Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

G. L. Tiemeier, J. M. Brown, S. E. Pratap, C. McCarthy, A. Kastrenopoulou, K. Bradley, S. Wilson, Z. Orosz, C. L. M. H. Gibbons, U. Oppermann, N. A. Athanasou

ABSTRACT

Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17.1) in the primary tumour as well as a metastasis in the right distal femur and multiple small pulmonary metastases. Histologically, the tumour was a pleomorphic liposarcoma containing large tumour cells with vacuolated cytoplasm and hyperchromatic pleomorphic nuclei as well as numerous lipoblasts and scattered brown fat-like cells. Tumour cells strongly expressed FABP4/aP2, a marker of adipocyte differentiation, and UCP1, a marker of brown fat, but not S100. The case was treated with neoadjuvant MAP chemotherapy, resulting in extensive (> 95%) necrosis in the primary tumour and almost complete resolution of the femoral and pulmonary metastases. Conclusions: Pleomorphic liposarcoma can present as a sclerotic primary malignant bone tumour; markers of adipose differentiation are useful in histological diagnosis and neoadjuvant MAP chemotherapy results in significant tumor necrosis. More... »

PAGES

2

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13569-018-0089-7

    DOI

    http://dx.doi.org/10.1186/s13569-018-0089-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100917552

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29449935


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    259 https://www.grid.ac/institutes/grid.461589.7 schema:alternateName Nuffield Orthopaedic Centre
    260 schema:name Department of Radiology, Nuffield Orthopaedic Centre, Oxford, UK
    261 Sarcoma Service, Nuffield Orthopaedic Centre, Oxford, UK
    262 rdf:type schema:Organization
    263 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
    264 schema:name Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, OX3 7HE, Oxford, UK
    265 rdf:type schema:Organization
     




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