Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

William Duddy, Stephanie Duguez, Helen Johnston, Tatiana V Cohen, Aditi Phadke, Heather Gordish-Dressman, Kanneboyina Nagaraju, Viola Gnocchi, SiewHui Low, Terence Partridge

ABSTRACT

BACKGROUND: Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits our ability to evaluate the effectiveness of putative therapies or their relevance to DMD. METHODS: Accordingly, we have measured the main cellular components of muscle growth and regeneration over the period of postnatal growth and early pathology in mdx and wild-type (WT) mice; phalloidin binding is used as a measure of fibre size, myonuclear counts and BrdU labelling as records of myogenic activity. RESULTS: We confirm a two-phase postnatal growth pattern in WT muscle: first, increase in myonuclear number over weeks 1 to 3, then expansion of myonuclear domain. Mdx muscle growth lags behind that of WT prior to overt signs of pathology. Fibres are smaller, with fewer myonuclei and smaller myonuclear domains. Moreover, satellite cells are more readily detached from mdx than WT muscle fibres. At 3 weeks, mdx muscles enter a phase of florid myonecrosis, accompanied by concurrent regeneration of an intensity that results in complete replacement of pre-existing muscle over the succeeding 3 to 4 weeks. Both WT and mdx muscles attain maximum size by 12 to 14 weeks, mdx muscle fibres being up to 50% larger than those of WT as they become increasingly branched. Mdx muscle fibres also become hypernucleated, containing twice as many myonuclei per sarcoplasmic volume, as those of WT, the excess corresponding to the number of centrally placed myonuclei. CONCLUSIONS: The best-known consequence of lack of dystrophin that is common to DMD and the mdx mouse is the conspicuous necrosis and regeneration of muscle fibres. We present protocols for measuring this in terms both of loss of muscle nuclei previously labelled with BrdU and of the intensity of myonuclear labelling with BrdU administered during the regeneration period. Both measurements can be used to assess the efficacy of putative antinecrotic agents. We also show that lack of dystrophin is associated with a number of previously unsuspected abnormalities of muscle fibre structure and function that do not appear to be directly associated with myonecrosis. More... »

PAGES

16

References to SciGraph publications

  • 2013-06. Dystrophin deficiency leads to disturbance of LAMP1-vesicle-associated protein secretion in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2012-03-18. MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function in NATURE
  • 1985. Evidence for Defective Myoblasts in Duchenne Muscular Dystrophy in GENE EXPRESSION IN MUSCLE
  • 2012-12. Metabolic remodeling agents show beneficial effects in the dystrophin- deficient mdx mouse model in SKELETAL MUSCLE
  • 2014-12. Myofiber branching rather than myofiber hyperplasia contributes to muscle hypertrophy in mdx mice in SKELETAL MUSCLE
  • 2010-12-08. Golden Retriever Muscular Dystrophy (GRMD): Developing and Maintaining a Colony and Physiological Functional Measurements in MUSCLE GENE THERAPY
  • 1986-03. Skeletal muscle pathology in X chromosome-linked muscular dystrophy (mdx) mouse in ACTA NEUROPATHOLOGICA
  • 2010-06. Elevated satellite cell number in Duchenne muscular dystrophy in CELL AND TISSUE RESEARCH
  • 2006-07. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells in NATURE CELL BIOLOGY
  • 1986-09. The myoblast defect identified in Duchenne muscular dystrophy is not a primary expression of the DMD mutation in HUMAN GENETICS
  • 1990-11. Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: Implications for cell and gene therapy in SOMATIC CELL AND MOLECULAR GENETICS
  • 2014-12. Incidence and severity of myofiber branching with regeneration and aging in SKELETAL MUSCLE
  • 2010-12. Dynamics of muscle fibre growth during postnatal mouse development in BMC DEVELOPMENTAL BIOLOGY
  • 1988-12. Functional regeneration in the hindlimb skeletal muscle of the mdx mouse in JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13395-015-0041-y

    DOI

    http://dx.doi.org/10.1186/s13395-015-0041-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013649675

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25987977


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