Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry View Full Text


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Article Info

DATE

2015-07-17

AUTHORS

Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs, Anne Roivainen

ABSTRACT

BACKGROUND: This study evaluated the absorption, distribution, and excretion of Gallium-68 ((68)Ga) radionuclide after a single intravenous (i.v.) injection of (68)Ge/(68)Ga generator eluate in healthy rats. Additionally, human radiation doses were estimated from the rat data. METHODS: Twenty-one female and 21 male Sprague-Dawley rats were i.v. injected with 47 ± 4 MBq of (68)Ge/(68)Ga generator eluate, and the radioactivity of excised organs was measured using a gamma counter at 5, 30, 60, 120, or 180 min afterwards (n = 3-7 for each time point). The radioactivity concentration and plasma pharmacokinetic parameters were calculated. Subsequently, the estimates for human radiation dosimetry were determined. Additionally, 4 female and 5 male rats were positron emission tomography (PET) imaged for in vivo visualization of biodistribution. RESULTS: (68)Ga radioactivity was cleared relatively slowly from blood circulation and excreted into the urine, with some retention in the liver and spleen. Notably, the (68)Ga radioactivity in female genital organs, i.e., the uterus and ovaries, was considerable higher compared with male genitals. Extrapolating from the female and male rat (68)Ga data, the estimated effective dose was 0.0308 mSv/MBq for a 57-kg woman and 0.0191 mSv/MBq for a 70-kg man. CONCLUSIONS: The estimated human radiation burden of the (68)Ge/(68)Ga generator eluate was slightly higher for females and similar for males as compared with somatostatin receptor ligands (68)Ga-DOTANOC, (68)Ga-DOTATOC, and (68)Ga-DOTATATE, which is probably due to the retention in the liver and spleen. Our results revealed some differences between female and male rat data, which, at least in part, may be explained by the small sample size. More... »

PAGES

40

References to SciGraph publications

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  • 2007-09-14. 68Ga-DOTANOC: biodistribution and dosimetry in patients affected by neuroendocrine tumors in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-02-15. Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-l-tyrosine in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2010-01-13. Biodistribution and radiation dosimetry of [11C]choline: a comparison between rat and human data in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2009-10-02. 68Ga-Chloride PET Reveals Human Pancreatic Adenocarcinoma Xenografts in Rats—Comparison with FDG in MOLECULAR IMAGING AND BIOLOGY
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    http://scigraph.springernature.com/pub.10.1186/s13550-015-0117-z

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    http://dx.doi.org/10.1186/s13550-015-0117-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000296417

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26183032


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    74 radiation burden
    75 radiation doses
    76 radiation dosimetry
    77 radioactivity
    78 radioactivity concentration
    79 rat data
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    81 receptor ligands
    82 results
    83 retention
    84 sample size
    85 single intravenous injection
    86 size
    87 small sample size
    88 somatostatin receptor ligands
    89 spleen
    90 study
    91 tomography
    92 urine
    93 uterus
    94 visualization
    95 vivo visualization
    96 women
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