Experimental infections of different carp strains with the carp edema virus (CEV) give insights into the infection biology of the ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-21

AUTHORS

Mikolaj Adamek, Anna Oschilewski, Peter Wohlsein, Verena Jung-Schroers, Felix Teitge, Andy Dawson, David Gela, Veronika Piackova, Martin Kocour, Jerzy Adamek, Sven M. Bergmann, Dieter Steinhagen

ABSTRACT

Outbreaks of koi sleepy disease (KSD) caused by carp edema virus (CEV) may seriously affect populations of farmed common carp, one of the most important fish species for global food production. The present study shows further evidence for the involvement of CEV in outbreaks of KSD among carp and koi populations: in a series of infection experiments, CEV from two different genogroups could be transmitted to several strains of naïve common carp via cohabitation with fish infected with CEV. In recipient fish, clinical signs of KSD were induced. The virus load and viral gene expression results confirm gills as the target organ for CEV replication. Gill explants also allowed for a limited virus replication in vitro. The in vivo infection experiments revealed differences in the virulence of the two CEV genogroups which were associated with infections in koi or in common carp, with higher virulence towards the same fish variety as the donor fish. When the susceptibility of different carp strains to a CEV infection and the development of KSD were experimentally investigated, Amur wild carp showed to be relatively more resistant to the infection and did not develop clinical signs for KSD. However, the resistance could not be related to a higher magnitude of type I IFN responses of affected tissues. Despite not having a mechanistic explanation for the resistance of Amur wild carp to KSD, we recommend using this carp strain in breeding programs to limit potential losses caused by CEV in aquaculture. More... »

PAGES

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13567-017-0416-7

DOI

http://dx.doi.org/10.1186/s13567-017-0416-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083854063

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28222784


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73 insights
74 involvement
75 involvement of CEV
76 koi
77 koi populations
78 koi sleepy disease
79 limited virus replication
80 load
81 loss
82 magnitude
83 mechanistic explanation
84 naïve common carp
85 organs
86 outbreak
87 outbreaks of KSD
88 population
89 possible solutions
90 potential loss
91 present study
92 problem
93 production
94 program
95 recipient fish
96 replication
97 resistance
98 response
99 results
100 same fish variety
101 series
102 signs
103 sleepy disease
104 solution
105 species
106 strains
107 study
108 susceptibility
109 target organs
110 tissue
111 type I IFN response
112 variety
113 viral gene expression results
114 virulence
115 virus
116 virus load
117 virus replication
118 vivo infection experiments
119 wild carp
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