Determination of the infectious titer and virulence of an original US porcine epidemic diarrhea virus PC22A strain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Xinsheng Liu, Chun-Ming Lin, Thavamathi Annamalai, Xiang Gao, Zhongyan Lu, Malak A Esseili, Kwonil Jung, Mohamed El-Tholoth, Linda J Saif, Qiuhong Wang

ABSTRACT

The infectious dose of a virus pool of original US PEDV strain PC22A was determined in 4-day-old, cesarean-derived, colostrum-deprived (CDCD) piglets. The median pig diarrhea dose (PDD50) of the virus pool was determined as 7.35 log10 PDD50/mL, similar to the cell culture infectious titer, 7.75 log10 plaque-forming units (PFU)/mL. 100 PDD50 caused watery diarrhea in all conventional suckling piglets (n = 12) derived from a PEDV-naive sow, whereas 1000 and 10 000 PDD50 did not cause diarrhea in piglets derived from two PEDV-field exposed-recovered sows. This information is important for future PEDV challenge studies and validation of PEDV vaccines. More... »

PAGES

109

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13567-015-0249-1

DOI

http://dx.doi.org/10.1186/s13567-015-0249-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006865950

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26408019


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