Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

G. L. Tiemeier, J. M. Brown, S. E. Pratap, C. McCarthy, A. Kastrenopoulou, K. Bradley, S. Wilson, Z. Orosz, C. L. M. H. Gibbons, U. Oppermann, N. A. Athanasou

ABSTRACT

Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17.1) in the primary tumour as well as a metastasis in the right distal femur and multiple small pulmonary metastases. Histologically, the tumour was a pleomorphic liposarcoma containing large tumour cells with vacuolated cytoplasm and hyperchromatic pleomorphic nuclei as well as numerous lipoblasts and scattered brown fat-like cells. Tumour cells strongly expressed FABP4/aP2, a marker of adipocyte differentiation, and UCP1, a marker of brown fat, but not S100. The case was treated with neoadjuvant MAP chemotherapy, resulting in extensive (> 95%) necrosis in the primary tumour and almost complete resolution of the femoral and pulmonary metastases. Conclusions: Pleomorphic liposarcoma can present as a sclerotic primary malignant bone tumour; markers of adipose differentiation are useful in histological diagnosis and neoadjuvant MAP chemotherapy results in significant tumor necrosis. More... »

PAGES

2

References to SciGraph publications

  • 2016-11. Intraosseous hibernoma: a rare adipocytic bone tumour in SKELETAL RADIOLOGY
  • 1993-12. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue in NATURE
  • 2011-10. Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity in PEDIATRIC RADIOLOGY
  • 2005-08. Primary liposarcoma of the thoracic spine: case report in EUROPEAN SPINE JOURNAL
  • 2016-12. UK guidelines for the management of soft tissue sarcomas in CLINICAL SARCOMA RESEARCH
  • 2006-07. Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature in SKELETAL RADIOLOGY
  • 2014-12. High-dose continuous-infusion ifosfamide in advanced well-differentiated/dedifferentiated liposarcoma in CLINICAL SARCOMA RESEARCH
  • 1982-03. Liposarcoma of bone with osteosarcomatous foci: Case report and review of the literature in SKELETAL RADIOLOGY
  • 1980-04. The primary liposarcoma of the bone in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 1981-09. Primary osteoliposarcoma of bone in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2010-10. Brown adipose tissue in humans in INTERNATIONAL JOURNAL OF OBESITY
  • 1962-07. Sarcomas arising in bone cysts in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 1991-01. Case report 652 in SKELETAL RADIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13569-018-0089-7

    DOI

    http://dx.doi.org/10.1186/s13569-018-0089-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100917552

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29449935


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tiemeier", 
            "givenName": "G. L.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brown", 
            "givenName": "J. M.", 
            "id": "sg:person.014451106510.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014451106510.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Orthopaedic Centre", 
              "id": "https://www.grid.ac/institutes/grid.461589.7", 
              "name": [
                "Sarcoma Service, Nuffield Orthopaedic Centre, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pratap", 
            "givenName": "S. E.", 
            "id": "sg:person.01323557022.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323557022.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Orthopaedic Centre", 
              "id": "https://www.grid.ac/institutes/grid.461589.7", 
              "name": [
                "Department of Radiology, Nuffield Orthopaedic Centre, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCarthy", 
            "givenName": "C.", 
            "id": "sg:person.01154136072.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154136072.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kastrenopoulou", 
            "givenName": "A.", 
            "id": "sg:person.016641430110.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016641430110.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Churchill Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415719.f", 
              "name": [
                "Department of Radiology, Churchill Hospital, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bradley", 
            "givenName": "K.", 
            "id": "sg:person.012153423337.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012153423337.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Orthopaedic Centre", 
              "id": "https://www.grid.ac/institutes/grid.461589.7", 
              "name": [
                "Sarcoma Service, Nuffield Orthopaedic Centre, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "S.", 
            "id": "sg:person.012477120450.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012477120450.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Orosz", 
            "givenName": "Z.", 
            "id": "sg:person.015465467477.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015465467477.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nuffield Orthopaedic Centre", 
              "id": "https://www.grid.ac/institutes/grid.461589.7", 
              "name": [
                "Sarcoma Service, Nuffield Orthopaedic Centre, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gibbons", 
            "givenName": "C. L. M. H.", 
            "id": "sg:person.015011047542.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015011047542.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oppermann", 
            "givenName": "U.", 
            "id": "sg:person.01325636072.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325636072.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Athanasou", 
            "givenName": "N. A.", 
            "id": "sg:person.013046236517.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00256-016-2460-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003782665", 
              "https://doi.org/10.1007/s00256-016-2460-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00256-016-2460-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003782665", 
              "https://doi.org/10.1007/s00256-016-2460-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.2150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006684969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.2150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006684969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.34188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006709797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1700700229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007016206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1700700229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007016206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00243729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008110917", 
              "https://doi.org/10.1007/bf00243729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00243729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008110917", 
              "https://doi.org/10.1007/bf00243729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(196610)19:10<1423::aid-cncr2820191015>3.0.co;2-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008154680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/230949900901700327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011545532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/230949900901700327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011545532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00957033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011984531", 
              "https://doi.org/10.1007/bf00957033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00957033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011984531", 
              "https://doi.org/10.1007/bf00957033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00413314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015257264", 
              "https://doi.org/10.1007/bf00413314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.48.10.950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016635969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00361369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016853577", 
              "https://doi.org/10.1007/bf00361369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archsurg.1934.01180040036004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016897305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2010.183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017706025", 
              "https://doi.org/10.1038/ijo.2010.183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/17453677508989275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018628187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19810715)48:2<274::aid-cncr2820480211>3.0.co;2-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021705496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366740a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022423312", 
              "https://doi.org/10.1038/366740a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/ajc.1936.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025011882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00586-004-0866-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026348715", 
              "https://doi.org/10.1007/s00586-004-0866-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00586-004-0866-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026348715", 
              "https://doi.org/10.1007/s00586-004-0866-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00256-005-0018-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029072769", 
              "https://doi.org/10.1007/s00256-005-0018-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00256-005-0018-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029072769", 
              "https://doi.org/10.1007/s00256-005-0018-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00247-011-2078-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036310473", 
              "https://doi.org/10.1007/s00247-011-2078-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcp/42.5.503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040964143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1700860136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041508103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1700860136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041508103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anl.2007.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041554057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdu254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041665642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00457789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042012898", 
              "https://doi.org/10.1007/bf00457789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00457789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042012898", 
              "https://doi.org/10.1007/bf00457789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2045-3329-4-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042015198", 
              "https://doi.org/10.1186/2045-3329-4-16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbspin.2007.06.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042629852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13569-016-0060-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045294493", 
              "https://doi.org/10.1186/s13569-016-0060-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13569-016-0060-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045294493", 
              "https://doi.org/10.1186/s13569-016-0060-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/cbo9781139031141.079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047819303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2106/00004623-196143010-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068883133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2106/00004623-197052010-00019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068884809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2106/00004623-198264020-00029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068887830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.5.9.1860614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077671667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077995988", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077996309", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1302/0301-620x.50b3.639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080929832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081672490", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Background: Liposarcoma is an extremely rare primary bone sarcoma.\nCase presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18\u00a0year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV\u00a0=\u00a017.1) in the primary tumour as well as a metastasis in the right distal femur and multiple small pulmonary metastases. Histologically, the tumour was a pleomorphic liposarcoma containing large tumour cells with vacuolated cytoplasm and hyperchromatic pleomorphic nuclei as well as numerous lipoblasts and scattered brown fat-like cells. Tumour cells strongly expressed FABP4/aP2, a marker of adipocyte differentiation, and UCP1, a marker of brown fat, but not S100. The case was treated with neoadjuvant MAP chemotherapy, resulting in extensive (>\u00a095%) necrosis in the primary tumour and almost complete resolution of the femoral and pulmonary metastases.\nConclusions: Pleomorphic liposarcoma can present as a sclerotic primary malignant bone tumour; markers of adipose differentiation are useful in histological diagnosis and neoadjuvant MAP chemotherapy results in significant tumor necrosis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13569-018-0089-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1046367", 
            "issn": [
              "2045-3329"
            ], 
            "name": "Clinical Sarcoma Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour", 
        "pagination": "2", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6aea25be20b8b6b76a6278ea40f7ece0ac468c23d6dd8084bd29583d652d7dbc"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29449935"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101577890"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13569-018-0089-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100917552"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13569-018-0089-7", 
          "https://app.dimensions.ai/details/publication/pub.1100917552"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89807_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs13569-018-0089-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0089-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0089-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0089-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13569-018-0089-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    265 TRIPLES      21 PREDICATES      66 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13569-018-0089-7 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N89a02bf43a804e7d892c4616dbf42e34
    4 schema:citation sg:pub.10.1007/bf00243729
    5 sg:pub.10.1007/bf00361369
    6 sg:pub.10.1007/bf00413314
    7 sg:pub.10.1007/bf00457789
    8 sg:pub.10.1007/bf00957033
    9 sg:pub.10.1007/s00247-011-2078-3
    10 sg:pub.10.1007/s00256-005-0018-8
    11 sg:pub.10.1007/s00256-016-2460-1
    12 sg:pub.10.1007/s00586-004-0866-2
    13 sg:pub.10.1038/366740a0
    14 sg:pub.10.1038/ijo.2010.183
    15 sg:pub.10.1186/2045-3329-4-16
    16 sg:pub.10.1186/s13569-016-0060-4
    17 https://app.dimensions.ai/details/publication/pub.1077995988
    18 https://app.dimensions.ai/details/publication/pub.1077996309
    19 https://app.dimensions.ai/details/publication/pub.1081672490
    20 https://doi.org/10.1001/archsurg.1934.01180040036004
    21 https://doi.org/10.1002/1097-0142(196610)19:10<1423::aid-cncr2820191015>3.0.co;2-6
    22 https://doi.org/10.1002/1097-0142(19810715)48:2<274::aid-cncr2820480211>3.0.co;2-v
    23 https://doi.org/10.1002/ajmg.a.34188
    24 https://doi.org/10.1002/path.1700700229
    25 https://doi.org/10.1002/path.1700860136
    26 https://doi.org/10.1016/j.anl.2007.02.003
    27 https://doi.org/10.1016/j.jbspin.2007.06.017
    28 https://doi.org/10.1017/cbo9781139031141.079
    29 https://doi.org/10.1093/ajcp/42.5.503
    30 https://doi.org/10.1093/annonc/mdu254
    31 https://doi.org/10.1096/fasebj.5.9.1860614
    32 https://doi.org/10.1136/jcp.48.10.950
    33 https://doi.org/10.1158/ajc.1936.37
    34 https://doi.org/10.1177/230949900901700327
    35 https://doi.org/10.1302/0301-620x.50b3.639
    36 https://doi.org/10.2106/00004623-196143010-00010
    37 https://doi.org/10.2106/00004623-197052010-00019
    38 https://doi.org/10.2106/00004623-198264020-00029
    39 https://doi.org/10.3109/17453677508989275
    40 https://doi.org/10.3892/ol.2014.2150
    41 schema:datePublished 2018-12
    42 schema:datePublishedReg 2018-12-01
    43 schema:description Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17.1) in the primary tumour as well as a metastasis in the right distal femur and multiple small pulmonary metastases. Histologically, the tumour was a pleomorphic liposarcoma containing large tumour cells with vacuolated cytoplasm and hyperchromatic pleomorphic nuclei as well as numerous lipoblasts and scattered brown fat-like cells. Tumour cells strongly expressed FABP4/aP2, a marker of adipocyte differentiation, and UCP1, a marker of brown fat, but not S100. The case was treated with neoadjuvant MAP chemotherapy, resulting in extensive (> 95%) necrosis in the primary tumour and almost complete resolution of the femoral and pulmonary metastases. Conclusions: Pleomorphic liposarcoma can present as a sclerotic primary malignant bone tumour; markers of adipose differentiation are useful in histological diagnosis and neoadjuvant MAP chemotherapy results in significant tumor necrosis.
    44 schema:genre research_article
    45 schema:inLanguage en
    46 schema:isAccessibleForFree true
    47 schema:isPartOf Nc386eef2d0654a97abd5eec4d407cf48
    48 Nd8494deedb784851a9af098ffc27f35b
    49 sg:journal.1046367
    50 schema:name Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour
    51 schema:pagination 2
    52 schema:productId N3b73d14a0b6748efae069c06c807c2b6
    53 N7edc183d81974f5f8da1dc49359e4c39
    54 Na1df32b4ccc74a30ae907f48776c71e6
    55 Nc592ec8c8f9945ff8e4dbd194a3857bf
    56 Nda9216c977624a4b8338457cb75f5156
    57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100917552
    58 https://doi.org/10.1186/s13569-018-0089-7
    59 schema:sdDatePublished 2019-04-11T09:57
    60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    61 schema:sdPublisher N08dc6e908c8c44f2bde64c7be9fa1044
    62 schema:url https://link.springer.com/10.1186%2Fs13569-018-0089-7
    63 sgo:license sg:explorer/license/
    64 sgo:sdDataset articles
    65 rdf:type schema:ScholarlyArticle
    66 N01d4bbc0173642dd95577f52c2ab3ceb schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    67 schema:familyName Tiemeier
    68 schema:givenName G. L.
    69 rdf:type schema:Person
    70 N08dc6e908c8c44f2bde64c7be9fa1044 schema:name Springer Nature - SN SciGraph project
    71 rdf:type schema:Organization
    72 N257252841b76400fa9c220a066e81263 rdf:first sg:person.01323557022.20
    73 rdf:rest Ndb34ee0afdc64832a551b48929b7a001
    74 N3b73d14a0b6748efae069c06c807c2b6 schema:name dimensions_id
    75 schema:value pub.1100917552
    76 rdf:type schema:PropertyValue
    77 N587650c2ab8a4eb08c03881de4f4c879 rdf:first sg:person.013046236517.87
    78 rdf:rest rdf:nil
    79 N73496eda1ec34abcab251a9d64a2c15d rdf:first sg:person.012477120450.18
    80 rdf:rest N91f5089202d54f8f9cbac56990561cb1
    81 N7edc183d81974f5f8da1dc49359e4c39 schema:name nlm_unique_id
    82 schema:value 101577890
    83 rdf:type schema:PropertyValue
    84 N89a02bf43a804e7d892c4616dbf42e34 rdf:first N01d4bbc0173642dd95577f52c2ab3ceb
    85 rdf:rest N8b09574780bb48a58b93fe0ec87f5f9b
    86 N8b09574780bb48a58b93fe0ec87f5f9b rdf:first sg:person.014451106510.29
    87 rdf:rest N257252841b76400fa9c220a066e81263
    88 N91f5089202d54f8f9cbac56990561cb1 rdf:first sg:person.015465467477.27
    89 rdf:rest Nbb127a38551a403ca3d0672b2c7b7dc4
    90 Na1df32b4ccc74a30ae907f48776c71e6 schema:name readcube_id
    91 schema:value 6aea25be20b8b6b76a6278ea40f7ece0ac468c23d6dd8084bd29583d652d7dbc
    92 rdf:type schema:PropertyValue
    93 Nbb127a38551a403ca3d0672b2c7b7dc4 rdf:first sg:person.015011047542.43
    94 rdf:rest Nf6293f9d6cd649fb9cd313201c53bb45
    95 Nc386eef2d0654a97abd5eec4d407cf48 schema:issueNumber 1
    96 rdf:type schema:PublicationIssue
    97 Nc592ec8c8f9945ff8e4dbd194a3857bf schema:name pubmed_id
    98 schema:value 29449935
    99 rdf:type schema:PropertyValue
    100 Ncb80e99954d04659b0bdfc829ca72848 rdf:first sg:person.016641430110.42
    101 rdf:rest Nccee632f7a38447ea6bd5e72afc33c78
    102 Nccee632f7a38447ea6bd5e72afc33c78 rdf:first sg:person.012153423337.05
    103 rdf:rest N73496eda1ec34abcab251a9d64a2c15d
    104 Nd8494deedb784851a9af098ffc27f35b schema:volumeNumber 8
    105 rdf:type schema:PublicationVolume
    106 Nda9216c977624a4b8338457cb75f5156 schema:name doi
    107 schema:value 10.1186/s13569-018-0089-7
    108 rdf:type schema:PropertyValue
    109 Ndb34ee0afdc64832a551b48929b7a001 rdf:first sg:person.01154136072.83
    110 rdf:rest Ncb80e99954d04659b0bdfc829ca72848
    111 Nf6293f9d6cd649fb9cd313201c53bb45 rdf:first sg:person.01325636072.10
    112 rdf:rest N587650c2ab8a4eb08c03881de4f4c879
    113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    114 schema:name Medical and Health Sciences
    115 rdf:type schema:DefinedTerm
    116 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    117 schema:name Oncology and Carcinogenesis
    118 rdf:type schema:DefinedTerm
    119 sg:journal.1046367 schema:issn 2045-3329
    120 schema:name Clinical Sarcoma Research
    121 rdf:type schema:Periodical
    122 sg:person.01154136072.83 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
    123 schema:familyName McCarthy
    124 schema:givenName C.
    125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154136072.83
    126 rdf:type schema:Person
    127 sg:person.012153423337.05 schema:affiliation https://www.grid.ac/institutes/grid.415719.f
    128 schema:familyName Bradley
    129 schema:givenName K.
    130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012153423337.05
    131 rdf:type schema:Person
    132 sg:person.012477120450.18 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
    133 schema:familyName Wilson
    134 schema:givenName S.
    135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012477120450.18
    136 rdf:type schema:Person
    137 sg:person.013046236517.87 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    138 schema:familyName Athanasou
    139 schema:givenName N. A.
    140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046236517.87
    141 rdf:type schema:Person
    142 sg:person.01323557022.20 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
    143 schema:familyName Pratap
    144 schema:givenName S. E.
    145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323557022.20
    146 rdf:type schema:Person
    147 sg:person.01325636072.10 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    148 schema:familyName Oppermann
    149 schema:givenName U.
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325636072.10
    151 rdf:type schema:Person
    152 sg:person.014451106510.29 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    153 schema:familyName Brown
    154 schema:givenName J. M.
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014451106510.29
    156 rdf:type schema:Person
    157 sg:person.015011047542.43 schema:affiliation https://www.grid.ac/institutes/grid.461589.7
    158 schema:familyName Gibbons
    159 schema:givenName C. L. M. H.
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015011047542.43
    161 rdf:type schema:Person
    162 sg:person.015465467477.27 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    163 schema:familyName Orosz
    164 schema:givenName Z.
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015465467477.27
    166 rdf:type schema:Person
    167 sg:person.016641430110.42 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    168 schema:familyName Kastrenopoulou
    169 schema:givenName A.
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016641430110.42
    171 rdf:type schema:Person
    172 sg:pub.10.1007/bf00243729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008110917
    173 https://doi.org/10.1007/bf00243729
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1007/bf00361369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016853577
    176 https://doi.org/10.1007/bf00361369
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/bf00413314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015257264
    179 https://doi.org/10.1007/bf00413314
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/bf00457789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042012898
    182 https://doi.org/10.1007/bf00457789
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/bf00957033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011984531
    185 https://doi.org/10.1007/bf00957033
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s00247-011-2078-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036310473
    188 https://doi.org/10.1007/s00247-011-2078-3
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s00256-005-0018-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029072769
    191 https://doi.org/10.1007/s00256-005-0018-8
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s00256-016-2460-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003782665
    194 https://doi.org/10.1007/s00256-016-2460-1
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/s00586-004-0866-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026348715
    197 https://doi.org/10.1007/s00586-004-0866-2
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/366740a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022423312
    200 https://doi.org/10.1038/366740a0
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/ijo.2010.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017706025
    203 https://doi.org/10.1038/ijo.2010.183
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1186/2045-3329-4-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042015198
    206 https://doi.org/10.1186/2045-3329-4-16
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1186/s13569-016-0060-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045294493
    209 https://doi.org/10.1186/s13569-016-0060-4
    210 rdf:type schema:CreativeWork
    211 https://app.dimensions.ai/details/publication/pub.1077995988 schema:CreativeWork
    212 https://app.dimensions.ai/details/publication/pub.1077996309 schema:CreativeWork
    213 https://app.dimensions.ai/details/publication/pub.1081672490 schema:CreativeWork
    214 https://doi.org/10.1001/archsurg.1934.01180040036004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016897305
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1002/1097-0142(196610)19:10<1423::aid-cncr2820191015>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008154680
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1002/1097-0142(19810715)48:2<274::aid-cncr2820480211>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1021705496
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1002/ajmg.a.34188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006709797
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1002/path.1700700229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007016206
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1002/path.1700860136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041508103
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/j.anl.2007.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041554057
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/j.jbspin.2007.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042629852
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1017/cbo9781139031141.079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047819303
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1093/ajcp/42.5.503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040964143
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1093/annonc/mdu254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041665642
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1096/fasebj.5.9.1860614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077671667
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1136/jcp.48.10.950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016635969
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1158/ajc.1936.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025011882
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1177/230949900901700327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011545532
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1302/0301-620x.50b3.639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080929832
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.2106/00004623-196143010-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068883133
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.2106/00004623-197052010-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068884809
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.2106/00004623-198264020-00029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068887830
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.3109/17453677508989275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018628187
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.3892/ol.2014.2150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006684969
    255 rdf:type schema:CreativeWork
    256 https://www.grid.ac/institutes/grid.415719.f schema:alternateName Churchill Hospital
    257 schema:name Department of Radiology, Churchill Hospital, Oxford, UK
    258 rdf:type schema:Organization
    259 https://www.grid.ac/institutes/grid.461589.7 schema:alternateName Nuffield Orthopaedic Centre
    260 schema:name Department of Radiology, Nuffield Orthopaedic Centre, Oxford, UK
    261 Sarcoma Service, Nuffield Orthopaedic Centre, Oxford, UK
    262 rdf:type schema:Organization
    263 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
    264 schema:name Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK
    265 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...