Application of response surface methodology for optimization of medium components for the production of secondary metabolites by Streptomyces diastatochromogenes KX852460 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-15

AUTHORS

Taswar Ahsan, Jianguang Chen, Yuanhua Wu, Muhammad Irfan

ABSTRACT

A bioactive strain Streptomyces diastatochromogenes KX852460 was selected for the production of secondary metabolites to control the target spot disease on tobacco leaves, caused by the Rhizoctonia solani AG-3. Peanut meal, soluble starch, NaCl, yeast extract, and ammonium sulphate were identified the best ingredient for high antifungal activity of S. diastatochromogenes KX852460 against the R. solani AG-3. For the improved production of secondary metabolites, central composite design of response surface methodology was applied in submerged fermentation. The best concentrations of ingredients were peanut meal 4.88%, soluble starch 4.40%, NaCl 0.52%, yeast extract 0.47%, and ammonium sulphate 0.0360%. Study of metabolism changes in the submerged fermentation process was analyzed. Level of the reducing sugar increased, as the total sugar consumed. Amino nitrogen and total sugar decrease tendency, which indicated the growth of bacteria in submerged fermentation batch. Production of secondary and other metabolites influenced the pH of the fermentation batch. More... »

PAGES

96

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13568-017-0388-z

DOI

http://dx.doi.org/10.1186/s13568-017-0388-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085418219

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28508386


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