In silico analysis as a strategy to identify candidate epitopes with human IgG reactivity to study Porphyromonas gingivalis virulence factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Ellen Karla Nobre dos Santos-Lima, Kizzes Araújo Paiva Andrade Cardoso, Patrícia Mares de Miranda, Ana Carla Montino Pimentel, Paulo Cirino de Carvalho-Filho, Yuri Andrade de Oliveira, Lília Ferreira de Moura-Costa, Teresa Olczak, Isaac Suzart Gomes-Filho, Roberto José Meyer, Márcia Tosta Xavier, Soraya Castro Trindade

ABSTRACT

Porphyromonas gingivalis (Pg) is one of the main pathogens in chronic periodontitis (CP). Studies on the immunogenicity of its virulence factors may contribute to understanding the host response to infection. The present study aimed to use in silico analysis as a tool to identify epitopes from Lys-gingipain (Kgp) and neuraminidase virulence factors of the Pg ATCC 33277 strain. Protein sequences were obtained from the NCBI Protein Database and they were scanned for amino acid patterns indicative of MHC II binding using the MHC-II Binding Predictions tool from the Immune Epitope Database (IEDB). Peptides from different regions of the proteins were chemically synthesized and tested by the indirect ELISA method to verify IgG immunoreactivity in serum of subjects with CP and without periodontitis (WP). T cell epitope prediction resulted in 16 peptide sequences from Kgp and 18 peptide sequences from neuraminidase. All tested Kgp peptides exhibited IgG immunoreactivity whereas tested neuraminidase peptides presented low IgG immunoreactivity. Thus, the IgG reactivity to Kgp protein could be reaffirmed and the low IgG reactivity to Pg neuraminidase could be suggested. The novel peptide epitopes from Pg were useful to evaluate its immunoreactivity based on the IgG-mediated host response. In silico analysis was useful for preselecting epitopes for immune response studies in CP. More... »

PAGES

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13568-019-0757-x

DOI

http://dx.doi.org/10.1186/s13568-019-0757-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112683314

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30859419


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Federal University of Bahia", 
          "id": "https://www.grid.ac/institutes/grid.8399.b", 
          "name": [
            "Postgraduate Program in Immunology, Federal University of Bahia, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "dos Santos-Lima", 
        "givenName": "Ellen Karla Nobre", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Bahia", 
          "id": "https://www.grid.ac/institutes/grid.8399.b", 
          "name": [
            "Biotechnology Postgraduate Program, Federal University of Bahia, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardoso", 
        "givenName": "Kizzes Ara\u00fajo Paiva Andrade", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Bahia", 
          "id": "https://www.grid.ac/institutes/grid.8399.b", 
          "name": [
            "Postgraduate Program in Immunology, Federal University of Bahia, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Miranda", 
        "givenName": "Patr\u00edcia Mares", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Bahia", 
          "id": "https://www.grid.ac/institutes/grid.8399.b", 
          "name": [
            "Postgraduate Program in Immunology, Federal University of Bahia, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pimentel", 
        "givenName": "Ana Carla Montino", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Escola Bahiana de Medicina e Sa\u00fade P\u00fablica", 
          "id": "https://www.grid.ac/institutes/grid.414171.6", 
          "name": [
            "Bahian School of Medicine and Public Health, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Carvalho-Filho", 
        "givenName": "Paulo Cirino", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dentistry Course, Feira de Santana State University, Feira de Santana, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Oliveira", 
        "givenName": "Yuri Andrade", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Bahia", 
          "id": "https://www.grid.ac/institutes/grid.8399.b", 
          "name": [
            "Department of Biointeraction, Federal University of Bahia, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Moura-Costa", 
        "givenName": "L\u00edlia Ferreira", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wroc\u0142aw", 
          "id": "https://www.grid.ac/institutes/grid.8505.8", 
          "name": [
            "Faculty of Biotechnology, University of Wroc\u0142aw, Wroc\u0142aw, Lower Silesia, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olczak", 
        "givenName": "Teresa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Health, Feira de Santana State University, Avenida Transnordestina s/n, Novo Horizonte, CEP 44036-900, Feira de Santana, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomes-Filho", 
        "givenName": "Isaac Suzart", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Bahia", 
          "id": "https://www.grid.ac/institutes/grid.8399.b", 
          "name": [
            "Department of Biointeraction, Federal University of Bahia, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meyer", 
        "givenName": "Roberto Jos\u00e9", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Escola Bahiana de Medicina e Sa\u00fade P\u00fablica", 
          "id": "https://www.grid.ac/institutes/grid.414171.6", 
          "name": [
            "Bahian School of Medicine and Public Health, Salvador, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xavier", 
        "givenName": "M\u00e1rcia Tosta", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Health, Feira de Santana State University, Avenida Transnordestina s/n, Novo Horizonte, CEP 44036-900, Feira de Santana, Bahia, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trindade", 
        "givenName": "Soraya Castro", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3389/fimmu.2014.00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001599071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-11-568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001814252", 
          "https://doi.org/10.1186/1471-2105-11-568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2010.01490.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002717120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2010.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006999469", 
          "https://doi.org/10.1038/nprot.2010.5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2010.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006999469", 
          "https://doi.org/10.1038/nprot.2010.5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m114.602052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007165360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m114.602052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007165360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.archoralbio.2011.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007180192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-7-153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009538215", 
          "https://doi.org/10.1186/1471-2105-7-153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-7-153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009538215", 
          "https://doi.org/10.1186/1471-2105-7-153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(05)80360-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013618994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micres.2015.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013940453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micres.2015.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013940453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2041-1014.2011.00630.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014068833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0757.2010.00377.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015569971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0757.2010.00377.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015569971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0757.2010.00377.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015569971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016122000", 
          "https://doi.org/10.1038/nrmicro2873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.12.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019369269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/omi.12149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019613575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3402/jom.v6.24800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020466246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-051x.2007.01141.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020857856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2013.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023307385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025498639", 
          "https://doi.org/10.1038/nri2368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/omi.12038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026213563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/omi.12038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026213563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3402/jom.v7.28788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027945945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0765.2011.01401.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028046063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201344202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029212024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201344202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029212024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4682-11-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029693051", 
          "https://doi.org/10.1186/1742-4682-11-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1000048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030541462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2015.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031407074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1678-77572007000300011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035556625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2013.00310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036827228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-10-134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038598034", 
          "https://doi.org/10.1186/1471-2180-10-134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038886514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.01902-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039189913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.01902-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039189913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp1004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040900903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042364267", 
          "https://doi.org/10.1038/nri3785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.72.3.1374-1382.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043338837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.72.3.1374-1382.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043338837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.05773-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044297302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/mmi.12311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045341335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.68.5.2704-2712.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045368806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.68.5.2704-2712.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045368806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0152794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045611336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0152794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045611336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0152794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045611336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049759511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/7465852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050409189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imbio.2016.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050537038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00106-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052477182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00106-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052477182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/dnares/dsn013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053396776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/omi.2013.0152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059304056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/glycob/cwv057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059638977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/annals.1999.4.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068728257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/annals.1999.4.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068728257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/annals.1999.4.1.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068728267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/annals.1999.4.1.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068728267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/jop.2003.74.10.1432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068734803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/jop.2003.74.10.1432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068734803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/jop.2012.120230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068737595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/jop.2016.160047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068738384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1902/jop.2016.160047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068738384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2017.00048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074203012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077663588", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078303674", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078570717", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12866-017-1087-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091237655", 
          "https://doi.org/10.1186/s12866-017-1087-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12866-017-1087-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091237655", 
          "https://doi.org/10.1186/s12866-017-1087-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12866-017-1087-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091237655", 
          "https://doi.org/10.1186/s12866-017-1087-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-02900-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100925161", 
          "https://doi.org/10.1038/s41467-018-02900-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fcimb.2018.00100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103156220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-04171-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103695333", 
          "https://doi.org/10.1038/s41467-018-04171-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jcpe.12935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105017543"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Porphyromonas gingivalis (Pg) is one of the main pathogens in chronic periodontitis (CP). Studies on the immunogenicity of its virulence factors may contribute to understanding the host response to infection. The present study aimed to use in silico analysis as a tool to identify epitopes from Lys-gingipain (Kgp) and neuraminidase virulence factors of the Pg ATCC 33277 strain. Protein sequences were obtained from the NCBI Protein Database and they were scanned for amino acid patterns indicative of MHC II binding using the MHC-II Binding Predictions tool from the Immune Epitope Database (IEDB). Peptides from different regions of the proteins were chemically synthesized and tested by the indirect ELISA method to verify IgG immunoreactivity in serum of subjects with CP and without periodontitis (WP). T cell epitope prediction resulted in 16 peptide sequences from Kgp and 18 peptide sequences from neuraminidase. All tested Kgp peptides exhibited IgG immunoreactivity whereas tested neuraminidase peptides presented low IgG immunoreactivity. Thus, the IgG reactivity to Kgp protein could be reaffirmed and the low IgG reactivity to Pg neuraminidase could be suggested. The novel peptide epitopes from Pg were useful to evaluate its immunoreactivity based on the IgG-mediated host response. In silico analysis was useful for preselecting epitopes for immune response studies in CP.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13568-019-0757-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1045217", 
        "issn": [
          "2191-0855"
        ], 
        "name": "AMB Express", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "In silico analysis as a strategy to identify candidate epitopes with human IgG reactivity to study Porphyromonas gingivalis virulence factors", 
    "pagination": "35", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5f75a81697cd425d20bcabd33810ef716f5e2d1a8869e7be17d122d3e0c52a7d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30859419"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101561785"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13568-019-0757-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112683314"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13568-019-0757-x", 
      "https://app.dimensions.ai/details/publication/pub.1112683314"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130823_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13568-019-0757-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13568-019-0757-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13568-019-0757-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13568-019-0757-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13568-019-0757-x'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      21 PREDICATES      87 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13568-019-0757-x schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N0654c27ef3d74cbf84eb8727cd8cf396
4 schema:citation sg:pub.10.1038/nprot.2010.5
5 sg:pub.10.1038/nri2368
6 sg:pub.10.1038/nri3785
7 sg:pub.10.1038/nrmicro2873
8 sg:pub.10.1038/s41467-018-02900-1
9 sg:pub.10.1038/s41467-018-04171-2
10 sg:pub.10.1186/1471-2105-11-568
11 sg:pub.10.1186/1471-2105-7-153
12 sg:pub.10.1186/1471-2180-10-134
13 sg:pub.10.1186/1742-4682-11-1
14 sg:pub.10.1186/s12866-017-1087-2
15 https://app.dimensions.ai/details/publication/pub.1077663588
16 https://app.dimensions.ai/details/publication/pub.1078303674
17 https://app.dimensions.ai/details/publication/pub.1078570717
18 https://doi.org/10.1002/eji.201344202
19 https://doi.org/10.1016/j.archoralbio.2011.09.003
20 https://doi.org/10.1016/j.cub.2006.12.034
21 https://doi.org/10.1016/j.imbio.2016.07.007
22 https://doi.org/10.1016/j.it.2013.09.001
23 https://doi.org/10.1016/j.micres.2015.05.008
24 https://doi.org/10.1016/j.semcdb.2015.07.001
25 https://doi.org/10.1016/s0022-2836(05)80360-2
26 https://doi.org/10.1038/sj.emboj.7601945
27 https://doi.org/10.1074/jbc.m114.602052
28 https://doi.org/10.1089/omi.2013.0152
29 https://doi.org/10.1093/dnares/dsn013
30 https://doi.org/10.1093/glycob/cwv057
31 https://doi.org/10.1093/nar/gkp1004
32 https://doi.org/10.1093/nar/gks438
33 https://doi.org/10.1111/j.1462-5822.2010.01490.x
34 https://doi.org/10.1111/j.1600-051x.2007.01141.x
35 https://doi.org/10.1111/j.1600-0757.2010.00377.x
36 https://doi.org/10.1111/j.1600-0765.2011.01401.x
37 https://doi.org/10.1111/j.2041-1014.2011.00630.x
38 https://doi.org/10.1111/jcpe.12935
39 https://doi.org/10.1111/mmi.12311
40 https://doi.org/10.1111/omi.12038
41 https://doi.org/10.1111/omi.12149
42 https://doi.org/10.1128/iai.00106-11
43 https://doi.org/10.1128/iai.01902-05
44 https://doi.org/10.1128/iai.05773-11
45 https://doi.org/10.1128/iai.68.5.2704-2712.2000
46 https://doi.org/10.1128/iai.72.3.1374-1382.2004
47 https://doi.org/10.1155/2016/7465852
48 https://doi.org/10.1371/journal.pcbi.1000048
49 https://doi.org/10.1371/journal.pone.0152794
50 https://doi.org/10.1590/s1678-77572007000300011
51 https://doi.org/10.1902/annals.1999.4.1.1
52 https://doi.org/10.1902/annals.1999.4.1.38
53 https://doi.org/10.1902/jop.2003.74.10.1432
54 https://doi.org/10.1902/jop.2012.120230
55 https://doi.org/10.1902/jop.2016.160047
56 https://doi.org/10.3389/fcimb.2018.00100
57 https://doi.org/10.3389/fimmu.2014.00022
58 https://doi.org/10.3389/fmicb.2013.00310
59 https://doi.org/10.3389/fmicb.2017.00048
60 https://doi.org/10.3402/jom.v6.24800
61 https://doi.org/10.3402/jom.v7.28788
62 schema:datePublished 2019-12
63 schema:datePublishedReg 2019-12-01
64 schema:description Porphyromonas gingivalis (Pg) is one of the main pathogens in chronic periodontitis (CP). Studies on the immunogenicity of its virulence factors may contribute to understanding the host response to infection. The present study aimed to use in silico analysis as a tool to identify epitopes from Lys-gingipain (Kgp) and neuraminidase virulence factors of the Pg ATCC 33277 strain. Protein sequences were obtained from the NCBI Protein Database and they were scanned for amino acid patterns indicative of MHC II binding using the MHC-II Binding Predictions tool from the Immune Epitope Database (IEDB). Peptides from different regions of the proteins were chemically synthesized and tested by the indirect ELISA method to verify IgG immunoreactivity in serum of subjects with CP and without periodontitis (WP). T cell epitope prediction resulted in 16 peptide sequences from Kgp and 18 peptide sequences from neuraminidase. All tested Kgp peptides exhibited IgG immunoreactivity whereas tested neuraminidase peptides presented low IgG immunoreactivity. Thus, the IgG reactivity to Kgp protein could be reaffirmed and the low IgG reactivity to Pg neuraminidase could be suggested. The novel peptide epitopes from Pg were useful to evaluate its immunoreactivity based on the IgG-mediated host response. In silico analysis was useful for preselecting epitopes for immune response studies in CP.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree false
68 schema:isPartOf N962d94badee745ddb903d071c038bc96
69 Nc5743c113be142ef9d0fcfa0c26ab2fa
70 sg:journal.1045217
71 schema:name In silico analysis as a strategy to identify candidate epitopes with human IgG reactivity to study Porphyromonas gingivalis virulence factors
72 schema:pagination 35
73 schema:productId N0c0ea86933bd4d6bb77817fbd0ace0bb
74 N0c349837c4dd47a7abb6266d6228c894
75 N12bfab9b0c1441fc99a2d8000e5b5c18
76 N8505d86d508d47268b217b4c25af13e6
77 Ncd4876d933c9423392cc8fa6e6b80da7
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112683314
79 https://doi.org/10.1186/s13568-019-0757-x
80 schema:sdDatePublished 2019-04-11T13:59
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher Ne275f928d0d247c2a3bccd66f66d8d5c
83 schema:url https://link.springer.com/10.1186%2Fs13568-019-0757-x
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0654c27ef3d74cbf84eb8727cd8cf396 rdf:first N375ebc4962f24e6b8ec38b72e0abbfad
88 rdf:rest N34d9822a8118426ab4014abccd605fe5
89 N0c0ea86933bd4d6bb77817fbd0ace0bb schema:name pubmed_id
90 schema:value 30859419
91 rdf:type schema:PropertyValue
92 N0c349837c4dd47a7abb6266d6228c894 schema:name nlm_unique_id
93 schema:value 101561785
94 rdf:type schema:PropertyValue
95 N101b5a3f4ad54fba8d22491ae70bb8eb schema:affiliation N250a9712bd3a4dc9ae154dfc6bbc01dd
96 schema:familyName Gomes-Filho
97 schema:givenName Isaac Suzart
98 rdf:type schema:Person
99 N12bfab9b0c1441fc99a2d8000e5b5c18 schema:name readcube_id
100 schema:value 5f75a81697cd425d20bcabd33810ef716f5e2d1a8869e7be17d122d3e0c52a7d
101 rdf:type schema:PropertyValue
102 N146e190a907b4abdab78678b82617e60 schema:affiliation https://www.grid.ac/institutes/grid.414171.6
103 schema:familyName Xavier
104 schema:givenName Márcia Tosta
105 rdf:type schema:Person
106 N250a9712bd3a4dc9ae154dfc6bbc01dd schema:name Department of Health, Feira de Santana State University, Avenida Transnordestina s/n, Novo Horizonte, CEP 44036-900, Feira de Santana, Bahia, Brazil
107 rdf:type schema:Organization
108 N34d9822a8118426ab4014abccd605fe5 rdf:first Nb77ea7c8a26d49a69b8164d61b82bbd2
109 rdf:rest N6cd15925ab62445199dbcf9c401c8aad
110 N375ebc4962f24e6b8ec38b72e0abbfad schema:affiliation https://www.grid.ac/institutes/grid.8399.b
111 schema:familyName dos Santos-Lima
112 schema:givenName Ellen Karla Nobre
113 rdf:type schema:Person
114 N40c74518f0624a838c351cdf65f16f51 rdf:first Nef8fde2efc5f4662ada89fe524752cee
115 rdf:rest Nf47a6b4cc85d48baa691a32011ce1d3a
116 N44584dd112bd4e82ab98d0c1f6c6aacc rdf:first Na05210a633274f19826aff5c85b915b3
117 rdf:rest N4e41207543d14a7e8604dc0bc3606037
118 N4e41207543d14a7e8604dc0bc3606037 rdf:first Nd2793ed69dab4db78f320292b6acecd4
119 rdf:rest Na0aabdcab23544ebb1c48e67470b9ffd
120 N56207a5c6b7b42a0bd1f34484a5ce2a5 schema:name Department of Health, Feira de Santana State University, Avenida Transnordestina s/n, Novo Horizonte, CEP 44036-900, Feira de Santana, Bahia, Brazil
121 rdf:type schema:Organization
122 N6367bc131e74485caa578436bd96ed0d rdf:first Nf4bd38531e01496baf6ec8d1f8710417
123 rdf:rest N6647b0db02f14b4e9f200823f87af0cb
124 N6647b0db02f14b4e9f200823f87af0cb rdf:first N146e190a907b4abdab78678b82617e60
125 rdf:rest Na7c5978e43f24bfaa02db04c2ad0850d
126 N6cd15925ab62445199dbcf9c401c8aad rdf:first Nd62bcdeb3c31483baa1cc3bd53df10aa
127 rdf:rest N40c74518f0624a838c351cdf65f16f51
128 N8505d86d508d47268b217b4c25af13e6 schema:name doi
129 schema:value 10.1186/s13568-019-0757-x
130 rdf:type schema:PropertyValue
131 N962d94badee745ddb903d071c038bc96 schema:volumeNumber 9
132 rdf:type schema:PublicationVolume
133 N9fc1f9bb6791482d9a0813fd0fbd7b66 rdf:first Nd310d3b476f44537acb4f180e3b3798b
134 rdf:rest N44584dd112bd4e82ab98d0c1f6c6aacc
135 Na05210a633274f19826aff5c85b915b3 schema:affiliation https://www.grid.ac/institutes/grid.8399.b
136 schema:familyName de Moura-Costa
137 schema:givenName Lília Ferreira
138 rdf:type schema:Person
139 Na0aabdcab23544ebb1c48e67470b9ffd rdf:first N101b5a3f4ad54fba8d22491ae70bb8eb
140 rdf:rest N6367bc131e74485caa578436bd96ed0d
141 Na1c05d61adff489eb9e743f430347b54 schema:affiliation N56207a5c6b7b42a0bd1f34484a5ce2a5
142 schema:familyName Trindade
143 schema:givenName Soraya Castro
144 rdf:type schema:Person
145 Na7c5978e43f24bfaa02db04c2ad0850d rdf:first Na1c05d61adff489eb9e743f430347b54
146 rdf:rest rdf:nil
147 Nb77ea7c8a26d49a69b8164d61b82bbd2 schema:affiliation https://www.grid.ac/institutes/grid.8399.b
148 schema:familyName Cardoso
149 schema:givenName Kizzes Araújo Paiva Andrade
150 rdf:type schema:Person
151 Nc419160403b44bec86a18266e2bae810 schema:affiliation https://www.grid.ac/institutes/grid.414171.6
152 schema:familyName de Carvalho-Filho
153 schema:givenName Paulo Cirino
154 rdf:type schema:Person
155 Nc5743c113be142ef9d0fcfa0c26ab2fa schema:issueNumber 1
156 rdf:type schema:PublicationIssue
157 Ncd4876d933c9423392cc8fa6e6b80da7 schema:name dimensions_id
158 schema:value pub.1112683314
159 rdf:type schema:PropertyValue
160 Nd2793ed69dab4db78f320292b6acecd4 schema:affiliation https://www.grid.ac/institutes/grid.8505.8
161 schema:familyName Olczak
162 schema:givenName Teresa
163 rdf:type schema:Person
164 Nd310d3b476f44537acb4f180e3b3798b schema:affiliation Nd5c1fa563aeb463498d049f87c2b54c2
165 schema:familyName de Oliveira
166 schema:givenName Yuri Andrade
167 rdf:type schema:Person
168 Nd5c1fa563aeb463498d049f87c2b54c2 schema:name Dentistry Course, Feira de Santana State University, Feira de Santana, Bahia, Brazil
169 rdf:type schema:Organization
170 Nd62bcdeb3c31483baa1cc3bd53df10aa schema:affiliation https://www.grid.ac/institutes/grid.8399.b
171 schema:familyName de Miranda
172 schema:givenName Patrícia Mares
173 rdf:type schema:Person
174 Ne275f928d0d247c2a3bccd66f66d8d5c schema:name Springer Nature - SN SciGraph project
175 rdf:type schema:Organization
176 Nef8fde2efc5f4662ada89fe524752cee schema:affiliation https://www.grid.ac/institutes/grid.8399.b
177 schema:familyName Pimentel
178 schema:givenName Ana Carla Montino
179 rdf:type schema:Person
180 Nf47a6b4cc85d48baa691a32011ce1d3a rdf:first Nc419160403b44bec86a18266e2bae810
181 rdf:rest N9fc1f9bb6791482d9a0813fd0fbd7b66
182 Nf4bd38531e01496baf6ec8d1f8710417 schema:affiliation https://www.grid.ac/institutes/grid.8399.b
183 schema:familyName Meyer
184 schema:givenName Roberto José
185 rdf:type schema:Person
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
190 schema:name Immunology
191 rdf:type schema:DefinedTerm
192 sg:journal.1045217 schema:issn 2191-0855
193 schema:name AMB Express
194 rdf:type schema:Periodical
195 sg:pub.10.1038/nprot.2010.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006999469
196 https://doi.org/10.1038/nprot.2010.5
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/nri2368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025498639
199 https://doi.org/10.1038/nri2368
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/nri3785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042364267
202 https://doi.org/10.1038/nri3785
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/nrmicro2873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016122000
205 https://doi.org/10.1038/nrmicro2873
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/s41467-018-02900-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100925161
208 https://doi.org/10.1038/s41467-018-02900-1
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/s41467-018-04171-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103695333
211 https://doi.org/10.1038/s41467-018-04171-2
212 rdf:type schema:CreativeWork
213 sg:pub.10.1186/1471-2105-11-568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001814252
214 https://doi.org/10.1186/1471-2105-11-568
215 rdf:type schema:CreativeWork
216 sg:pub.10.1186/1471-2105-7-153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009538215
217 https://doi.org/10.1186/1471-2105-7-153
218 rdf:type schema:CreativeWork
219 sg:pub.10.1186/1471-2180-10-134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038598034
220 https://doi.org/10.1186/1471-2180-10-134
221 rdf:type schema:CreativeWork
222 sg:pub.10.1186/1742-4682-11-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029693051
223 https://doi.org/10.1186/1742-4682-11-1
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/s12866-017-1087-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091237655
226 https://doi.org/10.1186/s12866-017-1087-2
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1077663588 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1078303674 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1078570717 schema:CreativeWork
231 https://doi.org/10.1002/eji.201344202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029212024
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.archoralbio.2011.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007180192
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.cub.2006.12.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019369269
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.imbio.2016.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050537038
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.it.2013.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023307385
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.micres.2015.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013940453
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.semcdb.2015.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031407074
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0022-2836(05)80360-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013618994
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1038/sj.emboj.7601945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049759511
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1074/jbc.m114.602052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007165360
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1089/omi.2013.0152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059304056
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1093/dnares/dsn013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053396776
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/glycob/cwv057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059638977
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/nar/gkp1004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040900903
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/nar/gks438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038886514
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1462-5822.2010.01490.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002717120
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1600-051x.2007.01141.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020857856
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1111/j.1600-0757.2010.00377.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015569971
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1111/j.1600-0765.2011.01401.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028046063
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1111/j.2041-1014.2011.00630.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014068833
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1111/jcpe.12935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105017543
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1111/mmi.12311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045341335
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/omi.12038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026213563
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/omi.12149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019613575
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1128/iai.00106-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052477182
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1128/iai.01902-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039189913
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1128/iai.05773-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044297302
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1128/iai.68.5.2704-2712.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045368806
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1128/iai.72.3.1374-1382.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043338837
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1155/2016/7465852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050409189
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1371/journal.pcbi.1000048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030541462
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1371/journal.pone.0152794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045611336
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1590/s1678-77572007000300011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035556625
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1902/annals.1999.4.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068728257
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1902/annals.1999.4.1.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068728267
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1902/jop.2003.74.10.1432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068734803
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1902/jop.2012.120230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068737595
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1902/jop.2016.160047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068738384
306 rdf:type schema:CreativeWork
307 https://doi.org/10.3389/fcimb.2018.00100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103156220
308 rdf:type schema:CreativeWork
309 https://doi.org/10.3389/fimmu.2014.00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001599071
310 rdf:type schema:CreativeWork
311 https://doi.org/10.3389/fmicb.2013.00310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036827228
312 rdf:type schema:CreativeWork
313 https://doi.org/10.3389/fmicb.2017.00048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074203012
314 rdf:type schema:CreativeWork
315 https://doi.org/10.3402/jom.v6.24800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020466246
316 rdf:type schema:CreativeWork
317 https://doi.org/10.3402/jom.v7.28788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027945945
318 rdf:type schema:CreativeWork
319 https://www.grid.ac/institutes/grid.414171.6 schema:alternateName Escola Bahiana de Medicina e Saúde Pública
320 schema:name Bahian School of Medicine and Public Health, Salvador, Bahia, Brazil
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.8399.b schema:alternateName Federal University of Bahia
323 schema:name Biotechnology Postgraduate Program, Federal University of Bahia, Salvador, Bahia, Brazil
324 Department of Biointeraction, Federal University of Bahia, Salvador, Bahia, Brazil
325 Postgraduate Program in Immunology, Federal University of Bahia, Salvador, Bahia, Brazil
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.8505.8 schema:alternateName University of Wrocław
328 schema:name Faculty of Biotechnology, University of Wrocław, Wrocław, Lower Silesia, Poland
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...