://www.grid.ac/institutes/grid.415719.f
158 schema:familyName Pratap
159 schema:givenName Sarah
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323557022.20
161 rdf:type schema:Person
162 sg:person.014047201420.54 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
163 schema:familyName Gibbons
164 schema:givenName Max
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014047201420.54
166 rdf:type schema:Person
167 sg:person.0670420011.72 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
168 schema:familyName Whitwell
169 schema:givenName Duncan
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670420011.72
171 rdf:type schema:Person
172 sg:person.0711707517.14 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
173 schema:familyName Giele
174 schema:givenName Henk
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711707517.14
176 rdf:type schema:Person
177 sg:person.0760022717.82 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
178 schema:familyName Critchley
179 schema:givenName Paul
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760022717.82
181 rdf:type schema:Person
182 sg:pub.10.1007/s00259-009-1203-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023885252
183 https://doi.org/10.1007/s00259-009-1203-0
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/s00259-012-2159-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1026128077
186 https://doi.org/10.1007/s00259-012-2159-z
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/s00259-013-2511-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1039775122
189 https://doi.org/10.1007/s00259-013-2511-y
190 rdf:type schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1074808947 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1075281548 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1077689341 schema:CreativeWork
194 https://doi.org/10.1002/cncr.27866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024244986
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/jso.23523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039661559
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.cpet.2015.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020115770
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.crad.2016.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022010554
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.ijrobp.2014.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003649526
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.soc.2007.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019034157
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s1470-2045(10)70010-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036598456
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/01.sla.0000152663.61348.6f schema:sameAs https://app.dimensions.ai/details/publication/pub.1039482592
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/j.1600-0854.2011.01178.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036283132
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1148/radiol.14140510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038780387
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1148/radiology.169.3.3055041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079528496
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1155/2012/960194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021576923
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1158/1078-0432.ccr-07-1762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045267524
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1158/1078-0432.ccr-11-2139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007319181
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1159/000355224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045594315
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1371/journal.pone.0085954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049490907
225 rdf:type schema:CreativeWork
226 https://doi.org/10.2152/jmi.60.184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019557430
227 rdf:type schema:CreativeWork
228 https://doi.org/10.2214/ajr.11.7560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069302043
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2214/ajr.14.12932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069303799
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2214/ajr.179.5.1791145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069325044
233 rdf:type schema:CreativeWork
234 https://www.grid.ac/institutes/grid.415719.f schema:alternateName Churchill Hospital
235 schema:name Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
236 Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.461589.7 schema:alternateName Nuffield Orthopaedic Centre
239 schema:name Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
240 Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
243 schema:name Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
244 Department of Paediatric Oncology, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
245 Department of Radiology, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
246 NIHR Musculoskeletal Biomedical Research Unit (Sarcoma Theme), Sarcoma and TYA Unit of the NHS Oncology Department, and Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK
247 Nuffield Orthopaedic Centre, Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
248 Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, OX3 7LE, Oxford, UK
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...