The role of FDG-PET/CT in preoperative staging of sentinel lymph node biopsy-positive melanoma patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Evan C. Frary, Dorte Gad, Lars Bastholt, Søren Hess

ABSTRACT

BACKGROUND: On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SLNB) underwent FDG-PET/CT preoperatively prior to lymph node dissection (LND). The purpose of this study is to determine FDG-PET/CT's efficacy in finding distant metastasis in the first year after the implementation of this new strategy, and to what extent these findings influence subsequent diagnostic testing and treatment in this patient group. We conducted a retrospective multicenter cohort study which included all patients with MM from all hospitals in the Region of Southern Denmark from April 1, 2015 to April 1, 2016 found to be SLNB-positive who subsequently underwent FDG-PET/CT. Patient information was acquired from the Danish Melanoma Database and was cross-referenced with OUH's patient records. The data was analyzed for a number of parameters including FDG-PET/CT findings and treatment strategy. Median follow-up time was 7 months. RESULTS: A total of 47 patients were eligible from the first year of this new diagnostic strategy. One patient was excluded due to undergoing LND prior to FDG-PET/CT. Thus, 46 patients were included in this study. Ultimately, preoperative FDG-PET/CT neither uncovered any distant metastases nor led to any alterations in treatment strategy in this patient group. CONCLUSIONS: Surprisingly, this new diagnostic strategy did not find any MM metastases or uncover anything else of relevance. FDG-PET/CT did, however, provide false positive findings in 13 % (6/46) of these patients. These scans triggered additional, predominantly invasive, procedures, which did not ultimately have an impact on the therapeutic strategy. Thus, these findings indicate a need for re-evaluation of this new diagnostic strategy as well as the necessity for further clinical trials evaluating FDG-PET/CT's utility in this clinical setting. More... »

PAGES

73

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13550-016-0228-1

DOI

http://dx.doi.org/10.1186/s13550-016-0228-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031191220

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27709489


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frary", 
        "givenName": "Evan C.", 
        "id": "sg:person.010522472211.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522472211.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Plastic Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gad", 
        "givenName": "Dorte", 
        "id": "sg:person.0714054001.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714054001.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Oncology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bastholt", 
        "givenName": "Lars", 
        "id": "sg:person.01322567407.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322567407.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern Denmark", 
          "id": "https://www.grid.ac/institutes/grid.10825.3e", 
          "name": [
            "Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark", 
            "Department of Radiology and Nuclear Medicine, Hospital of South West Jutland, Finsengade 10, 6700, Esbjerg, Denmark", 
            "Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Wisl\u00f8vparken 19, 3, 5000, Odense C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hess", 
        "givenName": "S\u00f8ren", 
        "id": "sg:person.01052166137.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052166137.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2010.33.1884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003095481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2016.01.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008240817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-014-2961-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008918527", 
          "https://doi.org/10.1007/s00259-014-2961-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-014-2961-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008918527", 
          "https://doi.org/10.1007/s00259-014-2961-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-3758-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011316899", 
          "https://doi.org/10.1245/s10434-014-3758-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.4799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013277178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1224-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017781580", 
          "https://doi.org/10.1007/s00259-009-1224-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1224-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017781580", 
          "https://doi.org/10.1007/s00259-009-1224-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1224-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017781580", 
          "https://doi.org/10.1007/s00259-009-1224-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2401-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018299738", 
          "https://doi.org/10.1245/s10434-012-2401-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-015-3187-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018897152", 
          "https://doi.org/10.1007/s00259-015-3187-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e32833cb8b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020517094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e32833cb8b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020517094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e32833cb8b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020517094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e32833cb8b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020517094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2015.3664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021176608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mnm.0000171779.65284.eb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024117073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mnm.0000171779.65284.eb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024117073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mnm.0000171779.65284.eb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024117073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mnm.0000171779.65284.eb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024117073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rlu.0000099805.36471.aa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027975291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rlu.0000099805.36471.aa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027975291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2006.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028226511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.acra.2013.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029020952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199110000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032707662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199110000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032707662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5402/2012/308279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033075442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-010-2025-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033784541", 
          "https://doi.org/10.1007/s00330-010-2025-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033790406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033790406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suronc.2013.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034432165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-010-1702-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035065355", 
          "https://doi.org/10.1007/s00259-010-1702-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e32827420cc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038550720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnm.0b013e32827420cc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038550720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djq455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038901158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-015-3217-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042915726", 
          "https://doi.org/10.1007/s00259-015-3217-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-015-3217-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042915726", 
          "https://doi.org/10.1007/s00259-015-3217-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2046-4053-1-62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046436463", 
          "https://doi.org/10.1186/2046-4053-1-62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2011.10247.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047226576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2493080240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047510232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e3282f62404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e3282f62404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.11.7280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069301940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.179.2.1790477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069324898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078152640", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SLNB) underwent FDG-PET/CT preoperatively prior to lymph node dissection (LND). The purpose of this study is to determine FDG-PET/CT's efficacy in finding distant metastasis in the first year after the implementation of this new strategy, and to what extent these findings influence subsequent diagnostic testing and treatment in this patient group. We conducted a retrospective multicenter cohort study which included all patients with MM from all hospitals in the Region of Southern Denmark from April 1, 2015 to April 1, 2016 found to be SLNB-positive who subsequently underwent FDG-PET/CT. Patient information was acquired from the Danish Melanoma Database and was cross-referenced with OUH's patient records. The data was analyzed for a number of parameters including FDG-PET/CT findings and treatment strategy. Median follow-up time was 7\u00a0months.\nRESULTS: A total of 47 patients were eligible from the first year of this new diagnostic strategy. One patient was excluded due to undergoing LND prior to FDG-PET/CT. Thus, 46 patients were included in this study. Ultimately, preoperative FDG-PET/CT neither uncovered any distant metastases nor led to any alterations in treatment strategy in this patient group.\nCONCLUSIONS: Surprisingly, this new diagnostic strategy did not find any MM metastases or uncover anything else of relevance. FDG-PET/CT did, however, provide false positive findings in 13\u00a0% (6/46) of these patients. These scans triggered additional, predominantly invasive, procedures, which did not ultimately have an impact on the therapeutic strategy. Thus, these findings indicate a need for re-evaluation of this new diagnostic strategy as well as the necessity for further clinical trials evaluating FDG-PET/CT's utility in this clinical setting.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13550-016-0228-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045165", 
        "issn": [
          "2191-219X"
        ], 
        "name": "EJNMMI Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "The role of FDG-PET/CT in preoperative staging of sentinel lymph node biopsy-positive melanoma patients", 
    "pagination": "73", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9497aaf6209f22270bdcea79ae8dbdefad3a95c24dbb21a668c4c2f53fc444a8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27709489"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101560946"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13550-016-0228-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031191220"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13550-016-0228-1", 
      "https://app.dimensions.ai/details/publication/pub.1031191220"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70053_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13550-016-0228-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13550-016-0228-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13550-016-0228-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13550-016-0228-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13550-016-0228-1'


 

This table displays all metadata directly associated to this object as RDF triples.

194 TRIPLES      21 PREDICATES      59 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13550-016-0228-1 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N1dd65596e2274e5e9d71a0a33f2d4479
4 schema:citation sg:pub.10.1007/s00259-009-1224-8
5 sg:pub.10.1007/s00259-010-1702-z
6 sg:pub.10.1007/s00259-014-2961-x
7 sg:pub.10.1007/s00259-015-3187-2
8 sg:pub.10.1007/s00259-015-3217-0
9 sg:pub.10.1007/s00330-010-2025-y
10 sg:pub.10.1186/2046-4053-1-62
11 sg:pub.10.1245/s10434-012-2401-8
12 sg:pub.10.1245/s10434-014-3758-7
13 https://app.dimensions.ai/details/publication/pub.1078152640
14 https://doi.org/10.1001/jamaoncol.2015.3664
15 https://doi.org/10.1002/cncr.21189
16 https://doi.org/10.1016/j.acra.2013.11.002
17 https://doi.org/10.1016/j.ejca.2006.11.014
18 https://doi.org/10.1016/j.jamcollsurg.2016.01.045
19 https://doi.org/10.1016/j.suronc.2013.06.004
20 https://doi.org/10.1093/jnci/djq455
21 https://doi.org/10.1097/00000658-199110000-00013
22 https://doi.org/10.1097/01.mnm.0000171779.65284.eb
23 https://doi.org/10.1097/01.rlu.0000099805.36471.aa
24 https://doi.org/10.1097/cmr.0b013e3282f62404
25 https://doi.org/10.1097/mnm.0b013e32827420cc
26 https://doi.org/10.1097/mnm.0b013e32833cb8b7
27 https://doi.org/10.1111/j.1365-2133.2011.10247.x
28 https://doi.org/10.1148/radiol.2493080240
29 https://doi.org/10.1200/jco.2009.23.4799
30 https://doi.org/10.1200/jco.2010.33.1884
31 https://doi.org/10.2214/ajr.11.7280
32 https://doi.org/10.2214/ajr.179.2.1790477
33 https://doi.org/10.5402/2012/308279
34 schema:datePublished 2016-12
35 schema:datePublishedReg 2016-12-01
36 schema:description BACKGROUND: On April 1, 2015, Odense University Hospital (OUH) began a new diagnostic strategy, wherein all malignant melanoma (MM) patients in the Region of Southern Denmark with a positive sentinel lymph node biopsy (SLNB) underwent FDG-PET/CT preoperatively prior to lymph node dissection (LND). The purpose of this study is to determine FDG-PET/CT's efficacy in finding distant metastasis in the first year after the implementation of this new strategy, and to what extent these findings influence subsequent diagnostic testing and treatment in this patient group. We conducted a retrospective multicenter cohort study which included all patients with MM from all hospitals in the Region of Southern Denmark from April 1, 2015 to April 1, 2016 found to be SLNB-positive who subsequently underwent FDG-PET/CT. Patient information was acquired from the Danish Melanoma Database and was cross-referenced with OUH's patient records. The data was analyzed for a number of parameters including FDG-PET/CT findings and treatment strategy. Median follow-up time was 7 months. RESULTS: A total of 47 patients were eligible from the first year of this new diagnostic strategy. One patient was excluded due to undergoing LND prior to FDG-PET/CT. Thus, 46 patients were included in this study. Ultimately, preoperative FDG-PET/CT neither uncovered any distant metastases nor led to any alterations in treatment strategy in this patient group. CONCLUSIONS: Surprisingly, this new diagnostic strategy did not find any MM metastases or uncover anything else of relevance. FDG-PET/CT did, however, provide false positive findings in 13 % (6/46) of these patients. These scans triggered additional, predominantly invasive, procedures, which did not ultimately have an impact on the therapeutic strategy. Thus, these findings indicate a need for re-evaluation of this new diagnostic strategy as well as the necessity for further clinical trials evaluating FDG-PET/CT's utility in this clinical setting.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N96e90fa37bfb4ab085397bba907f14c9
41 Na00a693567d04b54ac018a526bd4e8b8
42 sg:journal.1045165
43 schema:name The role of FDG-PET/CT in preoperative staging of sentinel lymph node biopsy-positive melanoma patients
44 schema:pagination 73
45 schema:productId N16a15ed59fcc423b8201e704a05e944c
46 Na83cfe5fcf854c728878d6e0f1ef3015
47 Nb96646b0629d4807b32c405051e55bda
48 Nc185f336f229470781e918220916ff6e
49 Nfc205b5e222c43e1b7666be60772c7a6
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031191220
51 https://doi.org/10.1186/s13550-016-0228-1
52 schema:sdDatePublished 2019-04-11T12:40
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher Nff1e635a37e448d5b85417255b33677c
55 schema:url https://link.springer.com/10.1186%2Fs13550-016-0228-1
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N05cefe853af94b6c96071435149ccd05 rdf:first sg:person.01052166137.43
60 rdf:rest rdf:nil
61 N16a15ed59fcc423b8201e704a05e944c schema:name pubmed_id
62 schema:value 27709489
63 rdf:type schema:PropertyValue
64 N1dd65596e2274e5e9d71a0a33f2d4479 rdf:first sg:person.010522472211.15
65 rdf:rest Ncdbae34138814c78baeb1ebd531d68e1
66 N2655ad9c27b44cd692dd9379ffc58ecc rdf:first sg:person.01322567407.20
67 rdf:rest N05cefe853af94b6c96071435149ccd05
68 N96e90fa37bfb4ab085397bba907f14c9 schema:volumeNumber 6
69 rdf:type schema:PublicationVolume
70 Na00a693567d04b54ac018a526bd4e8b8 schema:issueNumber 1
71 rdf:type schema:PublicationIssue
72 Na83cfe5fcf854c728878d6e0f1ef3015 schema:name dimensions_id
73 schema:value pub.1031191220
74 rdf:type schema:PropertyValue
75 Nb96646b0629d4807b32c405051e55bda schema:name doi
76 schema:value 10.1186/s13550-016-0228-1
77 rdf:type schema:PropertyValue
78 Nc185f336f229470781e918220916ff6e schema:name readcube_id
79 schema:value 9497aaf6209f22270bdcea79ae8dbdefad3a95c24dbb21a668c4c2f53fc444a8
80 rdf:type schema:PropertyValue
81 Ncdbae34138814c78baeb1ebd531d68e1 rdf:first sg:person.0714054001.04
82 rdf:rest N2655ad9c27b44cd692dd9379ffc58ecc
83 Nfc205b5e222c43e1b7666be60772c7a6 schema:name nlm_unique_id
84 schema:value 101560946
85 rdf:type schema:PropertyValue
86 Nff1e635a37e448d5b85417255b33677c schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
89 schema:name Medical and Health Sciences
90 rdf:type schema:DefinedTerm
91 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
92 schema:name Clinical Sciences
93 rdf:type schema:DefinedTerm
94 sg:journal.1045165 schema:issn 2191-219X
95 schema:name EJNMMI Research
96 rdf:type schema:Periodical
97 sg:person.01052166137.43 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
98 schema:familyName Hess
99 schema:givenName Søren
100 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052166137.43
101 rdf:type schema:Person
102 sg:person.010522472211.15 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
103 schema:familyName Frary
104 schema:givenName Evan C.
105 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010522472211.15
106 rdf:type schema:Person
107 sg:person.01322567407.20 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
108 schema:familyName Bastholt
109 schema:givenName Lars
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322567407.20
111 rdf:type schema:Person
112 sg:person.0714054001.04 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
113 schema:familyName Gad
114 schema:givenName Dorte
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714054001.04
116 rdf:type schema:Person
117 sg:pub.10.1007/s00259-009-1224-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017781580
118 https://doi.org/10.1007/s00259-009-1224-8
119 rdf:type schema:CreativeWork
120 sg:pub.10.1007/s00259-010-1702-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035065355
121 https://doi.org/10.1007/s00259-010-1702-z
122 rdf:type schema:CreativeWork
123 sg:pub.10.1007/s00259-014-2961-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008918527
124 https://doi.org/10.1007/s00259-014-2961-x
125 rdf:type schema:CreativeWork
126 sg:pub.10.1007/s00259-015-3187-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018897152
127 https://doi.org/10.1007/s00259-015-3187-2
128 rdf:type schema:CreativeWork
129 sg:pub.10.1007/s00259-015-3217-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042915726
130 https://doi.org/10.1007/s00259-015-3217-0
131 rdf:type schema:CreativeWork
132 sg:pub.10.1007/s00330-010-2025-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033784541
133 https://doi.org/10.1007/s00330-010-2025-y
134 rdf:type schema:CreativeWork
135 sg:pub.10.1186/2046-4053-1-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046436463
136 https://doi.org/10.1186/2046-4053-1-62
137 rdf:type schema:CreativeWork
138 sg:pub.10.1245/s10434-012-2401-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018299738
139 https://doi.org/10.1245/s10434-012-2401-8
140 rdf:type schema:CreativeWork
141 sg:pub.10.1245/s10434-014-3758-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011316899
142 https://doi.org/10.1245/s10434-014-3758-7
143 rdf:type schema:CreativeWork
144 https://app.dimensions.ai/details/publication/pub.1078152640 schema:CreativeWork
145 https://doi.org/10.1001/jamaoncol.2015.3664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021176608
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1002/cncr.21189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033790406
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/j.acra.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029020952
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/j.ejca.2006.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028226511
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.jamcollsurg.2016.01.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008240817
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.suronc.2013.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034432165
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1093/jnci/djq455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038901158
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1097/00000658-199110000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032707662
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1097/01.mnm.0000171779.65284.eb schema:sameAs https://app.dimensions.ai/details/publication/pub.1024117073
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1097/01.rlu.0000099805.36471.aa schema:sameAs https://app.dimensions.ai/details/publication/pub.1027975291
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1097/cmr.0b013e3282f62404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048595486
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1097/mnm.0b013e32827420cc schema:sameAs https://app.dimensions.ai/details/publication/pub.1038550720
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1097/mnm.0b013e32833cb8b7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020517094
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1111/j.1365-2133.2011.10247.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047226576
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1148/radiol.2493080240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047510232
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1200/jco.2009.23.4799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013277178
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1200/jco.2010.33.1884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003095481
178 rdf:type schema:CreativeWork
179 https://doi.org/10.2214/ajr.11.7280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069301940
180 rdf:type schema:CreativeWork
181 https://doi.org/10.2214/ajr.179.2.1790477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069324898
182 rdf:type schema:CreativeWork
183 https://doi.org/10.5402/2012/308279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033075442
184 rdf:type schema:CreativeWork
185 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
186 schema:name Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Wisløvparken 19, 3, 5000, Odense C, Denmark
187 Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark
188 Department of Radiology and Nuclear Medicine, Hospital of South West Jutland, Finsengade 10, 6700, Esbjerg, Denmark
189 rdf:type schema:Organization
190 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
191 schema:name Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark
192 Department of Oncology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark
193 Department of Plastic Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark
194 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...