Evaluation of repeated [18F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12-16

AUTHORS

Antti Silvoniemi, Jonna Silén, Sarita Forsback, Eliisa Löyttyniemi, Aleksi R Schrey, Olof Solin, Reidar Grénman, Heikki Minn, Tove J Grönroos

ABSTRACT

BackgroundTumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emission tomography (PET) tracer [18F]EF5 and tumor growth. Our second goal was to assess the variability in the uptake of [18F]EF5 in tumor between two scans.MethodsFour human head and neck squamous cell carcinoma (UT-SCC) cell lines were xenografted in flank or neck of nude mice, and tumor size was closely monitored over the study period. The tumors were clearly visible when the first [18F]EF5 scan was acquired. After an exponential growth phase, the tumors were imaged again with [18F]EF5 and also with 18F-fluorodeoxyglucose ([18F]FDG).ResultsThere was a clear correlation between the percentage of tumor growth rate per day and the [18F]EF5 uptake in the latter scan (r = 0.766, p = 0.01). The uptake of [18F]EF5 in the first scan and the uptake of [18F]FDG did not significantly correlate with the tumor growth rate. We also observed considerable variations in the uptake of [18F]EF5 between the two scans.ConclusionsThe uptake of [18F]EF5 in the late phase of exponential tumor growth is associated with the tumor growth rate in mice bearing HNC xenografts. More... »

PAGES

65

References to SciGraph publications

  • 2002-01-01. Hypoxia — a key regulatory factor in tumour growth in NATURE REVIEWS CANCER
  • 2011-05-24. Targeting hypoxia in cancer therapy in NATURE REVIEWS CANCER
  • 2012-10-18. PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2011-03-30. Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [18F]EF5 in MOLECULAR IMAGING AND BIOLOGY
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    http://scigraph.springernature.com/pub.10.1186/s13550-014-0065-z

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    http://dx.doi.org/10.1186/s13550-014-0065-z

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    https://app.dimensions.ai/details/publication/pub.1005089959

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25977879


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