First-in-class positron emission tomography tracer for the glucagon receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Irina Velikyan, Torsten Haack, Martin Bossart, Andreas Evers, Iina Laitinen, Philip Larsen, Oliver Plettenburg, Lars Johansson, Stefan Pierrou, Michael Wagner, Olof Eriksson

ABSTRACT

The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However, currently, there are no suitable biomarkers that reliably demonstrate GCG receptor target engagement. METHODS: Two potent GCG receptor peptide agonists, S01-GCG and S02-GCG, were labeled with positron emission tomography (PET) radionuclide gallium-68. The GCG receptor binding affinity and specificity of the resulting radiopharmaceuticals [68Ga]Ga-DO3A-S01-GCG and [68Ga]Ga-DO3A-S02-GCG were evaluated in HEK-293 cells overexpressing the human GCG receptor and on frozen hepatic sections from human, non-human primate, and rat. In in vivo biodistribution, binding specificity and dosimetry were assessed in rat. RESULTS: [68Ga]Ga-DO3A-S01-GCG in particular demonstrated GCG receptor-mediated binding in cells and liver tissue with affinity in the nanomolar range required for imaging. [68Ga]Ga-DO3A-S01-GCG binding was not blocked by co-incubation of a GLP-1 agonist. In vivo binding in rat liver was GCG receptor specific with low non-specific binding throughout the body. Moreover, the extrapolated human effective doses, predicted from rat biodistribution data, allow for repeated PET imaging potentially also in combination with GLP-1R radiopharmaceuticals. CONCLUSION: [68Ga]Ga-DO3A-S01-GCG thus constitutes a first-in-class PET tracer targeting the GCG receptor, with suitable properties for clinical development. This tool has potential to provide direct quantitative evidence of GCG receptor occupancy in humans. More... »

PAGES

17

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13550-019-0482-0

DOI

http://dx.doi.org/10.1186/s13550-019-0482-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112168851

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30771019


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "PET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden", 
            "Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velikyan", 
        "givenName": "Irina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanofi (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420214.1", 
          "name": [
            "Sanofi-Aventis Deutschland GmbH, Industriepark H\u00f6chst, 65926, Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haack", 
        "givenName": "Torsten", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanofi (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420214.1", 
          "name": [
            "Sanofi-Aventis Deutschland GmbH, Industriepark H\u00f6chst, 65926, Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bossart", 
        "givenName": "Martin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanofi (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420214.1", 
          "name": [
            "Sanofi-Aventis Deutschland GmbH, Industriepark H\u00f6chst, 65926, Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evers", 
        "givenName": "Andreas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanofi (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420214.1", 
          "name": [
            "Sanofi-Aventis Deutschland GmbH, Industriepark H\u00f6chst, 65926, Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laitinen", 
        "givenName": "Iina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanofi (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420214.1", 
          "name": [
            "Sanofi-Aventis Deutschland GmbH, Industriepark H\u00f6chst, 65926, Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larsen", 
        "givenName": "Philip", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Hannover", 
          "id": "https://www.grid.ac/institutes/grid.9122.8", 
          "name": [
            "Institute of Medicinal Chemistry, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany", 
            "Institute of Organic Chemistry, Leibniz Universit\u00e4t Hannover, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Plettenburg", 
        "givenName": "Oliver", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Antaros Medical AB, Uppsala Science Park, Dag Hammarskj\u00f6lds V\u00e4g 14B, M\u00f6lndal, SE-751 83, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johansson", 
        "givenName": "Lars", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Antaros Medical AB, Uppsala Science Park, Dag Hammarskj\u00f6lds V\u00e4g 14B, M\u00f6lndal, SE-751 83, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pierrou", 
        "givenName": "Stefan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanofi (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420214.1", 
          "name": [
            "Sanofi-Aventis Deutschland GmbH, Industriepark H\u00f6chst, 65926, Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagner", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Antaros Medical AB, Uppsala Science Park, Dag Hammarskj\u00f6lds V\u00e4g 14B, M\u00f6lndal, SE-751 83, Uppsala, Sweden", 
            "Science For Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eriksson", 
        "givenName": "Olof", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2337/db09-0278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000562521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10967-010-0555-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001584079", 
          "https://doi.org/10.1007/s10967-010-0555-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10967-010-0555-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001584079", 
          "https://doi.org/10.1007/s10967-010-0555-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-014-2745-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002997915", 
          "https://doi.org/10.1007/s00259-014-2745-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/304368a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015042332", 
          "https://doi.org/10.1038/304368a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1363-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015567221", 
          "https://doi.org/10.1007/s00259-009-1363-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1363-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015567221", 
          "https://doi.org/10.1007/s00259-009-1363-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-014-3166-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034253462", 
          "https://doi.org/10.1007/s00125-014-3166-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-014-3166-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034253462", 
          "https://doi.org/10.1007/s00125-014-3166-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037064127", 
          "https://doi.org/10.1038/nchembio.209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037064127", 
          "https://doi.org/10.1038/nchembio.209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.114066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041683043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc030078f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055153476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc030078f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055153476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2013-3541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064294700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079103046", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.7b00174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085347683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-017-4354-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090855737", 
          "https://doi.org/10.1007/s00125-017-4354-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-017-4354-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090855737", 
          "https://doi.org/10.1007/s00125-017-4354-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00592-017-1046-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091514188", 
          "https://doi.org/10.1007/s00592-017-1046-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However, currently, there are no suitable biomarkers that reliably demonstrate GCG receptor target engagement.\nMETHODS: Two potent GCG receptor peptide agonists, S01-GCG and S02-GCG, were labeled with positron emission tomography (PET) radionuclide gallium-68. The GCG receptor binding affinity and specificity of the resulting radiopharmaceuticals [68Ga]Ga-DO3A-S01-GCG and [68Ga]Ga-DO3A-S02-GCG were evaluated in HEK-293 cells overexpressing the human GCG receptor and on frozen hepatic sections from human, non-human primate, and rat. In in vivo biodistribution, binding specificity and dosimetry were assessed in rat.\nRESULTS: [68Ga]Ga-DO3A-S01-GCG in particular demonstrated GCG receptor-mediated binding in cells and liver tissue with affinity in the nanomolar range required for imaging. [68Ga]Ga-DO3A-S01-GCG binding was not blocked by co-incubation of a GLP-1 agonist. In vivo binding in rat liver was GCG receptor specific with low non-specific binding throughout the body. Moreover, the extrapolated human effective doses, predicted from rat biodistribution data, allow for repeated PET imaging potentially also in combination with GLP-1R radiopharmaceuticals.\nCONCLUSION: [68Ga]Ga-DO3A-S01-GCG thus constitutes a first-in-class PET tracer targeting the GCG receptor, with suitable properties for clinical development. This tool has potential to provide direct quantitative evidence of GCG receptor occupancy in humans.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13550-019-0482-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1045165", 
        "issn": [
          "2191-219X"
        ], 
        "name": "EJNMMI Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "First-in-class positron emission tomography tracer for the glucagon receptor", 
    "pagination": "17", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "15725580a4a58a438d85159f00df3f9a3a744c49270f51da0ffea63c17b5ba3e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30771019"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101560946"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13550-019-0482-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112168851"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13550-019-0482-0", 
      "https://app.dimensions.ai/details/publication/pub.1112168851"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11704_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13550-019-0482-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13550-019-0482-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13550-019-0482-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13550-019-0482-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13550-019-0482-0'


 

This table displays all metadata directly associated to this object as RDF triples.

190 TRIPLES      21 PREDICATES      43 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13550-019-0482-0 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author Na42dd10db929415991f7b641f0f0c473
4 schema:citation sg:pub.10.1007/s00125-014-3166-3
5 sg:pub.10.1007/s00125-017-4354-8
6 sg:pub.10.1007/s00259-009-1363-y
7 sg:pub.10.1007/s00259-014-2745-3
8 sg:pub.10.1007/s00592-017-1046-2
9 sg:pub.10.1007/s10967-010-0555-z
10 sg:pub.10.1038/304368a0
11 sg:pub.10.1038/nchembio.209
12 https://app.dimensions.ai/details/publication/pub.1079103046
13 https://doi.org/10.1021/acs.jmedchem.7b00174
14 https://doi.org/10.1021/bc030078f
15 https://doi.org/10.1210/jc.2013-3541
16 https://doi.org/10.2337/db09-0278
17 https://doi.org/10.2967/jnumed.112.114066
18 schema:datePublished 2019-12
19 schema:datePublishedReg 2019-12-01
20 schema:description The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However, currently, there are no suitable biomarkers that reliably demonstrate GCG receptor target engagement. METHODS: Two potent GCG receptor peptide agonists, S01-GCG and S02-GCG, were labeled with positron emission tomography (PET) radionuclide gallium-68. The GCG receptor binding affinity and specificity of the resulting radiopharmaceuticals [68Ga]Ga-DO3A-S01-GCG and [68Ga]Ga-DO3A-S02-GCG were evaluated in HEK-293 cells overexpressing the human GCG receptor and on frozen hepatic sections from human, non-human primate, and rat. In in vivo biodistribution, binding specificity and dosimetry were assessed in rat. RESULTS: [68Ga]Ga-DO3A-S01-GCG in particular demonstrated GCG receptor-mediated binding in cells and liver tissue with affinity in the nanomolar range required for imaging. [68Ga]Ga-DO3A-S01-GCG binding was not blocked by co-incubation of a GLP-1 agonist. In vivo binding in rat liver was GCG receptor specific with low non-specific binding throughout the body. Moreover, the extrapolated human effective doses, predicted from rat biodistribution data, allow for repeated PET imaging potentially also in combination with GLP-1R radiopharmaceuticals. CONCLUSION: [68Ga]Ga-DO3A-S01-GCG thus constitutes a first-in-class PET tracer targeting the GCG receptor, with suitable properties for clinical development. This tool has potential to provide direct quantitative evidence of GCG receptor occupancy in humans.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf Ncc5212f29fd045d1b0bb302efe8b173c
25 Nce32dec511cc41658d758e402770bfd9
26 sg:journal.1045165
27 schema:name First-in-class positron emission tomography tracer for the glucagon receptor
28 schema:pagination 17
29 schema:productId N11e9f28bed3a499797ce857b065f62c2
30 N41486392e2194747916c5f59a6a74a0a
31 N7695554b710c42f1a001c72704e5c486
32 N959cdd1db9e14476bcc006eb5c9c517b
33 Ne6b79bba65094f64a18f3e4a080c5f5f
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112168851
35 https://doi.org/10.1186/s13550-019-0482-0
36 schema:sdDatePublished 2019-04-11T11:18
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher Naa2ed34571554ad8a6bc47d4dfbce96e
39 schema:url https://link.springer.com/10.1186%2Fs13550-019-0482-0
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N02d2e401757649d19432be9e4b9e4cc5 schema:affiliation https://www.grid.ac/institutes/grid.420214.1
44 schema:familyName Bossart
45 schema:givenName Martin
46 rdf:type schema:Person
47 N11e9f28bed3a499797ce857b065f62c2 schema:name dimensions_id
48 schema:value pub.1112168851
49 rdf:type schema:PropertyValue
50 N221cba4e5e784bd99a43e9b237b7d331 schema:affiliation https://www.grid.ac/institutes/grid.9122.8
51 schema:familyName Plettenburg
52 schema:givenName Oliver
53 rdf:type schema:Person
54 N377f649aba67402eb3825bb692d0f3ad schema:name Antaros Medical AB, Uppsala Science Park, Dag Hammarskjölds Väg 14B, Mölndal, SE-751 83, Uppsala, Sweden
55 rdf:type schema:Organization
56 N41486392e2194747916c5f59a6a74a0a schema:name pubmed_id
57 schema:value 30771019
58 rdf:type schema:PropertyValue
59 N44e6fadeb7fc4008a106d4ba97609eb4 schema:affiliation https://www.grid.ac/institutes/grid.420214.1
60 schema:familyName Laitinen
61 schema:givenName Iina
62 rdf:type schema:Person
63 N49966f635a214a0d857ee5ef3fb0fdfd schema:name Antaros Medical AB, Uppsala Science Park, Dag Hammarskjölds Väg 14B, Mölndal, SE-751 83, Uppsala, Sweden
64 rdf:type schema:Organization
65 N4ab1ebb049bf479e9fa84c3ac67af3ec rdf:first N221cba4e5e784bd99a43e9b237b7d331
66 rdf:rest Ne851d65bd2a9431eb9a3d2f85d985a21
67 N56c219d78dbd4c0fa420611813de65b9 schema:affiliation N49966f635a214a0d857ee5ef3fb0fdfd
68 schema:familyName Pierrou
69 schema:givenName Stefan
70 rdf:type schema:Person
71 N64cfdc2690b44378b0cdd32fe5b3f6e3 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
72 schema:familyName Velikyan
73 schema:givenName Irina
74 rdf:type schema:Person
75 N6e4d783577d144e08b72eb6c11518b19 schema:affiliation https://www.grid.ac/institutes/grid.420214.1
76 schema:familyName Haack
77 schema:givenName Torsten
78 rdf:type schema:Person
79 N7695554b710c42f1a001c72704e5c486 schema:name doi
80 schema:value 10.1186/s13550-019-0482-0
81 rdf:type schema:PropertyValue
82 N815313d548c04be088d15a42b0033d5b rdf:first Nd7c99094945c418684d7acc7ae618cea
83 rdf:rest N4ab1ebb049bf479e9fa84c3ac67af3ec
84 N959cdd1db9e14476bcc006eb5c9c517b schema:name readcube_id
85 schema:value 15725580a4a58a438d85159f00df3f9a3a744c49270f51da0ffea63c17b5ba3e
86 rdf:type schema:PropertyValue
87 N9985d5e05b644a6ba46c035de7581775 rdf:first N6e4d783577d144e08b72eb6c11518b19
88 rdf:rest Nd75a69fac50f4972a673d49b20a04e54
89 Na42dd10db929415991f7b641f0f0c473 rdf:first N64cfdc2690b44378b0cdd32fe5b3f6e3
90 rdf:rest N9985d5e05b644a6ba46c035de7581775
91 Naa2ed34571554ad8a6bc47d4dfbce96e schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 Nb4f71f3f45b648c784887d70115052e0 rdf:first N56c219d78dbd4c0fa420611813de65b9
94 rdf:rest Ndcafe8b11bfb442692711b76c09ad8db
95 Nba3af0153d494861ac626a8350becf7e schema:affiliation https://www.grid.ac/institutes/grid.420214.1
96 schema:familyName Wagner
97 schema:givenName Michael
98 rdf:type schema:Person
99 Ncc5212f29fd045d1b0bb302efe8b173c schema:volumeNumber 9
100 rdf:type schema:PublicationVolume
101 Nce32dec511cc41658d758e402770bfd9 schema:issueNumber 1
102 rdf:type schema:PublicationIssue
103 Nced2eb22bda44ee798c458ea23ae6564 schema:affiliation N377f649aba67402eb3825bb692d0f3ad
104 schema:familyName Johansson
105 schema:givenName Lars
106 rdf:type schema:Person
107 Nd75a69fac50f4972a673d49b20a04e54 rdf:first N02d2e401757649d19432be9e4b9e4cc5
108 rdf:rest Ned7844ff7f2d4258905fd84a1dbbc643
109 Nd7c99094945c418684d7acc7ae618cea schema:affiliation https://www.grid.ac/institutes/grid.420214.1
110 schema:familyName Larsen
111 schema:givenName Philip
112 rdf:type schema:Person
113 Ndc26761a1dc44253a89fd4a6ffef60df rdf:first N44e6fadeb7fc4008a106d4ba97609eb4
114 rdf:rest N815313d548c04be088d15a42b0033d5b
115 Ndcafe8b11bfb442692711b76c09ad8db rdf:first Nba3af0153d494861ac626a8350becf7e
116 rdf:rest Nf4eddb113d18435c97a06de73402c6b0
117 Ne6b79bba65094f64a18f3e4a080c5f5f schema:name nlm_unique_id
118 schema:value 101560946
119 rdf:type schema:PropertyValue
120 Ne851d65bd2a9431eb9a3d2f85d985a21 rdf:first Nced2eb22bda44ee798c458ea23ae6564
121 rdf:rest Nb4f71f3f45b648c784887d70115052e0
122 Ned7844ff7f2d4258905fd84a1dbbc643 rdf:first Nf204a2f45a8342159fe5e427b7c30e8a
123 rdf:rest Ndc26761a1dc44253a89fd4a6ffef60df
124 Nf204a2f45a8342159fe5e427b7c30e8a schema:affiliation https://www.grid.ac/institutes/grid.420214.1
125 schema:familyName Evers
126 schema:givenName Andreas
127 rdf:type schema:Person
128 Nf4eddb113d18435c97a06de73402c6b0 rdf:first Nf52e9e19d742454c84849c87cd167b2a
129 rdf:rest rdf:nil
130 Nf52e9e19d742454c84849c87cd167b2a schema:affiliation https://www.grid.ac/institutes/grid.8993.b
131 schema:familyName Eriksson
132 schema:givenName Olof
133 rdf:type schema:Person
134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
135 schema:name Medical and Health Sciences
136 rdf:type schema:DefinedTerm
137 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
138 schema:name Pharmacology and Pharmaceutical Sciences
139 rdf:type schema:DefinedTerm
140 sg:journal.1045165 schema:issn 2191-219X
141 schema:name EJNMMI Research
142 rdf:type schema:Periodical
143 sg:pub.10.1007/s00125-014-3166-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034253462
144 https://doi.org/10.1007/s00125-014-3166-3
145 rdf:type schema:CreativeWork
146 sg:pub.10.1007/s00125-017-4354-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090855737
147 https://doi.org/10.1007/s00125-017-4354-8
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s00259-009-1363-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015567221
150 https://doi.org/10.1007/s00259-009-1363-y
151 rdf:type schema:CreativeWork
152 sg:pub.10.1007/s00259-014-2745-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002997915
153 https://doi.org/10.1007/s00259-014-2745-3
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s00592-017-1046-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091514188
156 https://doi.org/10.1007/s00592-017-1046-2
157 rdf:type schema:CreativeWork
158 sg:pub.10.1007/s10967-010-0555-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1001584079
159 https://doi.org/10.1007/s10967-010-0555-z
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/304368a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015042332
162 https://doi.org/10.1038/304368a0
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/nchembio.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037064127
165 https://doi.org/10.1038/nchembio.209
166 rdf:type schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1079103046 schema:CreativeWork
168 https://doi.org/10.1021/acs.jmedchem.7b00174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085347683
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1021/bc030078f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153476
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1210/jc.2013-3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064294700
173 rdf:type schema:CreativeWork
174 https://doi.org/10.2337/db09-0278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000562521
175 rdf:type schema:CreativeWork
176 https://doi.org/10.2967/jnumed.112.114066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041683043
177 rdf:type schema:CreativeWork
178 https://www.grid.ac/institutes/grid.420214.1 schema:alternateName Sanofi (Germany)
179 schema:name Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, 65926, Frankfurt am Main, Germany
180 rdf:type schema:Organization
181 https://www.grid.ac/institutes/grid.8993.b schema:alternateName Uppsala University
182 schema:name Antaros Medical AB, Uppsala Science Park, Dag Hammarskjölds Väg 14B, Mölndal, SE-751 83, Uppsala, Sweden
183 PET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden
184 Science For Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
185 Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
186 rdf:type schema:Organization
187 https://www.grid.ac/institutes/grid.9122.8 schema:alternateName University of Hannover
188 schema:name Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
189 Institute of Organic Chemistry, Leibniz Universität Hannover, Hannover, Germany
190 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...