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    "description": "BackgroundChronic kidney disease (CKD) is associated with endothelial dysfunction and increased cardiovascular mortality. Endothelial dysfunction can be studied measuring myocardial perfusion reserve (MPR). MPR is the ratio of stress and rest myocardial perfusion (MP) and reflects the capacity of vascular bed to increase perfusion and microvascular responsiveness. In this pilot study, our aim was to assess MPR of 19 patients with kidney transplant (CKD stages 2\u20133) and of ten healthy controls with quantitative [15O]H2O positron emission tomography (PET) method.ResultsBasal MP was statistically significantly higher at rest in the kidney transplant patients than in the healthy controls [1.3 (0.4)\u2009ml/min/g and 1.0 (0.2)\u2009ml/min/g, respectively, p\u2009=\u20090.0015]. After correction of basal MP by cardiac workload [MPcorr\u2009=\u2009basal MP/individual rate pressure product (RPP)\u2009\u00d7\u2009average RPP of the healthy controls], the difference between the groups disappeared [0.9 (0.2)\u2009\u2009ml/min/g and 1.0 (0.3)\u2009ml/min/g, respectively, p\u2009=\u20090.55)]. There was no difference in stress MP between the kidney transplant patients and the healthy subjects [3.8 (1.0)\u2009ml/min/g and 4.0 (0.9)\u2009ml/min/g, respectively, p\u2009=\u20090.53]. Although MPR was reduced, MPRcorr (stress MP/basal MPcorr) did not differ between the kidney transplant patients and the healthy controls [4.1 (1.1) and 4.3 (1.6), respectively, p\u2009=\u20090.8].ConclusionsMP during stress is preserved in kidney transplant patients with CKD stage 2\u20133. The reduced MPR appears to be explained by increased resting MP. This is likely linked with increased cardiac workload due to sympathetic overactivation in kidney transplant patients.", 
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      "myocardial perfusion reserve", 
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      "myocardial perfusion", 
      "healthy controls", 
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      "cardiac workload", 
      "BackgroundChronic kidney disease", 
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    "name": "Myocardial perfusion reserve of kidney transplant patients is well preserved", 
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